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\"Go for the gold. Achieve. Stand out. It's the American way to aim for perfection and excel in business, school, sports, and life. We're all trying to do more in less time and feeling overwhelmed as a result. But too many people in business are ineffecient, self-sabotaging perfectionists. If you spend three hours editing an annual report to get it 90% perfect, and then spend another two hours to get it 93% perfect, and another hour for 95% perfect, the incremental improvement is negligible. Think of the time and effort you can conserve and redistribute to other tasks. Unlike other negative advice given, to give up your perfectionism, The Perfectionist's Handbook challenges this mindset which makes it unique. Jeff Szymanski tells readers they got the right idea, but you're taking the wrong paths to achieve the outcome you want.The Perfectionist's Handbook teaches the art of being an Adaptive Perfectionist, someone who stands out and gets bigger playoffs: greater productivity with less effort, more energy, and balance in your work and life. Jeff's strategies to function more effectively and better reach your goals include: Analyze Your Effort Focus on Your Top 10 List Lose the Parachute Embrace Failure Shift and Delegate Secretly Observe Others Refuel and Refresh Invite Criticism \"--Provided by publisher.

Obsessive-Compulsive Disorder (OCD) often begins in childhood and significantly impacts family, social, and academic functioning of OCD-affected youth. Despite children spending most of their waking hours at school, evidence about the effects of OCD on school functioning is limited. Parents of OCD-affected youth completed a school functioning survey developed by the authors. Survey content captured parents’ perspectives about the impacts of OCD on their child’s school functioning, their experiences with, and rationale behind, disclosing versus not disclosing the OCD diagnosis and the involvement and supports provided at the school. Descriptive statistics, χ 2 tests, and independent samples t -tests were computed to analyze the survey data. Out of 233 invited participants, 37% ( n  = 87) of parents of OCD-affected youth (M age = 14.4 years, 60% female, 71% Caucasian) completed the survey. Most respondents endorsed a negative impact of OCD on their child’s school functioning (73%; n  = 49), especially related to avoidance of activities, places, objects, and people at school (93%; n  = 62). Most participants disclosed their child’s OCD diagnosis to the school (85%; n  = 74) and had an overall positive experience (93%; n  = 69). There were no statistically significant clinical and demographic characteristics differences between those who disclosed versus those who did not disclose the diagnosis. Individuals who participated in group family-based CBT and whose child had cleaning, symmetry or forbidden thoughts symptoms were more likely to complete the survey than invited non-survey respondents. Findings enhance the current understanding of how OCD affects the academic life of students and provide preliminary support for positive outcomes associated with disclosure to school professionals. Highlights Parents perceived negative impacts of OCD on students’ school functioning, especially related to avoidant behaviors. Most families disclosed their child’s OCD diagnosis to the school. Such disclosure had positive outcomes for their child. Increased awareness and knowledge about OCD in schools is crucial to enhance educators’ skills to support OCD-affected students.

Employing the skills we'd honed over our combined 39 years of acoustical engineering experience (including a combined 11 years of engineering college), we made sure we had good TV shows downloaded to our video-ready portable entertainment devices, as well as a good idea of the location of some decent Thai restaurants near our hotel. For our time-condensed plan to work, we had to collect the noise monitor from Site No. 1 at the appropriate time, download the data, replace the battery, set it to record another 24 hours of sound level data, and place it at a new location near Site No. 3.

Details of noise control design are presented for a recent power plant expansion project that involved adding heat-recovery steam generation to a gas-fired power plant in the U.S. The project, including its expansion, was subject to a 45-dBA nighttime property boundary sound level limit. The development and coordination of noise control design for large and small equipment packages, some of which would be located within several meters of the property boundary, are discussed in detail. Sound level measurements are presented and discussed, particularly with regard to the challenges involved with conducting sound level measurements in the presence of ambient sound levels that often approached the allowable noise limit. [PUBLICATION ABSTRACT]

One of the most controversial, if not the most controversial, aspect of behaviorism is its claims (actual and putative) concerning cognition. Part of this controversy is caused by egregious exegetical errors on the part of Skinner's critics. Critics can then easily \"refute\" behaviorism by attributing these problematic claims to Skinner. This paper attempts to faithfully describe Skinner's claims regarding cognition. Skinner advances several arguments regarding the role of cognitions in human behavior and in the science of human behavior. We suggest that there are two distinct kinds of claims in this web: 1) claims regarding the proper relation between science and cognitions and 2) claims regarding the status of cognitions as natural events. Due to the multiplicity and interdependence of many of these arguments, it is best to view Skinner's position on cognition as consisting of a web of interdependent claims.

