Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
36
result(s) for
"Symes, R. F"
Sort by:
Rocks & minerals
Text and photographs examine the creation, importance, erosion, mining, and uses of rocks, minerals and precious metals.
Book
Crystal & gem
Crystals are all around us -- in our plants, our homes, and even in our bodies! \"Eyewitness: Crystal & Gem\" describes the seven basic shapes of crystals and other aspects of crystallography, including how they form in nature, how crystals are studied and identified, what gives them their amazing color, and how they are used in everyday life.
Book
Influence of polyunsaturated fatty acids on Aeromonas hydrophila: sole carbon utilization, incorporation into membrane phospholipids, potentiation of cyclic lipopeptide activity, and other phenotypic impacts
Aeromonas hydrophila
is an adaptable and dangerous member of a genus capable of colonizing and infecting many hosts. Inhabitants of various aquatic environments,
A. hydrophila
can adversely affect aquaculture and cause human disease. The aim of this study was to determine the extent of polyunsaturated fatty acid (PUFA) handling in
A. hydrophila
with regard to incorporation into membrane phospholipids and effects on permeability, growth, antimicrobial resistance, biofilm formation, and swimming motility. Extracted phospholipids from PUFA-supplemented cultures were examined for lipid modification using both thin-layer chromatography and ultra performance liquid chromatography-mass spectrometry, demonstrating partial incorporation of all tested PUFAs. Phenotypic characteristics were evaluated using assays that tested for biofilm formation, membrane permeability, swimming motility, and antibiotic susceptibility. Temperature-dependent effects on biofilm formation and swimming motility were observed, and exposure to certain PUFAs resulted in significant (
P
< 0.005) increases to membrane permeability using a hydrophobic dye uptake assay. Importantly, several PUFAs caused substantial (up to 16-fold) lowering of minimum inhibitory concentrations (MICs) against the membrane-active cyclic peptides polymyxin B and colistin. These responses to exogenous PUFAs may predict cellular signaling capabilities that aid multi-host pathogenic bacteria in their diverse environmental interactions.
Journal Article
Narrow bandwidth, low-emittance positron beams from a laser-wakefield accelerator
The rapid progress that plasma wakefield accelerators are experiencing is now posing the question as to whether they could be included in the design of the next generation of high-energy electron-positron colliders. However, the typical structure of the accelerating wakefields presents challenging complications for positron acceleration. Despite seminal proof-of-principle experiments and theoretical proposals, experimental research in plasma-based acceleration of positrons is currently limited by the scarcity of positron beams suitable to seed a plasma accelerator. Here, we report on the first experimental demonstration of a laser-driven source of ultra-relativistic positrons with sufficient spectral and spatial quality to be injected in a plasma accelerator. Our results indicate, in agreement with numerical simulations, selection and transport of positron beamlets containing
N
e
+
≥
10
5
positrons in a 5% bandwidth around 600 MeV, with femtosecond-scale duration and micron-scale normalised emittance. Particle-in-cell simulations show that positron beams of this kind can be guided and accelerated in a laser-driven plasma accelerator, with favourable scalings to further increase overall charge and energy using PW-scale lasers. The results presented here demonstrate the possibility of performing experimental studies of positron acceleration in a laser-driven wakefield accelerator.
Journal Article
DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates
Protontherapy has emerged as more effective in the treatment of certain tumors than photon based therapies. However, significant capital and operational costs make protontherapy less accessible. This has stimulated interest in alternative proton delivery approaches, and in this context the use of laser-based technologies for the generation of ultra-high dose rate ion beams has been proposed as a prospective route. A better understanding of the radiobiological effects at ultra-high dose-rates is important for any future clinical adoption of this technology. In this study, we irradiated human skin fibroblasts-AG01522B cells with laser-accelerated protons at a dose rate of 10
9
Gy/s, generated using the Gemini laser system at the Rutherford Appleton Laboratory, UK. We studied DNA double strand break (DSB) repair kinetics using the p53 binding protein-1(53BP1) foci formation assay and observed a close similarity in the 53BP1 foci repair kinetics in the cells irradiated with 225 kVp X-rays and ultra- high dose rate protons for the initial time points. At the microdosimetric scale, foci per cell per track values showed a good correlation between the laser and cyclotron-accelerated protons indicating similarity in the DNA DSB induction and repair, independent of the time duration over which the dose was delivered.
