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"Swain, Gregg"
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PRIME: Sacubitril/valsartan shows benefits in mitral regurgitation
The researchers conducted the PRIME doubleblind trial of 118 patients (mean age, 63 years; 61% men) with HF with reduced ejection fraction and chronic functional mitral regurgitation secondary to left ventricular dysfunction who were taking standard medical therapy for HF. \"Angiotensin receptor-neprilysin inhibitor may be considered for optimal medical therapy of stable patients with heart failure and functional mitral regurgitation,\" Kang and colleagues wrote. - by Erik Swain ? PERSPECTIVE Sacubitril/valsartan has been demonstrated to reduce CV death and HF hospitalizations superior to that of the ACE inhibitor enalapril in patients with HF with reduced ejection fraction. Sacubitril/valsartan is already class I recommended in national and international HF guidelines to further reduce morbidity and mortality in patients with HF with reduced ejection fraction who are NYHA class II or III. [...]irrespective of the presence or absence of functional mitral regurgitation, a compelling rationale for treatment with sacubitril/valsartan exists in eligible patients without contraindications.
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Patient discussion about herbal medicines, CVD link encouraged
Physicians should have a clean understanding about the herbal medicines that patients with heart disease may take to be able to discuss their clinical implications, despite a lack of evidence-backed benefits, according to a review paper published in the Journal of the American College of Cardiology. Rosa Liperoti, MD, PhD, MPH, from the department of geriatrics, neurosciences and orthopedics at the A. Gemelli University Hospital in Rome, and colleagues selected 10 of the most common...
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MATRIX: In patients with ACS needing angiography, access site matters but anticoagulant might not
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TOTAL: Manual thrombectomy with PCI does not improve outcomes, increases short-term stroke rate
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PEGASUS-TIMI 54: Ti cagrelor linked with better outcomes in patients at least 1 year after MI
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