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Due to its high energy density and low interface impedance, in situ polymerized gel electrolytes were considered as a promising electrolyte candidate for lithium metal batteries (LMBs). In this work, a new flame‐retardant gel electrolyte was prepared via in situ ring‐opening polymerization of DOL and TEP. The PDOL–TEP electrolyte exhibits excellent room temperature ionic conductivity (0.38 mS cm−1), wide electrochemical window (4.4 V), high Li+ transference number (0.57), and enhanced safety. Thus, the NCM811||Li cells with PDOL–TEP electrolyte exhibit excellent cycle stability (82.7% of capacity retention rate after 300 cycles at 0.5 C) and rate performance (156 and 119 mAh g−1 at 0.5 and 1 C). Furthermore, phosphorus radicals decomposed from TEP can combine with hydrogen radicals to block the combustion reaction. This work provides an effective method for the preparation of solid‐state LMBs with high voltage, high energy density, and high safety. The PDOL–TEP electrolyte exhibits excellent room temperature ionic conductivity (0.38 mS cm−1), wide electrochemical window (4.4 V), high Li+ transference number (0.57), and enhanced safety.

The precursors that appear when geological disasters occur are geotechnical deformations. This paper studies the TDR (Time Domain Reflection) measurement technology for the distributed measurement of geotechnical deformation using parallel spiral wire as a sensor, which is used for monitoring and early warning detection of geological disasters. Based on the mechanism of the electromagnetic field distribution parameters of the parallel spiral sensing wire, the relationship between the stretching amount of the parallel spiral wire and the change in its characteristic impedance is analyzed. When the parallel spiral wire is buried in the soil, the geotechnical deformation causes the parallel spiral wire to be stretched, and according to its characteristic impedance change, the stretching position and the stretching degree can be obtained, thus realizing the distributed measurement of geotechnical deformation. Based on this principle, the TDR measurement system is developed, and a local single-point stretching amount and stretching positioning experiment are designed for the parallel spiral sensing line to verify the effectiveness of the sensing technology and the usability of the measurement system.

The low energy density, unsatisfied cycling performance, potential safety issue and slow charging kinetics of the commercial lithium-ion batteries restrained their further application in the fields of fast charging and long-haul electric vehicles. Monoclinic TiNb2O7 (TNO) with the theoretical capacity of 387 mAh g−1 has been proposed as a high-capacity anode materials to replace Li4Ti5O12. In this work, homovalent doping strategy was used to enhance the electrochemical performance of TiNb2O7 (TNO) by employing Zr to partial substitute Ti through solvothermal method. The doping of Zr4+ ions can enlarge the lattice structure without changing the chemical valence of the original elements, refine and homogenize the grains, improve the electrical conductivity, and accelerate the ion diffusion kinetics, and finally enhance the cycle and rate performance. Specifically, Z0.05-TNO shows initial discharge capacity of as high as 312.2 mAh g−1 at 1 C and 244.8 mAh g−1 at 10 C, and still maintains a high specific capacity of 171.3 mAh g−1 after 800 cycles at 10 C. This study provides a new strategy for high-performance fast-charging energy storage electrodes. The doping of Zr4+ ions into TiNb2O7 can enlarge the lattice structure, refine and homogenize the grains, improve the electrical conductivity, and accelerate the ion diffusion kinetics, and finally enhance the cycle and rate performance. [Display omitted] •We synthesized Ti0·95Zr0·05Nb2O7 anode materials by solvothermal method.•The electronic conductivity of TiNb2O7 can be improved by Zr doping.•The lithium-ion conductivity of TiNb2O7 can be enhanced by Zr doping.•The Z0.05-TNO possesses superior cycle and rate performance.

Background Coagulation dysfunction significantly impacts sepsis prognosis. Standardized methods for evaluating anticoagulant efficacy and safety in this population remain lacking. This study aimed to assess the efficacy and safety of anticoagulant therapy in sepsis patients. Methods We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCTs) comparing anticoagulants against placebo/no treatment in sepsis patients. The reduction in 28/30-day all-cause mortality or the regression of disseminated intravascular coagulation (DIC) was regarded as efficacy endpoints, while bleeding complications constituted the most prevalent adverse events. Results Eighteen RCTs involving 8053 patients were included. Anticoagulant therapy demonstrated an 8% mortality risk reduction versus placebo (relative risk [RR] 0.92, 95% CI 0.86–0.98; P  = 0.02). In six studies of baseline DIC patients, anticoagulants showed non-significant mortality reduction (RR 0.87, 95% CI 0.62–1.22; P  = 0.42) but significantly enhanced DIC regression (RR 1.62, 95% CI 1.32-2.00; P  < 0.00001). Anticoagulants increased bleeding risk (RR 1.32, 95% CI 1.16–1.49; P  < 0.0001). Conclusion Anticoagulant therapy confers survival benefit in the overall sepsis population despite increased bleeding risk. While improving DIC regression in sepsis-associated DIC, mortality reduction in this subgroup lacked statistical significance. Further research should clarify anticoagulants’ role in DIC-specific sepsis management.

