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"Thomas, Rob"
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Rats saw God
In hopes of graduating, Steve York agrees to complete a hundred-page writing assignment which helps him to sort out his relationship with his famous astronaut father and the events that changed him from promising student to troubled teen.
Book
ArTisaN trial protocol: a single Centre, open-label, phase II trial of the safety and efficacy of TheraSphere selective internal radiation therapy (SIRT) in the treatment of inoperable metastatic (liver) neuroendocrine neoplasia (NENs)
Background
Neuroendocrine neoplasias (NENs) are a rare type of malignancy that arise from the cells of the neuroendocrine system. Most patients present with advanced, unresectable disease, typically with metastases to the liver. The presence of liver metastases dictates prognosis and there has been a number of studies investigating therapies that reduce the burden of liver disease. Selective Internal Radiation Therapy (SIRT) allows the delivery of targeted high dose radiation directly to tumours, with relative sparing of the surrounding liver tissue. Here, we describe the design and rationale of ArtTisaN, a phase II study to assess efficacy and tolerability of SIRT using TheraSpheres for the management of liver metastases secondary to NENs.
Methods
Twenty-four eligible participants will be recruited to receive SIRT with TheraSpheres. The primary objective is to determine the objective response rate to treatment, defined as the rate of best overall response in the treated liver volume. In addition, total hepatic response and overall response will be assessed according to RECIST 1.1. The second co-primary objective is to determine the incidence of adverse and serious adverse device events. The secondary objectives are progression free survival, overall survival and quality of life. Additional exploratory objectives include investigation of circulating biomarkers of response and identification of a radiomic signature of response.
Discussion
This trial will provide prospective evidence on the efficacy of SIRT using TheraSpheres for the management of liver metastases.
Trial registration
NCT04362436
.
Journal Article
Veronica Mars. The thousand-dollar tan line
\"The first book in an original mystery series featuring twenty-eight-year-old Veronica Mars, back in action after the events of Veronica Mars: The Movie. With the help of old friends--Logan Echolls, Mac Mackenzie, Wallace Fennel, and even Dick Casablancas--Veronica is ready to take on Neptune's darkest cases with her trademark sass and smarts. Final title and cover to be announced\"-- Provided by publisher.
Book
Big Data Revolution
Exploit the power and potential of Big Data to revolutionize business outcomes Big Data Revolution is a guide to improving performance, making better decisions, and transforming business through the effective use of Big Data. In this collaborative work by an IBM Vice President of Big Data Products and an Oxford Research Fellow, this book presents inside stories that demonstrate the power and potential of Big Data within the business realm. Readers are guided through tried-and-true methodologies for getting more out of data, and using it to the utmost advantage. This book describes the major trends emerging in the field, the pitfalls and triumphs being experienced, and the many considerations surrounding Big Data, all while guiding readers toward better decision making from the perspective of a data scientist. Companies are generating data faster than ever before, and managing that data has become a major challenge. With the right strategy, Big Data can be a powerful tool for creating effective business solutions - but deep understanding is key when applying it to individual business needs. Big Data Revolution provides the insight executives need to incorporate Big Data into a better business strategy, improving outcomes with innovation and efficient use of technology. Examine the major emerging patterns in Big Data Consider the debate surrounding the ethical use of data Recognize patterns and improve personal and organizational performance Make more informed decisions with quantifiable results In an information society, it is becoming increasingly important to make sense of data in an economically viable way. It can drive new revenue streams and give companies a competitive advantage, providing a way forward for businesses navigating an increasingly complex marketplace. Big Data Revolution provides expert insight on the tool that can revolutionize industries.
eBook
Veronica Mars. Mr. Kiss and Tell
\"The second Veronica Mars novel, in which she investigates a mysterious crime at The Neptune Grand hotel\" -- Provided by publisher.
Book
Correction: Corrigendum: Both respiration and photosynthesis determine the scaling of plankton metabolism in the oligotrophic ocean
Nature Communications 6:6961 doi: (2015); Published 24 April 2015; Updated 15 June 2016 The original version of this Article failed to fully credit the use of the Ocean Data View software in figure 3, which appears below: Schlitzer, R., Ocean Data View, http://odv.awi.de, 2016.
