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Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity
The SARS-CoV-2 pandemic and particularly the emerging variants have deepened the need for widely available therapeutic options. We have demonstrated that hexamer-enhancing mutations in the Fc region of anti-SARS-CoV IgG antibodies lead to a noticeable improvement in IC 50 in both pseudo and live virus neutralization assay compared to parental molecules. We also show that hexamer-enhancing mutants improve C1q binding to target surface. To our knowledge, this is the first time this format has been explored for application in viral neutralization and the studies provide proof-of-concept for the use of hexamer-enhanced IgG1 molecules as potential anti-viral therapeutics.
Journal Article
Manufacturing processes for textile and fashion design professionals
To be truly prized and employable, textile and fashion designers have to be aware of, and knowledgeable about, a wide range of processes to enable their designs to be manufactured effectively, often thousands of miles from their design studio. This much-needed new reference is the only encyclopedic guide to manufacturing processes and materials that is truly relevant for textile and fashion designers. It is organized into five main parts: fiber and yarn technology; textile technology; construction technology; life cycle strategies; and materials appendix. This book is a complete overview of the life cycle of textile and fashion manufacturing, from the spinning of yarn to recycling. All the processes feature detailed step-by-step case studies showing the process in manufacture at a leading international supplier. The appendix features essential knowledge on over sixty natural and synthetic materials. With around 1,400 specially commissioned photographs and technical illustrations, this is the indispensable, reliable, convenient, and highly accessible practical reference for all textile and fashion designers.-- Source other than Library of Congress.
Book
A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study
Accessible and non‐invasive biomarkers that measure human ageing processes and the risk of developing age‐related disease are paramount in preventative healthcare. Here, we describe a novel framework to train saliva‐based DNA methylation (DNAm) biomarkers that are reproducible and biologically interpretable. By leveraging a reliability dataset with replicates across tissues, we demonstrate that it is possible to transfer knowledge from blood DNAm to saliva DNAm data using DNAm proxies of blood proteins (EpiScores). We apply these methods to create a new saliva‐based epigenetic clock (InflammAge) that quantifies systemic chronic inflammation (SCI) in humans. Using a large blood DNAm human cohort with linked electronic health records and over 18,000 individuals (Generation Scotland), we demonstrate that InflammAge significantly associates with all‐cause mortality, disease outcomes, lifestyle factors, and immunosenescence; in many cases outperforming the widely used SCI biomarker C‐reactive protein (CRP). We propose that our biomarker discovery framework and InflammAge will be useful to improve understanding of the molecular mechanisms underpinning human ageing and to assess the impact of gero‐protective interventions. In this study, we describe a novel multi‐omics framework to train saliva‐based DNA methylation (DNAm) biomarkers that are reproducible and biologically interpretable. By leveraging a reliability dataset with replicates across tissues, we demonstrate knowledge transfer from blood DNAm to saliva DNAm data using DNAm proxies of blood proteins (EpiScores). We apply these methods to create a new saliva‐based epigenetic clock (InflammAge) that quantifies systemic chronic inflammation (SCI) in humans.
Journal Article
Product and furniture design
With some 430 specially commissioned photographs and technical illustrations, this book describes more than 30 manufacturing processes, from the traditional and established to cutting-edge technologies.
Book
Space chimps
A trio of chimpanzees are recruited to retrieve a wayward space probe and find themselves having to save the peaceful inhabitants of a distant planet from an evil dictator.
DVD
Climate-informed HVAC increases in relative humidity may fight pandemic viruses
Humidification as a Unique HVAC Objective Other HVAC design aspects-ventilation, filtration, air movement, space pressure relationships, temperature and purification-can help reduce contagion, and each is important (Wang, et al., 2020). Humidification's Relationship with Building Envelopes While climate visualizations indicate representative areas for building envelope caution (gray boxes) and data to aid seasonal adjustments in RH setpoints (orange and white colors), we strongly urge facility managers to have their individual building envelopes evaluated for suitability with higher RH, using moisture migration programs or other means. For temporary medical facilities and alternate care sites, consider how to get to 40% RH, even with novel means in an emergency model: e.g., RO/UV-treated water feeding atomizing-mist evaporative fans.
Trade Publication Article
Innovative solutions considered as lenders tackle real estate debt
According to research from Knight Frank, RBS and Lloyds Banking Group seem to be adopting different approaches to their loan books.
Trade Publication Article