Background and Objectives: The long-term prognosis of acute myeloid leukemia (AML) is challenging due to limited understanding of the molecular markers involved in its development. This study investigates the role of DNA polymerases in AML to offer new insights for diagnosis and treatment. Materials and Methods: A retrospective study on pediatric AML patients with POL gene family mutations from 2021 to 2024 was conducted. Patients were categorized based on risk stratification criteria, and the DAH regimen was used for induction chemotherapy. Bioinformatics analysis integrated data from various databases to identify key genes and develop survival analysis plots and AUC curves. Results: The study included 59 pediatric AML patients, revealing no significant differences in demographic or clinical characteristics between those with and without POL family gene mutations. However, patients with POL gene mutations showed higher complete remission rates after initial DAH chemotherapy (91.67% vs. 59.57%, p = 0.03607), indicating a potential treatment benefit. High expression of four POL genes (POLD1, POLE, POLG, and POLQ) in bone marrow and immune cells suggests their crucial role in hematopoiesis and immune response. Survival analysis across different datasets indicated that AML patients with overexpressed POL family genes had significantly worse outcomes, proposing these genes as potential prognostic biomarkers for AML. Conclusions: This study on pediatric AML demonstrates that POL gene family mutations are associated with higher remission rates post-chemotherapy, indicating their potential as prognostic markers. Bioinformatics analysis emphasizes the significance of these mutations in AML, highlighting their impact on disease prognosis.

Graphene have been considered as the one of the most promising anode materials for the next generation lithium‐ion batteries (LIBs) due to its unique properties compared to that of the commercial available graphite anode. However, the tedious preparation process, high cost and easy aggregation of 2D graphene caused by the strong van der Waals interactions among nanosheets affect the high reversible capacity of graphene for LIBs. Herein, a laser‐induced strategy employing bituminous coal as a precursor for the preparation of porous graphene‐based materials (LIG‐B) is reported. LIG‐B exhibits a porous foam‐like structure and an enlarged interlayer spacing, which is larger than that of graphene with typical AB stacking. As the anode for LIBs, the LIG‐B shows a high specific capacity of 400 mAh g−1 at the current density of 100 mA g−1, and up to 95.0% of the initial reversible capacity retention after 900 cycles at 100 mA g−1. This result is higher than that of graphene‐based materials such as N‐doped rGO (200 mAh g−1), N‐doped Graphene film (150 mAh g−1), and rGO film (80 mAh g−1). Most importantly, a high capacity of 220 mAh g−1 can be maintained at 2000 mA g−1, indicating its superior rate capability. This work provides a low‐cost method to synthesize porous graphene‐based materials with fast Li+/electronic conductivity for high‐performance LIBs. A one‐step laser‐induced strategy is reported to prepare porous graphene by utilizing bituminous coal as a precursor (LIG‐B). Laser irradiation transforms coal into graphene, with small molecules from the polymer separating, recombining in gas and forming 3D porous graphene upon quick gas release. As a lithium‐ion battery (LIB) anode, LIG‐B ensures excellent rate and cycle performance.

Nonobstructive azoospermia (NOA) is one of the most important causes of male infertility, accounting for 10–15% of infertile men worldwide. Among these, more than 70% of cases are idiopathic NOA (iNOA), whose pathogenesis and molecular basis remain unknown. This work profiles 3696 human testicular single‐cell transcriptomes from 17 iNOA patients, which are classified into four classes with different arrest periods and variable cell proportions based on the gene expression patterns and pathological features. Genes related to the cell cycle, energy production, and gamete generation show obvious abnormalities in iNOA germ cells. This work identifies several candidate causal genes for iNOA, including CD164, LELP1, and TEX38, which are significantly downregulated in iNOA germ cells. Notably, CD164 knockdown promotes apoptosis in spermatogonia. Cellular communications between spermatogonial stem cells and Sertoli cells are disturbed in iNOA patients. Moreover, BOD1L2, C1orf194, and KRTCAP2 are found to indicate testicular spermatogenic capacity in a variety of testicular diseases, such as Y‐chromosome microdeletions and Klinefelter syndrome. In general, this study analyzes the pathogenesis of iNOA from the perspective of germ cell development, transcription factor (TF) regulatory networks, as well as germ cell and somatic cell interactions, which provides new ideas for clinical diagnosis. Based on the gene expression patterns and pathological features, idiopathic nonobstructive azoospermia (NOA) patients are classified into four classes. Transcriptional patterns are altered in idiopathic NOA patients, especially in cell cycle activity, energy production, and cellular communications between germ cells and somatic cells. A set of predictive genes is identified to indicate testicular spermatogenic capacity, which may be helpful for clinical diagnosis.

