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Christian doctrines in Islamic theology
By the tenth century, Islamic scholars were making use of Christian doctrines as examples of misguided thinking that showed the correctness of Islam. This volume explores key writings in this tradition, including those of al-Nashi' al-Akbar, al-Maturidi, al-Baqillani and 'Abd al-Jabbar.
Book
Global Elimination of Chronic Hepatitis
Chronic viral hepatitis is a public health hazard, leading to cirrhosis, liver failure, and hepatocellular carcinoma. Vaccination, reduction of transmission, and medical therapy have begun to provide tools necessary to eliminate the disease.
Journal Article
Understanding violent criminals : insights from the front lines of law enforcement
\"What causes people to commit violent crimes? The case studies in this book enable readers to evaluate the motivations behind crimes ranging from arson to rape to gang violence\"-- Provided by publisher.
Book
Global control of hepatitis C: where challenge meets opportunity
In this Review, David L. Thomas discusses how recent therapeutic and diagnostic advances could be implemented in public health strategies to prevent viral hepatitis infections and treat existing infected patients. Despite the still increasing incidence and prevalence of hepatitis C infection, available tools may bring viral eradication a step closer toward becoming a reality.
We are entering an important new chapter in the story of hepatitis C virus (HCV) infection. There are clear challenges and opportunities. On the one hand, new HCV infections are still occurring, and an estimated 185 million people are or have previously been infected worldwide. Most HCV-infected persons are unaware of their status yet are at risk for life-threatening diseases such as cirrhosis and hepatocellular carcinoma (HCC), whose incidences are predicted to rise in the coming decade. On the other hand, new HCV infections can be prevented, and those that have already occurred can be detected and treated—viral eradication is even possible. How the story ends will largely be determined by the extent to which these rapidly advancing opportunities overcome the growing challenges and by the vigor of the public health response.
Journal Article
A Switched-Line True Time Delay Unit for Wideband Phased Arrays Using Packaged RF MEMS Switches
The growing demand for wideband electronically scanned arrays (ESAs) in next-generation radar, satellite, and 5G/6G systems has renewed interest in true time delay units (TDUs) to overcome the limitations of phase-based beamforming. In parallel, recent advances in the commercial availability and reliability of packaged RF MEMS switches have enabled practical hardware implementations once considered infeasible. This paper presents the design, fabrication, and experimental validation of a broadband, 4-bit switched-line TDU using only off-the-shelf components and standard PCB processes. The unit operates from 0.4 to 6 GHz, with a total delay range of 0–413 ps, achieving an average insertion loss of 1.5 dB and delay error below 18.4 ps, resulting in a figure of merit (FOM) of 152.8 ps/dB. Measured results are reported alongside a refined switch/termination model that aligns simulations with measurements. This is among the first reported demonstrations of a complete RF MEMS-based TDU implemented entirely with commercially available components in a standard PCB-integrated implementation. These results demonstrate a practical pathway toward scalable MEMS-based TDUs for deployment in advanced beamforming systems.
Journal Article
Mite bombs or robber lures? The roles of drifting and robbing in Varroa destructor transmission from collapsing honey bee colonies to their neighbors
When honey bee colonies collapse from high infestations of Varroa mites, neighboring colonies often experience surges in their mite populations. Collapsing colonies, often called \"mite bombs\", seem to pass their mites to neighboring colonies. This can happen by mite-infested workers from the collapsing colonies drifting into the neighboring colonies, or by mite-free workers from the neighboring colonies robbing out the collapsing colonies, or both. To study inter-colony mite transmission, we positioned six nearly mite-free colonies of black-colored bees around a cluster of three mite-laden colonies of yellow-colored bees. We then monitored the movement of bees between the black-bee and yellow-bee colonies before, during, and after mite-induced collapse of the yellow-bee colonies. Throughout the experiment, we monitored each colony's mite level. We found that large numbers of mites spread to the black-bee colonies (in both nearby and distant hives) when the yellow-bee colonies collapsed from high mite infestations and became targets of robbing by the black-bee colonies. We conclude that \"robber lures\" is a better term than \"mite bombs\" for describing colonies that are succumbing to high mite loads and are exuding mites to neighboring colonies.
Journal Article
Religion and the making of modern East Asia
\"Religion and religious ideas have played a fundamental role in the shaping of Asian history, society, and cultural practices. In this engaging and informative book, Thomas David DuBois sets out to explain how religious traditions and philosophies in China and Japan have evolved and intersected since the birth of Confucianism in China and the arrival of Buddhism in Japan. Crossing a broad terrain from Tokyo to Tibet, the book concentrates on the post-fourteenth century, when the long-lasting political dynasties that transformed the political, social, and economic institutions of both countries came into being. It is these connections that the author is keen to highlight, and he does so to effect by using key moments, such as the Taiping Uprising and the Boxer Rebellion, to underscore the importance of religion in transforming the course of Asian history. Contemporary chapters reflect on the wartime deification of the Japanese emperor, Marxism as religion, and the persecution of the Dalai Lama\"-- Provided by publisher.
Book
The Hippo pathway and human cancer
Key Points
The Hippo pathway is an evolutionarily conserved regulator of tissue growth.
The Hippo pathway controls multiple cellular functions that are central to tumorigenesis, including proliferation and apoptosis.
Hippo pathway mutations in mice and flies give rise to tumours.
Hippo pathway activity seems to be frequently deregulated in different human cancers but most Hippo pathway genes are not commonly mutated.
Molecular events such as sensitivity to the mechanical properties of tumours and crosstalk with other cancer pathways might cause Hippo pathway deregulation in human cancers.
Hippo pathway therapeutics and new avenues to modulate pathway activity are beginning to emerge.
A wealth of recent studies has characterized roles for the Hippo pathway in diverse cancer-relevant processes. This Review discusses our latest understanding of Hippo pathway signalling in cancer, including mechanisms of pathway disruption in cancer, and the opportunities and challenges for therapeutic intervention.
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation can induce tumours in model organisms and occurs in a broad range of human carcinomas, including lung, colorectal, ovarian and liver cancer. Despite this, somatic or germline mutations in Hippo pathway genes are uncommon, with only the upstream pathway gene neurofibromin 2 (
NF2
) recognized as a bona fide tumour suppressor gene. In this Review, we appraise the evidence for the Hippo pathway as a cancer signalling network, and discuss cancer-relevant biological functions, potential mechanisms by which Hippo pathway activity is altered in cancer and emerging therapeutic strategies.
Journal Article