Explore the vast range of titles available.

Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies early in development are required to establish when sensory responsivity differences emerge and whether they predict later neurodevelopmental condition outcomes. We utilised data from a prospective longitudinal cohort of infants with and without a family history (FH) of autism and/or ADHD (N = 151; 55% male, 83% white). We extracted electroencephalography (EEG) metrics of E/I balance at 5, 10 and 14 months; the aperiodic exponent of the slope of the power spectrum (‘1/f’). Models estimated latent growth curves of parent-reported hyper and hypo-responsivity between 10 – 36 months. Analyses tested associations between developmental trajectories of FH, sensory responsivity, parent-rated neurodevelopmental traits at 3 years and E/I balance. We coded and entered binary variables indexing FH-autism and FH-ADHD in the same model, which allowed us to test for effects of one form of FH whilst adjusting for the impact of the other. Results showed that FH-autism was associated with greater increases in parent-reported hyper-responsivity between 10–36 months (over and above the effects of FH-ADHD), and in univariate models for hyper-responsivity only, the intercept and the slope of hyper-responsivity were positively associated with both autistic and ADHD traits at age 3 years. However, in joint models which included hypo-responsivity, associations between hyper-responsivity and autistic and ADHD traits became non-significant. In these joint models, FH-ADHD was associated with steeper increases in hypo-responsivity (over and above the effects of FH-autism). Higher hypo-responsivity at 10-month baseline was associated with both autistic and ADHD traits at 3 years. A steeper slope of hypo-responsivity predicted ADHD traits at 3 years. Males displayed higher baseline hypo-responsivity. Aperiodic exponent values at 5 and 10, but not 14 months, were associated with hyper-responsivity. Results suggest a dissociation in the type of sensory responsivity associated with a family history of autism as compared to a family of ADHD, and that hypo-responsivity in infancy may be an indicator of later autism and ADHD outcomes. However, better measurement of each domain is required to draw strong conclusions as many hypo-responsivity items overlapped with autistic and ADHD traits. Alterations in E/I balance may contribute to early differences in sensory responsivity but further research is required to determine the directionality of effects.

Attention-deficit/hyperactivity disorder (ADHD) is first diagnosed during middle childhood, when patterns of difficulty are often established. Pre-emptive approaches that strengthen developing cognitive systems could offer an alternative to post-diagnostic interventions. This proof-of-concept randomised controlled trial (RCT) tested whether computerised gaze-based attention training is feasible and improves attention in infants liable to develop ADHD. Forty-three 9- to 16-month-old infants with a first-degree relative with ADHD were recruited (11/2015–11/2018) at two UK sites and randomised with minimisation by site and sex to receive 9 weekly sessions of either (a) gaze-contingent attention training (intervention; n = 20); or (b) infant-friendly passive viewing of videos (control, n = 23). Sessions were delivered at home with blinded outcome assessments. The primary outcome was a composite of attention measures jointly analysed via a multivariate ANCOVA with a combined effect size (ES) from coefficients at baseline, midpoint and endpoint (Registration: ISRCTN37683928). Uptake and compliance was good but intention-to-treat analysis showed no significant differences between 20 intervention and 23 control infants on primary (ES −0.4, 95% CI −0.9 to 0.2; Complier-Average-Causal Effect ES −0.6, 95% CI −1.6 to 0.5) or secondary outcomes (behavioural attention). There were no adverse effects on sleep but a small increase in post-intervention session fussiness. Although feasible, there was no support for short-term effects of gaze-based attention training on attention skills in early ADHD. Longer-term outcomes remain to be assessed. The study highlights challenges and opportunities for pre-emptive intervention approaches to the management of ADHD.

In this response I compare Rebecca Tuvel’s article, “In Defense of Transracialism,” to several other recent examples of philosophical and social justice scholarship in which authors (Eli Clare, Alexandre Baril, Cressida Heyes, Ladelle McWhorter, Judith Butler) draw comparisons between diverse identities and oppressions, and draw ethical and political conclusions about experiences that are not necessarily their own. I ask what methodological or authorial differences can explain the dramatically different reception of these works compared to Tuvel’s, and whether these differences in reception were justified. In this response I also challenge the often-heard claim that Tuvel failed to draw on the evidence of experience in her article, as well as the assumption that social justice scholars should always do so. Finally, I consider Tuvel’s motivations in writing her article and describe them as intellectually generous, and I call for more intellectual generosity in academia as it is transformed by social media.

This paper provides an overview of Michel Foucault's continually changing observations on familial power, as well as the feminist-Foucauldian literature on the family. It suggests that these accounts offer fragments of a genealogy of the family that undermine any all-encompassing or transhistorical account of the institution. Approaching the family genealogically, rather than seeking a single model of power that can explain it, shows that far from this institution being a quasi-natural formation or a bedrock of unassailaUe values, it is in fact a continually contested fiction that masks its own histories of becoming.

