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This study examines the influence of machine learning model optimization on improving production efficiency within the footwear manufacturing domain. Through systematic refinement of the logistic regression model, predictive accuracy increased from 94.12 to 97.06%, while achieving complete specificity (100%), indicating a stronger capability to correctly classify defect free outputs. When benchmarked against other supervised learning algorithms, including Support Vector Machines, Naïve Bayes, and Multinomial classifiers, the optimized model exhibited superior sensitivity, F1-score, and balanced accuracy, demonstrating its robustness across diverse operational conditions. From an industrial performance perspective, these predictive gains translated into measurable process improvements a 7.2% enhancement in production throughput, a 9% reduction in equipment downtime, and a 5.3% decrease in overall energy consumption. Such improvements emphasize the practical relevance of integrating tuned classification models with real-time manufacturing analytics. The results collectively underscore the potential of advanced data driven optimization frameworks to enhance productivity, energy efficiency, and sustainability within intelligent footwear production shop floor.

Mastitis, which often manifests as udder infection in dairy animals, is of great concern as it affects public health and results in heavy economic losses to the dairy industry. A hospital-based cross-sectional study was conducted to determine the cultivable bacterial species associated with bovine clinical mastitis and their resistance patterns towards different antimicrobials. The milk samples from cows suffering from clinical mastitis during monsoon season were investigated. The prevalence of clinical mastitis was significantly high in Holstein–Friesian crossbred cows, followed by in Jersey crossbred, Red Kandhari and Deoni. Significantly high prevalence was observed during 4th to 6th months of lactation. A total of 110 bacterial isolates belonging to 14 different genera were isolated and identified. Aminoglycosides and quinolones were found to be the most effective antibiotics. Vancomycin resistant penicillinase producing Gram positive bacteria were demonstrated. Gram negative bacteria resistant to extended spectrum β lactamases, cephalosporins, tetracyclines, vancomycin and chloramphenicol as well as vancomycin resistant enterococci, multiple drug resistant (MDR) gram negative rods, MDR Pseudomonas and MDR Acinetobacter were found. Widespread resistance of Streptococcus uberis towards cephalosporins was documented. Variable MDR patterns were recorded within a single species. MDR transfer from non-pathogens to emerging foodborne and established mastitis pathogens could be a potential problem to the dairy industry as well as to public health.

Study designSystematic Review and Meta-analysis.PurposeThree-column injuries making the spine unstable require adequate fixation which can be achieved by anterior alone, posterior alone or combined anterior–posterior approach. There is no general consensus till date on a single best approach in sub-axial cervical spine trauma. This study comparing the three approaches is an attempt to establish a firmer guideline in this disputed topic. Material and methodsThe protocol was registered with PROSPERO. PubMed, Embase and Google Scholar were searched for relevant literature. For each study, pre-defined data were extracted which included correction of kyphosis, loss of correction, hospital stay, operative time, blood loss during surgery as the outcome variables. Studies were also screened for the complications. ResultsEleven studies were evaluated for qualitative analysis and quantitative synthesis of the data in our review. The result demonstrated significant difference with most correction achieved in combined approach subgroup. Though no significant difference was found, the anterior group was having maximum loss of correction. Combined approach showed significantly more operative time and blood loss followed by posterior approach and then anterior approach alone. The improvement in VAS was significantly more in anterior subgroup when compared to combined approach.ConclusionCervical alignment is best restored by combined approach compared to the other two. Anterior only approach showed more correction than posterior approach. However, there is no significant difference between all three approaches in loss of correction at long-term follow-up. Anterior only approach is superior to posterior and combined approach on basis of intraoperative and perioperative parameters.Level of Evidence IDiagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and devastating disorder. It is characterized by alveolar epithelial cell injury and activation, infiltration of inflammatory cells, initiation of epithelial mesenchymal transition (EMT), aberrant proliferation and activation of fibroblasts, exaggerated deposition of extracellular matrix (ECM) proteins, and finally leading to the destruction of lung parenchyma. MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that post-transcriptionally regulate gene expression in diverse biological and pathological processes, including cell proliferation, differentiation, apoptosis and metastasis. As a result, miRNAs have emerged as a major area of biomedical research with relevance to pulmonary fibrosis. In this context, the present review discusses specific patterns of dysregulated miRNAs in patients with IPF. Further, we discuss the current understanding of miRNAs involvement in regulating lung inflammation, TGF-β1-mediated EMT and fibroblast differentiation processes, ECM genes expression, and in the progression of lung fibrosis. The possible future directions that might lead to novel therapeutic strategies for the treatment of pulmonary fibrosis are also reviewed.

Electrochemical machining (ECM) was developed as a result of the manufacturing and production industry's need to cut extremely hard alloys without leaving a troublesome layer. Manufacturing industries involved in gas turbine blades and aerospace need intricate geometries that would be difficult to make using standard methods. Because of high tool wear (TW) and metal removal rate (MRR), traditional machining processes such as milling and other conventional machining are inefficient for extracting metal from hard materials. This study outlines, a comprehensive analysis of the ECM processes using different electrolytes for better process efficiency.

