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Precise morphological control and identification of structure-property relationships pose formidable challenges for high-entropy alloys, severely limiting their rational design and application in multistep and tandem reactions. Herein, we report the synthesis of sub-nanometric high-entropy metallenes with up to eight metallic elements via a one-pot wet-chemical approach. The PdRhMoFeMn high-entropy metallenes exhibit high electrocatalytic hydrogen evolution performances with 6, 23, and 26 mV overpotentials at −10 mA cm −2 in acidic, neutral, and alkaline media, respectively, and high stability. The electrochemical measurements, theoretical simulations, and operando X-ray absorption spectroscopy reveal the actual active sites along with their dynamics and synergistic mechanisms in various electrolytes. Specially, Mn sites have strong binding affinity to hydroxyl groups, which enhances the water dissociation process at Pd sites with low energy barrier while Rh sites with optimal hydrogen adsorption free energy accelerate hydride coupling, thereby markedly boosting its intrinsic ability for hydrogen production. High-entropy alloys are promising electrocatalysts for multistep and tandem reactions, yet its mechanism remains unclear. Here, the authors address this challenge by using in-situ XAS to reveal the multi-site hydrogen evolution mechanisms on high-entropy metallenes in wide pH electrolytes.

The effects of rotor-stator interactions induce complex wake disturbances in turbine blades, and the use of a serrated trailing edge (STE) has been recognized as an effective flow control strategy. In this study, STEs were applied to the rotor blades of an AACHEN 1.5-stage axial-flow turbine, and it was to investigate the impact of the STEs on the aerodynamic and acoustic performance. Detached eddy simulation (DES) was employed to analyze the internal flow characteristics for different serration configurations. The results indicated that an STE could effectively improve the wake velocity of the rotor blade. The growth rate of the wake velocity reached 40.18% at the serration tip and 21.23% at the serration root, indicating improvements throughout the serrated region. Additionally, the STE rotor blades enhanced the flow mixing and generated rotational vortex structures between the serration peaks and valleys while maintaining the original aerodynamic performance. These vortices facilitated energy exchange between low-speed and high-speed regions, thereby reducing the wake vortex intensity. Furthermore, pressure fluctuations were effectively suppressed by the effect of the STE rotor blades, leading to a significant noise reduction, with the sound pressure level (SPL) reduced by approximately 8.52 dB in the low-frequency range and 12.49 dB in the high-frequency range. These findings confirmed that the STE blade improved both aerodynamic and acoustic characteristics. Thus, this study provides valuable insights for turbine blade design optimization and noise reduction strategies.

With the increase of air transportation, some crossing waypoints (CWPs) are becoming bottlenecks in the operation of air traffic networks. This paper presents a CWP operation optimisation framework based on a two-stage optimisation method. First, we considered the interests of airlines and air traffic controllers and established a flight-level dynamic allocation model for the CWP to minimise the flight-level deviation and the number of flight conflicts. A multi-objective, self-adaptive differential evolution-local search hybrid algorithm was used to solve the model in a parallel computing manner. Subsequently, a flight conflict resolution algorithm based on the Monte-Carlo tree search was designed for flight conflicts that existed after the optimisation. Finally, based on real operation data, four experimental scenarios were constructed, and the air traffic operation simulation system was used for experimental validation. For daily traffic and 1.2 times peak traffic scenarios, the average flight-level deviation reduction rates after optimisation were 53% and 39%, and the successful flight conflict resolution rates reached 89% and 75%, respectively. The experimental results showed that this optimisation framework can effectively balance the number of flight conflicts with the efficiency of flight-level usage and directly improve the capacity of the CWP, which can be used as a reference for air traffic control auxiliary decision support systems.

