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Learn how to succeed in the digital economy The paradigms of big business have changed. Business models that were once lucrative now seem to barely move the needle. Incumbents of the old guard find themselves superseded by new, digitally-charged, data-fuelled organisations that leverage platform-based business models. How can pre-digital businesses survive? They're loaded with resources, brand power and deeply embedded networks, they just need a new playbook. Chasing Digital is that playbook. Outlining a clear and detailed framework, this book is designed to help leaders re-design their organisation from the bottom up by leveraging their strengths to create a new competitive advantage in the digital economy. From laying the foundations of transformation: developing a considered strategy, growing a conducive culture and building a receptive organisational design; to building core digital capabilities: taking advantage of data, harnessing artificial intelligence and embracing appropriate platforms; to adapting the accelerators of change: navigating board expectations, mitigating potential roadblocks and making the right investments, this playbook will give you the tools and mindsets needed to not only survive but to thrive and leave a legacy for future leaders. Integrate technology into your business strategy and culture Prioritise and manage your company's digital transition Create opportunities for fast and intentional digital growth Learn how to minimise friction with stakeholders Cut through the jargon and hype, and focus on what is critical to undertaking a truly successful, company-wide, digital transformation. In a world where digital is changing everything, Chasing Digital will help your organisation to transition beyond old business models to adopt the new digital paradigm and a new era of business. Embrace the chase.

Retroviruses are the aetiological agents of a range of human diseases including AIDS and T-cell leukaemias. They follow complex life cycles, which are still only partly understood at the molecular level. Maturation of newly formed retroviral particles is an essential step in production of infectious virions, and requires proteolytic cleavage of Gag polyproteins in the immature particle to form the matrix, capsid and nucleocapsid proteins present in the mature virion 1 . Capsid proteins associate to form a dense viral core 2 that may be spherical, cylindrical or conical depending on the genus of the virus 3 . Nonetheless, these assemblies all appear to be composed of a lattice formed from hexagonal rings, each containing six capsid monomers 2 , 4 , 5 . Here, we describe the X-ray structure of an individual hexagonal assembly from N-tropic murine leukaemia virus (N-MLV). The interface between capsid monomers is generally polar, consistent with weak interactions within the hexamer. Similar architectures are probably crucial for the regulation of capsid assembly and disassembly in all retroviruses. Together, these observations provide new insights into retroviral uncoating and how cellular restriction factors may interfere with viral replication.

•No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by caesarean section in the highest educational group had a reduced risk of ALL (NS). Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo. Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI). We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69). We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL.

A small molecule called EMD 57033 can repair motor proteins that have stopped working as a result of stress.A small molecule called EMD 57033 can repair motor proteins that have stopped working as a result of stress.

Learn how to succeed in the digital economyThe paradigms of big business have changed. Business models that were once lucrative now seem to barely move the needle. Incumbents of the old guard find themselves superseded by new, digitally-charged, data-fuelled organisations that leverage platform-based business models. How can pre-digital businesses survive? They’re loaded with resources, brand power and deeply embedded networks, they just need a new playbook. Chasing Digital is that playbook.Outlining a clear and detailed framework, this book is designed to help leaders re-design their organisation from the bottom up by leveraging their strengths to create a new competitive advantage in the digital economy. From laying the foundations of transformation: developing a considered strategy, growing a conducive culture and building a receptive organisational design; to building core digital capabilities: taking advantage of data, harnessing artificial intelligence and embracing appropriate platforms; to adapting the accelerators of change: navigating board expectations, mitigating potential roadblocks and making the right investments, this playbook will give you the tools and mindsets needed to not only survive but to thrive and leave a legacy for future leaders.Integrate technology into your business strategy and culturePrioritise and manage your company’s digital transitionCreate opportunities for fast and intentional digital growthLearn how to minimise friction with stakeholdersCut through the jargon and hype, and focus on what is critical to undertaking a truly successful, company-wide, digital transformation. In a world where digital is changing everything, Chasing Digital will help your organisation to transition beyond old business models to adopt the new digital paradigm and a new era of business. Embrace the chase.

Indigenous educational sovereignty is a question of equity and self-determination. Indigenous/non-Indigenous collaborations in practices of Indigenous educational sovereignty present pressing tensions and challenges to be negotiated. Speaking particularly to non-Indigenous scholar-educators, this article furthers understanding of the role(s) and responsibilities of non-Indigenous collaborators in support of community-driven educational sovereignty. Within the frameworks of Critical Indigenous Research Methodologies and Critical Discourse Studies, issues of when, where, and in what ways non-Indigenous scholar-educators may productively serve as allies in processes of community-driven education are addressed. Utilizing vignettes from the author's research and personal experience as a White scholar-educator collaborating with Indigenous communities, examples push beyond simple recognition of power relationships and move toward conscious allied power negotiation. This article concludes that alliance building between Indigenous and non-Indigenous scholar-educators requires increased emphasis on praxis-oriented relationships which explicitly redress asymmetrical movements of power in current institutions of education, to better support Indigenous educational sovereignty.