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The European and national regulations in the decarbonisation path towards 2050 promote district heating in achieving the goals of efficiency, energy sustainability, use of renewables, and reduction of fossil fuel use. Improved management and optimisation, use of RES, and waste heat/cold sources decrease the overall demand for primary energy, a condition that is further supported by building renovations and new construction of under (almost) zero energy buildings, with a foreseeable decrease in the temperature of domestic heating systems. Models for the simulation of efficient thermal networks were implemented and described in this paper, together with results from a real case study in Italy, i.e., University Campus of Parma. Activities include the creation and validation of calculation codes and specific models in the Modelica language (Dymola software), aimed at investigating stationary regimes and dynamic behaviour as well. An indirect heat exchange substation was coupled with a resistive-capacitive model, which describes the building behaviour and the thermal exchanges by the use of thermos-physical parameters. To optimise indoor comfort conditions and minimise consumption, dynamic simulations were carried out for different operating sets: modulating the supply temperature in the plant depending on external conditions (Scenario 4) decreases the supplied thermal energy (−2.34%) and heat losses (−8.91%), even if a lower temperature level results in higher electricity consumption for pumping (+12.96%), the total energy consumption is reduced by 1.41%. A simulation of the entire heating season was performed for the optimised scenario, combining benefits from turning off the supply in the case of no thermal demand (Scenario 3) and from the modulation of the supply temperature (Scenario 4), resulting in lower energy consumption (the thermal energy supplied by the power plant −3.54%, pumping +7.76%), operating costs (−2.40), and emissions (−3.02%). The energy balance ex-ante and ex-post deep renovation in a single user was then assessed, showing how lowering the network operating temperature at 55 °C decreases the supplied thermal energy (−22.38%) and heat losses (−22.11%) with a slightly higher pumping consumption (+3.28%), while maintaining good comfort conditions. These promising results are useful for evaluating the application of low-temperature operations to the existing district heating networks, especially for large interventions of building renovation, and confirm their potential contribution to the energy efficiency targets.

There are many existing buildings for which seismic rehabilitation interventions are required, especially in earthquake-prone areas like Italy. At the same time, the huge energy cost increase in Europe highlights the need for sustainable techniques that are able to increase the energy efficiency of buildings. These issues are even more significant for weak social groups living in social housing buildings, often in poor and vulnerable conditions. In order to address the solution regarding building renovations from the social, structural, and energy efficiency perspectives, in the framework of the Horizon Europe REHOUSE (Renovation packagEs for HOlistic improvement of EU’s bUildingS Efficiency, maximizing RES generation and cost-effectiveness) Project, this paper proposes an integrated methodology of building assessment that was tested on a social housing building in Margherita di Savoia, a small town of Apulia Region, Italy. In addition to the structural and energy aspects, the social one is particularly important since the building is located in the “Capitanata Area”, considered to be one of the most socially vulnerable areas in Italy. For this reason, an assessment methodology must consider reducing the overall impact of the assessment activities while explaining to tenants the purpose of the assessment and future renovation actions, maintaining the accuracy of the assessment results. Therefore, this study outlines an assessment methodology, demonstrated through its application to the case study building, that integrates the structural, energy, and social aspects, showing that the tenants’ involvement is also crucial for the technical evaluations. The final result is a low-impact approach for the building knowledge gathering needed to start a deep renovation intervention in social housing.

In this paper, results obtained by the numerical investigation on laminar mixed convection in triangular ducts, filled with nanofluids, are presented in order to evaluate the fluid dynamic and thermal features of the considered geometry by considering Al2O3/water based nanofluids. The system is heated by a constant and uniform heat flux also along the perimeter of the triangular duct section in H2 mode as thermal boundary condition and the single-phase model has been assigned for a Reynolds number value equal to 100. Results are given for different nanoparticle volume concentrations and Richardson number values ranging from 0% to 5% and from 0 to 5, respectively. Results, presented for the fully developed regime flow, show the enhancement of average convective heat transfer coefficients values for increasing values of Richardson number and particle fractions. However, wall shear stress and required pumping power profiles increase as expected. The PEC analysis showed that the use of nanofluids in mixed convection seems slightly convenient. It should be underlined that, at the moment, experimental data are not available to compare the numerical proposed model for mixed convection in horizontal triangular ducts with nanofluids.

