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Cities in motion : urban life and cosmopolitanism in Southeast Asia, 1920-1940
\"In the 1920s and 1930s, the port cities of Southeast Asia were staging grounds for diverse groups of ordinary citizens to experiment with modernity, as a rising Japan and the growth of American capitalism challenged the predominance of European empires after the First World War. Both migrants and locals played a pivotal role in shaping civic culture. Moving away from a nationalist reading of the period, Su Lin Lewis explores layers of cross-cultural interaction in various spheres: the urban built environment, civic associations, print media, education, and popular culture. While the book focuses on Penang, Rangoon, and Bangkok - three cities born amidst British expansion in the region - it explores connected experiences across Asia and in Asian intellectual enclaves in Europe. Cosmopolitan sensibilities were severely tested in the era of post-colonial nationalism, but are undergoing a resurgence in Southeast Asia's civil society and creative class today\"-- Provided by publisher.
Book
BERT-Based Approaches to Identifying Malicious URLs
Malicious uniform resource locators (URLs) are prevalent in cyberattacks, particularly in phishing attempts aimed at stealing sensitive information or distributing malware. Therefore, it is of paramount importance to accurately detect malicious URLs. Prior research has explored the use of deep-learning models to identify malicious URLs, using the segmentation of URL strings into character-level or word-level tokens, and embedding and employing trained models to differentiate between URLs. In this study, a bidirectional encoder representation from a transformers-based (BERT) model was devised to tokenize URL strings, employing its self-attention mechanism to enhance the understanding of correlations among tokens. Subsequently, a classifier was employed to determine whether a given URL was malicious. In evaluating the proposed methods, three different types of public datasets were utilized: a dataset consisting solely of URL strings from Kaggle, a dataset containing only URL features from GitHub, and a dataset including both types of data from the University of New Brunswick, namely, ISCX 2016. The proposed system achieved accuracy rates of 98.78%, 96.71%, and 99.98% on the three datasets, respectively. Additionally, experiments were conducted on two datasets from different domains—the Internet of Things (IoT) and Domain Name System over HTTPS (DoH)—to demonstrate the versatility of the proposed model.
Journal Article
فن الرسم الصيني
يوضح كتاب (فن الرسم الصيني) تأليف لين تسي فإن الإنجازات في صناعة الفخار الملون للحضارة البرونزية مهدت لظهور الخزف الصيني، كانت الأواني الفخارية والبرونزية والخزفية من أهم الناقلات للرسوم الصينية في قديم الزمان، وكان الرسامون للصور على هذه الأواني مجهولين، على سبيل المثال كان الرسامون للصور الملونة على الأواني الفخارية هم النساء، اللاتي ينتمين إلى القبائل التي لم تلبث أن اعتادت المعيشة المستقرة التي تسودها الزراعة، أما الرسامون للصور على الأواني البرونزية والخزفية فهم الحرفيون في العصر الإقطاعي الصيني، واعتبرت مهنة الرسام حقيرة جدا، فمن الصعب أن يسجل الرسام اسمه في التاريخ حتى ولو كان رساما ماهرا يعمل للأسرة الملكية فقط، وتنقسم الرسوم الصينية إلى نوعين حسب رساميها : الرسوم التي يرسمها المحترفون، والرسوم التي يرسمها المثقفون.
BOOK
Breakthrough applications of high-entropy materials
The concept of high-entropy alloys has been extended to ceramics, polymers, and composites. “High-entropy materials (HEMs)” are named to cover all these materials. Recently, HEMs has become a new emerging field through the collective efforts of many researchers. Basically, high mixing entropy can enhance the formation of solution-type phases for alloys, ceramics, and composites at high temperatures, and in general leads to simpler microstructure. Large degrees of freedom in composition design as well as process design have been found to provide a wide range of microstructure and properties for applications. There are many opportunities for HEMs to overcome the bottlenecks of conventional materials. In this article, several possible breakthrough applications are pointed out and emphasized for turbine blades, thermal spray bond coatings, high-temperature molds and dies, sintered carbides for cutting tools, hard coatings for cutting tools, hardfacings, and radiation-damage resistant materials. In addition, more possible breakthrough examples are briefly described.
Journal Article
The cabinet
Cabinet 13 looks like a normal filing cabinet, but it's filled with files on \"symptomers\"--People with weird abilities and bizarre experiences. And harried Mr. Kong, who is the office worker responsible for the cabinet, must deal with all the symptomers who call the office looking for help. A richly funny and fantastical novel about the strangeness at the heart of even the most everyday lives, from one of South Korea's most acclaimed novelists
Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
Neurodegenerative diseases represent a significant unmet medical need in our aging society. There are no effective treatments for most of these diseases, and we know comparatively little regarding pathogenic mechanisms. Among the challenges faced by those involved in developing therapeutic drugs for neurodegenerative diseases, the syndromes are often complex, and small animal models do not fully recapitulate the unique features of the human nervous system. Human induced pluripotent stem cells (iPSCs) are a novel technology that ideally would permit us to generate neuronal cells from individual patients, thereby eliminating the problem of species-specificity inherent when using animal models. Specific phenotypes of iPSC-derived cells may permit researchers to identify sub-types and to distinguish among unique clusters and groups. Recently, iPSCs were used for drug screening and testing for neurologic disorders including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), spinocerebellar atrophy (SCA), and Zika virus infection. However, there remain many challenges still ahead, including how one might effectively recapitulate sporadic disease phenotypes and the selection of ideal phenotypes and for large-scale drug screening. Fortunately, quite a few novel strategies have been developed that might be combined with an iPSC-based model to solve these challenges, including organoid technology, single-cell RNA sequencing, genome editing, and deep learning artificial intelligence. Here, we will review current applications and potential future directions for iPSC-based neurodegenerative disease models for critical drug screening.
