Explore the vast range of titles available.

The study aimed to examine the association between obesity and hyperuricemia in ob/ob mice. An animal model of obesity was developed using male ob/ob mice. Biochemical parameter test kits were used to measure serum uric acid (UA), hepatic xanthine oxidase (XOD) activity, serum creatinine (Scr), serum lipid profiles, and blood urea nitrogen (BUN). Then, liver tissues were collected for hematoxylin and eosin (H&E) staining, flow cytometry, and western blot (WB) analysis. Furthermore, Huh-7 cells were co-cultured with THP-1 macrophages for 24 hours, with or without LPS + IFN-γ or PA, and subsequently analyzed for XOD activity. In addition, the Huh-7 cells stimulated with PA were analyzed by metabolomics and validated by WB and RT-qPCR. Levels of Serum lipid profiles, UA, and XOD activity are elevated in ob/ob mice. In ob/ob mice, liver M1 macrophage polarization is markedly enhanced. In vitro studies show that elevated XOD activity in hepatocytes during hyperlipidemia does not correlate with M1 macrophage polarization. Metabolomics showed that the XOD activity of hepatocytes in hyperlipidemia may be related to pyruvate metabolism. Moreover, the protein and mRNA levels of pyruvate dehydrogenase (PDH), an enzyme that limits pyruvate accumulation, were significantly down-regulated in Huh-7 cells with PA stimulation. Hyperuricemia in ob/ob mice relates to hepatocellular pyruvate metabolism/ xanthine oxidase axis.

To compare the efficacy and safety of Ahmed glaucoma valve implantation (AGV) with trabeculectomy in the management of glaucoma patients. A comprehensive literature search (PubMed, Embase, Google, and the Cochrane library) was performed, including a systematic review with meta-analysis of controlled clinical trials comparing AGV versus trabeculectomy. Efficacy estimates were the weighted mean differences (WMDs) for the percentage intraocular pressure reduction (IOPR %) from baseline to end-point, the reduction in glaucoma medications, and the odds ratios (ORs) for complete and qualified success rates. Safety estimates were the relative risks (RRs) for adverse events. All outcomes were reported with a 95% confidence interval (CI). Statistical analysis was performed using the RevMan 5.0 software. Six controlled clinical trials were included in this meta-analysis. There was no significant difference between the AGV and trabeculectomy in the IOPR% (WMD = -3.04, 95% CI: -8.36- 2.26; P = 0.26). The pooled ORs comparing AGV with trabeculectomy were 0.46 (0.22, 0.99) for the complete success rate (P = 0.05) and 0.97 (0.78-1.20) for the quantified success rate (P = 0.76). No significant difference in the reduction in glaucoma medicines was observed (WMD = 0.24; 95% CI: -0.27-0.76; P = 0.35). AGV was found to be associated with a significantly lower frequency of all adverse events (RR = 0.71; 95%CI: 1.14-0.97; p = 0.001) than trabeculectomy, while the most common complications did not differ significantly (all p> 0.05). AGV was equivalent to trabeculectomy in reducing the IOP, the number of glaucoma medications, success rates, and rates of the most common complications. However, AGV was associated with a significantly lower frequency of overall adverse events.

Google proposed the bottleneck bandwidth and round-trip propagation time (BBR), which is a new congestion control algorithm. BBR creates a network path model by measuring the available bottleneck bandwidth and the minimum round-trip time (RTT) to maximize delivery rate and minimize latency. However, some studies have shown that there are serious RTT fairness problems in the BBR algorithm. The flow with longer RTT will consume more bandwidth and the flows with shorter RTT will be severely squeezed or even starved to death. Moreover, these studies pointed out that even small RTT differences will lead to the throughput of BBR flows being unfair. In order to solve the problem of RTT fairness, an improved algorithm BBR-gamma correction (BBR-GC) is proposed. BBR-GC algorithm takes RTT as feedback information, and then uses the gamma correction function to fit the adaptive pacing gain. This approach can make different RTT flows compete for bandwidth more fairly, thus alleviating the RTT fairness issue. The simulation results of Network Simulator 3 (NS3) show that that BBR-GC algorithm cannot only ensure the channel utilization, but also alleviate the RTT fairness problem of BBR flow in different periods. Through the BBR-GC algorithm, RTT fairness is improved by 50% and the retransmission rate is reduced by more than 26%, compared with that of the original BBR in different buffer sizes.

The network layer plays a crucial role in blockchain systems, enabling essential functions such as message broadcasting and data synchronization. Enhancing data transmission structures and methods at this layer is key to improving scalability and addressing performance limitations. Currently, the uneven distribution of neighboring node lists and the lack of awareness of underlying linkages in coverage networks hinder the efficiency and comprehensiveness of information transmission. To tackle these challenges, this study introduces a dual-layer transmission model, FPSblo-EP, which divides the blockchain P2P network into two layers: the regular node layer and the tagged node layer. In the initial stage, network nodes are treated as points in a point cloud, and farthest point sampling is applied to the P2P network nodes. During this process, geographic distances between nodes serve as input parameters, while node degrees are used as point weights. Tagged nodes can then provide efficient and stable inter-group routing for regular nodes, creating a hierarchical transmission architecture. This model improves both transmission performance and scalability in blockchain overlay networks. Experimental results show that FPSblo-EP reduces message coverage latency by 22%, redundancy by 26%, and the network stretch coefficient by 28%, demonstrating superior load-balancing capabilities and enhanced network reliability.

