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As a pioneer of symbolism in modern Chinese poetry, Li Jinfa's works have received complex evaluations in literary history. In the first half of the twentieth century, Li Jinfa's poetry contrasted sharply with the realism and romanticism of the time, and his obscure style, though criticized, opened up new aesthetic paths in poetry. This paper delves into the theme of time and the view of time in Li Jinfa's poetry, revealing his deep feelings about the passage of time and his reflections on modernity through a close reading of Li Jinfa's poetry. Starting from the theme of time in Li Jinfa's poetry, this paper explains Li's attitude towards the past and the present moment, as well as Li's criticism of the negative effects of modernity. From a cross-section of the single image of \"bee\", the paper also examines the special position and meaning of \"bee\" in Li Jinfa's imagery system. In conclusion, this study illustrates Lee Goldfarb's reflection on linear time and the heterotopias and heterotopias he creates in his poetry, demonstrating a rebellion against the rhythms of modern life and an emphasis on momentary experience.

The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear. Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was estimated by polygenic risk scores and further categorized into high, intermediate, and low genetic risk categories. Weighted healthy lifestyle scores were constructed based on 5 common lifestyle factors and categorized into favorable (4 or 5 healthy lifestyle factors), intermediate (3 healthy lifestyle factors), and unfavorable (0-2 healthy lifestyle factors) groups. Cox proportional hazards regression model was used to estimate the hazard ratios (HR) and 95% confidence interval (CI) for their associations. During the 12-year follow-up, 707 cases with CD and 1576 cases with UC were diagnosed in the UK Biobank cohort. Genetic risk and unhealthy lifestyle categories were monotonically associated with CD and UC risk with no multiplicative interaction between them. The HR of CD and UC were 2.24 (95% CI 1.75-2.86) and 2.15 (95% CI 1.82-2.53) for those with a high genetic risk, respectively. The HR of CD and UC for individuals with an unfavorable lifestyle were 1.94 (95% CI 1.61-2.33) and 1.98 (95% CI 1.73-2.27), respectively. The HR of individuals with a high genetic risk but a favorable lifestyle (2.33, 95% CI 1.58-3.44 for CD, and 2.05, 95% CI 1.58-2.66 for UC) were reduced nearly by half, compared with those with a high genetic risk but an unfavorable lifestyle (4.40, 95% CI 2.91-6.66 for CD and 4.44, 95% CI 3.34-5.91 for UC). Genetic and lifestyle factors were independently associated with susceptibility to incident CD and UC. Adherence to a favorable lifestyle was associated with a nearly 50% lower risk of CD and UC among participants at a high genetic risk.

In recent years, China’s economic development is dominated by an eco-friendly and low-carbon transition, making the low-carbon advancement of the construction sector urgent. Local governments play a crucial role in this process. This paper, utilizing provincial panel data from 2007 to 2021, empirically analyzes the impact of government environmental governance (EG) on the carbon intensity of the construction industry (CCEI) through the panel regression, spatial econometric and dynamic threshold models. The findings indicate that (1) EG has a significant inverted U-shaped effect on CCEI, with initial increases in carbon intensity followed by reductions once EG intensity surpasses a certain level. (2) Significant spatial spillover effects reveal that increased EG in one region exerts a similar inverted U-shaped impact on both local and neighboring CCEI. (3) Under China’s fiscal decentralization framework, two dimensions—vertical decentralization and horizontal competition—serve as forms of fiscal decentralization, each with dynamic threshold effects: EG’s influence on CCEI turns negative under high vertical decentralization, and positive under intense horizontal competition. These results could offer insights from China’s emission reduction experiences in the energy-intensive sector, serving as a valuable reference for environmental decision-makers worldwide.

