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The spin state transition from low spin to high spin upon substrate addition is one of the key steps in cytochrome P450 catalysis. External perturbations such as pH and hydrogen bonding can also trigger the spin state transition of hemes through deprotonated histidine (e.g. Cytochrome c ). In this work, we report the isolated 2-methylimidazole Cobalt(II) [Co(TPP)(2-MeHIm)] and [Co(TTP)(2-MeHIm)], and the corresponding 2-methylimidazolate derivatives where the N−H proton of axial 2-MeHIm is removed. Interestingly, various spectroscopies including EPR and XAFS determine a high-spin state ( S  = 3/2) for the imidazolate derivatives, in contrast to the low-spin state ( S  = 1/2) of all known imidazole analogs. DFT assisted stereoelectronic investigations are applied to understand the metal-ligand interactions, which suggest that the dramatically displaced metal center allowing a promotion e g (d π ) →  b 1g ( d x 2 - y 2 ) is crucial for the occurrence of the spin state transition. Studying the electronic structures and spin transitions of synthetic heme analogs is crucial to advancing our understanding of heme enzyme mechanisms. Here the authors show that a Co(II) porphyrin complex undergoes an unexpected spin state transition upon deprotonation of its axial imidazole ligand.

In the original version of this Article, the four structural depictions of orbital distributions were inadvertently omitted from Figure 5. This has now been corrected in both the HTML and PDF versions of the Article.

Molecular nanomagnets have been undergoing development for 20 years since the first single-molecule magnet (SMM), Mn12Ac, was characterized as the molecule-behaved magnet. The multi-disciplinary scientists promoted the magnetic characteristics to be more suitable for use in information science and spintronics. The concept of molecular nanomagnets has also evolved to include single-chain magnets (SCMs), single-ion magnets (SIMs) and even magnetic molecules that showed only slow magnetic relaxation, in addition to the initial cluster-type SMMs. In this review, several aspects, including SMMs, SCMs and SIMs, are introduced briefly through some representative examples. In particular, the contribution of Chinese chemists is highlighted in the design, synthesis and understanding of various types of molecular nanomagnets.

Molecular nanomagnets have been undergoing development for 20 years since the first single-molecule magnet (SMM), Mn₁₂Ac, was characterized as the molecule-behaved magnet. The multi-disciplinary scientists promoted the magnetic characteristics to be more suitable for use in information science and spintronics. The concept of molecular nanomagnets has also evolved to include single-chain magnets (SCMs), single-ion magnets (SIMs) and even magnetic molecules that showed only slow magnetic relaxation, in addition to the initial cluster-type SMMs. In this review, several aspects, including SMMs, SCMs and SIMs, are introduced briefly through some representative examples. In particular, the contribution of Chinese chemists is highlighted in the design, synthesis and understanding of various types of molecular nanomagnets.

Accurate estimation of heading direction from optic flow is a crucial aspect of human spatial perception. Previous psychophysical studies have shown that humans are typically biased in their heading estimates, but the reported results are inconsistent. While some studies found that humans generally underestimate heading direction (center bias), others observed the opposite, an overestimation of heading direction (peripheral bias). We conducted three psychophysical experiments showing that these conflicting findings may not reflect inherent differences in heading perception but can be attributed to the different sizes of the response range that participants were allowed to utilize when reporting their estimates. Notably, we show that participants' heading estimates monotonically scale with the size of the response range, leading to underestimation for small and overestimation for large response ranges. Additionally, neither the speed profile of the optic flow pattern nor the response method (mouse vs. keyboard) significantly affected participants' estimates. Furthermore, we introduce a Bayesian heading estimation model that can quantitatively account for participants' heading reports. The model assumes efficient sensory encoding of heading direction according to a prior inferred from human heading discrimination data. In addition, the model assumes a response mapping that linearly scales the perceptual estimate with a scaling factor that monotonically depends on the size of the response range. This simple perception-action model accurately predicts participants' estimates both in terms of mean and variance across all experimental conditions. Our findings underscore that human heading perception follows efficient Bayesian inference; differences in participants reported estimates can be parsimoniously explained as differences in mapping percept to probe response.

The direct utilization of solar energy for the artificial photosynthesis of hydrogen peroxide (H 2 O 2 ) provides a reliable approach for producing this high-value green oxidant. Here we report on the utility of high-entropy oxide (HEO) semiconductor as an all-in-one photocatalyst for visible light-driven H 2 O 2 production directly from H 2 O and atmospheric O 2 without the need of any additional cocatalysts or sacrificial agents. This high-entropy photocatalyst contains eight earth-abundant metal elements (Ti/V/Cr/Nb/Mo/W/Al/Cu) homogeneously arranged within a single rutile phase, and the intrinsic chemical complexity along with the presence of a high density of oxygen vacancies endow high-entropy photocatalyst with distinct broadband light harvesting capability. An efficient H 2 O 2 production rate with an apparent quantum yield of 38.8% at 550 nm can be achieved. The high-entropy photocatalyst can be readily assembled into floating artificial leaves for sustained on-site production of H 2 O 2 from open water resources under natural sunlight irradiation. An “all-in-one” high-entropy semiconductor photocatalyst enables the photocatalytic production of H 2 O 2 from H 2 O and O 2 under visible light without any external cocatalysts or sacrificial agents

