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Quality of Information in Gallstone Disease Videos on TikTok: Cross-sectional Study
TikTok was an important channel for consumers to access and adopt health information. But the quality of health content in TikTok remains underinvestigated.
Our study aimed to identify upload sources, contents, and feature information of gallstone disease videos on TikTok and further evaluated the factors related to video quality.
We investigated the first 100 gallstone-related videos on TikTok and analyzed these videos' upload sources, content, and characteristics. The quality of videos was evaluated using quantitative scoring tools such as DISCERN instrument, the Journal of American Medical Association (JAMA) benchmark criteria, and Global Quality Scores (GQS). Moreover, the correlation between video quality and video characteristics, including duration, likes, comments, and shares, was further investigated.
According to video sources, 81% of the videos were posted by doctors. Furthermore, disease knowledge was the most dominant video content, accounting for 56% of all the videos. The mean DISCERN, JAMA, and GQS scores of all 100 videos are 39.61 (SD 11.36), 2.00 (SD 0.40), and 2.76 (SD 0.95), respectively. According to DISCERN and GQS, gallstone-related videos' quality score on TikTok is not high, mainly at fair (43/100, 43%,) and moderate (46/100, 46%). The total DISCERN scores of doctors were significantly higher than that of individuals and news agencies, surgery techniques were significantly higher than lifestyle and news, and disease knowledge was significantly higher than news, respectively. DISCERN scores and video duration were positively correlated. Negative correlations were found between DISCERN scores and likes and shares of videos. In GQS analysis, no significant differences were found between groups based on different sources or different contents. JAMA was excluded in the video quality and correlation analysis due to a lack of discrimination and inability to evaluate the video quality accurately.
Although the videos of gallstones on TikTok are mainly provided by doctors and contain disease knowledge, they are of low quality. We found a positive correlation between video duration and video quality. High-quality videos received low attention, and popular videos were of low quality. Medical information on TikTok is currently not rigorous enough to guide patients to make accurate judgments. TikTok was not an appropriate source of knowledge to educate patients due to the low quality and reliability of the information.
Journal Article
Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment
Introduction Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South China. Methods In this retrospective case‐based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat‐sen University Cancer Center between January 2004 and May 2013 were included. The incidence, risk factors, and survival status of these patients were reviewed and analyzed. Results Of the 106 patients, 11 (10.4%) developed brain metastasis, accounting for 20.0% of 55 patients with relapse or progression. The age at initial diagnosis of the 11 patients ranged from 2 to 10 years (median 4 years), which was younger than that of the patients without brain metastasis (median 5 years, range 1–10 years, P = 0.073). The male to female ratio of the 11 patients was 8:3, which was not significantly different from that of the patients without brain metastasis (P = 0.86). Patients with brain metastasis had higher lactate dehydrogenase levels than those without brain metastasis, but the differences were not significant (P = 0.076). Eight patients died, and 3 patients survived. The median interval from the initial diagnosis to the development of brain metastasis was 18 months (range 6–32 months). The median survival was 4 months (range 1 day to 29 months) after the diagnosis of brain metastasis. The median interval from the manifestation of brain metastasis to death was 3 months (range 1 day to 11 months). Conclusions High‐risk factors for brain metastasis in cases of neuroblastoma include bone marrow involvement and a younger age at initial diagnosis. Nevertheless, multiple treatment modalities can improve disease‐free survival.