Bendamustine has shown a favorable safety profile when included in chemotherapy regimens for several types of lymphoma, including CLL. This study investigated the long-term effect of adding bendamustine to a conditioning regimen on survival, rate of engraftment, immune recovery and GvHD after allogeneic stem cell transplantation (alloSCT) in CLL patients. These outcomes were compared with the fludarabine, cyclophosphamide and rituximab (FCR) conditioning regimen. We reviewed the data for 89 CLL patients treated on three trials at our institution. Twenty-six (29%) patients received bendamustine, fludarabine and rituximab (BFR) and 63 (71%) received FCR. Patient characteristics were similar in both groups. Ten (38%) BFR-treated patients vs only two (3%) FCR-treated patients did not experience severe neutropenia ( P =<0.001). The 3-year overall survival estimates for the BFR and FCR groups were 82 and 51% ( P =0.03), and the 3-year PFS estimates were 63% and 27% ( P =0.001), respectively. The 2-year treatment-related mortality was 8 and 23% and the incidence of grade 3 or 4 GvHD was 4% and 10%, respectively. This study is the first to report that addition of bendamustine to alloSCT conditioning for CLL patients is associated with improved survival and lower mortality, myelosuppression, and GvHD.

The zona pellucida 3 (ZP3) plays a crucial role in reproductive immunology. We obtained a full-length cDNA encoding Chinese zokor ZP3, using rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR). The cDNA contains an open reading frame of 1269 nucleotides encoding a polypeptide of 422 amino acid residues. The amino acid sequence has a high degree of homology with those of hamster (78%), mouse (76%), and rat (74%). XhoI and SacI sites after restriction give an1158 bp fragment of zokor ZP3 cDNA, excluding the signal sequence and transmembrane-like domain, which was cloned under the phage T7 promoter-lac operator control in the pET-28a(+) vector. Recombinant pET-zokorZP3(r-ZP3) was expressed as a poly-histidine fusion protein in E. coli strain BL21 (DE3). Optimum expression of r-ZP3 was observed at 28°C, 1 mM IPTG and 2 h of inducing. The purified protein was tested by Western blot.

Geothermal energy is a sustainable and renewable energy source, which can be used in electricity production, space heating/cooling, and other industrial applications. In the recent years, it has been gathering more and more attention due to its numerous advantages as low impact on the surrounding environment, continuous power outputs, low greenhouse gas emissions, and worldwide availabilities. All make the geothermal energy a significant contributor to the global energy productions in an environmentally friendly way. One big concern of geothermal sources’ exploration is the expensive investment costs of geothermal wells. Utilizing abandoned petroleum wells for the purpose of geothermal extraction is a novel idea. Well temperature profiles help to estimate how much heat can be transferred and produced from the wells. In this paper, a literature review has been done to investigate the existing applications on geothermal energy extraction utilizing abandoned petroleum wells. Then, the case study demonstrates the importance of properties of working fluids, wellbore architecture, and operational parameters (circulation rate, inlet temperature, etc.) in geothermal energy production. The obtained results can be used to achieve an improved data interpretation and generate more optimal solutions. In geothermal projects, extensive knowledge of the heat transfer is of great importance for the economical aspect and the performance of wells. Our work demonstrates that it is a good approach to provide cost-effective solutions to enhance heat extraction from geothermal wells.

Objective. Panax ginseng is used widely for treatment of cardiovascular disorders in China. Ginsenoside Re is the main chemical component of P. ginseng. We aimed to investigate the protective effect of ginsenoside Re on isoproterenol-induced myocardial fibrosis and heart failure in rats. Methods. A model of myocardial fibrosis and heart failure was established by once-daily subcutaneous injection of isoproterenol (5 mg/kg/day) to rats for 7 days. Simultaneously, rats were orally administrated ginsenoside Re (5 or 20 mg/kg) or vehicle daily for 4 weeks. Results. Isoproterenol enhanced the heart weight, myocardial fibrosis, and hydroxyproline content in rat hearts. Ginsenoside Re inhibited (at least in part) the isoproterenol-induced increase in heart weight, myocardial fibrosis, and hydroxyproline content. Compared with the isoproterenol group, treatment with ginsenoside Re ameliorated changes in left ventricular systolic pressure, left ventricular end diastolic pressure, and the positive and negative maximal values of the first derivative of left ventricular pressure. Ginsenoside Re administration also resulted in decreased expression of transforming growth factor (TGF)-β1 in serum and decreased expression of Smad3 and collagen I in heart tissue. Conclusion. Ginsenoside Re can improve isoproterenol-induced myocardial fibrosis and heart failure by regulation of the TGF-β1/Smad3 pathway.

