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Chicken nuggets were prepared from spent hen meat using ground mustard as phyto-preservative without impairing the sensory attributes of the product and also the antioxidant and antimicrobial efficacy of mustard on keeping quality of the product was assessed. The emulsion stability (%), cooking yield (%) and moisture content (%) of the product containing ground mustard differed significantly ( p  ≤ 0.05) from the control. Nuggets containing ground mustard maintained significantly ( p  ≤ 0.05) higher sensory scores throughout the storage period (at 4 ± 1 °C for 15 days). The pH as well as thiobarbituric acid value increased significantly ( p  ≤ 0.05) with advancement of storage period. Ground mustard maintained significantly lower thiobarbituric acid values throughout the observation period than the control. Microbiological studies revealed significant increase in total plate count and lipolytic count with the length of storage period. Microbial counts were found to be significantly ( p  ≤ 0.05) higher in control than in nuggets containing ground mustard.

This study evaluated the effect of different flours on the physicochemical, textural, and sensory properties of chicken patties. pH; cooking yield %; water holding capacity (WHC); proximate analysis (cooked); cholesterol content; and storage stability studies of control (Con) and sorghum flour (SF; 10%w/w), finger millet flour (FMF; 10%w/w), and carrageenan (Cgn; 0.5% w/w) treated chicken patties were observed in this study. Texture profile analysis (TPA) parameters like hardness, springiness, cohesiveness, gumminess, chewiness, and sensory parameters were estimated on cooked patties. Highly significant (P < 0.01) difference in fat %, total ash %, and cholesterol content; significant (P < 0.05) difference in moisture % (cooked); and no significant (P > 0.05) difference in pH, WHC, and protein % among control and treatments were noticed. Storage stability was dependent on treatments and storage periods. Significant difference (P < 0.05) was observed in different TPA parameters among the treatments, except for hardness value. Sensory scores showed no significant difference (P > 0.05) between Con and treatments.

This study evaluated the effect of different flours on the physicochemical, textural, and sensory properties of chicken patties. pH; cooking yield %; water holding capacity (WHC); proximate analysis (cooked); cholesterol content; and storage stability studies of control (Con) and sorghum flour (SF; 10%w/w), finger millet flour (FMF; 10%w/w), and carrageenan (Cgn; 0.5% w/w) treated chicken patties were observed in this study. Texture profile analysis (TPA) parameters like hardness, springiness, cohesiveness, gumminess, chewiness, and sensory parameters were estimated on cooked patties. Highly significant (P < 0.01) difference in fat %, total ash %, and cholesterol content; significant (P < 0.05) difference in moisture % (cooked); and no significant (P > 0.05) difference in pH, WHC, and protein % among control and treatments were noticed. Storage stability was dependent on treatments and storage periods. Significant difference (P < 0.05) was observed in different TPA parameters among the treatments, except for hardness value. Sensory scores showed no significant difference (P > 0.05) between Con and treatments.

Abstract This study evaluated the effect of different flours on the physicochemical, textural, and sensory properties of chicken patties. pH; cooking yield %; water holding capacity (WHC); proximate analysis (cooked); cholesterol content; and storage stability studies of control (Con) and sorghum flour (SF; 10%w/w), finger millet flour (FMF; 10%w/w), and carrageenan (Cgn; 0.5% w/w) treated chicken patties were observed in this study. Texture profile analysis (TPA) parameters like hardness, springiness, cohesiveness, gumminess, chewiness, and sensory parameters were estimated on cooked patties. Highly significant (P < 0.01) difference in fat %, total ash %, and cholesterol content; significant (P < 0.05) difference in moisture % (cooked); and no significant (P > 0.05) difference in pH, WHC, and protein % among control and treatments were noticed. Storage stability was dependent on treatments and storage periods. Significant difference (P < 0.05) was observed in different TPA parameters among the treatments, except for hardness value. Sensory scores showed no significant difference (P > 0.05) between Con and treatments.

In recent years, the fall armyworm, Spodoptera frugiperda has rapidly emerged as a global invasive pest, challenging the maize production and leading to considerable economic losses. Developing resistant hybrids is essential for sustainable maize cultivation, which requires a comprehensive understanding of resistance traits and the underlying mechanisms in parental lines. To address this need, the present study aimed to identify the sources of resistance, age and stage-specific effects and role of phytochemicals in plant defense against S. frugiperda in thirty diverse maize parental lines [17 female (A) and 13 male (R) lines]. The study revealed that the larvae fed on maize A-lines CML 565, AI 501, AI 544 and PDIM 639, and R-lines AI 125, AI 542, AI 155, AI 1100 and PML 105 exhibited a reduced intrinsic (r) and finite rate of increase (λ), and net (R 0 ) and gross reproduction rates (GRR); while, increased mean generation time (T) and doubling time (DT). Among these, A-lines CML 565, PDIM 639 and AI 544, and R-lines AI 125, AI 155 and AI 1100 showed higher detrimental effect on reproductive value of S. frugiperda . Aforesaid A- and R-lines were also found with greater increase in insect-induced test phytochemicals compared to other lines, accounting for 25.0 to 72.8% variation in the life table parameters, indicating antibiosis effect on S. frugiperda . Among the test phytochemicals, tannins, CAT, PAL, TAL and APX inflicted greater effect, indicating their role in induced-biochemical defense against S. frugiperda.

