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"Thomas, H E"
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The border and its bodies : the embodiment of risk along the U.S.-México line
\"This volume offers a critical investigation of the risk and the physical toll of migration along the U.S. southern border\"-- Provided by publisher.
Book
Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)—study protocol for a phase 2, randomized, placebo controlled trial
Background
Type 1 diabetes (T1D) places an extraordinary burden on individuals and their families, as well as on the healthcare system. Despite recent advances in glucose sensors and insulin pump technology, only a minority of patients meet their glucose targets and face the risk of both acute and long-term complications, some of which are life-threatening.
The JAK-STAT pathway is critical for the immune-mediated pancreatic beta cell destruction in T1D. Our pre-clinical data show that inhibitors of JAK1/JAK2 prevent diabetes and reverse newly diagnosed diabetes in the T1D non-obese diabetic mouse model. The goal of this study is to determine if the JAK1/JAK2 inhibitor baricitinib impairs type 1 diabetes autoimmunity and preserves beta cell function.
Methods
This will be as a multicentre, two-arm, double-blind, placebo-controlled randomized trial in individuals aged 10–30 years with recent-onset T1D. Eighty-three participants will be randomized in a 2:1 ratio within 100 days of diagnosis to receive either baricitinib 4mg/day or placebo for 48 weeks and then monitored for a further 48 weeks after stopping study drug. The primary outcome is the plasma C-peptide 2h area under the curve following ingestion of a mixed meal. Secondary outcomes include HbA1c, insulin dose, continuous glucose profile and adverse events. Mechanistic assessments will characterize general and diabetes-specific immune responses.
Discussion
This study will determine if baricitinib slows the progressive, immune-mediated loss of beta cell function that occurs after clinical presentation of T1D. Preservation of beta cell function would be expected to improve glucose control and prevent diabetes complications, and justify additional trials of baricitinib combined with other therapies and of its use in at-risk populations to prevent T1D.
Trial registration
ANZCTR
ACTRN12620000239965
. Registered on 26 February 2020.
ClinicalTrials.gov
NCT04774224. Registered on 01 March 2021
Journal Article
Law, justice, and the individual : Thomas More Lecture, 's-Hertogenbosch, 30 March 2011
\"In this lecture ... Ernst Hirsch Ballin ... finds common ground between Thomas More's early sixteenth century Christian humanism and present-day issues of law and justice\"--Page [2].
Book
Sulphur dioxide as a volcanic ash proxy during the April–May 2010 eruption of Eyjafjallajökull Volcano, Iceland
The volcanic ash cloud from the eruption of Eyjafjallajökull volcano in April and May 2010 resulted in unprecedented disruption to air traffic in Western Europe causing significant financial losses and highlighting the importance of efficient volcanic cloud monitoring. The feasibility of using SO2 as a tracer for the ash released during the eruption is investigated here through comparison of ash retrievals from the Spinning Enhanced Visible and Infrared Imager (SEVIRI) with SO2 measurements from a number of infrared and ultraviolet satellite-based sensors. Results demonstrate that the eruption can be divided into an initial ash-rich phase, a lower intensity middle phase and a final phase where considerably greater quantities both ash and SO2 were released. Comparisons of ash-SO2 dispersion indicate that despite frequent collocation of the two species, there are a number of instances throughout the eruption where separation is observed. This separation occurs vertically due to the more rapid settling rate of ash compared to SO2, horizontally through wind shear and temporally through volcanological controls on eruption style. The potential for the two species to be dispersed independently has consequences in terms of aircraft hazard mitigation and highlights the importance of monitoring both species concurrently.
Journal Article
The Italic people of ancient Apulia : new evidence from pottery for workshops, markets, and customs
\"The focus of this book is on the Italic people of Apulia during the fourth century BC, when Italic culture seems to have reached its peak of affluence. Scholars have largely ignored these people and the region they inhabited. During the past several decades archaeologists have made significant progress in revealing the cultures of Apulia through excavations of habitation sites and un-plundered tombs, often published in Italian journals. This book makes the broad range of recent scholarship--from new excavations and contexts to archaeometric testing of production hypotheses to archaeological evidence for reconsidering painter attributions--available to English-speaking audiences. In it thirteen scholars from Italy, the United States, Great Britain, France, and Australia present targeted essays on aspects of the cultures of the Italic people of Apulia during the fourth century BC and the surrounding decades\"-- Provided by publisher.