Bioactive ingredients derived from brown algae have been extensively used in the food, medicine, and cosmetic industries. In this study, fucoidans of low and high molecular fractions (LMF and HMF) extracted and isolated from brown alga Turbinaria decurrens were analyzed for their efficacy on seed germination, seedling growth, callus induction, direct organogenesis, and adventitious root formation in eggplant and finger millet. The yield and sugar content of LMF were higher than HMF. FTIR confirmed that the isolated fractions containing fucoidan has more sulfate groups in HMF than in LMF. The results showed an enhanced seed germination and seedling growth in both crops. In eggplant, 1 mg/L LMF treatment showed the maximum germination (91.6%), whereas, in finger millet, 0.1 and 0.5 mg/L LMF recorded a substantial increase in germination percentage (41.6 and 46%). Maximum fresh weight (FW) was noted with 1.0 mg/L LMF, and 1.0 mg/L LMF and 0.5 mg/L HMF showed maximum dry weight (DW) in eggplant. In finger millet, maximum DW was observed in 0.5 mg/L LMF and 1.0 mg/L HMF. Maximum biomass was noted in the 0.1 mg/L LMF treated group in the case of callus growth in eggplant. Similarly, the shoot tip initiation, proliferation, and plantlet regeneration were significantly improved with fucoidan LMF (0.1 mg/L). In conclusion, fucoidan extracted from T. decurrens exhibiting natural growth promoter property is reported for the first time in this study. These fucoidan fractions, LMF and HMF, can be utilized as cost-effective supplements in plant tissue culture media replacing the commercial PGRs for micropropagation.

Mesoporous Ia3d cubic structured KIT-6 support was prepared by hydrothermal strategy and heteropoly acid content (10, 20 and 30%) was stacked on KIT-6 by wet-impregnation technique. The synthesized catalysts were characterized by XRD, N2-sorption, NH3-TPD, ATFT-IR, TEM and SEM–EDAX analyses. Acid properties of the supported catalysts were investigated by pyridine-adsorbed ATFT-IR and NH3-TPD, respectively. Poly-anion coordination present in the catalyst was confirmed by the DRS-UV spectrum. The dispersion of heteropoly acid on the catalyst surface was observed by TEM analysis. Also, the presence of the elements such as W and P on the catalyst and its morphology were represented by the HRSEM–EDAX technique. The catalytic activity of HPWA/KIT-6 was investigated by the transesterification of neem oil with methanol. Among the different wt% catalyst, 20% catalyst showed highest neem oil conversion and selectivity at an optimized reaction temperature of 60 °C. Further, the spent catalyst was recovered and recycled three times, and it showed activity losses of less than 4%.

PurposeTelemedicine is delivered to patient anywhere during emergency treatment care, and medical information is transferred from one site of patient to another site of specialist doctors by using mobile internet communication. Some rural areas have slow internet speed because of weak internet signal propagation from mobile towers. A good design of antenna is needed to improve mobile internet speed for big medial data transmission in telemedicine application. Hence, this paper aims to propose economically low-cost design of antenna.Design/methodology/approachTelemedicine recommended to design the satellite frequency modulation dish (SAT FMD) antenna ( where in FM radio antenna, dish antenna are combined ) to improve the internet speed at Telemedicine system and Hospitals for purpose of Telemedicine communication and information for emergency treatment.FindingsIn the proposed system, designed SAT FMD satellite-based antenna improved internet speed is achieved at 90.6% accuracy in this research method. Finding latitude and longitude angles to identify the patient location, nearest hospitals location and finding distance, shortest path routing between patient and hospital. Finding elevation, Azimuth, latitude, longitude, skew for alignment dish to focus satellite and mobile cell tower to improve internet speed at telemedicine area and hospitals and reduced transmission delay and nodal delay of big medical data.Social implicationsThe social awareness among people can be shared information of accident patient to communicate Hospital and Ambulance driver by internet mobile app tools and help find nearest hospitals to emergency treatment for accident people.Originality/valueThis paper presents SAT FMD antenna model based on satellite dish antenna consisting of FM radio receiver antenna and dish antenna for telemedicine communication.

PurposeTo compare the clinical and radiological outcomes in patients with congenital scoliosis (CS) and tethered cord syndrome (TCS) undergoing deformity correction with (NI group) versus without (NNI group) prior neurosurgical intervention aimed at detethering the cord.MethodsA systematic review and meta-analysis were performed. The databases PubMed, Embase and Google Scholar were searched until March 2020. Inclusion criteria was studied describing performance of deformity correction and fusion surgery for congenital scoliosis with tethered cord syndrome with or without prior detethering procedure. Studies describing growth sparing procedures or congenital scoliosis associated with non-tethering pathologies such as syrinx were excluded. Case reports and series with less than 10 subjects were also excluded. NIH quality assessment tool was used for assessing quality of individual study.ResultsSixteen studies were included for analysis of which eight were found to be retrospective case series (level IV evidence) and retrospective case–control studies (level III evidence) each. Overall proportional meta-analysis found no significant difference in correction rate, operative duration, blood loss or complication rate between the NI and NNI groups. However, subgroup analysis performed after inclusion of only level III evidence studies revealed significantly lesser operative duration and blood loss with comparable correction and complication rate in NNI group.ConclusionDeformity correction and fusion surgery may be performed safely and effectively in CS with TCS patients without the need of a prior detethering procedure.

A solar flat plate collector is a device that converts the solar radiation energy from the sun into heat energy. A solar flat plate collector was designed and fabricated. The solar air collector has an absorbing plate of 1m × 0.06m area made up of galvanized iron. Outer frame of collector is fabricated with plywood. It is painted black using metal paint in order to increase its heat absorbing capacity. In order to increase the heating efficiency of the collector a serpentine coil of copper pipe is welded to the bottom of the absorber plate through which hot water is passed. Efficiency of solar flat plate collector was increased by 15.58% using this method.