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result(s) for
"TAL Team"
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SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease
Lyme disease is a tick-borne disease caused by bacteria of the genus
Borrelia
. The host factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using epidemiological and genetic data from FinnGen and Estonian Biobank, we identify two previously known variants and an unknown common missense variant at the gene encoding for Secretoglobin family 1D member 2 (
SCGB1D2
) protein that increases the susceptibility for Lyme disease. Using live
Borrelia burgdorferi (Bb)
we find that recombinant reference SCGB1D2 protein inhibits the growth of
Bb
in vitro more efficiently than the recombinant protein with SCGB1D2 P53L deleterious missense variant. Finally, using an in vivo murine infection model we show that recombinant SCGB1D2 prevents infection by
Borrelia
in vivo. Together, these data suggest that
SCGB1D2
is a host defense factor present in the skin, sweat, and other secretions which protects against
Bb
infection and opens an exciting therapeutic avenue for Lyme disease.
The genetic basis of susceptibility to Lyme disease is largely unknown. Here, the authors discover a risk locus in the gene encoding the protein Secretoglobin family 1D member 2, which is expressed in skin and affects infection by the bacteria that causes Lyme disease in vitro and in vivo.
Journal Article
A planet in a polar orbit of 1.4 solar-mass star
Although more than a thousand transiting extrasolar planets have been discovered, only very few of them orbit stars that are more massive than the Sun. The discovery of such planets is interesting, because they have formed in disks that are more massive but had a shorter life time than those of solar-like stars. Studies of planets more massive than the Sun thus tell us how the properties of the proto-planetary disks effect the formation of planets. Another aspect that makes these planets interesting is that they have kept their original orbital inclinations. By studying them we can thus find out whether the orbital axes planets are initially aligned to the stars rotational axes, or not. Here we report on the discovery of a planet of a 1.4 solar-mass star with a period of 5.6 days in a polar orbit made by CoRoT. This new planet thus is one of the few known close-in planets orbiting a star that is substantially more massive than the Sun.
Journal Article
Experimental validation of the intensity refractometry principle for density measurements at the edge of a tokamak
Experimental validation is presented for a new type of microwave diagnostic, first introduced in the theoretical study in M. Usoltceva et al., Rev. Sci. Instrum. 93, 013502 (2022). A new term is adopted for this technique to highlight its difference from interferometry: intensity refractometry. The diagnostic allows measuring electron density, and in this work, it is applied at the edge of a tokamak. The implementation of this technique at ASDEX Upgrade, called Microwave Intensity refractometer in the Limiter Shadow (MILS), provides the first experimental proof of the diagnostic concept. Densities predicted by MILS are compared to several other diagnostics. The agreement and discrepancy in various radial regions of the density profile are analyzed and possible reasons are discussed. A wide density coverage is shown in the example discharges with densities from 2*10^17 m^-3 to 2*10^19 m^-3 at the limiter position. In these experiments, the radial location of the measurements varied from 5 cm in front of the limiter (up to 1 cm inside the separatrix was measured) to 3 cm in the limiter shadow. Experimental challenges of MILS operation and data processing are presented.
Paper
I-mode pedestal relaxation events at ASDEX Upgrade
The I-mode confinement regime can feature small edge temperature drops that can lead to an increase in the energy deposited onto the divertor targets. In this work, we show that these events are associated with a relaxation of both electron temperature and density edge profiles, with the largest drop found at the pedestal top position. Stability analysis of edge profiles reveals that the operational points are far from the ideal peeling-ballooning boundary. Also, we show that these events appear close to the H-mode transition in the typical I-mode operational space in ASDEX Upgrade, and that no further enhancement of energy confinement is found when they occur. Moreover, scrape-off layer transport during these events is found to be very similar to type-I ELMs, with regard to timescales (\\(\\approx\\) 800 \\(\\mu\\)s), filament propagation, toroidally asymmetric energy effluxes at the midplane and asymmetry between inner and outer divertor deposited energy. In particular, the latter reveals that more energy reaches the outer divertor target. Lastly, first measurements of the divertor peak energy fluence are reported, and projections to ARC - a reactor designed to operate in I-mode - are drawn.
Paper
Jamba-1.5: Hybrid Transformer-Mamba Models at Scale
We present Jamba-1.5, new instruction-tuned large language models based on our Jamba architecture. Jamba is a hybrid Transformer-Mamba mixture of experts architecture, providing high throughput and low memory usage across context lengths, while retaining the same or better quality as Transformer models. We release two model sizes: Jamba-1.5-Large, with 94B active parameters, and Jamba-1.5-Mini, with 12B active parameters. Both models are fine-tuned for a variety of conversational and instruction-following capabilties, and have an effective context length of 256K tokens, the largest amongst open-weight models. To support cost-effective inference, we introduce ExpertsInt8, a novel quantization technique that allows fitting Jamba-1.5-Large on a machine with 8 80GB GPUs when processing 256K-token contexts without loss of quality. When evaluated on a battery of academic and chatbot benchmarks, Jamba-1.5 models achieve excellent results while providing high throughput and outperforming other open-weight models on long-context benchmarks. The model weights for both sizes are publicly available under the Jamba Open Model License and we release ExpertsInt8 as open source.
Paper