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An intelligent reflecting surface (IRS)‐assisted wireless communication system with user mobility following random waypoint (RWP) model is investigated, where the user receives the reflection signal from the IRS controlled by the access point (AP) via a programmable controller, and the IRS is mounted on an unmanned aerial vehicle which is only an auxiliary device to enable IRS reflection communication at a certain altitude. As user moves, the AP makes the reflected beamforming of the IRS following with the user through coding the unit‐element of the IRS. To investigate the effect of joint IRS feature and user mobility on the outage performance, the cumulative distribution function of the received signal‐to‐noise ratio of the mobile user is first derived and then the close‐form expression for the outage probability is obtained. Numerical simulations are performed to validate the accuracy of the analytical results. The solutions are also compared with that for conventional amplify‐and‐forward relay system. Insights are drawn related to the number of meta‐surface elements, and the maximum activity radius of mobile user.

The outage performance of a reconfigurable intelligent surface- (RIS-) aided full-duplex cooperative nonorthogonal multiple access (NOMA) system is studied in this paper. Based on the statistical characteristics of the signal-to-noise ratio of the reflection channel from the access point via RIS to the near user, and the cooperative channel from the near user to the far NOMA user, the outage probability of both the near and far users is derived. Through the comparison with the outage performance of conventional cooperative NOMA without employing RIS, the superiority of the proposed scheme is demonstrated. Finally, the correctness of the analytical results is validated with simulation.

An intelligent reflecting surface (IRS)‐aided visible light secure communication system is investigated. In order to improve its security performance, a power splitting scheme is adopted at the light‐emitting diodes. In contrast to most current research on the physical‐layer security in IRS‐aided visible light secure communication systems where secrecy rate or secrecy capacity maximization problems subject to various resource constraints were formulated, this letter takes the reliability of secure transmission into account. The closed‐form expression of secrecy outage probability is derived based on the statistical characteristics of the signal‐to‐noise ratio of the legitimate user, and the effects of light‐emitting diodes and IRS parameters and power splitting ratio on the secrecy outage probability are validated through simulations. Contrary to most research that primarily focuses on formulating secrecy rate or secrecy capacity maximization problems in intelligent reflecting surface‐assisted visible light secure communication systems, this study innovatively emphasizes the reliability of secure transmissions. To enhance security performance, a novel power splitting scheme is implemented at the light‐emitting diodes. Furthermore, the research derives a closed‐form expression for the secrecy outage probability based on the statistical characteristics of the legitimate user's signal‐to‐noise ratio, and it validates the impact of light‐emitting diode, intelligent reflecting surface parameters, and the power splitting ratio through comprehensive simulations.

Since successive interference cancellation in non-orthogonal multiple access (NOMA) is enabled at the strong user to remove the signal of the weak user, if the information safety of the strong user cannot be ensured, neither can the weak user. The physical-layer security of the strong user in a two-user multiple-input single-output (MISO)-NOMA visible light communication (VLC) system in the presence of a passive eavesdropper was studied, with multiple light-emitting diodes (LEDs) transmitting and a photodiode (PD) receiver receiving. To demonstrate the superiority of the MISO-NOMA VLC system over the SISO-NOMA VLC system, numerical simulations were made, and results show that the secrecy outage probability (SOP) performance of the strong user in the MISO-NOMA VLC system is superior to that in the SISO-NOMA VLC system. Furthermore, the SOP of the strong user depends highly on the room arrangement, the difference between the legitimate channel and eavesdropper channel, and the properties of the LEDs and PD.

Based on a δ180 chronology, rare earth elements （REE） and other typical elements in sediments from core MD06-3047 in the western Philippine Sea were analyzed to constrain the provenances of the sediments and investigate quantitative changes in the Asian eolian input to the study area over the last 700 ka. Among the competing processes that might affect REE compositions, sediment provenance is the most important one. Provenance analysis suggests that the study sediments have two provenance end-members; local volcanic sources are dominant, and eolian dust from the Asian continent has a smaller contribution. During glacial periods, eolian input to the western Philippine Sea was enhanced. In contrast, material supply from local volcanics in- creased during interglacial periods. Changes in eolian input to the study area were probably related to the strength of the East Asian winter monsoon （EAWM） as well as aridity in the Asian continent on an orbital time scale, and were partly influenced by local control factors on shorter time scales. Therefore, we propose that the present study expands the application of the REE-based method for quantitatively estimating the eolian component from the mid-latitude northern Pacific to the low-latitude western Pacific. Additionally, the study preliminarily confirms the influence of EAWM-transported eolian materi- al on sedimentation in the western Philippine Sea since 700 ka.

