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By the end of 2020, with all rural residents living in poverty under the current standard lifted out of absolute poverty, marking a new phase in China’s anti-poverty efforts with new pursuit of the consolidation and expansion of poverty alleviation achievements in the effective connection with rural revitalization. The development and improvement of funding mechanisms for rural preschool education are crucially important to further promoting rural development. Employing an input-oriented three-stage DEA model and the Malmquist index, this study conducts a static and dynamic analysis of resource allocation performance in rural preschool education across 30 provinces in China (excluding Tibet, Hong Kong, Macao, and Taiwan). The findings reveal that random factors and environmental variables lead to an underestimation of rural preschool education investment performance. Secondly, economically developed regions are not necessarily equipped with higher performance in rural preschool education investment as regional differences stem from the combined effects of various economic, agglomeration, demographic, and scale factors across different areas of the country. Finally, based on these empirical results, this paper proposes policy recommendations to enhance resource allocation performance in China’s rural preschool education.

Rural preschool education is an integral part of rural society, and improving the efficiency system of evaluation of rural preschool education resource allocation is an important strategy for the implementation of the rural revitalization. This paper uses an input-oriented three-stage DEA model to analyze the efficiency of rural preschool education resource allocation in 30 provinces in China from 2012 to 2020. The results show that external factors such as the level of urbanization, birth rate, and the scale of kindergarten impacts the efficiency of rural preschool education resource allocation significantly. Without regard to the influence of environmental and random factors, the overall trend of the average efficiency of rural preschool education resource allocation in China has improved, showing a regional pattern of “central > eastern > western.” Therefore, based on the relevant policies, this paper puts forward rational suggestions for the improvement of rural preschool resource allocation efficiency in China from the perspectives of human, financial and material resources.

Coronary heart disease (CHD) is the most common clinical manifestation of cardiovascular disease. It is characterized by myocardial ischemia, which is caused by coronary atherosclerosis. CHD is a significant global health problem with increasing prevalence every year because of significant changes in the lifestyles and diets. Ginseng is a traditional Chinese medicinal herb that has been used in food preparations and traditional medicine for several centuries. Several studies have demonstrated that ginseng improved cardiac function by normalizing blood glucose levels and decreasing blood pressure, oxidative stress, platelet aggregation, and lipid dysregulation in vivo . This review describes the current understanding of the mechanisms by which ginseng alleviates CHD, and provides a reference for the clinical development and application of ginseng as an alternative therapy for CHD.

NF-YA transcription factors function in modulating tolerance to abiotic stresses that are serious threats to crop yields. In this study, GmNFYA13 , an NF-YA gene in soybean, was strongly induced by salt, drought, ABA, and H2O2, and suppressed by tungstate, an ABA synthesis inhibitor. The GmNFYA13 transcripts were detected in different tissues in seedling and flowering stages, and the expression levels in roots were highest. GmNFYA13 is a nuclear localization protein with self-activating activity. Transgenic Arabidopsis plants overexpressing GmNFYA13 with higher transcript levels of stress-related genes showed ABA hypersensitivity and enhanced tolerance to salt and drought stresses compared with WT plants. Moreover, overexpression of GmNFYA13 resulted in higher salt and drought tolerance in OE soybean plants, while suppressing it produced the opposite results. In addition, GmNFYA13 could bind to the promoters of GmSALT3 , GmMYB84 , GmNCED3 , and GmRbohB to regulate their expression abundance in vivo . The data in this study suggested that GmNFYA13 enhanced salt and drought tolerance in soybean plants.