Convective heat transfer can be enhanced passively by changing flow geometry and boundary conditions or by improving the thermal conductivity of the working fluid, for example, introducing suspended small solid nanoparticles. In this paper, a numerical investigation on laminar mixed convection in a water-Al 2 O 3 -based nanofluid, flowing in a triangular cross-sectioned duct, is presented. The duct walls are assumed at uniform temperature, and the single-phase model has been employed in order to analyze the nanofluid behaviour. The hydraulic diameter is equal to 0.01 m. A fluid flow with different values of Richardson number and nanoparticle volume fractions has been considered. Results show the increase of average convective heat transfer coefficient and Nusselt number for increasing values of Richardson number and particle concentration. However, also wall shear stress and required pumping power profiles grow significantly.

Convective heat transfer can be enhanced passively by changing flow geometry and boundary conditions or by improving the thermal conductivity of the working fluid, for example, introducing suspended small solid nanoparticles. In this paper, a numerical investigation on laminar mixed convection in a water-Al2O3-based nanofluid, flowing in a triangular cross-sectioned duct, is presented. The duct walls are assumed at uniform temperature, and the single-phase model has been employed in order to analyze the nanofluid behaviour. The hydraulic diameter is equal to 0.01 m. A fluid flow with different values of Richardson number and nanoparticle volume fractions has been considered. Results show the increase of average convective heat transfer coefficient and Nusselt number for increasing values of Richardson number and particle concentration. However, also wall shear stress and required pumping power profiles grow significantly.

Introduction Split phenomena in ALS refers to the preferential dysfunction of some groups of muscles over others. The split-elbow sign (SE) is characterized by the predominant weakness of the biceps compared to the triceps, but available results are conflicting. Objectives To evaluate the prevalence of the SE in two independent cohorts: the randomized controlled trial-based PRO-ACT cohort ( n  = 500) and a monocentric cohort of patients with ALS from Southern Italy ( n  = 144); to investigate the demographic and clinical variables associated with the SE sign. Methods Wilcoxon signed-rank test was used to compare biceps with triceps power in the same limb measured by hand-held dynamometry in the PRO-ACT cohort and Medical Research Council (MRC) in our cohort. Each limb was considered independently and not paired within the same individual. The arm where the triceps was stronger than the biceps was defined SE + , whereas the arm where the biceps was stronger than the triceps was considered SE-. A backward stepwise multivariate logistic regression was used to analyze the relationship between clinical and demographic variables and SE. PENN Upper Motor Neuron and Devine scales were used to evaluate the different upper (UMN) and lower (LMN) motor neuron impairments between the SE + and SE- arms. Results In both cohorts, the biceps were on average stronger than the triceps, and the SE sign was present in 41% of the PRO-ACT cohort and just 30% of the Southern Italy cohort. The multivariate logistic regression revealed that older age (OR: 1.45; p  = 0.01), male gender (OR: 1.55; p  = 0.002), spinal onset (OR: 1.59; p  = 0.007), and higher disease severity (OR: 1.70; p  = 0.001) were significant predictors of the SE sign in the PRO-ACT cohort. Conversely, in Southern Italy patients, only a lower ALSFRS-R score was a significant determinant of the SE (OR: 8.47; p  = 0.008). Finally, SE + arms exhibited a significantly higher median Devine sub-score compared to SE- [1 vs 0, p  = < 0.05], while arms SE- showed a significantly higher median PUMNS sub-score [2 vs 0; p  = < 0.05)]. Conclusion In our study, most patients with ALS do not show SE. Patients with SE are more likely older, males, with spinal onset, a higher degree of disease severity, and predominant and wider LMN impairment.