It is crucial for a mix engineer, producer, client, etc. to be able to discern exactly what the true sound is for each channel. So why are we seeing applications of diffusion in the front of 5.1 rooms? How did we get from LEDE to LELE? Room influences are detrimental and undesirable in 5.1 environments. Ram Hidley, whose articles and wisdom with respect to studio design have been enjoyed by many over the years, has recently written several articles expressing the importance of room symmetry and absorptive treatments in 5.1 environments. Recently, I noticed a room, originally designed with diffusion on the front wall, had absorptive panels placed over the diffusers by the mix engineer. The only explanation I can think of is that perhaps the architect, for aesthetic reasons, adds diffusion to the most visible part of the room.

Malignant peripheral nerve sheath tumour (MPNST) is an aggressive soft-tissue sarcoma that arises in peripheral nerves. MPNST occurs either sporadically or in people with neurofibromatosis type 1 (NF1), a common cancer predisposition syndrome caused by germline pathogenic variants in NF1. Although MPNST is the most common cause of death and morbidity for individuals with NF1, the molecular underpinnings of MPNST pathogenesis remain unclear. Here, we report the analysis of whole-genome sequencing, multi-regional exome sequencing, transcriptomic and methylation profiling data for 95 MPNSTs and precursor lesions (64 NF1-related; 31 sporadic) from 77 individuals. Early events in tumour evolution include biallelic inactivation of NF1 followed by inactivation of CDKN2A and in some cases also TP53 and polycomb repressive complex 2 (PRC2) genes. Subsequently, both sporadic and NF1-related MPNSTs acquire a high burden of somatic copy number alterations (SCNAs). Our analysis revealed distinct pathways of tumour evolution and immune infiltration associated with inactivation of PRC2 genes and H3K27 trimethylation (H3K27me3) status. Tumours with loss of H3K27me3 evolve through extensive chromosomal losses with retention of chromosome 8 heterozygosity followed by whole genome doubling and chromosome 8 amplification. These tumours show lower levels of immune cell infiltration with low cytotoxic activity and low expression of immune checkpoints. In contrast, tumours with retention of H3K27me3 evolve through extensive genomic instability in the absence of recurrent alterations and exhibit an immune cell-rich phenotype. Specific SCNAs detected in both tumour samples and cell-free DNA (cfDNA) act as a surrogate for loss of H3K27me3 and immune infiltration, and predict prognosis. Our results suggest that SCNA profiling of tumour or cfDNA could serve as a biomarker for early diagnosis and to stratify patients into prognostic and treatment-related subgroups. Competing Interest Statement A.A., A.C., I.C.C., B.C.D., V.E., A.F., A.M.F., A.G., J.H., K.B.J., R.H.K., D.L., C.M., P.J.P., K.P., N.P., P.P., J.S., M.S., C.D.S., R.T.S., J.J.S., D.V., and X.W. have no conflicting interests to declare. M.B. Advisory boards for BioAtlas, Epizyme, Bristol-Myers Squibb, ContextVision, Airforia, Caris Life Sciences, and GlaxoSmithKline, consultant for AstraZeneca Pharmaceuticals LP, Foundation Medicine Inc, Visiopharm, Roche Laboratories, Inc.; B.C.D. received lab supplies from Illumina; J.F.G. consulted for Pfizer; A.C.H. Advisory boards for AstraZeneca and Springworks Consulting, received Intellisphere Research Funding from Tango Therapeutics Licensing Agreement with Deutsches Krebsforschungszentrum; J.T.J: Navio Theragnostics consultant, Recursion member scientific advisory board and consulting, Health2047 consultant, CEC Oncology speaker at a single CME conference regarding plexiform neurofibromas; D.T.M: Advisory Board, AstraZeneca; Y.N. Chairman, Japanese Society of Recklinghausen Disease; N.U. received royalties from University of Alabama, Birmingham and UpToDate, paid lecture to the advisory board of Astra Zeneca, expert testimony for Wolf, Horowitz & Etlinger, LLC Footnotes * Removed extended and supplementary figures into separate PDF files * https://ega-archive.org/access/data-access

Cognitive-behavioral models of depression identify several interpersonal and intrapersonal factors that may play a role in the etiology and/or maintenance of depression. These include: cognitive distortions, negative automatic cognitions, hopelessness, social problem-solving skills, coping strategies, and social support. Initial attempts to demonstrate the role of each of these constructs in depression have resulted in a proliferation of self-report questionnaires, and numerous studies have demonstrated that these questionnaires are correlated with self-reports of depressive symptoms. Although each of the constructs reflected in these self-report questionnaires is presumed to be at least partially independent of the others, to date, the discriminant validity of these questionnaires has yet to be established. In the absence of information regarding the discriminability of these questionnaires, several possibilities exist regarding their actual factor structure (i.e., how many constructs are being measured, what constitutes each of the constructs). These possibilities are investigated in this study. Two-hundred forty-nine participants completed several questionnaires measuring depressive symptoms and correlates of depression. Structural Equation Modeling (SEM) was used to assess the underlying factor structure of these questionnaires. Results indicate that the above mentioned constructs can be differentiated from one another and from depressive symptoms. Theoretical, assessment, and treatment implications are discussed.