Background Known as the prerequisite component for the heterosis breeding system, the male sterile line determines the hybrid yield and seed purity. Therefore, a deep understanding of the mechanism and gene network that leads to male sterility is crucial. BS366, a temperature-sensitive genic male sterile (TGMS) line, is male sterile under cold conditions (12 °C with 12 h of daylight) but fertile under normal temperature (20 °C with 12 h of daylight). Results During meiosis, BS366 was defective in forming tetrads and dyads due to the abnormal cell plate. During pollen development, unusual vacuolated pollen that could not accumulate starch grains at the binucleate stage was also observed. Transcriptome analysis revealed that genes involved in the meiotic process, such as sister chromatid segregation and microtubule-based movement, were repressed, while genes involved in DNA and histone methylation were induced in BS366 under cold conditions. MethylRAD was used for reduced DNA methylation sequencing of BS366 spikes under both cold and control conditions. The differentially methylated sites (DMSs) located in the gene region were mainly involved in carbohydrate and fatty acid metabolism, lipid metabolism, and transport. Differentially expressed and methylated genes were mainly involved in cell division. Conclusions These results indicated that the methylation of genes involved in carbon metabolism or fatty acid metabolism might contribute to male sterility in BS366 spikes, providing novel insight into the molecular mechanism of wheat male sterility.

Low-carbon economy is not only an important topic for the globe but also a serious challenge for China with its economy entering a new level. Based on the DEA-undesirable model and Malmquist index model, urban agglomeration of the Yangtze River Delta and the Guangdong–Hong Kong–Macao Greater Bay Area from 2010 to 2021 were selected as research samples. Based on that, a panel generalized method of moments model was constructed to analyze the effects of the education level, technological development, and their interaction on urban carbon emission efficiency. It found that 1) the carbon emission efficiency of the Yangtze River Delta and the Guangdong–Hong Kong–Macao Greater Bay Area urban agglomerations shows a steady growth trend, but the overall level is low and there are regional differences, among which pure technical efficiency mainly limits the improvement of comprehensive efficiency; 2) the education level and technological development have a high positive correlation on urban carbon emission, and their interaction is conducive to the improvement of carbon emission efficiency. The carbon emission efficiency has a significant advantage under the influence of control variables, such as the economic development level, industrial structure upgrading, opening-up degree, and Internet penetration rate. 3) According to the economic dimension and population dimension, the samples of the Yangtze River Delta and the Guangdong–Hong Kong–Macao Greater Bay Area were divided into large cities and small cities, and regression results showed no substantial changes. It shows that the research conclusion is scientific. According to the aforementioned conclusion, this paper puts forward corresponding countermeasures and suggestions.

Ultralong room‐temperature phosphorescence (RTP) is highly useful for information encryption, organic electronics, bioelectronics, etc. However, the preparation of related metal‐free materials with multiple colors across the full spectrum remains a major challenge. Herein, a facile method is developed to fabricate boron‐doped carbon dot (B‐CD) composites with full‐color long lifetime RTP continuously tailorable in the range of 466–638 nm simply by pyrolysis of the citric acid and boric acid precursors with various mass ratios at different temperatures. This leads to the formation of luminescent B‐CD centers in a rigid polycrystalline B2O3 matrix, which effectively stabilizes the triplet excited states of B‐CDs. Thus, the composites become phosphorescent over a relatively long period (5–12 s) after the removal of the irradiation source. Meanwhile, the increased particle size and oxidation degree of B‐CDs obtained at larger citric acid feeding or higher pyrolysis temperature continuously shift the phosphorescence from blue to red. Due to the formation of multiple luminescence centers, the RTP can also be finely modulated by the excitation wavelength. The resulting B‐CD composites with highly tunable long lifetime RTP further allow a variety of distinctive applications in multidimensional encryption handily utilizing space, time, and color variations. Simple pyrolysis of citric acid and boric acid leads to the formation of carbon dot composites with highly tailorable full‐color ultralong room temperature phosphorescence, which subsequently favors a variety of distinctive applications in multidimensional encryption.

