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"Strzyz, Paulina"
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ATP and ROS signal cell extrusion
Mori et al. identify ATP and reactive oxygen species as key upstream cues for cell extrusion.
Journal Article
CRISPR–Cas9 wins Nobel
The discovery of the CRISPR–Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.
Journal Article
AMPK against NASH
A new study in Science shows that AMPK is an inhibitor of caspase 6-driven hepatic cell death in non-alcoholic steatohepatitis.
Journal Article
microRNA communication in plants
Betti et al. show that plants can take up microRNAs generated by other plants, and that these exogenous miRNAs are active in silencing the expression of their target genes.
Journal Article
Chaperoning solid aggregates for autophagy
Ma et al. show the role of CCT2, a chaperonin TRiC subunit, in aggrephagy, specifically in the removal of mature, solid-like protein aggregates.
Journal Article
Drugs enter a liquid phase
Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.
Journal Article
The healing role of gasdermin B in IBD
Rana et al. show that in the gut epithelium, gasdermin B has an inherent, non-pyroptotic function, supporting the maintenance of the epithelial barrier when challenged with inflammatory damage.
Journal Article
Alternative cycle for citrate
Arnold et al. document an alternative tricarboxylic acid cycle that takes place between the mitochondria and the cytosol and that can be adopted in specific cell states.
Journal Article
Lysosome transport interrupted
Roney et al. show that neuronal loss in Niemann-Pick disease type C is associated with the impairment of lysosome trafficking by cholesterol that accumulates on lysosome membranes.
Journal Article
Big cells, small potential
Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.
Journal Article