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In the Western Alps, a first Late Cretaceous to Eocene \"Pyrenean-Provençal\" compressive phase accommodating N-S shortening resulting from the convergence between Africa and Eurasia is classically described. It is followed by the Neogene \"Alpine phase\" accommodating E-W shortening. Since this major tectonic change is not explained by a modification of the global Africa-Eurasia convergence, it should be explained instead by more local causes, possibly by the subduction of the Ligurian Ocean that initiated in the Oligocene beneath the European and Iberian plates. In this paper, we present analogue models simulating the Neogene evolution of this subduction zone, in order to understand how it impacted the regional tectonics. Although models do not include the lithospheric plate overriding the subduction zone, their surface deformations share many similarities with the Neogene tectonics of Western Europe and Iberia. We observe that the tectonic evolution is largely controlled by the roll-back of the slab, that occurred much faster than the Africa-Eurasia convergence. Models reproduce the opening of the Western Mediterranean Basins and the dispersion of the AlKaPeCa continental fragments (Alboran, Kabylian, Peloritan and Calabrian blocks). They also show that the subduction of the Ligurian Ocean favors the counterclockwise rotation of Adria. In more elaborated models, we introduced a pre-existing weakness along the Africa and Adria margins, to reproduce the break-off of the oceanic slab that followed the beginning of continental subduction both in Northern Africa and Adria. Slab break-off is followed by the exhumation of the subducted continent. We observe that the influence of subduction on the kinematics of Adria largely decreases following slab break-off. In the models, the total counterclockwise rotation of Adria varies between 7° and more than 30°, depending on the timing of slab break-off. Since the process of subduction modifies the displacement of Adria, it also impacts the tectonic evolution of surrounding regions, especially in the Alpine belt: Our models show that during slab-roll back and before the Ligurian slab break-off, the azimuth of convergence between Adria and Europe shifts from ∼N-S to ∼ENE-WSW. Hence, they suggest that the oceanic subduction in the Western Mediterranean may contribute to the \"Oligocene revolution\" described by Dumont et al. (2011), leading to E-W shortening in the Western Alps and to the activation of the Periadriatic right-lateral shear zones in the Central Alps. We conclude that the western Mediterranean region is a spectacular example showing how the tectonics of mountain ranges and plate boundaries may be controlled by distant subduction processes.

IntroductionMany patients with tuberculosis (TB) suffer from a huge economic burden, even though TB services are often provided free of charge at the point of care. Costs can create significant barriers, hindering patients’ access to TB treatment. These costs include direct medical costs (such as consultation fees), direct non-medical costs (such as transportation costs) and indirect costs (such as wages foregone). This systematic review aims to synthesise the best available evidence on economic evaluations of patient-cost studies on self-administered treatment (SAT) for drug-sensitive TB compared with facility-based directly observed treatment, short-course (FB DOTS), globally.Methods and analysisWe will conduct a systematic review following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines and search PubMed, Academic Search Complete, Scopus, CINAHL Plus (EBSCO) and Google Scholar for articles published up to 2025, without date restrictions. Eligible studies must be full or partial (cost analyses without effectiveness data) economic evaluations conducted globally, comparing SAT to FB DOTS regarding TB patient costs. Grey literature will be included. Exclusion criteria include studies not reporting patient costs between SAT and FB DOTS, and non-economic evaluations (non-original research). Two independent reviewers will conduct the screening, data extraction and quality assessment. A quality assessment will be performed using the Consolidated Health Economic Evaluation Reporting Standards statement, the Consensus on Health Economic Criteria checklist and the ROBINS-I tool.Ethics and disseminationEthics approval is not required for this systematic review because it does not use individual patient data. Instead, we will use publicly available economic evaluation research studies. Findings will be presented at international and national conferences and published in open-access, peer-reviewed journals. PROSPERO registration number CRD42024591221.

An asthenospheric window underneath much of the South American continent increases the heat flow in the southern Patagonian Andes where glacial–interglacial cycles drive the building and melting of the Patagonian Icefields since the latest Miocene. The Last Glacial Maximum (LGM) was reached ∼26 000 yr BP (years before present). Significant deglaciation onsets between 21 000 and 17 000 yr BP were subject to an acceleration since the Little Ice Age (LIA), which was ∼400 yr BP. Fast uplift rates of up to 41±3 mm yr−1 are measured by global navigation satellite system (GNSS) around the Southern Patagonian Icefield and are currently ascribed to post-LIA lithospheric rebound, but the possible longer-term post-LGM rebound is poorly constrained. These uplift rates, in addition, are 1 order of magnitude higher than those measured on other glaciated orogens (e.g. the European Alps), which raises questions about the role of the asthenospheric window in affecting the vertical surface displacement rates. Here, we perform geodynamic thermo-mechanical numerical modelling to estimate the surface uplift rates induced by post-LIA and post-LGM deglaciation, accounting for temperature-dependent rheologies and different thermal regimes in the asthenosphere. Our modelled maximum post-glacial rebound matches the observed uplift rate budget only when both post-LIA and post-LGM deglaciation are accounted for and only if a standard continental asthenospheric mantle potential temperature is increased by 150–200 °C. The asthenospheric window thus plays a key role in controlling the magnitude of presently observed uplift rates in the southern Patagonian Andes.

