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Anode-free lithium metal batteries are the most promising candidate to outperform lithium metal batteries due to higher energy density and reduced safety hazards with the absence of metallic lithium anode during initial cell fabrication. In general, researchers report capacity retention, reversible capacity, or rate capability of the cells to study the electrochemical performance of anode-free lithium metal batteries. However, evaluating the behavior of batteries from limited aspects may easily overlook other information hidden deep inside the meretricious results or even lead to misguided data interpretation. In this work, we present an integrated protocol combining different types of cell configuration to determine various sources of irreversible coulombic efficiency in anode-free lithium metal cells. The decrypted information from the protocol provides an insightful understanding of the behaviors of LMBs and AFLMBs, which promotes their development for practical applications. Anode-free lithium metal battery is one of the most promising candidates for next-generation high energy density battery but suffer from poor cycle life. Here the authors present an integrated protocol to dissect and quantify the irreversible coulombic efficiencies for better understanding of the battery.

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues, which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction. Currently, there is no cure for OA, partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease. Therefore, a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development. In this review, we first summarize the epidemiology of OA, including its prevalence, incidence and burdens, and OA risk factors. We then focus on the roles and regulation of the pathological signaling pathways, such as Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/ΒΜP and FGF signaling pathways, and key regulators AMPK, mTOR, and RUNX2 in the onset and development of OA. In addition, the roles of factors associated with OA, including MMPs, ADAMTS/ADAMs, and PRG4, are discussed in detail. Finally, we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA. Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies.

Objective While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolonged joint immobilization can cause multiple complications. A better understanding how joint immobilization and remobilization impact joint function and homeostasis will help clinicians develop novel strategies to reduce complications. Design We first determined the effects of long-term immobilization on joint pain and osteophyte formation in patients after an extraarticular fracture or ligament injury. We then developed a mouse model of joint immobilization and harvested the knee joint samples at 2, 4, and 8 weeks. We further determined the effects of remobilization on recovery of the osteoarthritis (OA) lesions induced by immobilization in mice. Results We found that the long-term (6 weeks) joint immobilization caused significant joint pain and osteophytes in patients. In mice, 2-week immobilization already induced moderate sensory innervation and increased pain sensitivity and infiltration in synovium without inducing marked osteophyte formation and cartilage loss. Long-term immobilization (4 and 8 weeks) induced more severe sensory innervation and inflammatory infiltration in synovium, massive osteophyte formation on both sides of the femoral condyle, and the edge of the tibial plateau and significant loss of the articular cartilage in mice. Remobilization, which ameliorates normal joint load and activity, restored to certain extent some of the OA lesions and joint function in mice. Conclusions Joint immobilization caused multiple OA-like lesions in both mice and humans. Joint immobilization induced progressive sensory innervation, synovitis, osteophyte formation, and cartilage loss in mice, which can be partially ameliorated by remobilization.

With the exponential growth in data density and user ends of wireless networks, fronthaul is tasked with supporting aggregate bandwidths exceeding thousands of gigahertz while accommodating high-order modulation formats. However, it must address the bandwidth and noise limitations imposed by optical links and devices in a cost-efficient manner. Here we demonstrate a high-fidelity fronthaul system enabled by self-homodyne digital-analog radio-over-fiber superchannels, using a broadband electro-optic comb and uncoupled multicore fiber. This self-homodyne superchannel architecture not only offers capacity boosting but also supports carrier-recovery-free reception. Our approach achieves a record-breaking 15,000 GHz aggregated wireless bandwidth, corresponding to a 0.879 Pb/s common public radio interface (CPRI) equivalent data rate. Higher-order formats up to 1,048,576 quadrature-amplitude-modulated (QAM) are showcased at a 100 Tb/s class data rate. Furthermore, we employ a packaged on-chip electro-optic comb as the sole optical source to reduce the cost, supporting a data rate of 100.5 Tb/s with the 1024-QAM format. These demonstrations propel fronthaul into the era of Pb/s-level capacity and exhibit the promising potential of integrated-photonics implementation, pushing the boundaries to new heights in terms of capacity, fidelity, and cost. Here the authors propose a self-homodyne fronthaul architecture, utilizing DA-RoF super channels and multicore fiber, paving the way for the Pb/s era in fronthaul transmission, enabling ultra-highspeed Internet access. The remarkable data speeds reaching 0.879 Pb/s and the 256-QAM format make it possible for 150,000 5G channels to be accessed simultaneously.

