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When Lew, Gary, and Lugnut are trapped in their middle school basement, they discover that at night it becomes the domain of zombie teachers and students--will they survive or be forced to join the undead?

When I was growing up in the beautiful Red Lick Valley in eastern Kentucky, I saw many families practicing intensive subsistence production. They grew large gardens, raised chickens for eggs and meat, built their own homes, and fixed their own cars and trucks. On the Yurok Reservation, I again saw a profound and ongoing engagement with hunting, gathering, and crafting activities - and then encountered contemporary subsistence yet again when I visited my wife's childhood home in rural Ireland. When I began my graduate studies, however, I could find little reflection of these activities in either the scholarly record or popular media. When they were noticed at all, they were often targeted for stereotyped ridicule: contemporary homesteaders in the US were either remnant hippies from the `60s, or quaint mountain folks lost in time. I already knew that these stereotypes were misleading and insufficient. However, they also highlighted the lack of understanding of a genuinely puzzling phenomenon: why, in the heart of an advanced industrial nation, are so many people still embracing what is, in essence, peasant production? Using multiple research methods - including in-depth, semi-structured interviews, participant observation, surveys, and archival work - I have found that contemporary homesteading is not a window lingering open upon the past, but a thoughtful and serious attempt to respond to the present. It is best thought of as an unusual kind of social movement. Rather than attempting to foster change by modifying policy or reforming dominant institutions, homesteaders pursue change through a conscious reworking of the economic foundations of their lives. Barbara Epstein calls this a \"prefigurative\" strategy: it aims to directly manifest - to prefigure - ways of life and relationships that dissidents believe are more appropriate. Because they do not require the visible organizational armature and attention-grabbing strategies of more traditional social movements, prefigurative movements - like the back-to-the-land movement - have often been overlooked by researchers. Contemporary homesteading is also an unusual social movement in that it attracts participants from widely different socioeconomic backgrounds. In eastern Kentucky there is an acute cultural distinction between two groups, known to each other, somewhat pejoratively, as hicks and hippies. I have found that neither group is accurately described by the dismissive stereotypes to which they are often subjected. There is indeed a countercultural back-to-the-land movement in the research area that emerged originally out of the radical leftist ferment of the 1960s. But rather than representing a dwindling cohort of aging hippie communards, this movement is comprised of people of all ages; my research suggests that there are more back-to-the-landers in the area now than there were forty years ago. Moreover, it is a movement comprised of a multi-stranded left, in which participants are as likely to have been radicalized through, say, the Quaker tradition or Catholic liberation theology as through the Grateful Dead or Timothy Leary. The stereotype of the \"hick\" homesteaders is no more accurate. They are not simply country folks carrying on Appalachian subsistence traditions despite the fact that those traditions have lost all practical relevance. Many of them have lived in cities and worked modern jobs, and consciously embrace homesteading in response to those experiences. They, too, are part of a back-to-the-land movement, in the sense of having chosen to live a certain way as a strategy of resistance. The presence of two groups who embrace homesteading, and yet remain distinct and somewhat distanced from one another provides one of the most profound and difficult questions that my research confronts. While there are individuals who move freely between these two groups, in general they remain remarkably segregated - even when they live side by side along the same country road. What accounts for this cultural distance? Whatever the difference between \"hick\" and \"hippie\" homesteaders, it is not straightforward: nearly half of those who can clearly be identified as belonging to the group of \"countercultural back-to-the-land homesteaders\" are themselves from rural Appalachian families. By far, the single most consistent difference between these two groups is that one group is not only college educated, but actively and independently literate; members of the other group, with few exceptions, have not attended college and seldom read. But this finding begs another question: why should a difference in the practice of literate intellectuality stand at the heart of profound cultural differences that encompass everything from diet and diction to religious belief and political orientation? The answer is complicated, but it emerges from the recognition that a modern capitalist society is one in which people have profoundly different experiences in all aspects of their lives, from cradle to grave, based on their socioeconomic position. As children, they attend radically different kinds of schools, or are slotted into separate tracks within a given school. After they leave school they have access to different kinds of jobs - shelving products at Wal-Mart, say, versus teaching in a college classroom. When people spend decades of their lives working such jobs, they end up with such divergent life experiences that they might as well be living in different societies. These divided institutional experiences are reinforced in turn by sharp segregation and by the development of opposition to the culture of those in other socioeconomic positions. The command or lack of literate intellectuality plays multiple roles in shaping and sustaining these starkly distinct life experiences, perhaps most clearly by shaping how a particular individual moves through the positions provided by dominant institutions. Taken together, these dynamics culminate in a forceful process that I refer to as \"capitalist ethnogenesis\": a process of cultural differentiation within a single society, rather than through geographic separation within separate, non-interacting or weakly interacting societies. The homesteading movement contains two groups who turn to the rural landscape for answers to the problems of modern civilization - but how they perceive and interpret that civilization and its problems are markedly different. They are, in effect, responding to different modernities. They turn to homesteading as people indelibly marked by the system they dream of escaping.

