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"Sun, Hong"
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Cold War Germany, the Third World, and the global humanitarian regime
\"This book examines competition and collaboration among Western powers, the socialist bloc, and the Third World for control over humanitarian aid programs during the Cold War. Young-sun Hong's analysis reevaluates the established parameters of German history. On the one hand, global humanitarian efforts functioned as an arena for a three-way political power struggle. On the other, they gave rise to transnational spaces that allowed for multidimensional social and cultural encounters. Hong paints an unexpected view of the global humanitarian regime: Algerian insurgents flown to East Germany for medical care, barefoot Chinese doctors in Tanzania, and West and East German doctors working together in the Congo. She also provides a rich analysis of the experiences of African trainees and Asian nurses in the two Germanys. This book brings an urgently needed historical perspective to contemporary debates on global governance, which largely concern humanitarianism, global health, south-north relationships, and global migration\"-- Provided by publisher.
Book
Double‐edged sword of mesenchymal stem cells: Cancer‐promoting versus therapeutic potential
Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and other tissues, have recently attracted much attention as potential therapeutic agents in various diseases because of their trans‐differentiation capacity. However, recent studies have suggested that MSCs also appear to contribute to tumor pathogenesis by supporting tumor microenvironments, increasing tumor growth, and eliciting antitumor immune responses. Although some studies suggest that MSCs have inhibitory effects on tumor development, they are overwhelmed by a number of studies showing that MSCs exert stimulatory effects on tumor pathogenesis. In the present review, we summarize a number of findings to provide current information about the therapeutic potential of MSCs in various diseases. We then discuss the potential roles of MSCs in tumor progression. In this review article, we summarized a number of findings to provide current information about their therapeutic potential in various diseases; we then discussed the potential roles of MSCs in tumor progression.
Journal Article
Acoustic non-Hermitian skin effect from twisted winding topology
The recently discovered non-Hermitian skin effect (NHSE) manifests the breakdown of current classification of topological phases in energy-nonconservative systems, and necessitates the introduction of non-Hermitian band topology. So far, all NHSE observations are based on one type of non-Hermitian band topology, in which the complex energy spectrum winds along a closed loop. As recently characterized along a synthetic dimension on a photonic platform, non-Hermitian band topology can exhibit almost arbitrary windings in momentum space, but their actual phenomena in real physical systems remain unclear. Here, we report the experimental realization of NHSE in a one-dimensional (1D) non-reciprocal acoustic crystal. With direct acoustic measurement, we demonstrate that a twisted winding, whose topology consists of two oppositely oriented loops in contact rather than a single loop, will dramatically change the NHSE, following previous predictions of unique features such as the bipolar localization and the Bloch point for a Bloch-wave-like extended state. This work reveals previously unnoticed features of NHSE, and provides the observation of physical phenomena originating from complex non-Hermitian winding topology.
Non-Hermitian skin effect fundamentally challenges the conventional topological description of a system. Here the authors demonstrate a bipolar non-Hermitian skin effect, where bulk eigenstates localize towards two directions, in a one-dimensional non-reciprocal acoustic crystal with twisted topology.
Journal Article
Observation of an acoustic octupole topological insulator
Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exhibit a hierarchy of multipole topology: a quantised octupole moment in a three-dimensional bulk induces quantised quadrupole moments on its two-dimensional surfaces, which in turn induce quantised dipole moments on one-dimensional hinges. Here, we report on the realisation of an octupole topological insulator in a three-dimensional acoustic metamaterial. We observe zero-dimensional topological corner states, one-dimensional gapped hinge states, two-dimensional gapped surface states, and three-dimensional gapped bulk states, representing the hierarchy of octupole, quadrupole and dipole moments. Conditions for forming a nontrivial octupole moment are demonstrated by comparisons with two different lattice configurations having trivial octupole moments. Our work establishes the multipole topology and its full hierarchy in three-dimensional geometries.
The concept of topological corner states in two dimensional topological insulators can be generalised to higher dimensions. Here, authors present a three dimensional acoustic metamaterial that exhibits the full hierarchy of topological multipole states including corner, hinge, surface and bulk states.
Journal Article
Femtosecond laser programmed artificial musculoskeletal systems
Natural musculoskeletal systems have been widely recognized as an advanced robotic model for designing robust yet flexible microbots. However, the development of artificial musculoskeletal systems at micro-nanoscale currently remains a big challenge, since it requires precise assembly of two or more materials of distinct properties into complex 3D micro/nanostructures. In this study, we report femtosecond laser programmed artificial musculoskeletal systems for prototyping 3D microbots, using relatively stiff SU-8 as the skeleton and pH-responsive protein (bovine serum albumin, BSA) as the smart muscle. To realize the programmable integration of the two materials into a 3D configuration, a successive on-chip two-photon polymerization (TPP) strategy that enables structuring two photosensitive materials sequentially within a predesigned configuration was proposed. As a proof-of-concept, we demonstrate a pH-responsive spider microbot and a 3D smart micro-gripper that enables controllable grabbing and releasing. Our strategy provides a universal protocol for directly printing 3D microbots composed of multiple materials.
Musculoskeletal systems are recognized as a model for designing robust yet flexible microbots but the development of artificial musculoskeletal systems at nanoscale currently remains challenging. Here the authors report a laser programmed artificial musculoskeletal systems for prototyping 3D microbots, using relatively stiff SU-8 as the skeleton and pH-responsive proteins as the smart muscle.