Strychnine is well known as a highly toxic alkaloid derived from the plant Strychnos nux-vomica . It has been applied for chiral separations as a resolving agent for co-crystallizations, as a standard for chromatographic separations, as a rodenticide, as a natural therapy and stimulant, and as a poisonous plot device in works of fiction. Dissolving strychnine into the common organic solvent dichloromethane results in the spontaneous crystallization of the title compound N -(chloromethyl)strychninium chloride. Crystals of the compound were isolated in the orthorhombic space group P 2 1 2 1 2 1 with a  = 7.6819(2) Å, b  = 7.9621(2) Å, c  = 30.7170(9) Å, α = 90°, β = 90°, γ = 90°. The crystal structure has bilayers of N -(chloromethyl)strychninium cations with corresponding bilayers of chloride ions interacting to the cations through C–H hydrogen bonds. Graphical Abstract

Stimuli-responsive textiles are a rapidly evolving class of functional fiber-based materials that sense and adapt to environmental triggers. Within these enabling technologies, hydrogels and microcapsules are very illustrative, as they offer complementary mechanisms for moisture management, controlled release, and adaptive performance. Hydrogels provide soft, water-rich polymer networks with modifiable swelling, permeability, and mechanics, while microcapsules offer protection and targeted delivery of active agents through engineered shell structures. When integrated into fibrous networks, they impart dynamic detection responses for moisture, temperature, pH, mechanical stress, light, and chemical or biological agents. This review critically examines progress in design, synthesis, and textile integration of hydrogel- and microcapsule-based systems, with emphasis on materials that exhibit stimuli-responsive behavior rather than passive or extended-release functionality. Strategies for incorporating bulk hydrogels, micro- and nanogels, and stimuli-responsive microcapsules into fibers, yarns, and fabrics are discussed in addition to applications such as smart apparel, medical and hygienic textiles, controlled drug delivery, antimicrobial fabrics, and adaptive filtration media. Existing challenges for durability, washability, response kinetics, scalability, and sustainability are highlighted, while future research directions are proposed to advance the development of robust and intelligent textile systems at the nexus of soft matter science and fiber engineering.

Ecological valence theory (EVT; Palmer & Schloss, Proceedings of the National Academy of Sciences 107:8877–8882, 2010 ) proposes that color preferences are due to affective responses to color-associated objects: That is, people generally like colors to the degree that they like the objects associated with those colors. Palmer and Schloss found that the average valence of objects associated with a color, when weighted by how well the objects matched the color (weighted affective valence estimates: WAVE) explained 80% of the variation in preference across colors. Here, we replicated and extended Palmer and Schloss’s investigation to establish whether color–object associations can account for sex differences in color preference and whether the relationship between associated objects and color preference is equally strong for males and females. We found some degree of sex specificity to the WAVEs, but the relationship between WAVE and color preference was significantly stronger for males than for females (74% shared variance for males, 45% for females). Furthermore, analyses identified a significant inverse relationship between the number of objects associated with a color and preference for the color. Participants generally liked colors associated with few objects and disliked colors associated with many objects. For the sample overall and for females alone, this association was not significantly weaker than the association of the WAVE and preference. The success of the WAVE at capturing color preference was partly due to the relationship between the number of associated objects and color preference. The findings identify constraints of EVT in its current form, but they also provide general support for the link between color preference and color–object associations.

This study investigates the relationship between students’ political engagement, civic knowledge, socioeconomic status, gender, and digital media use and their pro-environmental attitudes and behaviors in Denmark, Sweden, Spain, and Romania. To do this, we use data from the International Civic and Citizenship Study (ICCS:22) and employ hierarchical level modeling. We found that students with higher civic knowledge and greater confidence in their ability to be active citizens were more likely to report both pro-environmental behaviors and positive attitudes in every country studied. Socioeconomic status also showed positive links with environmental engagement. Digital media use was linked to more pro-environmental behaviors in all countries, but to less positive attitudes in Spain. These results demonstrate the need for context-specific strategies that teach students how to engage collectively towards a more sustainable future.

We previously demonstrated that muscle sympathetic nerve activity (MSNA) increases to contracting muscle as well as to non-contracting muscle, but this was only assessed during isometric exercise at ∼10% of maximum voluntary contraction (MVC). Given that high-intensity isometric contractions will release more metabolites, we tested the hypothesis that the metaboreflex is expressed in the contracting muscle during high-intensity but not low-intensity exercise. MSNA was recorded continuously via a tungsten microelectrode inserted percutaneously into the right common peroneal nerve in 12 participants, performing isometric dorsiflexion of the right ankle at 10, 20, 30, 40, and 50% MVC for 2 min. Contractions were immediately followed by 6 min of post-exercise ischemia (PEI); 6 min of recovery separated contractions. Cross-correlation analysis was performed between the negative-going sympathetic spikes of the raw neurogram and the ECG. MSNA increased as contraction intensity increased, reaching mean values (± SD) of 207 ± 210 spikes/min at 10% MVC ( P = 0.04), 270 ± 189 spikes/min at 20% MVC ( P < 0.01), 538 ± 329 spikes/min at 30% MVC ( P < 0.01), 816 ± 551 spikes/min at 40% MVC ( P < 0.01), and 1,097 ± 782 spikes/min at 50% MVC ( P < 0.01). Mean arterial pressure also increased in an intensity-dependent manner from 76 ± 3 mmHg at rest to 90 ± 6 mmHg ( P < 0.01) during contractions of 50% MVC. At all contraction intensities, blood pressure remained elevated during PEI, but MSNA returned to pre-contraction levels, indicating that the metaboreflex does not contribute to the increase in MSNA to contracting muscle even at these high contraction intensities.