Journal Article
Automation and control of laser wakefield accelerators using Bayesian optimization
Laser wakefield accelerators promise to revolutionize many areas of accelerator science. However, one of the greatest challenges to their widespread adoption is the difficulty in control and optimization of the accelerator outputs due to coupling between input parameters and the dynamic evolution of the accelerating structure. Here, we use machine learning techniques to automate a 100 MeV-scale accelerator, which optimized its outputs by simultaneously varying up to six parameters including the spectral and spatial phase of the laser and the plasma density and length. Most notably, the model built by the algorithm enabled optimization of the laser evolution that might otherwise have been missed in single-variable scans. Subtle tuning of the laser pulse shape caused an 80% increase in electron beam charge, despite the pulse length changing by just 1%.
Laser wakefield accelerators are compact sources of ultra-relativistic electrons which are highly sensitive to many control parameters. Here the authors present an automated machine learning based method for the efficient multi-dimensional optimization of these plasma-based particle accelerators.
Journal Article
Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model
Traumatic Brain injury-induced disturbances in mitochondrial fission-and-fusion dynamics have been linked to the onset and propagation of neuroinflammation and neurodegeneration. However, cell-type-specific contributions and crosstalk between neurons, microglia, and astrocytes in mitochondria-driven neurodegeneration after brain injury remain undefined. We developed a human three-dimensional in vitro triculture tissue model of a contusion injury composed of neurons, microglia, and astrocytes and examined the contributions of mitochondrial dysregulation to neuroinflammation and progression of injury-induced neurodegeneration. Pharmacological studies presented here suggest that fragmented mitochondria released by microglia are a key contributor to secondary neuronal damage progression after contusion injury, a pathway that requires astrocyte-microglia crosstalk. Controlling mitochondrial dysfunction thus offers an exciting option for developing therapies for TBI patients.
Journal Article
Parametric study of high-energy ring-shaped electron beams from a laser wakefield accelerator
Laser wakefield accelerators commonly produce on-axis, low-divergence, high-energy electron beams. However, a high charge, annular shaped beam can be trapped outside the bubble and accelerated to high energies. Here we present a parametric study on the production of low-energy-spread, ultra-relativistic electron ring beams in a two-stage gas cell. Ring-shaped beams with energies higher than 750 MeV are observed simultaneously with on axis, continuously injected electrons. Often multiple ring shaped beams with different energies are produced and parametric studies to control the generation and properties of these structures were conducted. Particle tracking and particle-in-cell simulations are used to determine properties of these beams and investigate how they are formed and trapped outside the bubble by the wake produced by on-axis injected electrons. These unusual femtosecond duration, high-charge, high-energy, ring electron beams may find use in beam driven plasma wakefield accelerators and radiation sources.
Journal Article
Stable laser-acceleration of high-flux proton beams with plasma collimation
Laser-plasma acceleration of protons offers a compact, ultra-fast alternative to conventional acceleration techniques, and is being widely pursued for potential applications in medicine, industry and fundamental science. Creating a stable, collimated beam of protons at high repetition rates presents a key challenge. Here, we demonstrate the generation of multi-MeV proton beams from a fast-replenishing ambient-temperature liquid sheet. The beam has an unprecedentedly low divergence of 1° (≤20 mrad), resulting from magnetic self-guiding of the proton beam during propagation through a low density vapour. The proton beams, generated at a repetition rate of 5 Hz using only 190 mJ of laser energy, exhibit a hundred-fold increase in flux compared to beams from a solid target. Coupled with the high shot-to-shot stability of this source, this represents a crucial step towards applications.
Applications of laser-plasma accelerated protons in fundamental, applied and medical sciences crucially depend on the creation of stable collimated beams with high repetition rates. Here the authors demonstrate the generation of multi-MeV protons at 5 Hz, with low (degree-level) proton beam divergence from a laser pulse focused onto a water sheet target, potentially mitigating the need for beam capturing techniques.
Journal Article