The Southeastern Tyrrhenian Sea is a back-arc basin characterized by the onset of volcanism over the past ~11 million years and the development of numerous volcanic seamounts. Hydrothermal venting is predominantly concentrated in the southeastern sector, encompassing the Aeolian volcanic arc and major volcanic edifices, such as Palinuro and Marsili. These systems frequently exhibit zones of localized magnetic depletion (demagnetization) within otherwise magnetized volcanic structures, often linked to hydrothermal alteration. Notably, volcanic rejuvenation phases are commonly associated with active hydrothermal circulation. In response to mounting ecological concerns, the Italian government has delineated extensive Ecological Protection Zones (EPZs), including those in the Eastern Tyrrhenian sector. These EPZs encompass a series of prominent seamounts—Palinuro, Marsili, Vercelli, Vavilov, Magnaghi, Enarete, and Anchise—that exhibit morphological evidence of rejuvenation and magnetic anomalies consistent with hydrothermal modification. Such features are indicative of potentially mineralized systems, relevant for future resource exploration. A comprehensive evaluation of both the ecological significance and the mineral potential of these areas is now imperative. Balancing environmental conservation with the strategic assessment of deep-sea mining prospects will be essential to mitigate biodiversity loss while promoting the sustainable use of marine mineral resources.

The dynamics of deep sea explosive eruptions, the dispersion of the pyroclasts, and how submarine eruptions differ from the subaerial ones are still poorly known due to the limited access to sea environments. Here, we analyze two ash layers representative of the proximal and distal deposits of two submarine eruptions from a 500 to 800 m deep cones of the Marsili Seamount (Italy). Fall deposits occur at a distance of more than 1.5 km from the vent, while volcanoclastic flows are close to the flanks of the cone. Ash shows textures indicative of poor magma-water interaction and a gas-rich environment. X-ray microtomography data on ash morphology and bubbles, along with gas solubility and ash dispersion models suggest 200–400 m high eruptive columns and a sea current velocity <5 cm/s. In deep sea environments, Strombolian-like eruptions are similar to the subaerial ones provided that a gas cloud occurs around the vent.

This paper illustrates the development of a recursive QR technique for the analysis of transient events, such as disruptions or scenario evolution, in fusion devices with three-dimensional conducting structures using an integral eddy current formulation. An integral formulation involves the solution, at each time step, of a large full linear system. For this reason, a direct solution is impractical in terms of time and memory consumption. Moreover, typical fusion devices show a symmetric/periodic structure. This can be properly exploited when the plasma and other sources possess the same symmetry/periodicity of the structure. Indeed, in this case, the computation can be reduced to only a single sector of the overall structure. In this work the periodicity and the symmetries are merged in the recursive QR technique, exhibiting a huge decrease in the computational cost. Finally, the proposed technique is applied to a realistic large-scale problem related to the International Thermonuclear Experimental Reactor (ITER).

Background Currently, there is a lack of knowledge concerning where the pathological process starts and how the neurodegeneration spreads during the course of amyotrophic lateral sclerosis (ALS). Aims This study aims to evaluate the spreading direction of the disease and the corresponding clinical characteristics in a cohort of patients with limb‐onset ALS. Patients and methods Consecutive incident ALS patients referring to an ALS tertiary center from Southern Italy, between 2015 and 2021, were recruited in the study. According to the initial directions of spread, patients were dichotomized into horizontal spreading pattern (HSP) or vertical spreading pattern (VSP) groups. Results Among 137 newly diagnosed ALS, 87 presented a spinal onset. Ten patients with pure LMN were not included in the study. All cases reported a clear spread direction. The frequency of HSP and VSP spreading was similar overall (47 vs. 30). The prevalence of HSP was higher (74% vs. 50%) in patients with upper limb‐onset (UL‐ALS), compared to patients with lower limb‐onset (LL‐ALS; p < .05). Conversely, the occurrence of VSP spread was threefold higher in patients with LL‐ALS, compared to UL‐ALS (p < .05). Patients with VSP showed a wider upper motor neuron impairment, whereas the involvement of LMN resulted greater in patients with HSP. Patients with HSP exhibited a greater drop of ALSFRS‐r sub‐score in the region of onset, while VSP showed a slighter but more diffuse reduction of ASLFRS‐r subscore in more body districts beyond the site of onset. Patients with VSP were also characterized by a higher median progression rate and an earlier median bulbar involvement, compared to HSP. Conclusions Our findings suggested investigating the spreading direction of ALS among patients with spinal onset, to better delineate the clinical profiles of patients with ALS, and predict an earlier impairment of bulbar muscle and a more rapid progression of the disease