Book
Determination of time- and height-resolved volcanic ash emissions and their use for quantitative ash dispersion modeling: the 2010 Eyjafjallajökull eruption
The April–May, 2010 volcanic eruptions of Eyjafjallajökull, Iceland caused significant economic and social disruption in Europe whilst state of the art measurements and ash dispersion forecasts were heavily criticized by the aviation industry. Here we demonstrate for the first time that large improvements can be made in quantitative predictions of the fate of volcanic ash emissions, by using an inversion scheme that couples a priori source information and the output of a Lagrangian dispersion model with satellite data to estimate the volcanic ash source strength as a function of altitude and time. From the inversion, we obtain a total fine ash emission of the eruption of 8.3 ± 4.2 Tg for particles in the size range of 2.8–28 μm diameter. We evaluate the results of our model results with a posteriori ash emissions using independent ground-based, airborne and space-borne measurements both in case studies and statistically. Subsequently, we estimate the area over Europe affected by volcanic ash above certain concentration thresholds relevant for the aviation industry. We find that during three episodes in April and May, volcanic ash concentrations at some altitude in the atmosphere exceeded the limits for the \"Normal\" flying zone in up to 14 % (6–16 %), 2 % (1–3 %) and 7 % (4–11 %), respectively, of the European area. For a limit of 2 mg m−3 only two episodes with fractions of 1.5 % (0.2–2.8 %) and 0.9 % (0.1–1.6 %) occurred, while the current \"No-Fly\" zone criterion of 4 mg m−3 was rarely exceeded. Our results have important ramifications for determining air space closures and for real-time quantitative estimations of ash concentrations. Furthermore, the general nature of our method yields better constraints on the distribution and fate of volcanic ash in the Earth system.
Journal Article
Sertraline treatment influences 18FFE-PE2I PET imaging for Parkinsonism
BackgroundThe dopamine transporter (DaT) PET ligand [18F]FE-PE2I is used to aid the diagnosis of Parkinson’s disease. After encountering four patients with a history of daily sertraline use, who all showed atypical findings on [18F]FE-PE2I PET, we suspected that the selective serotonin reuptake inhibitor (SSRI), sertraline, might interfere with the results and lead to globally reduced striatal [18F]FE-PE2I binding due to sertraline’s high affinity for DaT.MethodsWe rescanned the four patients with [18F]FE-PE2I PET after a 5-day sertraline pause. Sertraline plasma concentration was estimated based on body weight and dose, and specific binding ratios (SBR) in caudate nucleus, known to be more preserved in Parkinson’s, were used to estimate the effect on tracer binding. Comparison was made to a patient with [18F]FE-PE2I PET before and after a 7-day Modafinil pause.ResultsWe found a significant effect of sertraline on caudate nucleus SBR (p = 0.029). The effect showed a linear dose-dependent relationship that corresponds to a reduction in SBR by 0.32 or 0.44 for a 75 kg male or a 65 kg female, respectively, taking a daily dose of 50 mg sertraline.ConclusionSertraline is one of the most commonly used antidepressants and in contrast to other SSRI’s, sertraline show high affinity for DaT. We recommend that sertraline treatment is taken into account when patients are undergoing [18F]FE-PE2I PET especially in patients showing apparent globally reduced PE2I binding. If tolerable, pausing of the sertraline treatment should be considered, especially for doses above 50 mg/day.
Journal Article
Observations of volcanic emissions from space: current and future perspectives
Volcanoes worldwide pose a major threat to humans at both local and global scales. The effective monitoring of volcanoes is essential to manage and reduce risk associated with the threat that they pose. The measurement of volcanic cloud composition can provide important clues to the underlying volcanic processes and can be indicative of impending eruption. Hazards posed by plumes to humans and animals are significant, as well as the potential climatic impacts and the threat to aircraft by the ingestion of volcanic ash all justify careful monitoring. Recent advances in instrument technology have allowed for high resolution monitoring of volcanic clouds from satellite-based instruments. There exists a suite of instruments with varying spatial, spectral and temporal resolutions, which when used in conjunction can provide detailed information about cloud properties. Such instruments have the capability to quantify sulphur dioxide, ash and aerosol content as well as the spatial and vertical distribution of species. Here we present an overview of the range of instruments useful for such monitoring, outline their functionality and describe the potential of future missions.
Journal Article