Journal Article
CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain
Circular RNAs are non-coding RNAs, and are enriched in the CNS. Dorsal horn neurons of the spinal cord contribute to pain-like hypersensitivity after nerve injury in rodents. Here we show that spinal nerve ligation is associated with an increase in expression of circAnks1a in dorsal horn neurons, in both the cytoplasm and the nucleus. Downregulation of circAnks1a by siRNA attenuates pain-like behaviour induced by nerve injury. In the cytoplasm, we show that circAnks1a promotes the interaction between transcription factor YBX1 and transportin-1, thus facilitating the nucleus translocation of YBX1. In the nucleus, circAnks1a binds directly to the
Vegfb
promoter, increases YBX1 recruitment to the
Vegfb
promoter, thereby facilitating transcription. Furthermore, cytoplasmic circAnks1a acts as a miRNA sponge in miR-324-3p-mediated posttranscriptional regulation of VEGFB expression. The upregulation of VEGFB contributes to increased excitability of dorsal horn neurons and pain behaviour induced by nerve injury. We propose that circAnks1a and VEGFB are regulators of neuropathic pain.
Circular RNAs are non-coding RNAs that are enriched in the CNS, but their role in chronic pain is not known. Here the authors show that CircAnks1a in dorsal horn neurons contributes to pain-like hypersensitivity in a rodent model of neuropathic pain, via a VEGF mechanism.
Journal Article
Clinical application and mechanism of traditional Chinese medicine in treatment of lung cancer
Lung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in vitro and in vivo. We summarized the recent 5 years of different research progress on clinical applications and antitumor mechanisms of TCM in the treatment of lung cancer. As a potent adjuvant therapy, TCM could enhance conventional treatments (chemotherapy, radiation therapy, and epidermal growth factor receptors [EGFRs] tyrosine kinase inhibitors [TKIs]) effects as well as provide synergistic effects, enhance chemotherapy drugs chemosensitivity, reverse drug resistance, reduce adverse reactions and toxicity, relieve patients' pain and improve quality of life (QOL). After treating with TCM, lung cancer cells will induce apoptosis and/or autophagy, suppress metastasis, impact immune reaction, and therapeutic effect of EGFR-TKIs. Therefore, TCM is a promisingly potent adjuvant therapy in the treatment of lung cancer and its multiple mechanisms are worthy of an in-depth study.
Journal Article
Transferring Xenogenic Mitochondria Provides Neural Protection against Ischemic Stress in Ischemic Rat Brains
Transferring exogenous mitochondria has therapeutic effects on damaged heart, liver, and lung tissues. Whether this protective effect requires the symbiosis of exogenous mitochondria in host cells remains unknown. Here xenogenic mitochondria derived from a hamster cell line were applied to ischemic rat brains and rat primary cortical neurons. Isolated hamster mitochondria, either through local intracerebral or systemic intra-arterial injection, significantly restored the motor performance of brain-ischemic rats. The brain infarct area and neuronal cell death were both attenuated by the exogenous mitochondria. Although internalized mitochondria could be observed in neurons and astrocytes, the low efficacy of mitochondrial internalization could not completely account for the high rate of rescue of the treated neural cells. We further illustrated that disrupting electron transport or ATPase synthase in mitochondria significantly attenuated the protective effect, suggesting that intact respiratory activity is essential for the mitochondrial potency on neural protection. These results emphasize that nonsymbiotic extracellular mitochondria can provide an effective cell defense against acute injurious ischemic stress in the central nervous system.
Journal Article
Predictors of academic efficacy and dropout intention in university students: Can engagement suppress burnout?
In this study we modelled possible causes and consequences of student burnout and engagement on academic efficacy and dropout intention in university students. Further we asked, can student engagement protect against the effects of burnout? In total 4,061 university students from Portugal, Brazil, Mozambique, the United Kingdom, the United States of America, Finland, Serbia, and Macao SAR, Taiwan participated in this study. With the data collected we analyzed the influence of Social Support, Coping Strategies, and school/course related variables on student engagement and burnout using structural equation modeling. We also analyzed the effect of student engagement, student burnout, and their interaction, on Academic Performance and Dropout Intention. We found that both student engagement and burnout are good predictors of subjective academic performance and dropout intention. However, student burnout suppresses the effect of student engagement on these variables. This result has strong implications for practitioners and administrators. To prevent student dropout, it is not enough to promote student engagement-additionally, and importantly, levels of student burnout must be kept low. Other variables such as social support and coping strategies are also relevant predictors of student engagement and burnout and should be considered when implementing preventive actions, self-help and guided intervention programs for college students.
Journal Article