In this paper, we adopt the bibliometric analysis software CiteSpace to analyze the research status quo and evolution trend of pickup and delivery problem (PDP), an important real-world issue occurring in logistics and transportation. We obtain 819 documents with the topic of PDP that were published in the Web of Science core collection during the period 1995–2021, and acquire their basic situation of posting trend and category distribution. Next, we employ CiteSpace to draw scientific knowledge maps and perform the corresponding visualization analysis, which mainly include the following aspects: (a) collaboration analysis of author, country, and institution; (b) co-citation analysis of author, journal, and reference; (c) citation burst detection of keyword; (d) co-citation clustering analysis of reference. The results show that PDP research has gradually become interdisciplinary and highly comprehensive, and the evolution trend of hot topics also reflects that the research directions involve multiple academic disciplines and professional areas ranging from algorithm design to logistics management. The changing knowledge components reveal the fact that the development of PDP research is highly related to the diversity and uncertainty of realistic logistics industry contexts. Study in this paper provides comprehensive understandings of PDP research for scholars and logistics practitioners, inspiring its further investigation.

This study aims to investigate if addition of fibroblast-stromal cell markers to a classification of synovial pathotypes improves their predictive value on clinical outcomes in rheumatoid arthritis (RA). Active RA patients with a knee needle synovial biopsy at baseline and finished 1-year follow-up were recruited from a real-world prospective cohort. Positive staining for CD20, CD38, CD3, CD68, CD31, and CD90 were scored semiquantitatively (0-4). The primary outcome was radiographic progression defined as a minimum increase of 0.5 units of the modified total Sharp score from baseline to 1 year. Among 150 recruited RA patients, 123 (82%) had qualified synovial tissue. Higher scores of CD20+ B cells, sublining CD68+ macrophages, CD31+ endothelial cells, and CD90+ fibroblasts were associated with less decrease in disease activity and greater increase in radiographic progression. A new fibroblast-based classification of synovial pathotypes giving more priority to myeloid and stromal cells classified samples as myeloid-stromal (57.7%, 71/123), lymphoid (31.7%, 39/123), and paucicellular pathotypes (10.6%, 13/123). RA patients with myeloid-stromal pathotype showed the highest rate of radiographic progression (43.7% vs. 23.1% vs. 7.7%, = 0.011), together with the lowest rate of Boolean remission at 3, 6, and 12 months. Baseline synovial myeloid-stromal pathotype independently predicted radiographic progression at 1 year (adjusted OR: 3.199, 95% confidence interval (95% CI): 1.278, 8.010). Similar results were obtained in a subgroup analysis of treatment-naive RA. This novel fibroblast-based myeloid-stromal pathotype could predict radiographic progression at 1 year in active RA patients which may contribute to the shift of therapeutic decision in RA.

