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"Sun, Yan"
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Memory and agency in ancient China : shaping the life history of objects
\"Memory and Agency in Ancient China offers a novel perspective on China's material culture. The volume explores the complex 'life histories' of selected objects, whose trajectories as ginle objects ('biographies') and object types ('lineages') cut across both temporal and physical space. The essays, written by a team of international scholars, analyse the objects in an effort to understand how they were shaped by the constraints of their social, political and aesthetic contexts, just as they were also guided by individual preference and capricious memory. They also demonstrate how objects were capable of effecting change\"-- Provided by publisher.
Book
Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review
Pandemics have become more frequent and more complex during the twenty-first century. Posttraumatic stress disorder (PTSD) following pandemics is a significant public health concern. We sought to provide a reliable estimate of the worldwide prevalence of PTSD after large-scale pandemics as well as associated risk factors, by a systematic review and meta-analysis. We systematically searched the MedLine, Embase, PsycINFO, Web of Science, CNKI, WanFang, medRxiv, and bioRxiv databases to identify studies that were published from the inception up to August 23, 2020, and reported the prevalence of PTSD after pandemics including sudden acute respiratory syndrome (SARS), H1N1, Poliomyelitis, Ebola, Zika, Nipah, Middle Eastern respiratory syndrome coronavirus (MERS-CoV), H5N1, and coronavirus disease 2019 (COVID-19). A total of 88 studies were included in the analysis, with 77 having prevalence information and 70 having risk factors information. The overall pooled prevalence of post-pandemic PTSD across all populations was 22.6% (95% confidence interval (CI): 19.9–25.4%, I2: 99.7%). Healthcare workers had the highest prevalence of PTSD (26.9%; 95% CI: 20.3–33.6%), followed by infected cases (23.8%: 16.6–31.0%), and the general public (19.3%: 15.3–23.2%). However, the heterogeneity of study findings indicates that results should be interpreted cautiously. Risk factors including individual, family, and societal factors, pandemic-related factors, and specific factors in healthcare workers and patients for post-pandemic PTSD were summarized and discussed in this systematic review. Long-term monitoring and early interventions should be implemented to improve post-pandemic mental health and long-term recovery.
Journal Article
Central circuit mechanisms of itch
Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.
Itch is an important somatosensation, but the central mechanisms underlying it are not fully understood. Here, Chen and Sun review recent studies on the spinal and supraspinal circuits involved in itch processing.
Journal Article
Ancient China and its Eurasian neighbors : artifacts, identity and death in the frontier, 3000-700 BCE
\"This volume examines the role of objects in the region north of early dynastic state centers, at the intersection of Ancient China and Eurasia, a large area that stretches from Xinjiang to the China Sea, from c.3000 BCE to the mid-eighth century BCE. This area was a frontier, an ambiguous space that lay at the margins of direct political control by the metropolitan states, where local and colonial ideas and practices were reconstructed transculturally. These identities were often merged and displayed in material culture. Types of objects, styles, and iconography were often hybrids or new to the region, as were the tomb assemblages in which they were deposited and found. Patrons commissioned objects that marked a symbolic vision of place and person and that could mobilize support, legitimize rule, and bind people together.\"--Back cover.
Book
Green and Reliable Freight Routing Problem in the Road-Rail Intermodal Transportation Network with Uncertain Parameters: A Fuzzy Goal Programming Approach
In this study, the author focuses on modeling and optimizing a freight routing problem in a road-rail intermodal transportation network that combines the hub-and-spoke and point-to-point structures. The operations of road transportation are time flexible, while rail transportation has fixed departure times. The reliability of the routing is improved by modeling the uncertainty of the road-rail intermodal transportation network. Parameters that are influenced by the real-time status of the network, including capacities, travel times, loading and unloading times, and container trains’ fixed departure times, are considered uncertain in the routing decision-making. Based on fuzzy set theory, triangular fuzzy numbers are employed to formulate the uncertain parameters as well as resulting uncertain variables. Green routing is also discussed by treating the minimization of carbon dioxide emissions as an objective. First of all, a multiobjective fuzzy mixed integer nonlinear programming model is established for the specific reliable and green routing problem. Then, defuzzification, linearization, and weighted sum method are implemented to present a crisp linear model whose global optimum solutions can be effectively obtained by the exact solution algorithm run by mathematical programming software. Finally, a numerical case is given to demonstrate how the proposed methods work. In the case, sensitivity analysis is adopted to reveal the effects of uncertainty on the routing optimization. Fuzzy simulation is then performed to help decision makers to select the best crisp route plan by determining the best confidence level shown in the fuzzy chance constraints.