Orogens and volcanic arcs at continental plate margins are primary surface expressions of convergent plate tectonics. Although it is established that climate affects the shape, size, and architecture of orogens via orographic erosion gradients, the ascent of magma through the crust and location of volcanoes along magmatic arcs have been considered insensitive to erosion. However, available data reveal westward migration of late-Cenozoic volcanic activity in the Southern Andes and Cascade Range where orography drives an eastward migration of the topographic water divide by increased precipitation and erosion along west-facing slopes. Thermomechanical numerical modeling shows that orographic erosion and the associated leeward topographic migration may entail asymmetric crustal structures that drive the magma ascent toward the region of enhanced erosion. Despite the different tectonic histories of the Southern Andes and the Cascade Range, orographic erosion is a shared causal mechanism that can explain the late-Cenozoic westward migration of the volcanic front along both magmatic arcs.

The analysis of the seismicity catalog (1996 to 2019) covering the region from the Jura mountains to Corsica provides a first-order image of the distribution of earthquakes, highlighting large structures such as the Briançonnais and Piedmontais seismic arcs, the eastward deepening of the focal depths through the Western Alps, several large active faults (e.g. Belledonne, Middle Durance, Ligure). Over this period the magnitudes are moderate and the focal mechanisms of the main events display a diversity of seismic behaviors that can be explained by the complexity of the different geological domains with a more or less strong structural inheritage, by variable rheological characteristics at the scale of the crust and by the joint action of different mechanisms of deformation. The distribution of the historical events is in fairly good agreement with the instrumental seismicity, but several earthquakes of M > 6 are highlighted since the 14th century until the beginning of the 20th.

Due to the low to moderate seismicity of the European Western Alps, few focal mechanisms are available in this region to this day, and the corresponding current seismic stress and strain fields remain partly elusive. The development of dense seismic networks in past decades now provides a substantial number of seismic records in the 0–5 magnitude range. The corresponding data, while challenging to handle due to their amount and relative noise, represent a new opportunity to increase the spatial resolution of seismic deformation fields. The aim of this paper is to quantitatively assess the current seismic stress and strain fields within the Western Alps, from a probabilistic standpoint, using new seismotectonic data. The dataset comprises more than 30 000 earthquakes recorded by dense seismic networks between 1989 and 2013 and more than 2200 newly computed focal mechanisms in a consistent manner. The global distribution of P and T axis plunges confirms a majority of transcurrent focal mechanisms in the entire western Alpine realm, combined with pure extension localized in the core of the belt. We inverted this new set of focal mechanisms through several strategies, including a seismotectonic zoning scheme and grid procedure, revealing extensional axes oriented obliquely to the strike of the belt. The Bayesian inversion of this new dataset of focal mechanisms provides a probabilistic continuous map of the style of seismic deformation in the Western Alps. Extension is found to be clustered, instead of continuous, along the backbone of the belt. Robust indications for compression are only observed at the boundary between the Adriatic and Eurasian plates. Short-wavelength spatial variations of the seismic deformation are consistent with surface horizontal Global Navigation Satellite System (GNSS) measurements, as well as with deep lithospheric structures, thereby providing new elements with which to understand the current 3D dynamics of the belt. We interpret the ongoing seismotectonic and kinematic regimes as being controlled by the joint effects of far-field forces – imposed by the anticlockwise rotation of Adria with respect to Europe – and buoyancy forces in the core of the belt, which together explain the short-wavelength patches of extension and marginal compression overprinted on an overall transcurrent tectonic regime.

In collision belts, the first-order role of the mantle in localizing deformation has remained elusive, as the resolution of geophysical imaging remains too low to constrain crustal geometry. To address this issue, we geologically interpret a recent high-resolution shear-wave velocity model from ambient-noise tomography of Western Alps. We show that the lower crustal Alpine geometry is highly variable at depth, evolving from a preserved European crustal slab in the South to a smooth crustal root in the North. Moho morphology is controlled by numerous pre-existing major faults reactivated during the Alpine orogeny. Two mantle indenters located above the subducted European plate at different depths appear to control the locus of active deformation. The rigid nature of Adria mantle explains the localization of brittle deformation that is transferred towards the upper crust. The strain-field partitioning results in a combination of strike-slip with either shortening or extension controlled by the anticlockwise rotation of Adria.

