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Japan : top sights, authentic experiences
\"Lonely Planet Best of Japan is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. See traditional geisha in Kyoto, hike up Mt Fuji, or shop around the clock in Tokyo; all with your trusted travel companion.\"--Publisher.
Book
The cultural evolutionary trade-off of ritualistic synchrony
From Australia to the Arctic, human groups engage in synchronous behaviour during communal rituals. Because ritualistic synchrony is widespread, many argue that it is functional for human groups, encouraging large-scale cooperation and group cohesion. Here, we offer a more nuanced perspective on synchrony's function. We review research on synchrony's prosocial effects, but also discuss synchrony's antisocial effects such as encouraging group conflict, decreasing group creativity and increasing harmful obedience. We further argue that a tightness–looseness (TL) framework helps to explain this trade-off and generates new predictions for how ritualistic synchrony should evolve over time, where it should be most prevalent, and how it should affect group well-being. We close by arguing that synthesizing the literature on TL with the literature on synchrony has promise for understanding synchrony's role in a broader cultural evolutionary framework. This article is part of the theme issue ‘Ritual renaissance: new insights into the most human of behaviours'.
Journal Article
Japan
Lonely Planet Japan is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Explore a bamboo grove in Arashiyama, marvel at Shinto and Buddhist architecture in Kyoto, or relax in the hot springs of Noboribetsu Onsen; all with your trusted travel companion.
Book
Warm Handoffs for Improving Client Receipt of Services: A Systematic Review
IntroductionWarm handoffs intend to improve receipt of services by clients who receive referrals to services that are stigmatized or not easily accessible. Such strategies are characterized as the handoff or transfer of an individual between two service providers through a face-to-face, phone, or technology-assisted interaction. This approach may be useful for maternal and child health home visitors who provide direct services and facilitate connections to community resources for client families. However, little is known about the effectiveness of warm handoffs.MethodsA systematic review of the literature on warm handoffs was conducted with studies identified in four databases. Full text was reviewed for studies for which abstracts met inclusion criteria or for which abstracts were not available. Evidence tables summarizing study characteristics, outcome measures and data sources, intervention descriptions, intervention components, and study results were constructed.ResultsOf the 42,816 unique articles identified, 32,163 titles/abstracts were screened, 227 qualified for full text review, and five comprised the study sample. Three studies examined referrals from substance use treatment centers to self-help groups, one from federally qualified health centers to community mental health clinics, and one from a mobile needle exchange program to substance use treatment/intake. Three studies showed increases in receipt of services by clients following referral between the warm handoff intervention and control group.DiscussionCurrent evidence regarding the effectiveness of warm handoffs is limited. An examination of the effectiveness of warm handoffs in the context of home visits is needed to assess whether they facilitate client referrals.
Journal Article
Repetitive Negative Thinking Shared Across Rumination and Worry Predicts Symptoms of Depression and Anxiety
Rumination and worry are two types of repetitive negative thinking (RNT) that have been identified as risk factors for depression and anxiety, but it remains unclear whether the common (i.e., RNT) and/or distinct (i.e., temporal orientation and thought content) features of these thinking styles are associated with internalizing psychopathology. The goal of the current study was to represent rumination and worry with common and distinct components and test their associations to internalizing symptoms. Bifactor modeling was used to create common RNT, rumination-specific, and worry-specific factors in an emerging adult undergraduate sample (N=224) at the beginning of the academic semester. Structural equation modeling tested these factors as predictors of anhedonic depression and anxious arousal symptoms at the end of the semester. The common RNT factor was a predictor of later (but not change in) anhedonic depression and anxious arousal symptoms, while the specific factors did not show any consistent associations with either symptom dimension. These results suggest that the common process of RNT is the primary pathway through which rumination and worry are associated with risk for internalizing psychopathology. Clinical interventions that reduce RNT as a general thought process, rather than targeting specific thought content, may be effective.