Understanding the dynamic nature of biological systems is fundamental to deciphering cellular behavior, developmental processes, and disease progression. Single-cell RNA sequencing (scRNA-seq) has provided static snapshots of gene expression, offering valuable insights into cellular states at a single time point. Recent advancements in temporally resolved scRNA-seq, spatial transcriptomics (ST), and time-series spatial transcriptomics (temporal-ST) have further revolutionized our ability to study the spatiotemporal dynamics of individual cells. These technologies, when combined with computational frameworks such as Markov chains, stochastic differential equations (SDEs), and generative models like optimal transport and Schrödinger bridges, enable the reconstruction of dynamic cellular trajectories and cell fate decisions. This review discusses how these dynamical system approaches offer new opportunities to model and infer cellular dynamics from a systematic perspective.

People who smoke cigarettes or drink large amounts of alcohol are more likely to develop disorders with their digestive system. But it is difficult to prove that heavy drinking or smoking is the primary cause of these gastrointestinal diseases. For example, it is possible that having a digestive disorder makes people more likely to take up these habits to reduce pain or discomfort caused by the illness (an effect known as reverse causation). The association may also be the result of confounding factors, such as age or diet, which contribute to digestive problems as well as the health outcomes of smoking and drinking. Additionally, many people who smoke also drink alcohol and vice versa, making it challenging to determine if one or both behaviors contribute to the disease. One solution is to employ Mendelian randomization which uses genetics to determine if two variables are linked. Using this statistical approach, Yuan, Chen, Ruan et al. investigated if people who display genetic variants that predispose someone to becoming a smoker or drinker are at greater risk of developing certain digestive disorders. This reduces the possibility of confounding and reverse causation, as any association between genetic variants will have been present since birth, and will have not been impacted by external factors. Yuan, Chen, Ruan et al. used data from two studies that had collected the genetic and health information of thousands of people living in the United Kingdom or Finland. The analyses revealed that genetic variants associated with cigarette smoking increase the risk of 20 of the 24 gastrointestinal diseases investigated. This risk persisted for most of the disorders, even after adjusting for genes linked with alcohol consumption. Further analysis showed that genetic variants linked to heavy drinking increase the risk of duodenal ulcer, alcoholic liver disease, cirrhosis, and chronic pancreatitis. However, accounting for smoking-linked genes eliminated the relationship with duodenal ulcer. These findings suggest that smoking has detrimental effects on gastrointestinal health. Reducing the number of people who start smoking or encouraging smokers to quit may help prevent digestive diseases. Even though there were fewer associations between heavy alcohol consumption and gastrointestinal illness, further studies are needed to investigate this relationship in more depth.

Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches. Copper maintains the cell oxidation levels, regulates the protein activity and metabolism, and is involved in inflammation. Various copper-based compounds, such as nanoparticles or metal-based organic complexes, show specific activity against cancer cells according to preclinical studies. Herein, we summarize the major principles of copper metabolism in cancer cells and its potential in cancer theranostics.

The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted Mendelian randomization (MR) analyses to systematically explore the associations of depression with 24 gastrointestinal diseases. Independent genetic variants associated with depression at the genome-wide significance level were selected as instrumental variables. Genetic associations with 24 gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analysis was conducted to explore the mediation effects of body mass index, cigarette smoking, and type 2 diabetes. After multiple-testing corrections, genetic liability to depression was associated with an increased risk of irritable bowel syndrome, non-alcohol fatty liver disease, alcoholic liver disease, gastroesophageal reflux, chronic pancreatitis, duodenal ulcer, chronic gastritis, gastric ulcer, diverticular disease, cholelithiasis, acute pancreatitis, and ulcerative colitis. For the causal effect of genetic liability to depression on non-alcoholic fatty liver disease, a substantial proportion was mediated by body mass index. Genetic predisposition to smoking initiation mediated half of effect of depression on acute pancreatitis. This MR study suggests that depression may play a causal role in many gastrointestinal diseases.