Copper-catalyzed radical transformations have seen extensive investigations over recent decades. Due to the complexity of controlling factors and the diversity of reaction components, accurately delineating the bond formation mechanisms—namely reductive elimination, outer-sphere radical substitution, and ion pair-type bond formation—poses a formidable challenge. This study reveals the linear free energy relationships (LFER) for the C–C bond formation of Cu-catalyzed radical transformations. Leveraging this discovery, we formulate an accurate LFER model for predicting radical bond formation mechanisms in this catalytic system. By establishing LFER scales for ligands, radicals, and nucleophiles, the bond formation mechanisms across 132,300 potential Cu-catalyzed radical transformations are revealed, offering a detailed mechanistic guide for future C–C bond designs. This research advances the mechanistic understanding of Cu-catalyzed radical transformations, providing systematic and quantitative insights into the mechanistic preference of radical bond formations. Due to the complexity of controlling factors and the diversity of reaction components, accurately delineating the bond formation mechanisms for copper-catalyzed radical transformations poses a challenge. Here, the authors reveal the linear free energy relationships for the C–C bond formation of Cu-catalyzed radical transformations.

BackgroundWe previously found that autoantibodies against a panel of six tumor-associated antigens (p53, NY-ESO-1, MMP-7, Hsp70, PRDX6 and Bmi-1) may aid in early detection of esophageal squamous cell carcinoma. Here we aimed to evaluate the diagnostic value of this autoantibody panel in esophagogastric junction adenocarcinoma (EJA) patients.MethodsSerum autoantibody levels were measured by enzyme-linked immunosorbent assay in a training cohort and a validation cohort. We used receiver-operating characteristics (ROC) to calculate diagnostic accuracy.ResultsWe recruited 169 normal controls and 122 EJA patients to the training cohort, and 80 normal controls and 70 EJA patients to the validation cohort. Detection of the autoantibody panel demonstrated an area under the curve (AUC) of 0.818, sensitivity 59.0% and specificity 90.5% in training cohort, and AUC 0.815, sensitivity 61.4% and specificity 90.0% in validation cohort in the diagnosis of EJA. Measurement of the autoantibody panel could distinguish early stage EJA patients from normal controls (AUC 0.786 and 0.786, sensitivity 50.0% and 56.0%, and specificity 90.5% and 90.0%, for training and validation cohorts, respectively). Moreover, a restricted panel consisting of autoantibodies against p53, NY-ESO-1 and Bmi-1 exhibited similar diagnostic performance for EJA (AUC 0.814 and 0.823, sensitivity 53.5% and 60.0%, and specificity 90.5% and 93.7%, for training and validation cohorts, respectively) and early stage EJA (AUC 0.744 and 0.773, sensitivity 55.6% and 52.0%, and specificity 90.5% and 93.7%, for training and validation cohorts, respectively).ConclusionsAutoantibodies against an optimized TAA panel as serum biomarkers appear to help identify the present of early stage EJA.

Background To investigate whether prone position can reduce the risk of patients with mild or moderate COVID-19 who progress to severe or critical illness. Methods The prone position group was treated in prone position on the day of admission in addition to conventional treatment. Indicators such as saturation of pulse oximetry (SpO 2 ), heart rate, blood pressure, respiratory rate, and prone position-related adverse events were recorded before prone ventilation, 5 min after prone position and 30 min after prone position. Meanwhile, the cases of severe and critical patients, the percentage of transformation and the final clinical outcome of this group were analyzed. Conversion rates and mortality were calculated for patients with mild or moderate COVID-19 retrieved from the database who received only conventional care without combined prone positioning as control group. Results (1) A total of 34 patients were included in prone position group. There were significant differences in SpO 2 between the first 4 days after admission and the day of discharge ( F  = 3.17, P  < 0.001). (2) The main complications were back and neck muscle soreness (55.9%), followed by abdominal distension (8.9%). (3) In control group, a total of 4873 cases of mild and moderate patients were included from 19 literatures, with an average deterioration rate of 22.7% and mortality rate of 1.7%. (4) In prone position group, there were no severe or critical transformation cases and also no death cases. The prone position group had a significantly lower deterioration rate when compared with the control group (χ 2  = 9.962, P  < 0.01). Conclusion Prone position improves SpO 2 in patients with mild or moderate COVID-19. It can also reduce the percentage of mild or moderate patients progressing to severe or critical patients. The application of prone position is a simple, feasible, safe and effective treatment method in such patients.