\"Your Future Is Bright! After all, your mother is a robot, your father has joined the alien hive mind, and your dinner will be counterfeit 3D-printed steak. Even though your worker bots have staged a mutiny, and your tour guide speaks only in memes, you can always sell your native language if you need some extra cash.\" -- From publisher's description.

\"The concert series is about bringing some of the best performers in the world to Marquette to play on campus, while at the same time exposing people to different cultures and different musical genres,\" Truckey said.

Keelan has lightning speed, his work ethic is excellent and his balance is outstanding, but his biggest strength is that he can play rugby because he understands the game and what to do.

The term ‘artificial intelligence’ has arguably come to function in political discourse as, what Laclau called, an ‘empty signifier’. This article traces the shifting political discourse on AI within three key institutions of global governance–OHCHR, WHO, and UNESCO–and, in so doing, highlights the role of ‘crisis’ moments in justifying a series of pivotal re-articulations. Most important has been the attachment of AI to the narrative around digital automation in human healthcare. Greatly enabled by the societal context of the pandemic, all three institutions have moved from being critical of the unequal power relations in the economy of AI to, today, reframing themselves primarily as facilitators tasked with helping to ensure the application of AI technologies. The analysis identifies a shift in which human health and healthcare is framed as in a ‘crisis’ to which AI technology is presented as the remedy. The article argues the need to trace these discursive shifts as a means by which to understand, monitor, and where necessary also hold to account these changes in the governance of AI in society.

The global biodiversity crisis has invigorated the search for generalized patterns in most disciplines within the natural sciences. Studies based on organismal functional traits attempt to broaden implications of results by identifying the response of functional traits, instead of taxonomic units, to environmental variables. Determining the functional trait responses enables more direct comparisons with, or predictions for, communities of different taxonomic composition. The North American freshwater fish fauna is both diverse and increasingly imperiled through human mediated disturbances, including climate change. The Tennessee River, USA, contains one of the most diverse assemblages of freshwater fish in North America and has more imperiled species than other rivers, but there has been no trait-based study of community structure in the system. We identified 211 localities in the upper Tennessee River that were sampled by the Tennessee Valley Authority between 2009 and 2011 and compiled fish functional traits for the observed species and environmental variables for each locality. Using fourth corner analysis, we identified significant correlations between many fish functional traits and environmental variables. Functional traits associated with an opportunistic life history strategy were correlated with localities subject to greater land use disturbance and less flow regulation, while functional traits associated with a periodic life history strategy were correlated with localities subject to regular disturbance and regulated flow. These are patterns observed at the continental scale, highlighting the generalizability of trait-based methods. Contrary to studies that found no community structure differences when considering riparian buffer zones, we found that fish functional traits were correlated with different environmental variables between analyses with buffer zones vs. entire catchment area land cover proportions. Using existing databases and fourth corner analysis, our results support the broad application potential for trait-based methods and indicate trait-based methods can detect environmental filtering by riparian zone land cover.