Journal Article
Fire in the forest
\"How destructive or beneficial are forest fires to wildlife? Should we be trying to reduce or increase the amount of fire in forests? How are forest fires controlled, and why does this sometimes fail? What effect will climate change have? These and many other questions are answered in this richly illustrated book, written in non-technical language. The journey starts in the long geological history of fire leading up to our present love-hate relationship with it. Exploring the physics of how a single flame burns, the journey continues through how whole forests burn and the anatomy of firestorms. The positive and negative ecological effects of fires are explored, from plants and wildlife to whole landscapes. The journey ends with how fires are controlled, and a look to the future. This book will be of interest to ecologists, biogeographers and anyone with an interest in forest fires and the role they play\"-- Provided by publisher.
Book
Using novel methodologies to examine the impact of artificial light at night on the cortisol stress response in dispersing Atlantic salmon ( Salmo salar L.) fry
Artificial light at night (ALAN) is known to disrupt the nocturnal dispersal behaviour of Atlantic salmon fry, yet the underlying physiological mechanism is unknown. Here novel methodologies are utilised to examine whether behavioural disruption seen in dispersing fry is mediated via a cortisol stress response. Fry showed the capacity to mount a stress response, however, the two methods for sampling cortisol provide conflicting results as to whether ALAN acts as a stressor to dispersing fry.Abstract
Artificial light at night (ALAN) is gaining recognition as having an important anthropogenic impact on the environment, yet the behavioural and physiological impacts of this stressor are largely unknown. This dearth of information is particularly true for freshwater ecosystems, which are already heavily impacted by anthropogenic pressures. Atlantic salmon (
Salmo salar
L.) is a species of conservation and economic importance whose ecology and behaviour is well studied, making it an ideal model species. Recent investigations have demonstrated that salmon show disrupted behaviour in response to artificial light; however, it is not yet clear which physiological processes are behind the observed behavioural modifications. Here, two novel non-invasive sampling methods were used to examine the cortisol stress response of dispersing salmon fry under different artificial lighting intensities. Fish egg and embryos were reared under differing ALAN intensities and individual measures of stress were subsequently taken from dispersing fry using static sampling, whereas population-level measures were achieved using deployed passive samplers. Dispersing fry exposed to experimental confinement showed elevated cortisol levels, indicating the capacity to mount a stress response at this early stage in ontogenesis. However, only one of the two methods for sampling cortisol used in this study indicated that ALAN may act as a stressor to dispersing salmon fry. As such, a cortisol-mediated response to light was not strongly supported. Furthermore, the efficacy of the two non-invasive methodologies used in this study is, subject to further validation, indicative of them proving useful in future ecological studies.
Journal Article
Host density predicts presence of cuckoo parasitism in reed warblers
In some hosts of avian brood parasites, several populations apparently escape parasitism, while others are parasitized. Many migratory specialist brood parasites like common cuckoos, Cuculus canorus, experience a short breeding season, and in order to maintain local parasite populations host densities should be sufficiently high to allow efficient nest search. However, no studies have investigated the possible effect of host density on presence of cuckoo parasitism among populations of a single host species. Here, we investigated possible predictors of common cuckoo parasitism in 16 populations of reed warblers, Acrocephalus scirpaceus, across Europe. In more detail, we quantified the effect of host density, number of host breeding pairs, habitat type, mean distance to nearest cuckoo vantage point, predation rate and latitude on the presence of cuckoo parasitism while controlling for geographical distance among study populations. Host density was a powerful predictor of parasitism. We also found a less pronounced effect of habitat type on occurrence of parasitism, while the other variables did not explain why cuckoos utilize some reed warbler populations and not others. This is the first study focusing on patterns of common cuckoo-host interactions within a specific host species on a large geographic scale. The results indicate that if host density is below a specific threshold, cuckoo parasitism is absent regardless of the state of other potentially confounding variables.
Journal Article