Journal Article
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tumor adjacent tissues, we find that ccRCC shows extensive metabolic dysregulation and an enhanced immune response. Molecular subtyping classifies ccRCC tumors into three subtypes (GP1–3), among which the most aggressive GP1 exhibits the strongest immune phenotype, increased metastasis, and metabolic imbalance, linking the multi-omics-derived phenotypes to clinical outcomes of ccRCC. Nicotinamide N-methyltransferase (NNMT), a one-carbon metabolic enzyme, is identified as a potential marker of ccRCC and a drug target for GP1. We demonstrate that NNMT induces DNA-dependent protein kinase catalytic subunit (DNA-PKcs) homocysteinylation, increases DNA repair, and promotes ccRCC tumor growth. This study provides insights into the biological underpinnings and prognosis assessment of ccRCC, revealing targetable metabolic vulnerabilities.
Clear cell renal cell carcinoma is an aggressive form of renal cancer, with differences in genomic mutations reported between Western and Eastern populations. In this study, the authors have compiled proteogenomic analysis of Chinese ccRCC to reveal genomic alterations and dysregulation of immune and metabolic responses.
Journal Article
Resilience-based seismic design method for reinforced concrete structures
As high-rise buildings gradually increase, their seismic performance has become a focus in the engineering field. To improve the functional recovery ability and economy of buildings after earthquakes, a resilience-based seismic design method for reinforced concrete structures is proposed. An indicator system that can reflect the functional loss of buildings after earthquakes is developed. A seismic design strategy based on functional recovery indicators is proposed to improve the seismic performance and economy, while shortening the recovery time after earthquakes. The research results indicated that the average inter story displacement of the standard seismic method for reinforced concrete structures was 168 mm. The inter story displacement of the seismic resistance method for reinforced concrete structures based on resilience objectives was 192 mm. The repair time for standard seismic method of reinforced concrete structures was 33 days. The repair time for the seismic resistance method of reinforced concrete structures based on resilience was 24 days. The resilience-based seismic design method is superior to traditional methods in controlling structural damage, reducing repair cost, and shortening repair time. The designed method proposed in the study not only enhances the seismic resilience of the structure, but also has significant economic and social benefits, providing a new perspective and practical tools for the seismic design of high-rise buildings
Journal Article
Quantum sensing with optically accessible spin defects in van der Waals layered materials
Quantum sensing has emerged as a powerful technique to detect and measure physical and chemical parameters with exceptional precision. One of the methods is to use optically active spin defects within solid-state materials. These defects act as sensors and have made significant progress in recent years, particularly in the realm of two-dimensional (2D) spin defects. In this article, we focus on the latest trends in quantum sensing that use spin defects in van der Waals (vdW) materials. We discuss the benefits of combining optically addressable spin defects with 2D vdW materials while highlighting the challenges and opportunities to use these defects. To make quantum sensing practical and applicable, the article identifies some areas worth further exploration. These include identifying spin defects with properties suitable for quantum sensing, generating quantum defects on demand with control of their spatial localization, understanding the impact of layer thickness and interface on quantum sensing, and integrating spin defects with photonic structures for new functionalities and higher emission rates. The article explores the potential applications of quantum sensing in several fields, such as superconductivity, ferromagnetism, 2D nanoelectronics, and biology. For instance, combining nanoscale microfluidic technology with nanopore and quantum sensing may lead to a new platform for DNA sequencing. As materials technology continues to evolve, and with the advancement of defect engineering techniques, 2D spin defects are expected to play a vital role in quantum sensing.
Journal Article
Non-Abelian braiding on photonic chips
Non-Abelian braiding has attracted substantial attention because of its pivotal role in describing the exchange behaviour of anyons—candidates for realizing quantum logics. The input and outcome of non-Abelian braiding are connected by a unitary matrix that can also physically emerge as a geometric-phase matrix in classical systems. Hence it is predicted that non-Abelian braiding should have analogues in photonics, although a feasible platform and the experimental realization remain out of reach. Here we propose and experimentally realize an on-chip photonic system that achieves the non-Abelian braiding of up to five photonic modes. The braiding is realized by controlling the multi-mode geometric-phase matrix in judiciously designed photonic waveguide arrays. The quintessential effect of braiding—sequence-dependent swapping of photon dwell sites—is observed in both classical-light and single-photon experiments. Our photonic chips are a versatile and expandable platform for studying non-Abelian physics, and we expect the results to motivate next-generation non-Abelian photonic devices.Non-Abelian braiding—a candidate for realizing quantum logics—is demonstrated by controlling the geometric-phase matrix in a photonic chip, and its key characteristics are observed.
Journal Article
Comparison of leaf transcriptome in response to Rhizoctonia solani infection between resistant and susceptible rice cultivars
Background
Sheath blight (SB), caused by
Rhizoctonia solani
, is a common rice disease worldwide. Currently, rice cultivars with robust resistance to
R. solani
are still lacking. To provide theoretic basis for molecular breeding of
R. solani
-resistant rice cultivars, the changes of transcriptome profiles in response to
R. solani
infection were compared between a moderate resistant cultivar (Yanhui-888, YH) and a susceptible cultivar (Jingang-30, JG).
Results
In the present study, 3085 differentially express genes (DEGs) were detected between the infected leaves and the control in JG, with 2853 DEGs in YH. A total of 4091 unigenes were significantly upregulated in YH than in JG before infection, while 3192 were significantly upregulated after infection. Further analysis revealed that YH and JG showed similar molecular responses to
R. solani
infection, but the responses were earlier in JG than in YH. Expression levels of trans-cinnamate 4-monooxygenase (C4H), ethylene-insensitive protein 2 (EIN2), transcriptome factor WRKY33 and the KEGG pathway plant-pathogen interaction were significantly affected by
R. solani
infection. More importantly, these components were all over-represented in YH cultivar than in JG cultivar before and/or after infection.
Conclusions
These genes possibly contribute to the higher resistance of YH to
R. solani
than JG and were potential target genes to molecularly breed
R. solani
-resistant rice cultivar.
Journal Article