Explore the vast range of titles available.

The Mega-Science project NICA (Nuclotron-based Ion Collider fAcility) is under construction at the Joint Institute for Nuclear Research (JINR) in Dubna (Russia). This is the first international mega-science project which will be build on the territory of the Russian Federation. The heavy ion programme at NICA includes two planned detector systems: the Baryonic Matter at Nuclotron (BM@N) and the Multi-Purpose Detector (MPD). The mission of future experiments at NICA is to explore the phase diagram of QCD matter at collision energies, where the highest net-baryon densities will be created. The perspectives for the experiments at NICA and the designed physics performance of the detector components will be presented and discussed.

Heparin therapy and prophylaxis may be accompanied by bleeding and thrombotic complications due to individual responses to treatment. Dosage control based on standard laboratory assays poorly reflects the effect of the therapy. The aim of our work was to compare the heparin sensitivity of new thrombodynamics (TD) assay with sensitivity of other standard and global coagulation tests available to date. A total of 296 patients with high risk of venous thromboembolism (deep vein thrombosis (DVT), early postoperative period, hemoblastosis) were enrolled in the study. We used a case-crossover design to evaluate the sensitivity of new thrombodynamics assay (TD) to the hemostatic state before and after unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) therapy/prophylaxis and to compare it with the activated partial thromboplastin time (APTT), anti-Xa activity test, thrombin generation test (TGT) and thromboelastography (TEG). A receiver operating characteristic (ROC) curve analysis was used to evaluate changes before and after heparin prophylaxis and therapy. Blood was sampled before heparin injection, at the time of maximal blood heparin concentration and before the next injection. Hypercoagulation before the start of heparin treatment was detected by TD, TGT and TEG but not by APTT. The area under the ROC curve (AUC) was maximal for TD and anti-Xa, intermediate for TGT and TEG and minimal for APTT. These results indicate that TD has a high sensitivity to the effects of UFH and LMWH after both prophylactic and therapeutic regimes and may be used for heparin monitoring.

The centrality of heavy-ion collisions is a key parameter in the study of the properties of the strongly interacting matter at extreme temperature or baryon density. We present the different procedures of centrality determination for the Baryonic Matter at Nuclotron (BM@N) experiment. The validity of the procedures is assessed using the simulated data for Xe Cs(I) collisions at beam kinetic energy of 4 A GeV.

The elliptic ( ) flow is one of the important observables sensitive to the equation of state (EOS) and transport properties of the strongly interacting matter created in relativistic heavy-ion collisions. In this work, we discuss the scaling properties of elliptic flow at Nuclotron-NICA energies: GeV.

The permanent of a multidimensional matrix is the sum of the products of entries over all diagonals. In this survey, we consider the basic properties of the multidimensional permanent, sufficient conditions for its positivity, available upper bounds, and the specifics of the permanents of polystochasticmatrices.We prove that the number of various combinatorial objects can be expressed via multidimensional permanents. Special attention is paid to the number of 1-factors of uniform hypergraphs and the number of transversals in Latin hypercubes.

The first phase of the Beam Energy Scan (BES-I) program at the Relativistic Heavy Ion Collider (RHIC) is based on Au+Au collision data collected between 2010 and 2014 at center-of-mass energies = 7.7, 11.5, 14.5, 19.6, 27, and 39 GeV. The BES-I program has four physics goals: search for the turning off of the signatures of the Quark Gluon Plasma (QGP), the search for the possible first-order phase transition between hadronic gas and QGP, the search for the possible critical end point and the study of the transport properties of the strongly interacting matter as a function of the temperature T and baryon chemical potential μB. In this article, we briefly review and discuss the main results and their understanding from the BES-I program and future plans for the BES-II program (2019-2020).

A submatrix hypergraph is a hypergraph whose vertices are entries of an matrix and hyperedges are submatrices of order . In this paper, we consider perfect colorings of submatrix hypergraphs and study their parameters. We provide several constructions of perfect colorings of and prove that the incidence matrices of -designs are perfect colorings of the submatrix hypergraph. Moreover, we describe all perfect 2-colorings of hypergraphs and .

Objective To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes. Material and methods A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7 ± 4.7 years old). The main group was made up of 140 G20210A patients, while the control group comprised 150 women with the wild G20210G type. The aim was to evaluate the activity of Factor II in the venous blood plasma during the stages of pregnancy with regard to trophoblast invasion waves. As per results, association analysis of Factor II activity value and gestational complications was carried out. Results In the control group, the median (Me) of Factor II activity ranged from 108% (preconception period) to 144% (pregnancy) [95% CI 130–150]. In patients with the GA type, the value was significantly higher in related periods, ranging from 149 to 181% [95% CI 142–195], p  < 0.0001. With Factor II activity ranging from 148.5 to 180.6%, pregnancies in the main group had no complications. Higher levels of Factor II activity were associated with the development of early and/or severe preeclampsia (PE) and fetal growth retardation (FGR). Conclusion The data obtained regarding Factor II activity in blood plasma, juxtaposed with the development of great obstetrical syndromes, allow to assume that manifestation of G20210A in early and/or severe PE and FGR is associated with this coagulation factor’s level of activity. Threshold value of the Factor II activity with G20210A mutation, allowing to predict the development of PE, comprised 171.0% at the preconception stage (AUC – 0.86; p  < 0.0001) and within 7–8 weeks of gestation it was 181.3% (AUC – 0.84; p < 0.0001).

To research the association of prothrombin (factor II) activity given the prothrombin G20210A mutation carriage with its clinical manifestations as thrombotic complications. A prospective clinical cohort study of 290 women of reproductive age was conducted. Two cohort groups were identified: the study group of 140 patients with prothrombin mutation G20210A genotype and the control group of 150 women with G20210G genotype. The prothrombin G20210A mutation carriage is associated with the risk of thrombotic complications compared to the wild G20210G type (RR =17.1; <0.0001) and is characterized by thrombosis localized both in the venous (66.7%) and arterial (33.3%) vascular pools. The threshold value of prothrombin activity (174.8%) for G20210A genotype was calculated, making it possible to conclusively predict the risk of thrombotic events with the accuracy of 90.4%. The phenotypic manifestation of the prothrombin G20210A mutation in the form of venous and arterial thromboses in women of reproductive age is associated with a super-threshold increase in prothrombin (factor II) activity, which makes it possible to stratify the patients into the group of high risk of thromboses.

The anisotropic collective flow is one of the important observable values sensitive to transport properties of strongly interacting matter created in relativistic heavy-ion collisions. The performance of Multi-Purpose Detector (MPD) at NICA collider for elliptic flow measurements with Monte-Carlo simulations using collisions of Au+Au and Bi+Bi ions employing several state of the art event generators is studied. Different methods for flow measurements as event plane and direct cumulants are used to investigate the contribution of non-flow correlations and flow fluctuations.