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Worldwide, native predators are killed to protect livestock, an action that can undermine wildlife conservation efforts and create conflicts among stakeholders. An ongoing example is occurring in the western United States, where wolves (Canis lupus) were eradicated by the 1930s but are again present in parts of their historic range. While livestock losses to wolves represent a small fraction of overall livestock mortality, the response to these depredations has resulted in widespread conflicts including significant efforts at lethal wolf control to reduce impacts on livestock producers, especially those with large-scale grazing operations on public lands. A variety of nonlethal methods have proven effective in reducing livestock losses to wolves in small-scale operations but in large-scale, open-range grazing operations, nonlethal management strategies are often presumed ineffective or infeasible. To demonstrate that nonlethal techniques can be effective at large scales, we report a 7-year case study where we strategically applied nonlethal predator deterrents and animal husbandry techniques on an adaptive basis (i.e., based on terrain, proximity to den or rendezvous sites, avoiding overexposure to techniques such as certain lights or sound devices that could result in wolves losing their fear of that device, etc.) to protect sheep (Ovis aries) and wolves on public grazing lands in Idaho. We collected data on sheep depredation mortalities in the protected demonstration study area and compared these data to an adjacent wolf-occupied area where sheep were grazed without the added nonlethal protection measures. Over the 7-year period, sheep depredation losses to wolves were 3.5 times higher in the Nonprotected Area (NPA) than in the Protected Area (PA). Furthermore, no wolves were lethally controlled within the PA and sheep depredation losses to wolves were just 0.02% of the total number of sheep present, the lowest loss rate among sheep-grazing areas in wolf range statewide, whereas wolves were lethally controlled in the NPA. Our demonstration project provides evidence that proactive use of a variety of nonlethal techniques applied conditionally can help reduce depredation on large open-range operations.

1. While the return of wolves (Canis lupus) to many European countries is a conservation milestone, the negative impacts are unevenly distributed across society, placing high pressure on livestock grazing systems. 2. For this perspective, scientists from diverse disciplines and geographical backgrounds reflect on the state of livestock–wolf interactions in Europe and formulate recommendations for enabling wolf–livestock coexistence. 3. We argue that co-designing, co-implementing and co-disseminating research with key stakeholders, such as livestock farmers, is a productive approach to developing and implementing locally appropriate coexistence strategies. 4. Decision-making should be informed by scientific evidence. We recommend that ecological data on wolves and livestock are collected and shared across borders. Evidence from the social sciences is important for understanding the human dimension of wolf–livestock interactions. 5. We suggest bridging the gaps within multidisciplinary wolf–livestock research to strengthen interdisciplinary insights, comprehensively evaluate management approaches and guide governance and policy decisions that properly account for inherent complexities. 6. Policy implications: As wolf populations and their impacts continue to grow in Europe, policymakers at all levels must make decisions that adequately safeguard wolf populations while simultaneously protecting livestock and livelihoods. This requires access to reliable scientific evidence. adaptive management, Canis lupus, co-implementation, grazing systems, human–wildlife coexistence, interdisciplinary research, science communication, stakeholder engagement

An important and under-quantified facet of the risks associated with human-induced climate change emerges through extreme weather. In this paper, we present an initial attempt to quantify recent costs related to extreme weather due to human interference in the climate system, focusing on economic costs arising from droughts and floods in New Zealand during the decade 2007–2017. We calculate these using previously collected information about the damages and losses associated with past floods and droughts, and estimates of the “fraction of attributable risk” that characterizes each event. The estimates we obtain are not comprehensive, and almost certainly represent an underestimate of the full economic costs of climate change, notably chronic costs associated with long-term trends. However, the paper shows the potential for developing a new stream of information that is relevant to a range of stakeholders and research communities, especially those with an interest in the aggregation of the costs of climate change or the identification of specific costs associated with potential liability.

What do \"microbes\" have to do with social equity? These microorganisms are integral to our health, that of our natural environment, and even the \"health\" of the environments we build. The loss, gain, and retention of microorganisms-their flow between humans and the environment-can greatly impact our health. It is well-known that inequalities in access to perinatal care, healthy foods, quality housing, and the natural environment can create and arise from social inequality. Here, we focus on the argument that access to beneficial microorganisms is a facet of public health, and health inequality may be compounded by inequitable microbial exposure.