The Hujierte-Chaganhadamiao volcanic-plutonic sequence is located in the Mandula area of northen Damaoqi, Inner Mongo- lia. It contains mainly mafic volcanics, with several ultramafic blocks in its central part and mafic- ntermediate intrusions in the east. The zircon U-Pb ages of the gabbro and basalt samples are 278.5±3.0 Ma （MSWD=）.66） and 273.7±1.0 Ma （MSWD=0.36）, respectively. These ages constrain the magmatism occurred in the Early Permian. The Mandula Permian mafic rocks are characterized by low abundances of REE and slightly LREE-enriched chondrite-normal zed N-MORB-type REE patterns. And these mafic samples have high （143Nd/144Nd）i （0.51262-0.51270）, relatively high pos tive εNd（t） （3.4-8.0）, and high Mg# （49-54）, suggesting derivation from the depleted asthenosphere mantle source. But they al, show the enrichment in large ion lithophile elements （LILE, e.g. Rb, Ba and Sr）, depletion in high field strength elements （I-FSE）; distinctly negative Nb, Ta anomalies and slightly negative P, Ti anomalies; high （875r/86Sr）i （0.70490-0.70537）, low （206pb/204pb）i （17.39-17.93）. All of these resemble the characteristics of the enriched mantle source or involvement of arc materials in the magma genesis. Furthermore, as shown in the correlation plots of eNd（t） VS （87Sr/86Sr）i, （206pb/204Pb）ivs （207pb/204Pb）i and （208pb/204pb）i, La/Ba La/Nb vs La/Nb, and La/Nb ratio, the magma source could have been experienced the contamination and metasomation from the previous subduction process. And the positive correlation between the selected major oxides and trace elements could be explained by the contamination from continental crust and arc materials during the magmatic emplacement. Combined with the distinct geochemistry features of Mandula mafic samples and many previous researches in the study area, the Early Permian magmatism in Mandula occurred under an extensional rift setting, and a juvenile ocean basin probably had already been formed after further development.

An aerobic nitrite-denitrifying bacterium Pseudomonas putida Y-12 was used to remove sole and mixed nitrogen sources at 15 °C. When strain Y-12 was incubated for 4 days with a sole nitrogen source and initial NH4+-N, NO3−-N, and NO2−-N concentrations of 208.1, 204.7, and 199.0 mg/L, respectively, the removal ratios of NH4+-N, NO3−-N, and NO2−-N were 98.8, 73.6, and 77.1%, respectively. The average removal rates of NH4+-N, NO3−-N, and NO2−-N reached 2.14, 1.57, and 1.60 mg/L/h, respectively. Intermediate products (NO3−-N and NO2−-N) were detected at a low level. Total nitrogen removal was mainly achieved during the stationary phase in the denitrification process. All the results indicated that strain Y-12 could perform heterotrophic nitrification and aerobic denitrification at 15 °C, which was beneficial for future applications in wastewater treatment at low temperatures.

Klebsiella species, including Klebsiella pneumoniae and Klebsiella quasipneumoniae, present significant challenges in clinical microbiology due to their genetic similarity, which complicates accurate species identification using established methods, including matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry (MALDI‐TOF MS) on the protein/peptide level. Although the treatment choice for infections caused by these pathogens is often similar, precise species characterization enhances our epidemiological understanding. While whole‐genome sequencing can accurately distinguish Klebsiella species accurately, those analyses are time‐consuming, requiring specialized expertise, and are not currently used in routine clinical laboratories. Therefore, developing a timely and accurate pathogen characterization method is essential for effective treatment, management, and infection control measures. This study combined MALDI‐TOF MS in negative ion mode with machine learning techniques to identify potential lipid biomarkers as a novel method to distinguish between K. pneumoniae and K. quasipneumoniae. Using this method, we identified discriminative features between the species, with peaks at m/z 2157, m/z 1931, m/z 1964, m/z 2042, and m/z 1407 highlighted as potential biomarkers for species identification. Our findings suggest that the lipid profiles of the species obtained from MALDI‐TOF MS can serve as effective biomarkers for distinguishing Klebsiella species. Further research should focus on the structural identification of these biomarkers and expand the data set to include more isolates for each of the species. This approach holds promise for developing more cost‐effective and rapid diagnostic tools in clinical microbiology, ultimately improving patient outcomes and infection control. Lipid profiling using routine MALDI‐TOF MS can serve as effective biomarkers for distinguishing Klebsiella species.