Phosphorus (P) is essential for crop production. Adequate application P rate is critical for enhancing productivity and profitability of snap bean (Phaseolus vulgaris L.). The goal of this study was to optimize P application rate for commercial snap bean production in south Florida. Six trials were conducted on sandy soils and muck soils in Hendry County and Palm Beach County, Florida, USA. Before planting cv. Caprice snap bean, plots were fertilized with different P application rates in the form of triple superphosphate (0-45-0). An increase in P2O5 application rates up to 134 kg/ha P2O5 significantly increased the marketable bean yields. However, beyond that point, significant field gains did not occur with further increased application. At 134 kg/ha P2O5, bean appearance quality was the best compared to the other treatments. These results indicate that 134 kg/ha P2O5 produced best bean appearance quality and was the optimum rate for commercial production of snap bean in high-pH soils in south Florida.

Vigilance for predators is omnipresent among species of prey. We report an investigation of vigilance of white-tailed prairie dogs (Sciuridae: Cynomys leucurus) living under natural conditions. Our most important conclusion concerns variation in vigilance within and among uniquely marked adult individuals (n = 53 in 2007, n = 62 in 2008). Within a single day, the percentage of observations when an individual was scanning for predators ranged from 0–100%, with a mean of 24.4%. Over a period of 3 months, some individuals were vigilant for <5% of observations, but others were vigilant for >50% of observations. For 12 of 24 individuals that we monitored for vigilance in consecutive years, levels of vigilance were significantly different between years. Some of the variation within and between individuals might have resulted from differences in vulnerability to predation. Las especies de presa constantemente se mantienen vigilantes en contra de los depredadores. Presentamos una investigación sobre la vigilancia de los perros llaneros de cola blanca (Sciuridae: Cynomys leucurus) que viven en condiciones naturales. Nuestra conclusión más importante se refiere a la variación en la vigilancia dentro y entre los individuos adultos marcados únicamente (n = 53 en el 2007, n = 62 en 2008). En un solo día, el porcentaje de observaciones cuando un individuo estuvo escaneado por depredadores variaron de 0–100%, con una media de 24.4%. Durante un período de 3 meses, algunos individuos se mantuvieron alerta <5% de las observaciones, pero otros estaban atentos a >50% de las observaciones. En 12 de 24 individuos a los que se ha monitoreado la vigilancia en años consecutivos, los niveles de vigilancia fueron significativamente diferentes entre años. Parte de la variación dentro y entre los individuos podría ser el resultado de diferencias en la vulnerabilidad a la depredación.

We have determined the DNA sequence of the unique long (UL) region and the repeat long (RL) region in the genome of serotype 1 GA strain of Marek's disease virus (MDV), a member of the α -herpesvirus family. With this information, the complete nucleotide sequence of GA-MDV is now known. The entire GA-MDV genome is predicted to be about 174 kbp in size, with an organization of TRL-UL-IRL-IRS-US-TRS, typical of a α -herpesvirus. The UL sequence contains 113,508 bp and has a base composition of 41.7% G + C. A total of 67 ORFs were identified completely within the UL region, among which 55 are homologous to genes encoded by herpes simplex virus-1. Twelve of them are unique with presently unknown functions. The sequence of RL reported here together with those published earlier reveal the major structural features of the RL. Virtually all of the ORFs encoded by RL are specific to serotype I of MDV. These ORFs are likely to contribute to some of the unique biological properties of MDV. Among the proteins encoded by MDV-specific ORFs are Meq, a jun/fos family of transcriptional factor implicated in transformation and latency, virus-encoded interleukin-8, a CXC chemokine, and pp38 and pp24, two phosphoproteins with undefined functions. There is also a putative lipase gene (LORF2) that has homologies in HPRS-24 (serotype II) strain of MDV and in various avian adenoviruses. An additional unique feature of MDV is the presence of long terminal repeat remnant sequences of avian retrovirus reticuloendotheliosis virus. These remnant sequences are derived from the U3-enhancer region through ancestral insertions by reticuloendotheliosis virus proviruses.