Global temperature changes have emphasized the need to understand how species adapt to thermal stress across their ranges. Genetic mechanisms may contribute to variation in thermal tolerance, providing evidence for how organisms adapt to local environments. We determine physiological thermal limits and characterize genome-wide transcriptional changes at these limits in bumble bees using laboratory-reared Bombus vosnesenskii workers. We analyze bees reared from latitudinal (35.7–45.7°N) and altitudinal (7–2154 m) extremes of the species’ range to correlate thermal tolerance and gene expression among populations from different climates. We find that critical thermal minima (CT MIN ) exhibit strong associations with local minimums at the location of queen origin, while critical thermal maximum (CT MAX ) was invariant among populations. Concordant patterns are apparent in gene expression data, with regional differentiation following cold exposure, and expression shifts invariant among populations under high temperatures. Furthermore, we identify several modules of co-expressed genes that tightly correlate with critical thermal limits and temperature at the region of origin. Our results reveal that local adaptation in thermal limits and gene expression may facilitate cold tolerance across a species range, whereas high temperature responses are likely constrained, both of which may have implications for climate change responses of bumble bees.

AbstractObjectivesTo determine whether patient reported outcomes improve after single stage versus two stage revision surgery for prosthetic joint infection of the hip, and to determine the cost effectiveness of these procedures.DesignPragmatic, parallel group, open label, randomised controlled trial.SettingHigh volume tertiary referral centres or orthopaedic units in the UK (n=12) and in Sweden (n=3), recruiting from 1 March 2015 to 19 December 2018.Participants140 adults (aged ≥18 years) with a prosthetic joint infection of the hip who required revision (65 randomly assigned to single stage and 75 to two stage revision).InterventionsA computer generated 1:1 randomisation list stratified by hospital was used to allocate participants with prosthetic joint infection of the hip to a single stage or a two stage revision procedure.Main outcome measuresThe primary intention-to-treat outcome was pain, stiffness, and functional limitations 18 months after randomisation, measured by the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) score. Secondary outcomes included surgical complications and joint infection. The economic evaluation (only assessed in UK participants) compared quality adjusted life years and costs between the randomised groups.ResultsThe mean age of participants was 71 years (standard deviation 9) and 51 (36%) were women. WOMAC scores did not differ between groups at 18 months (mean difference 0.13 (95% confidence interval −8.20 to 8.46), P=0.98); however, the single stage procedure was better at three months (11.53 (3.89 to 19.17), P=0.003), but not from six months onwards. Intraoperative events occurred in five (8%) participants in the single stage group and 20 (27%) in the two stage group (P=0.01). At 18 months, nine (14%) participants in the single stage group and eight (11%) in the two stage group had at least one marker of possible ongoing infection (P=0.62). From the perspective of healthcare providers and personal social services, single stage revision was cost effective with an incremental net monetary benefit of £11 167 (95% confidence interval £638 to £21 696) at a £20 000 per quality adjusted life years threshold (£1.0; $1.1; €1.4).ConclusionsAt 18 months, single stage revision compared with two stage revision for prosthetic joint infection of the hip showed no superiority by patient reported outcome. Single stage revision had a better outcome at three months, fewer intraoperative complications, and was cost effective. Patients prefer early restoration of function, therefore, when deciding treatment, surgeons should consider patient preferences and the cost effectiveness of single stage surgery.Trial registrationISRCTN registry ISRCTN10956306.

Stress-induced islet graft loss during the peri-transplantation period reduces the efficacy of islet transplantation. In this prospective, randomized, double-blind clinical trial, we evaluated the safety and efficacy of 60 mg/kg human alpha-1 antitrypsin (AAT) or placebo infusion weekly for four doses beginning before surgery in chronic pancreatitis (CP) patients undergoing total pancreatectomy and islet autotransplantation (TP-IAT). Subjects were followed for 12 months post-TP-IAT. The dose of AAT was safe, as there was no difference in the types and severity of adverse events in participants from both groups. There were some biochemical signals of treatment effect with a higher oxygen consumption rate in AAT islets before transplantation and a lower serum C-peptide (an indicator of islet death) in the AAT group at 15 min after islet infusion. Findings per the statistical analysis plan using a modified intention to treat analysis showed no difference in the C-peptide area under the curve (AUC) following a mixed meal tolerance test at 12 months post-TP-IAT. There was no difference in the secondary and exploratory outcomes. Although AAT therapy did not show improvement in C-peptide AUC in this study, AAT therapy is safe in CP patients and there are experiences gained on optimal clinical trial design in this challenging disease.