Journal Article
Achieving High Tensile Strength of Heat-Resistant Ni-Fe-Based Alloy by Controlling Microstructure Stability for Power Plant Application
A new, wrought Ni-Fe-based alloy with excellent creep rupture life has been developed for 700 °C-class advanced ultra-supercritical (A-USC) steam turbine rotor application. In this study, its tensile deformation behaviors and related microstructure evolution were investigated. Tensile tests were carried out at room temperature, 700 °C, and 750 °C. The results show that the Ni-Fe-based alloy has excellent yield strength at 700 °C, which is higher than that of some other Ni-based/Ni-Fe-based alloys. The fracture surface characteristics indicate trans-granular and intergranular fracture modes at room temperature, 700 °C, and 750 °C. However, the intergranular fraction mode became dominant above 700 °C. Dynamic recrystallization occurred at 700 °C and 750 °C with increasing average misorientation angles. The volume fraction of the γ′ precipitate was around 20%, and the average size of the γ′ precipitates was around 30 μm, which had no noticeable change after the tensile tests. The predominant deformation mechanisms were planar slip at room temperature, bypassing of the γ′ precipitates by the Orowan mechanism, and dislocation shearing at 700 °C and 750 °C. The tensile properties, fracture characteristics, and deformation mechanisms have been well-correlated. The results are helpful in providing experimental evidence for the development and optimization of high-temperature alloys for 700 °C-class A-USC applications.
Journal Article
Revealing and reconstructing the 3D Li-ion transportation network for superionic poly(ethylene) oxide conductor
Understanding the Li-ions conduction network and transport dynamics in polymer electrolyte is crucial for developing reliable all-solid-state batteries. In this work, advanced nano- X-ray computed tomography combined with Raman spectroscopy and solid state nuclear magnetic resonance are used to multi-scale qualitatively and quantitatively reveal ion conduction network of poly(ethylene) oxide (PEO)-based electrolyte (from atomic, nano to macroscopic level). With the clear mapping of the microstructural heterogeneities of the polymer segments, aluminium-oxo molecular clusters (AlOC) are used to reconstruct a high-efficient conducting network with high available Li-ions (76.7%) and continuous amorphous domains via the strong supramolecular interactions. Such superionic PEO conductor (PEO-LiTFSI-AlOC) exhibites a molten-like Li-ion conduction behaviour among the whole temperature range and delivers an ionic conductivity of 1.87 × 10
−4
S cm
−1
at 35 °Ϲ. This further endows Li electrochemical plating/stripping stability under 50 μA cm
−2
and 50 μAh cm
−2
over 2000 h. The as-built Li|PEO-LiTFSI-AlOC|LiFePO
4
full batteries show a high rate performance and a capacity retention more than 90% over 200 cycling at 250 μA cm
−2
, even enabling a high-loading LiFePO
4
cathode of 16.8 mg cm
−2
with a specific capacity of 150 mAh g
−1
at 50 °Ϲ.
The sluggish ionic conductivity of polymer electrolytes has been a long-standing concern. Here, authors present a multiscale study of the lithium ion conduction network of poly(ethylene) oxide-based electrolytes and elucidate how aluminium-oxo molecular clusters improve the transport properties.
Journal Article
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear. We investigate the effect of fasting on glucose metabolism and malignancy in CRC. We find that fasting upregulates the expression of a cholesterogenic gene, Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), during the inhibition of CRC cell aerobic glycolysis and proliferation. In addition, the downregulation of FDFT1 is correlated with malignant progression and poor prognosis in CRC. Moreover, FDFT1 acts as a critical tumor suppressor in CRC. Mechanistically, FDFT1 performs its tumor-inhibitory function by negatively regulating AKT/mTOR/HIF1α signaling. Furthermore, mTOR inhibitor can synergize with fasting in inhibiting the proliferation of CRC. These results indicate that FDFT1 is a key downstream target of the fasting response and may be involved in CRC cell glucose metabolism. Our results suggest therapeutic implications in CRC and potential crosstalk between a cholesterogenic gene and glycolysis.
Journal Article
Physical activity in older people: a systematic review
Background
Physical activity (PA) in older people is critically important in the prevention of disease, maintenance of independence and improvement of quality of life. Little is known about the physical activity of the older adults or their compliance with current physical activity guidelines.
Methods
A systematic literature search of the published literature was conducted. Included were published reports of original research that independently reported: the PA level of non-institutional older adults (aged 60 years and over); and the proportion of older adults in the different samples who met PA recommendations or guidelines. The review was restricted to studies published since 2000 to provide a current picture of older adults’ PA levels.