Journal Article
Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with various cellular components of the tumor microenvironment including platelets is crucial for tumor growth and metastasis. Although it is known that platelets can infiltrate into tumor tissue, secrete pro-angiogenic and pro-tumorigenic factors and thereby increase tumor growth, the precise molecular interactions between platelets and metastatic cancer cells are not well understood. Here we demonstrate that platelets induce resistance to anoikis in vitro and are critical for metastasis in vivo. We further show that platelets activate RhoA-MYPT1-PP1-mediated YAP1 dephosphorylation and promote its nuclear translocation which induces a pro-survival gene expression signature and inhibits apoptosis. Reduction of
YAP1
in cancer cells in vivo protects against thrombocytosis-induced increase in metastasis. Collectively, our results indicate that cancer cells depend on platelets to avoid anoikis and succeed in the metastatic process.
Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.
Journal Article
Communicating COVID-19 exposure risk with an interactive website counteracts risk misestimation
During the COVID-19 pandemic, individuals depended on risk information to make decisions about everyday behaviors and public policy. Here, we assessed whether an interactive website influenced individuals’ risk tolerance to support public health goals. We collected data from 11,169 unique users who engaged with the online COVID-19 Event Risk Tool ( https://covid19risk.biosci.gatech.edu/ ) between 9/22/21 and 1/22/22. The website featured interactive elements, including a dynamic risk map, survey questions, and a risk quiz with accuracy feedback. After learning about the risk of COVID-19 exposure, participants reported being less willing to participate in events that could spread COVID-19, especially for high-risk large events. We also uncovered a bias in risk estimation: Participants tended to overestimate the risk of small events but underestimate the risk of large events. Importantly, even participants who voluntarily sought information about COVID risks tended to misestimate exposure risk, demonstrating the need for intervention. Participants from liberal-leaning counties were more likely to use the website tools and more responsive to feedback about risk misestimation, indicating that political partisanship influences how individuals seek and engage with COVID-19 information. Lastly, we explored temporal dynamics and found that user engagement and risk estimation fluctuated over the course of the Omicron variant outbreak. Overall, we report an effective large-scale method for communicating viral exposure risk; our findings are relevant to broader research on risk communication, epidemiological modeling, and risky decision-making.
Journal Article
The Role of Intrasexual Competition and the Big 5 in the Perpetration of Digital Dating Abuse
Recent research has examined digital dating abuse through an evolutionary lens, finding people who report intrasexual competitiveness engage in digital dating abuse. Here, we replicated this finding and extended the literature by examining the role of the Big Five personality traits in the perpetration of digital dating abuse, which, to our knowledge, has not been examined in relation to digital dating abuse (n=280). This paper reports findings showing intrasexual competitiveness positively predicts the perpetration of digitaldating abuse; whereby high intrasexual competition is related to high levels of digital dating abuse. Agreeableness was a negative predictor of digital dating abuse; whereby high agreeableness was related to low perpetration of digital dating abuse. Our findings extend the literature exploring digital dating abuse through an evolutionary lens.
Journal Article
Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and psychiatric consequences that can persist long after injury. TBI induces a physiological stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of injury on the stress response become more complex in the long term. Clinical and experimental evidence suggests long lasting dysfunction of the stress response after TBI. Additionally, pre- and post-injury stress both have negative impacts on outcome following TBI. This bidirectional relationship between stress and injury impedes recovery and exacerbates TBI-induced psychiatric and cognitive dysfunction. Previous clinical and experimental studies have explored the use of synthetic glucocorticoids as a therapeutic for stress-related TBI outcomes, but these have yielded mixed results. Furthermore, long-term steroid treatment is associated with multiple negative side effects. There is a pressing need for alternative approaches that improve stress functionality after TBI. Glucocorticoid receptor (GR) has been identified as a fundamental link between stress and immune responses, and preclinical evidence suggests GR plays an important role in microglia-mediated outcomes after TBI and other neuroinflammatory conditions. In this review, we will summarize GR-mediated stress dysfunction after TBI, highlighting the role of microglia. We will discuss recent studies which target microglial GR in the context of stress and injury, and we suggest that cell-specific GR interventions may be a promising strategy for long-term TBI pathophysiology.
Journal Article