Sub‐50 nm iron–nitrogen‐doped hollow carbon sphere‐encapsulated iron carbide nanoparticles (Fe3C‐Fe,N/C) are synthesized by using a triblock copolymer of poly(styrene‐b‐2‐vinylpyridine‐b‐ethylene oxide) as a soft template. Their typical features, including a large surface area (879.5 m2 g−1), small hollow size (≈16 nm), and nitrogen‐doped mesoporous carbon shell, and encapsulated Fe3C nanoparticles generate a highly active oxygen reduction reaction (ORR) performance. Fe3C‐Fe,N/C hollow spheres exhibit an ORR performance comparable to that of commercially available 20 wt% Pt/C in alkaline electrolyte, with a similar half‐wave potential, an electron transfer number close to 4, and lower H2O2 yield of less than 5%. It also shows noticeable ORR catalytic activity under acidic conditions, with a high half‐wave potential of 0.714 V, which is only 59 mV lower than that of 20 wt% Pt/C. Moreover, Fe3C‐Fe,N/C has remarkable long‐term durability and tolerance to methanol poisoning, exceeding Pt/C regardless of the electrolyte. Sub‐50 nm iron–nitrogen‐doped hollow carbon sphere‐encapsulated iron carbide nanoparticles (Fe3C‐Fe,N/C) are synthesized by using a triblock copolymer of poly(styrene‐b‐2‐vinylpyridine‐b‐ethylene oxide) as a soft template. Their typical features include a large surface area (879.5 m2 g−1), small hollow size (≈16 nm), and nitrogen‐doped mesoporous carbon shell. Encapsulated Fe3C nanoparticles generate a highly active oxygen reduction reaction performance.

Koninginins X-Z (1–3), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus Trichoderma koningiopsis SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, 13C NMR, DFT GIAO 13C NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against Candida albicans.

New ambuic acid derivatives, pestallic acids R–V ( 1 − 5 ), together with ambuic acid ( 6 ), were isolated from the endophytic fungus Pestalotiopsis trachicarpicola SC-J551 derived from the fern Blechnum orientale L., of which compound 2 , being racemic, was separated to two optically pure enantiomers (+)- 2 and (−)- 2 . The structures including absolute configurations of these new compounds were elucidated by extensive spectroscopic analysis and theoretical simulations of their ECD spectra and 13 C NMR chemical shifts. Compounds 1 and 3 exhibited cytotoxicity against human carcinoma A549, HeLa, HepG2, and MCF-7 cells (IC 50 : 3.6–12.5 μM) and compound 3 was also active against Staphylococcus aureus and MRSA (MIC = 20 μg ml −1 ). Compound (±)- 2 showed inhibitory activity against LPS-induced NO release (IC 50  = 21.1 μM) and t -BHP-induced ROS production (IC 50  = 8.5 μM) in RAW264.7 macrophages.

A new bergamotane sesquiterpenoid, named xylariterpenoid H (1), along with fourteen known compounds (2–15), were isolated from the crude extract of Aspergillus fumigatus, an endophytic fungus isolated from Delphinium grandiflorum L. Their structures were elucidated mainly by extensive analyses of NMR and MS spectroscopic data. In addition, the screening results of antibacterial and cytotoxic activities of compounds 1–15 showed that compound 4 displayed antibacterial activities against Staphylococcus aureus and MRSA (methicillin-resistant S. aureus) with an MIC value of 3.12 µg/mL.

Two previously undescribed lactones, phomolides A and B ( 1 and 2 ), and three new sesquiterpenoids, phomenes A–C ( 3 – 5 ), together with one known compound, colletotricholide A ( 6 ), were isolated from the endophytic fungus Phomopsis sp. SZSJ-7B. Their chemical structures, including the absolute configurations, were comprehensively established by extensive analyses of NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism powered by theoretical calculations, and X-ray diffractions. Moreover, the cytotoxic and antibacterial activities of compounds 1–6 were also evaluated, and the results demonstrated that compound 2 showed significant antibacterial effects towards methicillin-resistant Staphylococcus aureus and S. aureus strains with minimum inhibitory concentration as low as 6.25 μg/ml, which was comparable to that of the clinical drug vancomycin. Moreover, all compounds showed no cytotoxic activity.

Two new alkylresorcinols named herein 5’-methoxy-integracins A-B (1-2), two new monomeric alkyl aromatic derivatives 3-(7-hydroxyheptyl)-5-methoxyphenol (5) and 7-(3,5-dihydroxyphenyl) heptyl acetate (6), along with four known compounds including integracins A-B (3-4), 2,4-dihydroxy-6-(8-hydroxyoctyl) benzene (7), and cytosporone B (8) were isolated from the endophytic fungus Cytospora rhizophorae A761. The structures of the four new compounds were elucidated by NMR, HRESIMS data, and electronic circular dichroism (ECD) calculations, whereas the compounds 1 and 2 were disclosed as a class of the natural rare-occurring dimeric alkylresorcinol derivatives. Moreover, the bioassays of the new compounds clarified that compound 1 was a potent inhibitor for the α-glucosidase, and compound 2 showed relatively good activity against the tumor cell lines. It is worth mentioning that the known compound integracin B (4) was first reported to display significant antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 6.25 μg ml−1.