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"Sullivan, A"
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Case studies in cultural entrepreneurship : how to create relevant and sustainable institutions
\"Case Studies in Cultural Entrepreneurship offers highly focused case studies that demonstrate the critical role entrepreneurs and entrepreneurial thinking play in reinventing cultural organizations. The reader has access to the full complexity of the situation facing these leaders. Historical background, choices, actors, external and internal forces, decision points, and results are detailed and examined in a way that is highly readable, approachable and accessible to a wide audience of professionals working in the museum field or with other cultural organizations\"--Provided by publisher.
Book
Global threats to human water security and river biodiversity
Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts for downstream impacts. We find that nearly 80% of the world’s population is exposed to high levels of threat to water security. Massive investment in water technology enables rich nations to offset high stressor levels without remedying their underlying causes, whereas less wealthy nations remain vulnerable. A similar lack of precautionary investment jeopardizes biodiversity, with habitats associated with 65% of continental discharge classified as moderately to highly threatened. The cumulative threat framework offers a tool for prioritizing policy and management responses to this crisis, and underscores the necessity of limiting threats at their source instead of through costly remediation of symptoms in order to assure global water security for both humans and freshwater biodiversity.
Dual threat to river biodiversity and water security
Access to fresh water is essential for all life forms, but water security for humans and biodiversity are often seen as competing priorities. A new analysis of the threats to the world's rivers breaks new ground by accounting for a broad array of stressors and their downstream effects, from both human and biodiversity perspectives. A subsequent analysis of investments in water resources offers insights into the sources of global disparities in human water security that separate rich from poor. The authors conclude that rivers are in a state of crisis, and that nearly 80% of humanity lives in areas where threat levels are relatively high. River-dwelling species face similarly great challenges around the world. Achieving a sustainable solution to these problems, the authors say, will require creative solutions that jointly address water security for humans and biodiversity, and that treat underlying causes rather than merely symptoms.
Water security affects human wellbeing both directly and indirectly, through its effects on biodiversity. Here, a global map has been generated that shows threats to both direct and indirect water security from a full range of potential stressors. Technological investments have also been incorporated. The map shows that nearly 80% of the world's population is exposed to high levels of threat to water security. Investment enables rich nations to offset high stressor levels, but less wealthy nations remain vulnerable.
Journal Article
The Cambridge companion to English Renaissance tragedy
\"Written by major international scholars, this Companion combines analysis of topics crucial to Renaissance tragedy with the interpretation of canonical and frequently taught texts. Part I introduces key topics, such as religion, revenge, and the family, and, uniquely, discusses modern performance traditions on stage and screen. Bridging this section with Part II is a chapter which engages with Shakespeare's generic distinctiveness as well as the difficulties our familiarity with Shakespearean tragedy engenders for our appreciation of the tragedies of his contemporaries. Individual essays in Part II introduce important critical conversations about specific canonical tragedies and provide their own contributions to those discussions. Topics include The Revenger's Tragedy and the theatrics of original sin, Arden of Faversham and the preternatural, and The Duchess of Malfi and the erotics of literary form. Providing fresh readings of key texts, the Companion is an essential guide for all students of Renaissance tragedy\"--Provided by publisher.
Book
A critical evaluation of proxy methods used to estimate the acidity of atmospheric particles
Given significant challenges with available measurements of aerosol acidity, proxy methods are frequently used to estimate the acidity of atmospheric particles. In this study, four of the most common aerosol acidity proxies are evaluated and compared: (1) the ion balance method, (2) the molar ratio method, (3) thermodynamic equilibrium models, and (4) the phase partitioning of ammonia. All methods are evaluated against predictions of thermodynamic models and against direct observations of aerosol–gas equilibrium partitioning acquired in Mexico City during the Megacity Initiative: Local and Global Research Objectives (MILAGRO) study. The ion balance and molar ratio methods assume that any deficit in inorganic cations relative to anions is due to the presence of H+ and that a higher H+ loading and lower cation / anion ratio both correspond to increasingly acidic particles (i.e., lower pH). Based on the MILAGRO measurements, no correlation is observed between H+ levels inferred with the ion balance and aerosol pH predicted by the thermodynamic models and NH3–NH4+ partitioning. Similarly, no relationship is observed between the cation / anion molar ratio and predicted aerosol pH. Using only measured aerosol chemical composition as inputs without any constraint for the gas phase, the E-AIM (Extended Aerosol Inorganics Model) and ISORROPIA-II thermodynamic equilibrium models tend to predict aerosol pH levels that are inconsistent with the observed NH3–NH4+ partitioning. The modeled pH values from both E-AIM and ISORROPIA-II run with gas + aerosol inputs agreed well with the aerosol pH predicted by the phase partitioning of ammonia. It appears that (1) thermodynamic models constrained by gas + aerosol measurements and (2) the phase partitioning of ammonia provide the best available predictions of aerosol pH. Furthermore, neither the ion balance nor the molar ratio can be used as surrogates for aerosol pH, and previously published studies with conclusions based on such acidity proxies may need to be reevaluated. Given the significance of acidity for chemical processes in the atmosphere, the implications of this study are important and far reaching.