In the 5 G era, the demand for high-capacity and fast fiber-optic communication underscores the importance of inorganic optical materials with high electro-optical (EO) coefficients, rapid responses, and stability for efficient electro-optical modulators. The exploration of novel EO materials and their applications remains in the early stages. At present, research mainly focuses on the performance of EO materials and devices. However, the EO coefficients of different preparation methods for the same material and different materials vary significantly. Currently, a crucial gap lies in understanding the link between the EO effect and ferroelectric polarization, hindering advancements in ferroelectric material optimization. This article offers a comprehensive insight into the EO effect, initially discussing ferroelectric polarization and its relationship to the phenomenon. It then reviews standard inorganic ABO 3 metal oxide ferroelectric ceramics and thin films, followed by an examination of emerging ferroelectrics such as HfO 2 -based polymorph ferroelectrics and ZnO/AlN-based materials. The article concludes by addressing the challenges in investigating ferroelectric EO mechanisms and provides an outlook on the future of EO material research, including a review of the latest developments in EO effect mechanisms and their optimization for light modulation, as well as an exploration of potential areas for high-performance EO materials research. This review highlights the advancement of inorganic electro-optical materials. It underscores strategies for optimizing performance through multiscale analysis and design, offering guidance for developing high-performance electro-optic devices.

Combining integrated photonics and radiofrequency (RF) signals in the optical domain can help overcome the limitations of traditional RF systems. However, it is challenging to achieve environmentally insensitive filtering in wireless communications using integration schemes. In this report, the performance of robust RF filters based on a single silicon in-phase/quadrature modulator with significantly improved temperature and optical carrier wavelength sensitivities, which were suppressed by more than three orders of magnitude compared with those of silicon resonators, was experimentally evaluated. Upconversion and the processing of signals were simultaneously realized on the modulator by setting the relative phases of the arms and the bias voltages. Moreover, the filters can be reconfigured as low-pass, high-pass, band-pass, or band-stop filters. From 25 to 75 °C, the center frequency variation was within 0.2 GHz. From 1500 to 1600 nm, the center frequency variation was within 2 GHz. The proposed scheme allows for filtering and reconfiguration without the use of optical processing modules such as resonators or delay lines, thus providing a novel approach to signal processing and a new robust filter for scenarios with dynamic environments.

Breast cancer has become one of the most common malignant tumors in women, and the incidence rate is increasing annually in men. This study focused on exploring the prognostic significance of the combined detection of serum ALP and LDH in patients with breast cancer. We enrolled 80 individuals with male breast cancer (MBC), female breast cancers (FBCs) were randomly matched via propensity score matching (PSM). In the MBC cohort, the optimal cutoff values for ALP and LDH were determined to be 114 U/L and 207 U/L, respectively, whereas in the FBC cohort, they were 68 U/L and 133 U/L, respectively. There was a difference in median survival between patient groups classified by the optimal cutoff values of ALP and LDH in the FBC cohort. However, in the FBC cohort, there was no significant correlation between the levels of ALP or LDH and patient prognosis. We developed a “joint score” system that incorporates the values of both ALP and LDH and separates MBCs into three groups. Survival was significantly different among the three groups. In the multivariate analysis, the “joint score” was identified as an independent prognostic factor for both disease-free survival(DFS) and overall survival (OS).

Driven by the principles of sustainable development and green chemistry, phosphorus‐free flame‐retardant systems have become a key focus in the development of high‐performance polymers because they feature improved ecological safety relative to phosphorus‐based systems. This review focuses on two main phosphorus‐free flame‐retardant strategies: (i) additive phosphorus‐free flame retardants and (ii) intrinsically phosphorus‐free flame‐retardant epoxy resins. Emphasis is placed on the relationship between chemical structure and comprehensive properties, including flame retardancy, thermal properties, and mechanical performance. The flame‐retardant modes‐of‐action for the phosphorus‐free flame‐retardant epoxy systems are also summarized. Finally, current challenges and future development opportunities are presented. This work is expected to facilitate the development of phosphorus‐free flame‐retardant systems. Phosphorus‐free flame‐retardant epoxy systems offer eco‐friendly, low‐toxicity solutions by avoiding hazardous byproducts. This work highlights structure–performance relationships, with emphasis on how rigid backbones, multifunctional groups, and crosslinked networks enhance char formation, flame retardancy, and mechanical strength. Advancements in molecular design position these systems as promising candidates for sustainable, high‐performance polymer materials.