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In the search for new biological imaging agents, metal coordination compounds able to emit from triplet metal-to-ligand charge transfer (MLCT) states offer many advantages as luminescent probes of DNA structure. However, poor cellular uptake restricts their use in live cells. Here, we present a dinuclear ruthenium( II ) polypyridyl system that works as a multifunctional biological imaging agent staining the DNA of eukaryotic and prokaryotic cells for both luminescence and transition electron microscopy. This MLCT ‘light switch’ complex directly images nuclear DNA of living cells without requiring prior membrane permeabilization. Furthermore, inhibition and transmission electron microscopy studies show this to be via a non-endocytotic, but temperature-dependent, mechanism of cellular uptake in MCF-7 cells, and confocal microscopy reveals multiple emission peaks that function as markers for cellular DNA structure. The ability to study structural changes of DNA in live cells is of considerable interest. Here, a dinuclear ruthenium ( II ) complex that acts as a multifunctional stain for DNA and its use in both luminescence and transmission electron microscopy studies is described.

Hydrogen-bonded dimers of one and two base-pair nucleotides can be stabilized inside the hydrophobic pocket provided by self-assembled molecular cages. The results could bring DNA-based computing a step closer to reality.

Sir: The correspondence on Albert Einstein's religious beliefs seems restricted to whether or not he believed in Western notions of God.

Sir: D J Taylor's portrait of \"Northern Chemist Bloke\", one of the \"crucial types that Messrs Blair and Hague must woo in the weeks to come\", exposes a typical metropolitan arts prejudice that anywhere beyond Watford Gap is stuck in a 1970s timewarp...

While Hollinger board members consulted with attorneys about how to block the deal, Black sought help from the Superior Court of Justice in Ontario to ensure a successful sale. Argus Corp. Ltd. and Ravelston Corp., two closely held firms that Black controls, which also own controlling shares in Hollinger's parent, asked the judge to declare the sale \"effective, valid and binding.\" \"The offer by Press Holdings International will provide substantial value to all shareholders of Hollinger Inc. as well as benefiting Hollinger International by allowing the company's fine media properties to move forward without further distractions or financial uncertainty,\" [Conrad Black] said in a statement Monday. \"As a result, we are taking appropriate legal action to prevent any interference whatsoever with the completion of this transaction.\" Black and [David Radler] were forced out of Hollinger International in November after a special committee determined that they and two other executives had received $15.6 million in unauthorized payments connected to the sale of several Hollinger properties. Another $16.5 million was wrongly diverted to Hollinger Inc.

Georgia Frontiere, owner of the Los Angeles Rams, says it's likely that the team will move out of Anaheim Stadium after the 1994 National Football League season. Frontiere said she would consider selling part of the team to facilitate either a move to one of the cities courting the Rams, or the chance to stay in Southern California. \"When friends and associates asked me earlier about the Rams moving, I told them I was doing my best to keep the team here,\" she said. \"But now it's obvious that would financially kill us - unless we come up with something different.\"

As a part of the [Donald Trump]-Hollinger joint venture, the Sun-Times site is valued at $75 million, or just under $1,000 per square foot. That price is about $30 million more than the next-highest offer ever made for the property.