Journal Article
Diplomacy of quasi-alliances in the Middle East
Quasi-alliance refers to the ideation, mechanism and behavior of policy-makers to carry out security cooperation through informal political and security arrangements. As a \"gray zone\" between alliance and neutrality, quasi-alliance is a hidden national security statecraft. Based on declassified archives and secondary sources, this book probes the theory and practice of quasi-alliances in the Middle East. Four cases are chosen to test the hypotheses of quasi-alliance, one of which is the Anglo-French-Israeli quasi-alliance during the Suez Canal War of 1956.
Book
LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway
Background
Osteosarcoma is highly malignant. The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma. Research reported that endogenous bornavirus-like nucleoprotein 3 pseudogene (EBLN3P) promotes the progression of osteosarcoma.
Methods
In this study, the expression of EBLN3P in osteosarcoma tissue with different methotrexate (MTX) treatment responses was measured. Osteosarcoma cell lines with MTX resistance were constructed, and bioinformatic analysis was performed to explore the potential involved targets and pathways.
Results
Higher EBLN3P was associated with MTX resistance. Downregulation of LncEBLN3P decreased the MTX resistance of osteosarcoma cells by sponging miR-200a-3p, an important microRNA that affects epithelial-mesenchymal transition (EMT). The decreased miR-200a-3p resulted in the upregulation of its target gene O-GlcNAc transferase (OGT), which in turn promoted the EMT process of osteosarcoma cells. Further analysis confirmed that the loss of OGT and over-expression of miR-200a-3p could partly abolish the MTX resistance induced by LncEBLN3P.
Conclusion
LncEBLN3P is upregulated in osteosarcoma and increases the MTX resistance in osteosarcoma cells through downregulating miR-200a-3p, which in turn promoted the EMT process of osteosarcoma cells by increasing the OGT.
Journal Article
Enhanced Weather-Based Index Insurance Design for Hedging Crop Yield Risk
This study proposes an optimization-based weather-yield model to reduce the basis risk of weather-based index insurance. This weather-yield model helps us capture the growing season's monthly variation as it involves monthly explanatory weather indices. In addition, it can capture additional extreme weather effects by including extreme cooling or heating weather indices. This study presents an innovative machine learning framework incorporating optimization approaches to ensure the parsimony of weather index models and the accuracy of crop yield predictions, which can be integrated into the conventional policy design and pricing process. The advantages of this modeling approach and the effectiveness of weather index-based insurance based on this approach in reducing basis risk and revenue risk are demonstrated by applying county-level yield data for mid-season rice in the Anhui province, China.
Journal Article
Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids
Mu-opioid receptors (MORs) are crucial for analgesia by both exogenous and endogenous opioids. However, the distinct mechanisms underlying these two types of opioid analgesia remain largely unknown. Here, we demonstrate that analgesic effects of exogenous and endogenous opioids on inflammatory pain are mediated by MORs expressed in distinct subpopulations of neurons in mice. We found that the exogenous opioid-induced analgesia of inflammatory pain is mediated by MORs in Vglut2+ glutamatergic but not GABAergic neurons. In contrast, analgesia by endogenous opioids is mediated by MORs in GABAergic rather than Vglut2+ glutamatergic neurons. Furthermore, MORs expressed at the spinal level is mainly involved in the analgesic effect of morphine in acute pain, but not in endogenous opioid analgesia during chronic inflammatory pain. Thus, our study revealed distinct mechanisms underlying analgesia by exogenous and endogenous opioids, and laid the foundation for further dissecting the circuit mechanism underlying opioid analgesia.
Journal Article