MicroRNA-34 (miR-34) plays central roles in human diseases, especially cancers. Inactivation of miR-34 is detected in cancer cell lines and tumor tissues versus normal controls, implying its potential tumor-suppressive effect. Clinically, miR-34 has been identified as promising prognostic indicators for various cancers. In fact, members of the miR-34 family, especially miR-34a, have been convincingly proved to affect almost the whole cancer progression process. Here, a total of 512 (miR-34a, 10/21), 85 (miR-34b, 10/16), and 114 (miR-34c, 10/14) putative targets of miR-34a/b/c are predicted by at least ten miRNA databases, respectively. These targets are further analyzed in gene ontology (GO), KEGG pathway, and the Reactome pathway dataset. The results suggest their involvement in the regulation of signal transduction, macromolecule metabolism, and protein modification. Also, the targets are implicated in critical signaling pathways, such as MAPK, Notch, Wnt, PI3K/AKT, p53, and Ras, as well as apoptosis, cell cycle, and EMT-related pathways. Moreover, the upstream regulators of miR-34a, mainly including transcription factors (TFs), lncRNAs, and DNA methylation, will be summarized. Meanwhile, the potential TF upstream of miR-34a/b/c will be predicted by PROMO, JASPAR, Animal TFDB 3.0, and GeneCard databases. Notably, miR-34a is an attractive target for certain cancers. In fact, miR-34a-based systemic delivery combined with chemotherapy or radiotherapy can more effectively control tumor progression. Collectively, this review will provide a panorama for miR-34a in cancer research.

Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including anti-oxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The anti-inflammatory effects of RosA have been revealed through and studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the anti-inflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

Large-sized components with numerous small key local features are essential in advanced manufacturing. Achieving high-precision quality control necessitates accurate and highly efficient three-dimensional (3D) measurement techniques. A flexible measurement system integrating a fringe-projection-based 3D scanner with an industrial robot is developed to enable the rapid measurement of large object surfaces. To enhance overall measurement accuracy, we propose an enhanced calibration method utilizing a multidimensional ball-based calibrator to simultaneously calibrate for hand-eye transformation and robot kinematic parameters. Firstly, a preliminary hand-eye calibration method is introduced to compensate for measurement errors at observation points, leveraging geometric-constraint-based optimization and a virtual single point derived via the barycentric calculation method. Subsequently, a distance-constrained calibration method is proposed to jointly estimate the hand-eye transformation and robot kinematic parameters, wherein a distance error model is constructed to link parameter errors with the measured deviations of a virtual single point. Finally, calibration and validation experiments were carried out, and the results indicate that the maximum and average measurement errors were reduced from 1.053 mm and 0.814 mm to 0.421 mm and 0.373 mm, respectively, thereby confirming the effectiveness of the proposed method.

The rhizosheath, or the layer of soil closely adhering to roots, can help plants to tolerate drought under moderate soil drying conditions. Rhizosheath formation is the result of poorly understood interactions between root exudates, microbes, and soil conditions. Here, we study the roles played by the soil microbiota in rhizosheath formation in barley (a dry crop). We show that barley rhizosheath formation is greater in acid soil than in alkaline soil, and inoculation with microbiota from acid soil enhances rhizosheath formation in alkaline soil. The rhizosheath-promoting activity is associated with the presence of Flavobacteriaceae and Paenibacillaceae bacteria that express genes for biosynthesis of indole-3-acetic acid (IAA, a common auxin), as determined by metagenomics and metatranscriptomics. Two bacterial strains isolated from rhizosheath ( Chryseobacterium culicis and Paenibacillus polymyxa ) produce IAA and enhance barley rhizosheath formation, while their IAA-defective mutants are unable to promote rhizosheath formation. Co-inoculation with the IAA-producing strains enhances barley grain yield in field experiments through an increase in spike number. Our findings contribute to our understanding of barley rhizosheath formation, and suggest potential strategies for crop improvement. The rhizosheath, or the soil layer closely attached to roots, can help plants tolerate drought. Here, the authors show that rhizosheath formation in barley is promoted by soil bacteria that produce indole-3-acetic acid, a common auxin.

Kiwifruit bacterial canker is a devastating disease threatening kiwifruit production. To clarify the defense mechanism in response to Pseudomonas syringae pv. actinidiae (Psa), we observed phenotypic changes in resistant Huate (HT) and susceptible Hongyang (HY) kiwifruit varieties at 0, 12, 24, 48, 96, and 144 hour after inoculation (hai) with Psa. Brown lesions appeared in the inoculation areas 12 hai in HY shoots, and the lesion length gradually increased from 24 to 144 h. In contrast, no lesions were found in HT shoots at any time points. Furthermore, RNA-seq analysis showed significantly more differentially expressed genes between HT and HY at 12 hai than at any other time point. According to weighted gene co-expression network analysis, five modules were notably differentially expressed between HT and HY; pathway mapping using the Kyoto Encyclopedia of Gene and Genomes database was performed for the five modules. In MEgreenyellow and MEyellow modules, pathways related to\"plant-pathogen interaction\", \"Endocytosis\", \"Glycine, serine and threonine metabolism\", and \"Carbon fixation in photosynthetic organisms\" were enriched, whereas in the MEblack module, pathways related to \"protein processing in endoplasmic reticulum\", \"plant-pathogen interaction\", and \"Glycolysis / Gluconeogenesis\" were enriched. In particular, the Pti1 and RPS2 encoding effector receptors, and the NPR1, TGA, and PR1 genes involved in the salicylic acid signaling pathway were significantly up-regulated in HT compared with HY. This indicates that the effector-triggered immunity response was stronger and that the salicylic acid signaling pathway played a pivotal role in the Psa defense response of HT. In addition, we identified other important genes, involved in phenylpropanoid biosynthesis and Ca2+ internal flow, which were highly expressed in HT. Taken together, these results provide important information to elucidate the defense mechanisms of kiwifruit during Psa infection.