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Shaping a developing organ or embryo relies on the spatial regulation of cell division and shape. However, morphogenesis also occurs through changes in cell-neighbourhood relationships produced by intercalation. Intercalation poses a special problem in epithelia because of the adherens junctions, which maintain the integrity of the tissue. Here we address the mechanism by which an ordered process of cell intercalation directs polarized epithelial morphogenesis during germ-band elongation, the developmental elongation of the Drosophila embryo. Intercalation progresses because junctions are spatially reorganized in the plane of the epithelium following an ordered pattern of disassembly and reassembly. The planar remodelling of junctions is not driven by external forces at the tissue boundaries but depends on local forces at cell boundaries. Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are required for planar junction remodelling and cell intercalation. This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs.

Overexpression of the human REL transcription factor can malignantly transform chicken spleen cells in vitro . In this report, we have created and characterized a cDNA encoding a chimeric protein (RELΔ424–490-ER) in which sequences of a highly transforming REL mutant (RELΔ424–490) are fused to the ligand-binding domain of the human estrogen receptor (ER). Surprisingly, RELΔ424–490-ER is constitutively nuclear in A293 cells, and RELΔ424–490-ER activates transcription in the absence, but not in the presence, of estrogen in κ B-site reporter gene assays. Furthermore, RELΔ424–490-ER transforms chicken spleen cells in the absence of estrogen, but the addition of estrogen blocks the ability of RELΔ424–490-ER-transformed cells to form colonies in soft agar, even though estrogen induces increased nuclear translocation of RELΔ424–490-ER in these cells. ER α can also inhibit REL-dependent transactivation in trans in an estrogen-dependent manner, and ER α can interact with REL in vitro . Thus, the RELΔ424–490-ER fusion protein shows an unusual, reverse hormone regulation, in that its most prominent biological activities (transformation and transactivation) are inhibited by estrogen, probably due to an estrogen-induced interaction between the ER sequences and sequences in the Rel homology domain. Nevertheless, these results indicate that the continual activity of REL is required to sustain the transformed state of chicken spleen cells in culture, suggesting that direct and specific inhibitors of REL may have therapeutic efficacy in certain human lymphoid cancers.

From the manner of its discovery in 2012, it was apparent that the 125 GeV Higgs boson couples to bosons, but does it couple to fermions too? Yes, says the CMS Collaboration at CERN, who present combined evidence of Higgs decay to pairs of bottom quarks and pairs of tau leptons. The discovery of a new boson with a mass of approximately 125 GeV in 2012 at the Large Hadron Collider 1 , 2 , 3 has heralded a new era in understanding the nature of electroweak symmetry breaking and possibly completing the standard model of particle physics 4 , 5 , 6 , 7 , 8 , 9 . Since the first observation in decays to γγ , WW and ZZ boson pairs, an extensive set of measurements of the mass 10 , 11 and couplings to W and Z bosons 11 , 12 , 13 , as well as multiple tests of the spin-parity quantum numbers 10 , 11 , 13 , 14 , have revealed that the properties of the new boson are consistent with those of the long-sought agent responsible for electroweak symmetry breaking. An important open question is whether the new particle also couples to fermions, and in particular to down-type fermions, as the current measurements mainly constrain the couplings to the up-type top quark. Determination of the couplings to down-type fermions requires direct measurement of the corresponding Higgs boson decays, as recently reported by the Compact Muon Solenoid (CMS) experiment in the study of Higgs decays to bottom quarks 15 and τ leptons 16 . Here, we report the combination of these two channels, which results in strong evidence for the direct coupling of the 125 GeV Higgs boson to down-type fermions, with an observed significance of 3.8 standard deviations, when 4.4 are expected.

A tagging algorithm to identify jets that are significantly displaced from the proton-proton (pp) collision region in the CMS detector at the LHC is presented. Displaced jets can arise from the decays of long-lived particles (LLPs), which are predicted by several theoretical extensions of the standard model. The tagger is a multiclass classifier based on a deep neural network, which is parameterised according to the proper decay length cτ0 of the LLP. A novel scheme is defined to reliably label jets from LLP decays for supervised learning. Samples of pp collision data, recorded by the CMS detector at a centre-of-mass energy of 13 TeV, and simulated events are used to train the neural network. Domain adaptation by backward propagation is performed to improve the simulation modelling of the jet class probability distributions observed in pp collision data. The potential performance of the tagger is demonstrated with a search for long-lived gluinos, a manifestation of split supersymmetric models. The tagger provides a rejection factor of 10 000 for jets from standard model processes, while maintaining an LLP jet tagging efficiency of 30%-80% for gluinos with 1 mm≤cτ0≤ 10 m. The expected coverage of the parameter space for split supersymmetry is presented.

We report on the test beam results and calibration methods using high energy electrons, pions and muons with the CMS forward calorimeter (HF). The HF calorimeter covers a large pseudorapidity region ( ), and is essential for a large number of physics channels with missing transverse energy. It is also expected to play a prominent role in the measurement of forward tagging jets in weak boson fusion channels in Higgs production. The HF calorimeter is based on steel absorber with embedded fused-silica-core optical fibers where Cherenkov radiation forms the basis of signal generation. Thus, the detector is essentially sensitive only to the electromagnetic shower core and is highly non-compensating (e/h≈5). This feature is also manifest in narrow and relatively short showers compared to similar calorimeters based on ionization. The choice of fused-silica optical fibers as active material is dictated by its exceptional radiation hardness. The electromagnetic energy resolution is dominated by photoelectron statistics and can be expressed in the customary form as . The stochastic term a is 198% and the constant term b is 9%. The hadronic energy resolution is largely determined by the fluctuations in the neutral pion production in showers, and when it is expressed as in the electromagnetic case, a = 280% and b = 11%.

A search is presented for decays beyond the standard model of the 125 GeV Higgs bosons to a pair of light bosons, based on models with extended scalar sectors. Light boson masses between 5 and 62.5 GeV are probed in final states containing four tau leptons, two muons and two b quarks, or two muons and two tau leptons. The results are from data in proton-proton collisions corresponding to an integrated luminosity of 19.7 inverse-femtobarns, accumulated by the CMS experiment at the LHC at a center-of-mass energy of 8 TeV. No evidence for such exotic decays is found in the data. Upper limits are set on the product of the cross section and branching fraction for several signal processes. The results are also compared to predictions of two-Higgs-doublet models, including those with an additional scalar singlet.

The differential cross section for inclusive particle production as a function of energy in proton-proton collisions at a center-of-mass energy of 13 TeV is measured in the very forward region of the CMS detector. The measurement is based on data collected with the CMS apparatus at the LHC, and corresponds to an integrated luminosity of 0.35 inverse microbarns. The energy is measured in the CASTOR calorimeter, which covers the pseudorapidity region -6.6

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