This study adopted a novel pulse current–assisted laser shock AZ31B sheet micro-forming method (EP-LSF). The mechanism of improving the formability of AZ31B magnesium alloy by pulse current–assisted laser shock forming and the reason of improving the corrosion resistance were studied for the first time. Through laser shock–free bulging experiment, tensile test, optical microscope (OM), and X-ray diffraction, the change in formability was studied. After pulse current assisted–laser shock forming, the forming height of AZ31B magnesium alloy increases by 28.8%, the thinning gradient decreases by 6.7%, and the strain rate–sensitivity coefficient increases to 0.1452. The results show that the decrease of grain size and texture density is the reason why EP-LSF can further improve the formability of AZ31B magnesium alloy. The changes in corrosion resistance were studied by scanning electron microscopy and electrochemical tests. The results show that after EP-LSF, the corrosion current density of AZ31 magnesium alloy decreased, and the electrochemical impedance increased, indicating that this method further improved the corrosion resistance.

Meat consumption was found to be associated with the incidence and developmental course of inflammatory bowel diseases (IBD), but its roles in the risk of all-cause mortality in IBD patients remained unknown. The aim of this study (UK Biobank Resource under application number 73595) was to assess the associations between meat consumption and all-cause mortality among IBD patients. We leveraged data of 5763 IBD patients in the UK Biobank recruited from 2007 to 2010 and followed up to March 13, 2021. Dietary information was collected using a simplified food frequency questionnaire (FFQ) in the touchscreen questionnaire at baseline recruitment. Death events were ascertained from the death registry. Cox proportional hazards models were used to estimate potential associations of each meat consumption with mortality in IBD patients, 0.1-0.9 time per week was seen as the reference, and hazard ratios (HRs) and 95% confidence interval (CIs) were reported. Moreover, we conducted a series of subgroup and sensitivity analyses. During an average follow-up of 11.7 years, we documented 590 deaths over 67,095 person-years. Of the 5763 IBD patients with a mean (SD) age of 57.3 (7.9) years, 3028 (52.5%) were female and 2735 (47.5%) were male, 1834 were with Crohn's diseases (CD) and 3929 were with ulcerative colitis (UC). Consuming processed meat more than 4 times per week (>4 times/week) was associated with an increased risk of mortality in IBD patients (HR 1.53, 95%CI 1.06-2.23, P = 0.025) compared with consumption of less than once per week (0.1-0.9 time/week), while consumptions of fish, unprocessed poultry, or unprocessed red meat were not found to be related to mortality. The association of processed meat with mortality was also observed in CD patients (HR 2.01, 95%CI 1.12-3.62, P = 0.020), but not significantly in UC patients (HR 1.27, 95% CI 0.77-2.09, P = 0.346). In subgroup analyses, we also observed the associations in IBD patients with diseases duration more than 10 years (HR 1.67, 95%CI 1.03-2.69) or patients who had high physical activities (HR 2.21, 95%CI 1.13-4.33), but was not significant in other subgroup analyses, also, the associations manifested robust in sensitivity analyses. In this study, more frequent consumption of processed meat was found to be associated with the increased risk of mortality in IBD patients, while no such associations were observed in IBD patients who consuming fish, unprocessed poultry meat or unprocessed red meat. Therefore, based on the results above, we recommend a remodified diet with restricting processed meat as well as supplying an additional healthy diet for IBD patients, using alone or in combination with pharmacotherapy.

To address issues like excessive energy consumption, insufficient deep air intake, and improper airflow control, optimizations were made to both the shallow and deep ventilation systems. By conducting comprehensive wind measurements across the entire mine, the distribution of underground wind speed and airflow was thoroughly understood, allowing for an analysis of the mine’s ventilation capacity and wind resistance. A theoretical model of underground ventilation and wind resistance was developed using Ventsim software. Additionally, a three-dimensional numerical model of Linglong Gold Mine’s ventilation system was created with three-dimensional ventilation numerical simulation software. This model facilitated dynamic airflow simulation within the ventilation system, enabling the proposal of optimization and adjustment plans. The effects of air regulation were simulated and analyzed to optimize the ventilation network. Results indicate that, following the optimal adjustment scheme for deep airflow distribution, airflow disorder can be resolved and air supply in deep mining areas can be increased, effectively addressing the issue of insufficient air supply there. Post-optimization, the ventilation system’s stability is improved, and air volume distribution becomes more reasonable, providing valuable guidance for Linglong Gold Mine’s ventilation management.