Antibiotic-resistant Staphylococcus aureus remains a leading cause of antibiotic resistance-associated mortality in the United States. Given the reality of multi-drug resistant infections, it is imperative that we establish and maintain a pipeline of new compounds to replace or supplement our current antibiotics. A first step towards this goal is to prioritize targets by identifying the genes most consistently required for survival across the S. aureus phylogeny. Here we report the first direct comparison of multiple strains of S. aureus via transposon sequencing. We show that mutant fitness varies by strain in key pathways, underscoring the importance of using more than one strain to differentiate between core and strain-dependent essential genes. We treated the libraries with daptomycin to assess whether the strain-dependent differences impact pathways important for survival. Despite baseline differences in gene importance, several pathways, including the lipoteichoic acid pathway, consistently promote survival under daptomycin exposure, suggesting core vulnerabilities that can be exploited to resensitize daptomycin-nonsusceptible isolates. We also demonstrate the merit of using transposons with outward-facing promoters capable of overexpressing nearby genes for identifying clinically-relevant gain-of-function resistance mechanisms. Together, the daptomycin vulnerabilities and resistance mechanisms support a mode of action with wide-ranging effects on the cell envelope and cell division. This work adds to a growing body of literature demonstrating the nuanced insights gained by comparing Tn-Seq results across multiple bacterial strains.

Although the detrimental influence of parenting stress on child problem behavior is well established, it remains unknown how these constructs affect each other over time. In accordance with a transactional model, this study investigates how the development of internalizing and externalizing problems is related to the development of parenting stress in children aged 4–9. Mothers of 1582 children participated in three one-year interval data waves. Internalizing and externalizing problems as well as parenting stress were assessed by maternal self-report. Interrelated development of parenting with internalizing and externalizing problems was examined using Latent Growth Modeling. Directionality of effects was further investigated by using cross-lagged models. Parenting stress and externalizing problems showed a decrease over time, whereas internalizing problems remained stable. Initial levels of parenting stress were related to initial levels of both internalizing and externalizing problems. Decreases in parenting stress were related to larger decreases in externalizing problems and to the (stable) course of internalizing problems. Some evidence for reciprocity was found such that externalizing problems were associated with parenting stress and vice versa over time, specifically for boys. Our findings support the transactional model in explaining psychopathology.

Weather and climate service providers around the world are looking to issue assessments of the human role in recent extreme weather events. For this attribution to be of value, it is important that vulnerability is acknowledged and questions are framed appropriately.

Real-world data encompass data primarily captured for the provision or operation of services, for example, electronic health records for direct care purposes, but which may have secondary uses for informing research or commissioning. Public benefit is potentially forfeited by the underutilisation of real-world data for secondary uses, in part due to risk aversion when faced with the prospect of navigating necessary and important data governance processes. Such processes can be perceived as complex, daunting, time-consuming and exposing organisations to risk. By providing an overview description and discussion around the role of six key legal and information governance frameworks and their role regarding responsible data access, linkage and sharing, our intention is to make data governance a less daunting prospect and reduce the perception that it is a barrier to secondary uses, thus enabling public benefit.

Cyclone Gabrielle passed along the northern coast of Aotearoa New Zealand in February 2023, producing historic rainfall accumulations and impacts. Gabrielle was an ex‐tropical cyclone that stalled and re‐energised off the north coast, resembling descriptions of worst case scenarios for the northeast of the country. Here we report on a comparison of the actual forecast of the storm against forecasts under conditions representative of a climate without anthropogenic interference and of a climate +2.0°C warmer than pre‐industrial (about 1.0°C cooler and warmer than present respectively). We find that regional total rainfall accumulations from a Gabrielle‐like storm are about 10% higher because of the historical anthropogenic warming, and will increase by a larger amount under similar future warming. These differences are driven by a 20% (relative to a non‐anthropogenic world) to 30% (relative to a +2.0°C world) rise in peak rainfall rates, which in turn is mainly driven by a more temporally concentrated column‐integrated moisture flux. The forecast model generates the larger increase for the +2.0°C world through greater precipitation efficiency, reflecting the importance of unresolved precipitation processes in the climate change response of rainfall extremes. Plain Language Summary Tropical Cyclone Gabrielle formed in the Coral Sea in February 2023, then moved southeast and passed along the northern coast of Aotearoa New Zealand as an ex‐tropical cyclone. The storm's rainfall produced one of the worst natural disasters in the country's history. We compare the weather forecast of the storm against forecasts in which past anthropogenic warming is removed and in which future warming is added. We find that the storm would have dumped about 10% less total rainfall and 20% less peak hourly rainfall without human interference. A similar future amount of warming will result in a comparable total increase in storm rainfall but with about a 30% increase in the peak hourly rate. Key Points Cyclone Gabrielle delivered large amounts of rain to northeastern Aotearoa New Zealand in February 2023 Anthropogenic warming increases the total amount of rain delivered by a Gabrielle‐like storm by about 10%/°C Anthropogenic warming increases the peak amount of rain delivered by a Gabrielle‐like storm by about 20%–30%/°C