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Minoxidil directly promotes hair growth via the stimulation of dermal papilla (DP) and epithelial cells. Alternatively, there is little evidence for indirect promotion of hair growth via stimulation of adipose-derived stem cells (ASCs). We investigated whether minoxidil stimulates ASCs and if increased growth factor secretion by ASCs facilitates minoxidil-induced hair growth. Telogen-to-anagen induction was examined in mice. Cultured DP cells and vibrissae hair follicle organ cultures were used to further examine the underlying mechanisms. Subcutaneous injection of minoxidil-treated ASCs accelerated telogen-to-anagen transition in mice, and increased hair weight at day 14 post-injection. Minoxidil did not alter ASC proliferation, but increased migration and tube formation. Minoxidil also increased the secretion of growth factors from ASCs, including chemokine (C-X-C motif) ligand 1 (CXCL1), platelet-derived endothelial cell growth factor (PD-ECGF), and platelet-derived growth factor-C (PDGF-C). Minoxidil increased extracellular signal–regulated kinases 1/2 (ERK1/2) phosphorylation, and concomitant upregulation of PD-ECGF and PDGF-C mRNA levels were attenuated by an ERK inhibitor. Subcutaneous injection of CXCL1, PD-ECGF, or PDGF-C enhanced anagen induction in mice, and both CXCL1 and PDGF-C increased hair length in ex vivo organ culture. Treatment with CXCL1, PD-ECGF, or PDGF-C also increased the proliferation index in DP cells. Finally, topical application of CXCL1, PD-ECGF, or PDGF-C with 2% minoxidil enhanced anagen induction when compared to minoxidil alone. Minoxidil stimulates ASC motility and increases paracrine growth factor signaling. Minoxidil-stimulated secretion of growth factors by ASCs may enhance hair growth by promoting DP proliferation. Therefore, minoxidil can be used as an ASC preconditioning agent for hair regeneration.

Automated medical image analysis is an emerging field of research that identifies the disease with the help of imaging technology. Diabetic retinopathy (DR) is a retinal disease that is diagnosed in diabetic patients. Deep neural network (DNN) is widely used to classify diabetic retinopathy from fundus images collected from suspected persons. The proposed DR classification system achieves a symmetrically optimized solution through the combination of a Gaussian mixture model (GMM), visual geometry group network (VGGNet), singular value decomposition (SVD) and principle component analysis (PCA), and softmax, for region segmentation, high dimensional feature extraction, feature selection and fundus image classification, respectively. The experiments were performed using a standard KAGGLE dataset containing 35,126 images. The proposed VGG-19 DNN based DR model outperformed the AlexNet and spatial invariant feature transform (SIFT) in terms of classification accuracy and computational time. Utilization of PCA and SVD feature selection with fully connected (FC) layers demonstrated the classification accuracies of 92.21%, 98.34%, 97.96%, and 98.13% for FC7-PCA, FC7-SVD, FC8-PCA, and FC8-SVD, respectively.

We examine the relationships between the observed long‐term trends of the zonal wind in the mesopause regions at King Sejong Station (KSS), Antarctica, and wind trends in the Southern Hemisphere (SH) middle atmosphere using the 15‐year data set from KSS meteor radar, Aura MLS and MERRA‐2. During July, significant positive trends of zonal winds appear above z = 90 km and near the stratopause over the KSS, while negative trends exist between the two layers. In the SH winter, the observed mesopause winds correlate positively (negatively) with stratospheric (mesospheric) winds in the polar region, while they exhibit opposite correlations with the low‐latitude winds. The positive mesopause trends of zonal winds near KSS are connected, through the thermal wind relationship, to cooling (warming) trends induced by the upward (downward) trends of residual circulation over the high‐latitude mesosphere and low‐latitude stratosphere (high‐latitude stratosphere), which shows vertical coupling throughout the SH winter middle atmosphere. Plain Language Summary Based on 15‐year (2007–2021) observations of horizontal winds obtained at mesopause altitudes of 80–100 km by a meteor radar at King Sejong Station (KSS; 62.22°S, 58.78°W), Antarctica, we find long‐term trends of eastward winds above 90 km in July. To investigate the relationship between the observed long‐term trends of the mesopause wind over the Southern Hemisphere (SH) polar region and winds in the SH middle atmosphere, we analyze Aura MLS satellite data and MERRA‐2 reanalysis data. In the SH winter, the mesopause zonal winds over polar regions are positively (negatively) correlated with zonal winds in the polar stratosphere (polar mesosphere), while the opposite correlations are found between the polar mesopause and low latitudes. We demonstrate that the trends of temperature induced by adiabatic warming or cooling associated with meridional circulation in the stratosphere and mesosphere are connected to the observed mesopause wind trends in the polar region (KSS), which accounts for the vertical coupling between the mesopause region and stratosphere across the mesosphere. Key Points Trends of zonal winds in the Southern Hemisphere mesopause and stratosphere are investigated using meteor radar and satellite observations Significant correlations are found between the mesopause wind at high latitudes and the winds in the middle atmosphere The observed wind trends in austral winter are coupled vertically between the mesopause region and stratosphere across the mesosphere

We investigate the characteristics of long‐lasting summertime heavy precipitation events (HPEs) over South Korea associated with quasi‐stationary atmospheric rivers (QSARs) based on the 29‐year (1996–2024) daily column water vapor (CWV) from the ERA5 reanalysis data and the Global Precipitation Climatology Project (GPCP) precipitation data. Through a case study and composite analysis, we found that the QSARs in the Pacific region gradually moved westward toward Korea, resulting in the stagnation of large amounts of CWV and precipitation near Korea. The dynamical mechanisms of the HPEs associated with the QSARs are investigated based on the finite‐amplitude local wave activity (LWA) calculated using the ERA5 reanalysis data. Downstream amplification of the LWA, which is associated with the westward movement of the Pacific QSAR, occurred approximately 1 week before HPEs over South Korea. These results suggest that LWA offers the potential to be used in forecasting long‐duration HPEs in South Korea in summer.