Snakebite, a neglected tropical disease is a major cause of mortality and morbidity in India, despite which reliable nationwide data are limited. To address this, we carried out a survey in 25 districts across 11 states, covering a 60 million population. The community-based study was led by frontline health workers who tracked cases and deaths, while field teams collected details on the bite, the type of snake, treatment received, and costs. Data were gathered continuously for a one-year period. Here we show that 7,094 snakebite cases were recorded, with a mortality rate of 0.33 per 100,000 population. Nearly half of the reported deaths occurred outside hospital settings. Bites were most common in males (64.1%), adults aged 30–39 years (20.9%), and during the monsoon season (62.1%). Most victims (86.4%) sought hospital care, 60.2% received anti-snake venom, and 17.2% experienced side effects to the anti-venom. Treatment placed a heavy financial burden on families; average out-of-pocket expenditure was INR 6,500, with higher costs in private hospitals (INR 27,400) compared to public facilities (INR 3,900). And 47.5% of the victims belonged to households below the poverty line. These findings show that faster access to hospitals, improved anti-venoms, and health insurance are urgently needed to prevent avoidable deaths. Snakebite envenoming is a significant public health problem in India, particularly in rural tropical and subtropical regions. Here, the authors report findings from a community-based cross-sectional study in India on the incidence, clinical outcomes, and costs associated with snake bites.

Background Breast cancer is the most common malignancy diagnosed in women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive subtype, accounting for nearly one third of all breast cancers in India. The addition of pembrolizumab to neoadjuvant chemotherapy improved the pathological response and event free survival in patients with TNBC. However, for most patients in low- and middle-income countries, immunotherapy remains inaccessible due to its high cost. Pharmacological and early clinical data suggest that a lower dose of pembrolizumab may be effective. However, there are no prospective clinical trials in patients with TNBC. Methods This is a single-site phase II, randomized, open-labeled, parallel-group trial. Eligible patients will be randomized (1:1) to either of the two treatment groups. Patients in the control arm will be administered standard of care chemotherapy [4 cycles of dose-dense doxorubicin (60 mg/m 2 ) and cyclophosphamide (600 mg/m 2 ), followed by 4 cycles of dose-dense paclitaxel (175 mg/m 2 )]. Patients in the experimental arm will receive 3 doses of pembrolizumab 50 mg every 6 weeks along with neoadjuvant dose-dense chemotherapy. The primary objective of the study is to compare the pathological complete response with the addition of low-dose pembrolizumab to neoadjuvant chemotherapy in patients with TNBC. Secondary objectives include invasive disease-free survival and quality of life assessment. Discussion The PLANeT trial aims to establish the efficacy of low-dose pembrolizumab in addition to neoadjuvant chemotherapy in patients with triple-negative breast cancer patients. This strategy, if found effective, will help improve the outcomes of women with TNBC who currently have limited access to pembrolizumab. Trial registration Clinical Trials Registry of India—CTRI/2024/01/062088.

Maize genotypes with diverse morpho-physiological traits exhibit varying levels of resistance to Chilo partellus. This study explored the developmental biology of C. partellus across thirty maize lines to determine their antibiosis effects. Additionally, the role of photosynthetic pigments in conferring resistance or susceptibility to C. partellus was investigated. The results revealed significant variations in the bionomics of C. partellus when fed on different maize lines. Notably, the preference of C. partellus neonates, the extent of damage, and plant phenological traits varied significantly among the tested maize lines. Photosynthetic pigments, including chlorophyll A, chlorophyll B, total chlorophyll, and total carotenoids, showed significant variation under both healthy and stem borer-damaged conditions across all tested A- and R-lines. Stem borer damage led to a marked decrease in these pigments across the maize lines. Longer developmental durations, lower survival rates, reduced pupal weight, and decreased fecundity of C. partellus was observed on the maize lines such as A-lines CML 565, AI 501, DDM 2309-O, PDIM 639, C 70, and R-lines AI 125 and AI 542, including the resistant check CML 442. Photosynthetic pigments and resistance showed a strong and negative association that accounted for 54% and 50% of the variation in C. partellus preference index and antibiosis index, respectively. The R-lines AI 125 and AI 542, as well as the A-lines CML 565, AI 501, and DDM 2309-O, were found to have antibiosis resistance mechanism against C. partellus and show potential for application in maize improvement initiatives.

Prostate cancer (PCa) is not well understood because of its enormous biological heterogeneity and unreliable progression. We conducted this retrospective analysis to examine the variables predicting early and late progression to castration-resistant PCa (CRPC) for better management of this disease. This single institutional retrospective study was conducted from January 2018 to January 2022. A total of 98 consecutive men meeting with the diagnosis of CRPC as per the inclusion criteria were included in the study and were stratified in four quartiles on the basis of time to CRPC (time to castration resistance [TTCR]) development. Early CRPC (1 quartile, TTCR = 6-12 months) and late CRPC (4 quartile, TTCR = 38-120 months) were then compared on the basis of different clinical, pathological and AR-LBD sequence to find the correlation with response duration. Median time to develop castration resistance was 25 ± 26.44 months. The mean age of the patients was 66.8 ± 9.20 years and median baseline PSA was calculated 100±685.06 ng/mL respectively. Higher Gleason score (≥7-10) was found to be significantly associated with early development of CRPC (p<0.001) and lower nadir PSA was significantly indicating late CRPC progression (p<0.005). No mutations were found in androgen receptor exon-5, 6, 7 except a homozygous mutation in the 7 intronic region, which is involved in splice variants formation playing noteworthy role in CRPC development. Time for metastatic PCa to CRPC ranges from 6-120 months revealing its heterogeneous nature. Early age presentation in the clinic and high initial PSA and high grade (GS>7) at diagnosis were positively associated with early CRPC while lower nadir PSA was correlated with late CRPC progression. No remarkable genomic mutations were discovered. Therefore, more data are needed and further research is required with large no. of patients to discover the predictive prognostic biomarkers for better patients' management.