Journal Article
How to build a life in the humanities : meditations on the academic work-life balance
\"A follow-up to the popular Graduate Study for the 21st Century: How to Build an Academic Career in the Humanities, this book seeks to expand current models of \"professional development\" by placing an emphasis on the human and humane aspects of daily lives in the humanities. It does so in response to a conviction that the contemporary academy has given rise to a host of complex personal challenges which demand serious reflection due to their direct impact on us as scholars, pedagogues, and university citizens. A collection of 25 short essays by leading humanists in all stages of their careers, How to Build a Life in the Humanities will delve into such under-discussed academic \"life\" issues as the following: maternity leaves; tenure-track stress; adjunct exploitation; post-tenure depression; personal relationships; exercise and hobbies; managing ambition; administrative burdens; institutional politics; classism; racism; sexism; and identity politics, among others. These candid, illuminating essays, which combine practical wisdom with meditative reflections upon the challenges of academic life, will be of interest to humanists of all ranks, from potential or beginning graduate students to seasoned professionals\"-- Provided by publisher.
Book
The Fragile Middle Class
Why have so many middle-class Americans encountered so much financial trouble? In this classic analysis of hard-pressed families, the authors discover that financial stability for many middle-class Americans is all too fragile. The authors consider the changing cultural and economic factors that threaten financial security and what they imply for the future vitality of the middle class. A new preface examines the persistent and new threats that have emerged since the original publication. \"[A] fascinating, alarming study. . . . [This] chilling diagnosis of middle-class affliction demonstrates that we all may be only a job loss, medical problem or credit card indulgence away from the downward spiral leading to bankruptcy.\"-Publishers Weekly \"A well-designed and carefully executed study.\"-Andrew Greeley, University of Chicago \"The Fragile Middle Class, a well-written work of social science that is about as gripping as the genre gets, forces us to reevaluate notions about consumerism.\"-American Prospect
eBook
الأبناء والتربية المثالية في ظل الضغوط الحياتية
يتعرض الأطفال فى عصرنا الحالي لكم هائل من الضغوط يفوق أي وقت مضى، ويناقش هذا الدليل الشامل المشكلات الحقيقية التى تؤثر على جعل حياتهم أكثر توازنا وصحة وسعادة، إنه بحق مرجع لاغنى عنه للآباء والمدرسين وأولئك المسئولين عن رعاية الأطفال وتنشئتهم تنشئة صحية سوية، ومن أمثلة النصائح التى يشتمل عليها الكتاب، بناء ثقة الطفل بنفسه وتقديره لذاته ، التعامل مع المضايقات المدرسية والضغط الذي يمارسه الأقران على الطفل - إيجاد جو أسري سعيد - مساعدة الطفل على الاسترخاء بشكل طبيعى - التعامل بشكل إيجابي مع الضغوط النفسية التي تسببها الامتحانات.
Book
Telomere-to-telomere assembly of a complete human X chromosome
After two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no single chromosome has been finished end to end, and hundreds of unresolved gaps persist
1
,
2
. Here we present a human genome assembly that surpasses the continuity of GRCh38
2
, along with a gapless, telomere-to-telomere assembly of a human chromosome. This was enabled by high-coverage, ultra-long-read nanopore sequencing of the complete hydatidiform mole CHM13 genome, combined with complementary technologies for quality improvement and validation. Focusing our efforts on the human X chromosome
3
, we reconstructed the centromeric satellite DNA array (approximately 3.1 Mb) and closed the 29 remaining gaps in the current reference, including new sequences from the human pseudoautosomal regions and from cancer-testis ampliconic gene families (CT-X and GAGE). These sequences will be integrated into future human reference genome releases. In addition, the complete chromosome X, combined with the ultra-long nanopore data, allowed us to map methylation patterns across complex tandem repeats and satellite arrays. Our results demonstrate that finishing the entire human genome is now within reach, and the data presented here will facilitate ongoing efforts to complete the other human chromosomes.
High-coverage, ultra-long-read nanopore sequencing is used to create a new human genome assembly that improves on the coverage and accuracy of the current reference (GRCh38) and includes the gap-free, telomere-to-telomere sequence of the X chromosome.
Journal Article
Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and functionally distinct areas. To investigate the diversity of cell types across the mouse neocortex, here we analysed 23,822 cells from two areas at distant poles of the mouse neocortex: the primary visual cortex and the anterior lateral motor cortex. We define 133 transcriptomic cell types by deep, single-cell RNA sequencing. Nearly all types of GABA (γ-aminobutyric acid)-containing neurons are shared across both areas, whereas most types of glutamatergic neurons were found in one of the two areas. By combining single-cell RNA sequencing and retrograde labelling, we match transcriptomic types of glutamatergic neurons to their long-range projection specificity. Our study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex.
Single-cell transcriptomics of more than 20,000 cells from two functionally distinct areas of the mouse neocortex identifies 133 transcriptomic types, and provides a foundation for understanding the diversity of cortical cell types.
Journal Article