PurposeThe National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) is a cohort of participants who participated in health screening programmes provided by the NHIS in the Republic of Korea. The NHIS constructed the NHIS-HEALS cohort database in 2015. The purpose of this cohort is to offer relevant and useful data for health researchers, especially in the field of non-communicable diseases and health risk factors, and policy-maker.ParticipantsTo construct the NHIS-HEALS database, a sample cohort was first selected from the 2002 and 2003 health screening participants, who were aged between 40 and 79 in 2002 and followed up through 2013. This cohort included 514 866 health screening participants who comprised a random selection of 10% of all health screening participants in 2002 and 2003.Findings to dateThe age-standardised prevalence of anaemia, diabetes mellitus, hypertension, obesity, hypercholesterolaemia and abnormal urine protein were 9.8%, 8.2%, 35.6%, 2.7%, 14.2% and 2.0%, respectively. The age-standardised mortality rate for the first 2 years (through 2004) was 442.0 per 100 000 person-years, while the rate for 10 years (through 2012) was 865.9 per 100 000 person-years. The most common cause of death was malignant neoplasm in both sexes (364.1 per 100 000 person-years for men, 128.3 per 100 000 person-years for women).Future plansThis database can be used to study the risk factors of non-communicable diseases and dental health problems, which are important health issues that have not yet been fully investigated. The cohort will be maintained and continuously updated by the NHIS.

We analyze the response of mean winds and semidiurnal tides (SDTs) in the mesosphere and lower thermosphere (MLT; ∼70–110 km altitude) to the May 2024 geomagnetic super storm, based on meteor radar (MR) observations from King Sejong Station (KSS; geographic: 62.22°S, 58.78°W; geomagnetic: 53.27°S, 10.88°E) in the Antarctic Peninsula. During the recovery phase of the storm, we observe significant intensifications in both westward and equatorward winds. The SDT amplitude exhibits a marked reduction immediately following the main phase, falling below the 1st percentile of May‐time values derived from 18 years (2007–2024) of long‐term MR observations at KSS. In addition, an enhancement of short‐period oscillations with 3–8 hr periods is accompanied by the decrease in SDT amplitude. As possible generation mechanisms for these oscillations, we discuss the effect of Joule heating with similar periodicities and nonlinear wave interactions during the storm.

Oxysulfide semiconductors have narrow bandgaps suitable for water splitting under visible-light irradiation, because the electronegative sulfide ions negatively shift the valence band edges of the corresponding oxides1,2. However, the instability of sulfide ions during the water oxidation is a critical obstacle to simultaneous evolution of hydrogen and oxygen3. Here, we demonstrate the activation and stabilization of Y2Ti2O5S2, with a bandgap of 1.9 eV, as a photocatalyst for overall water splitting. On loading of IrO2 and Rh/Cr2O3 as oxygen and hydrogen evolution co-catalysts, respectively, and fine-tuning of the reaction conditions, simultaneous production of stoichiometric amounts of hydrogen and oxygen was achieved on Y2Ti2O5S2 during a 20 h reaction. The discovery of the overall water splitting capabilities of Y2Ti2O5S2 extends the range of promising materials for solar hydrogen production.

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomédical science and engineering.

The role of gravity waves (GWs) in a sudden stratospheric warming (SSW) event that occurred in January 2009 (SSW09) is investigated using the MERRA-2 dataset. Nearly 2 weeks prior to the central date (lag = 0), at which the zonal-mean zonal wind at 10 hPa and 60°N first becomes negative, westward GW drag (GWD) is significantly enhanced in the lower mesosphere and stratosphere. At 5 days before lag = 0, planetary waves (PWs) of zonal wavenumber 2 (ZWN-2) in the stratosphere are enhanced, while PWs of ZWN-1 are weakened, which are evident from the amplitudes of the PWs and their Eliassen–Palm flux divergence (EPD). To examine the relationship between PWs and GWs, a nonconservative GWD (NCGWD) source term of the linearized quasigeostrophic potential vorticity equation is considered. A ZWN-2 pattern of the NCGWD forcing is developed around z = 55–60 km with a secondary peak around z = 40 km just before the PWs of ZWN-2 in the stratosphere began to enhance. A significant positive correlation between the NCGWD forcing in the upper stratosphere and lower mesosphere (USLM; 0.3–0.1 hPa in the present data) and the PWs of ZWN-2 in the stratosphere (5–1 hPa) exists. This result demonstrates that the amplification of the PWs of ZWN-2 in the stratosphere before the onset of SSW09 is likely related to the generation of PWs by GWD in the USLM, which is revealed by the enhanced downward-propagating PWs of ZWN-2 into the stratosphere from above.

NRC publication: Yes