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"Stern, M."
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Tommy Thompson : new-timey string band musician
\"Tommy Thompson was a banjo player, writer, actor, teacher and thinker. Drawing on interviews and writings from Thompson, his friends and family, the author depicts a life that revolved around music and creativity. Appendices cover Thompson's banjos, his discography and notes on his collaborative lyric writing\"-- Provided by publisher.
Book
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, and progression-associated dynamics. The overall lesional spectrum of T-PLL is mainly annotated to axes of DNA damage responses, T-cell receptor/cytokine signaling, and histone modulation. We formulate a multi-dimensional model of T-PLL pathogenesis centered around a unique combination of
TCL1
overexpression with damaging
ATM
aberrations as initiating core lesions. The effects imposed by TCL1 cooperate with compromised ATM toward a leukemogenic phenotype of impaired DNA damage processing. Dysfunctional ATM appears inefficient in alleviating elevated redox burdens and telomere attrition and in evoking a p53-dependent apoptotic response to genotoxic insults. As non-genotoxic strategies, synergistic combinations of p53 reactivators and deacetylase inhibitors reinstate such cell death execution.
T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy with a poor prognosis. Here, the authors investigate the genomic landscape, gene expression profiles and functional mechanisms in 111 patients, highlighting TCL1 overexpression and ATM aberrations as core lesions which co-operate to impair DNA damage processing.
Journal Article
Putting on the brakes : understanding and taking control of your ADD or ADHD
\"Self-help guide and resource for preteens with attention deficit disorder (ADD) or attention deficit-hyperactivity disorder (ADHD). Includes strategies to manage disorder and practical ways to improve organization, focus, studying, and homework skills. Also tips for making friends, controlling emotions, and being healthy\"-- Provided by publisher.
Book
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation
Genetically modified pig kidney xenografts were transplanted into two brain-dead human recipients. The xenografts functioned immediately and showed no evidence of acute rejection on serial biopsy over a period of 54 hours. The serum creatinine level decreased in both recipients.
Journal Article
The dyslexia checklist : a practical reference for parents and teachers
The book is filled with the most current research available on dyslexia, and contains a wealth of practical strategies, supports, and interventions.
Book
Coherent manipulation of Andreev states in superconducting atomic contacts
Coherent control of quantum states has been demonstrated in a variety of superconducting devices. In all of these devices, the variables that are manipulated are collective electromagnetic degrees of freedom: charge, superconducting phase, or flux. Here we demonstrate the coherent manipulation of a quantum system based on Andreev bound states, which are microscopic quasi-particle states inherent to superconducting weak links. Using a circuit quantum electrodynamics setup, we performed single-shot readout of this Andreev qubit. We determined its excited-state lifetime and coherence time to be in the microsecond range. Quantum jumps and parity switchings were observed in continuous measurements. In addition to having possible quantum information applications, such Andreev qubits are a test-bed for the physics of single elementary excitations in superconductors.
Journal Article
Paradise planned : the garden suburb and the modern city
\"From the same team that produced the monumental five-volume architectural history of New York comes the definitive work on the development of the garden suburb, a phenomenon that first emerged in England in the 1830s and still dominates residential architecture today\"-- Provided by publisher.
Book
MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor
Ewing sarcoma is a pediatric bone tumor characterized in 85% of cases by the fusion between
EWS
and
FLI1
genes that results in the expression of the EWS-FLI1 aberrant transcription factor. Histologically, the Ewing tumor expresses high levels of the CD99 membrane glycoprotein. It has been recently described that CD99 expression contributes to the Ewing tumor oncogenesis by modulating growth and differentiation of tumor cells. Different studies have also shown that overexpression of EWS-FLI1 induces CD99 expression in non-Ewing cells. At the opposite, the knockdown of EWS-FLI1 expression by siRNA approaches has no significant effect on CD99 mRNA level in Ewing cells. Here, by
in vivo
and
in vitro
studies, we show that while EWS-FLI1 inhibition has only slight effects on the amount of CD99 transcript, it induces a dramatic decrease of the CD99 protein expression level, hence suggesting post-transcriptional regulations, possibly mediated by microRNAs. To further investigate this issue, we identified a set of 91 miRNAs that demonstrate EWS-FLI1 modulation, three of them being predicted to bind CD99 3′ untranslated region (3′UTR). Among these, we show that miR-30a-5p has the ability to interact with the 3′UTR region of CD99 and to regulate its expression. Moreover, the re-expression of miRNA-30a-5p in Ewing cell line induces decreased cell proliferation and invasion. In this study, we therefore show that miR-30a-5p constitutes a major functional link between EWS-FLI1 and CD99, two critical biomarkers and therapeutic targets in Ewing sarcoma.
Journal Article
A proposal for the future of scientific publishing in the life sciences
Science advances through rich, scholarly discussion. More than ever before, digital tools allow us to take that dialogue online. To chart a new future for open publishing, we must consider alternatives to the core features of the legacy print publishing system, such as an access paywall and editorial selection before publication. Although journals have their strengths, the traditional approach of selecting articles before publication (\"curate first, publish second\") forces a focus on \"getting into the right journals,\" which can delay dissemination of scientific work, create opportunity costs for pushing science forward, and promote undesirable behaviors among scientists and the institutions that evaluate them. We believe that a \"publish first, curate second\" approach with the following features would be a strong alternative: authors decide when and what to publish; peer review reports are published, either anonymously or with attribution; and curation occurs after publication, incorporating community feedback and expert judgment to select articles for target audiences and to evaluate whether scientific work has stood the test of time. These proposed changes could optimize publishing practices for the digital age, emphasizing transparency, peer-mediated improvement, and post-publication appraisal of scientific articles.
Journal Article