Rural solid waste (RSW) exhibits distinct characteristics compared to municipal solid waste (MSW), such as dispersed distribution, long governance chains, and low recycling value, making it unsuitable to apply the same management measures as MSW. Government-led RSW management results in excessive administrative costs, and the inherent characteristics of RSW reduce market enthusiasm for its management. To address these issues, this paper integrates the “ multi-subject governance “ model with RSW management and establishes a systematic evaluation index system for RSW governance. Utilizing the Best-Worst Method (BWM), key factors were identified. Utilizing the VIKOR method, representative provinces in China were used as case studies to validate the scientific nature of the evaluation indices. The research findings indicate that the multi-subject governance model is an effective approach for RSW management. Key factors influencing RSW management effectiveness include various governmental measures, waste sorting, and a long-term multi-subject governance mechanism. Case analysis reveals a strong correlation between the level of economic development and the effectiveness of RSW management. However, constructing a government-led, multi-subject collaborative urban-rural interconnected RSW management model can effectively address RSW management issues in economically underdeveloped areas. This research provides innovative solutions for RSW management, contributing to high-quality and sustainable development in rural areas.

The comprehension of spoken language is one of the most essential language functions in humans. However, the neurological underpinnings of auditory comprehension remain under debate. Here we used multi‐modal neuroimaging analyses on a group of patients with low‐grade gliomas to localize cortical regions and white matter tracts responsible for auditory language comprehension. Region‐of‐interests and voxel‐level whole‐brain analyses showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity assessed with diffusion tensor imaging of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with both auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri. Together, our findings provide direct evidence for an integrated network of auditory comprehension whereby the superior temporal gyrus and sulcus, the posterior parts of the middle and inferior temporal gyri serve as auditory comprehension cortex, and the arcuate fasciculus and the inferior longitudinal fasciculus subserve as crucial structural connectivity. These findings provide critical evidence on the neural underpinnings of language comprehension. Our findings provide direct evidence for an integrated network of auditory comprehension whereby not only the superior temporal gyrus and sulcus but the posterior parts of the middle and inferior temporal gyri also serve as auditory comprehension cortex, and the arcuate fasciculus and the inferior longitudinal fasciculus subserve as crucial structural connectivity. These findings provide new evidence on the neural underpinnings of language comprehension

To investigate the risk factors for metabolic bone disease of prematurity (MBDP), and to provide a reference for the prevention of MBDP. The databases including China Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database, PubMed, Web of Science, Embase, Cochrane Library and other databases were searched for studies on the risk factors for MBDP published up to June 18, 2021. RevMan 5.3 and Stata 14.1 software were used to perform a Meta analysis. A total of 15 articles were included, including 13 case-control studies, 1 current investigation, and 1 retrospective cohort study. There were 1,435 cases in the case group and 2,057 cases in the control group, with a total sample size of 3,492 cases. Meta analysis showed that risk factors for MBDP include birth weight <1000g (OR = 6.62, 95%CI: 2.28-19.25), gestational age <32 weeks (OR = 2.73, 95%CI: 1.07-6.95), septicemia (OR = 2.53, 95%CI: 1.69-3.79), parenteral nutrition time (OR = 4.04, 95%CI: 1.72-9.49), cholestasis (OR = 3.50, 95%CI: 1.49-8.23), intrauterine growth retardation (OR = 6.89, 95%CI: 3.81-12.44), while the birth weight(OR = 0.44, 95%CI: 0.21-0.90) and gestational age (OR = 0.57, 95%CI: 0.44-0.73)are the protective factors of MBDP. Factors like birth weight <1000g, gestational age <32 weeks, septicemia, parenteral nutrition time, cholestasis, and intrauterine growth retardation may increase the risk of metabolic bone disease of prematurity.

The epigenetic reader SntB was identified as an important transcriptional regulator of growth, development, and secondary metabolite synthesis in Aspergillus flavus . However, the underlying molecular mechanism is still unclear. In this study, by gene deletion and complementation, we found SntB is essential for mycelia growth, conidial production, sclerotia formation, aflatoxin synthesis, and host colonization. Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) analysis revealed that SntB played key roles in oxidative stress response of A. flavus , influencing related gene activity, especially catC encoding catalase. SntB regulated the expression activity of catC with or without oxidative stress, and was related to the expression level of the secretory lipase (G4B84_008359). The deletion of catC showed that CatC participated in the regulation of fungal morphogenesis, reactive oxygen species (ROS) level, and aflatoxin production, and that CatC significantly regulated fungal sensitive reaction and AFB1 yield under oxidative stress. Our study revealed the potential machinery that SntB regulated fungal morphogenesis, mycotoxin anabolism, and fungal virulence through the axle of from H3K36me3 modification to fungal virulence and mycotoxin biosynthesis. The results of this study shed light into the SntB-mediated transcript regulation pathways of fungal mycotoxin anabolism and virulence, which provided potential strategy to control the contamination of A. flavus and its aflatoxins.