Results
Fifty three papers were included in the review. The percentage of older adults meeting recommended physical activity ranged from 2.4 – 83.0% across the studies. Definitions of “recommended” physical activity in older adults varied across the studies as did approaches to measurement which posed methodological challenges to data analysis. Older age groups were less likely than the reference group to be regularly active, and women were less likely than men to achieve regular physical activity, especially leisure time physical activity, when measured by both subjective and objective criteria.
Conclusion
The review highlights the need for studies which recruit representative random samples of community based older people and employ validated measurement methods consistently to enable comparison of PA levels over time and between countries.
Journal Article
DeepETPicker: Fast and accurate 3D particle picking for cryo-electron tomography using weakly supervised deep learning
To solve three-dimensional structures of biological macromolecules in situ, large numbers of particles often need to be picked from cryo-electron tomograms. However, adoption of automated particle-picking methods remains limited because of their technical limitations. To overcome the limitations, we develop DeepETPicker, a deep learning model for fast and accurate picking of particles from cryo-electron tomograms. Training of DeepETPicker requires only weak supervision with low numbers of simplified labels, reducing the burden of manual annotation. The simplified labels combined with the customized and lightweight model architecture of DeepETPicker and accelerated pooling enable substantial performance improvement. When tested on simulated and real tomograms, DeepETPicker outperforms the competing state-of-the-art methods by achieving the highest overall accuracy and speed, which translate into higher authenticity and coordinates accuracy of picked particles and higher resolutions of final reconstruction maps. DeepETPicker is provided in open source with a user-friendly interface to support cryo-electron tomography in situ.
Picking particles of biological macromolecules is critical for solving their structures in situ using cryo-electron tomograms. Here, authors develop DeepETPicker, a deep learning-based tool for fast, accurate, and automated picking of three-dimensional particles.
Journal Article
B12-dependent photoresponsive protein hydrogels for controlled stem cell/protein release
Thanks to the precise control over their structural and functional properties, genetically engineered protein-based hydrogels have emerged as a promising candidate for biomedical applications. Given the growing demand for creating stimuli-responsive “smart” hydrogels, here we show the synthesis of entirely protein-based photoresponsive hydrogels by covalently polymerizing the adenosylcobalamin (AdoB12)-dependent photoreceptor C-terminal adenosylcobalamin binding domain (CarHC) proteins using genetically encoded SpyTag-SpyCatcher chemistry under mild physiological conditions. The resulting hydrogel composed of physically self-assembled CarHC polymers exhibited a rapid gel-sol transition on light exposure, which enabled the facile release/recovery of 3T3 fibroblasts and human mesenchymal stem cells (hMSCs) from 3D cultures while maintaining their viability. A covalently cross-linked CarHC hydrogel was also designed to encapsulate and release bulky globular proteins, such as mCherry, in a light-dependent manner. The direct assembly of stimuli-responsive proteins into hydrogels represents a versatile strategy for designing dynamically tunable materials.
Journal Article
Necrotizing soft tissue infection of the shoulder caused by non-penetrating trauma - a case report
Necrotizing soft tissue infection is a rare and severe infection of the skin and fascial tissues, characterized by extensive and rapid subcutaneous soft tissue infection. The onset of necrotizing fasciitis often occurs in areas such as the perineum, limbs, abdomen, oral cavity, and neck. In this case, a 49-year-old male patient with a history of type 2 diabetes presented with right shoulder pain for three days. An MRI of the shoulder indicated edema and hematoma formation in the supraspinatus muscle, subscapularis muscle, and surrounding soft tissues of the clavicle. After receiving anti-infective treatment in a local hospital, the patient was readmitted due to redness, swelling, and pain in the right anterior chest area seven days later. The infection gradually worsened, and after three surgeries and multidisciplinary collaborative treatment, the patient’s condition stabilized, allowing for discharge. This case of NF occurred in the chest wall due to non-penetrating trauma to the shoulder, with rapid progression and a unique location, making it rarely reported in the literature.
Journal Article