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"Sutherland, Claire"
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Neuropathology of a Case With Fatal CAR T-Cell-Associated Cerebral Edema
Abstract
Chimeric antigen receptor (CAR) T cells are a new and powerful class of cancer immunotherapeutics that have shown potential for the treatment of hematopoietic malignancies. The tremendous promise of this approach is tempered by safety concerns, including potentially fatal neurotoxicity, sometimes but not universally associated with cytokine release syndrome. We describe the postmortem examination of a brain from a 21-year-old patient with relapsed pre-B cell acute lymphoblastic leukemia (ALL) who died from fulminant cerebral edema following CAR T-cell infusion. We found a range of changes that included activation of microglia, expansion of perivascular spaces by proteinaceous exudate, and clasmatodendrosis-a beading of glial fibrillary acidic protein consistent with astrocyte injury. Notably, within the brain parenchyma, we identified only infrequent T cells and did not identify ALL cells or CAR T cells. The overall findings are nonspecific but raise the possibility of astrocyte and blood-brain barrier dysfunction as a potential etiology of fatal CAR T-cell neurotoxicity in this patient.
Journal Article
Soldered states: nation-building in Germany and Vietnam
The book examines the power of nationalism to solder nation-states back together rather than break them apart. In this innovative, cross-continental comparison of nation-building in Germany and Vietnam, the focus is on their shared experience of division, communism and regional integration.The book examines the power of nationalism to solder nation-states back together rather than break them apart. In this innovative, cross-continental comparison of nation-building in Germany and Vietnam, the focus is on their shared experience of division, communism and regional integration, offering original insights into how governments go about maintaining nation-state legitimacy in the twenty-first century. Neither German nor Vietnamese governments have succeeded in effacing national division, for a host of historical, economic, psychological, sociological and even climatic reasons. Yet their efforts tell us a great deal about how national identity is negotiated today. The study offers a fresh perspective on nationalist ideology which will be of interest to specialists and students in comparative politics, European and Southeast Asian studies as well as nationalism studies. For the general reader, it provides a fascinating introduction to contemporary nation-building in a unique combination of cases across two continents.
eBook
Soldiered states
The book examines the power of nationalism to solder nation-states back together rather than break them apart. In this innovative, cross-continental comparison of nation-building in Germany and Vietnam, the focus is on their shared experience of division, communism and regional integration. -- .
eBook
Introduction: Nation-building in China and Vietnam
This introduction explores the changing nature of Chinese and Vietnamese nation-building in the era of globalisation and specifically, transnationalism. The first part sets out a conceptual framework designed to put contemporary Chinese and Vietnamese nation-building in comparative, international perspective. The second part looks at the borders of nation-building from the point of view of diasporas living the nation-state, while the third part focuses on a series of trends working to reinterpret the nation from within.
Journal Article
Soldered States
The book examines the power of nationalism to solder nation-states back together rather than break them apart. In this innovative, cross-continental comparison of nation-building in Germany and Vietnam, the focus is on their shared experience of division, communism and regional integration.
eBook
Special Issue: German Politics and Society from a Cosmopolitan Perspective: Introduction
[...] this introduction aims to outline several key strands of cosmopolitan thought with reference both to contemporary Germany and the wider global conjuncture, in order to provide a conceptual framework for the articles that follow. Celia Applegate, however, points out that the concept was pulled out of the rubble of the Nazi Reich as a victim, not a perpetrator and came to embody once more the local patriotism which had been discouraged by Nazism.2 Both authors are of the view that the Heimat-as a symbolic haven of peace and thus the antithesis of war-was an apolitical focus of solidarity.3 As such, it became a vehicle for speaking the unspeakable horror of the Third Reich in order to transcend it.4 Nevertheless, as Peter Blickle notes: Any concrete interaction with the idea of Heimat in the political realm has, historically speaking, served sooner or later to further sharp exclusions of certain groups-usually ethnic minorities.
Journal Article