We report apatite fission-track and 10Be terrestrial cosmogenic nuclide (TCN) dating of 14 moraine boulders originating from inland Terre Adélie, East Antarctica. These data show cooling of the Proterozoic Terre Adélie craton at < ~120°C between 350 and 300 Ma, suggesting > 4 km temperate glacial erosion during the Late Palaeozoic Ice Age, followed by nearly null Mesozoic erosion and low glacial erosion (< 2 km) in the Cenozoic. Based on glacial flux maps, the origin of the boulders may be located ~400 km upstream. Preliminary TCN (10Be) datings of moraine boulders cluster within the last 30 ka. Cosmogenic ages from the Lacroix Nunatak suggest a main deglaciation after the Younger Dryas at c. 10 ka, while those of Cap Prud'homme mostly cluster at 0.6 ka, in agreement with an exhumation of boulders during the Little Ice Age.

IntroductionPoverty, HIV and perinatal depression represent a triple threat to public health in sub-Saharan Africa because of their combined negative effects on parenting and child development. In the resource-constrained context of low-income and middle-income countries, a lay-counsellor-delivered intervention that combines a psychological and parenting intervention could offer the potential to mitigate the consequences of perinatal depression while also optimising scarce resources for healthcare.Measuring the cost-effectiveness of such a novel intervention will help decision-makers to better understand the relative costs and effects associated with replicating the intervention, thereby supporting evidence-based decision-making. This protocol sets out the methodological framework for analysing the cost-effectiveness of a cluster randomised controlled trial (RCT) that compares a combined intervention to enhanced standard of care when treating depressed, HIV-positive pregnant women and their infants in rural South Africa.Methods and analysisThis cost-effectiveness analysis (CEA) protocol complies with the Consolidated Health Economic Evaluation Reporting Standards 2022 checklist. A societal perspective will be chosen.The proposed methods will determine the cost and efficiency of implementing the intervention as per the randomised control trial protocol, as well as the cost of replicating the intervention in a non-research setting. The costs will be calculated using an appropriately adjusted version of the Standardised Early Childhood Development Costing Tool.Primary health outcomes will be used in combination with costs to determine the cost per improvement in maternal perinatal depression at 12 months postnatal and the cost per improvement in child cognitive development at 24 months of age. To facilitate priority setting, the incremental cost-effectiveness ratios for improvements in child cognitive development will be ranked against six other child cognitive-development interventions according to Verguet et al’s methodology (2022).A combination of activity-based and ingredient-based costing approaches will be used to identify, measure and value activities and inputs for all alternatives. Outcomes data will be sourced from the RCT team.Ethics and disseminationThe University of Oxford is the sponsor of the CEA. Ethics approval has been obtained from the Human Sciences Research Council (HSRC, #REC 5/23/08/17), South Africa and the Oxford Tropical Research Ethics Committee (OxTREC #31–17), UK.Consent for publication is not applicable since no participant data are used in this protocol.We plan to disseminate the CEA results to key policymakers and researchers in the form of a policy brief, meetings and academic papers.Trial registration detailsISRCTN registry #11 284 870 (14/11/2017) and SANCTR DOH-27-102020-9097 (17/11/2017).

On November 11, 2019, a M\\(_{\\mathrm{w}}\\) 4.9 earthquake hit the region close to Montelimar (lower Rhône Valley, France), on the eastern margin of the Massif Central close to the external part of the Alps. Occuring in a moderate seismicity area, this earthquake is remarkable for its very shallow focal depth (between 1 and 3 km), its magnitude, and the moderate to large damages it produced in several villages. InSAR interferograms indicated a shallow rupture about 4 km long reaching the surface and the reactivation of the ancient NE–SW La Rouvière normal fault in reverse faulting in agreement with the present-day E–W compressional tectonics. The peculiarity of this earthquake together with a poor coverage of the epicentral region by permanent seismological and geodetic stations triggered the mobilisation of the French post-seismic unit and the broad French scientific community from various institutions, with the deployment of geophysical instruments (seismological and geodesic stations), geological field surveys, and field evaluation of the intensity of the earthquake. Within 7 days after the mainshock, 47 seismological stations were deployed in the epicentral area to improve the Le Teil aftershocks locations relative to the French permanent seismological network (RESIF), monitor the temporal and spatial evolution of microearthquakes close to the fault plane and temporal evolution of the seismic response of 3 damaged historical buildings, and to study suspected site effects and their influence in the distribution of seismic damage. This seismological dataset, completed by data owned by different institutions, was integrated in a homogeneous archive and distributed through FDSN web services by the RESIF data center. This dataset, together with observations of surface rupture evidences, geologic, geodetic and satellite data, will help to unravel the causes and rupture mechanism of this earthquake, and contribute to account in seismic hazard assessment for earthquakes along the major regional Cévenne fault system in a context of present-day compressional tectonics.