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\"A Cultural History of the Atlantic World, 1250-1820 explores the idea that strong links exist in the histories of Africa, Europe and North and South America. John K. Thornton provides a comprehensive overview of the history of the Atlantic Basin before 1830 by describing political, social and cultural interactions between the continents' inhabitants. He traces the backgrounds of the populations on these three continental landmasses brought into contact by European navigation. Thornton then examines the political and social implications of the encounters, tracing the origins of a variety of Atlantic societies and showing how new ways of eating, drinking, speaking and worshipping developed in the newly created Atlantic World. This book uses close readings of original sources to produce new interpretations of its subject\"-- Provided by publisher.

A Cultural History of the Atlantic World, 1250–1820 explores the idea that strong links exist in the histories of Africa, Europe and North and South America. John K. Thornton provides a comprehensive overview of the history of the Atlantic Basin before 1830 by describing political, social and cultural interactions between the continents' inhabitants. He traces the backgrounds of the populations on these three continental landmasses brought into contact by European navigation. Thornton then examines the political and social implications of the encounters, tracing the origins of a variety of Atlantic societies and showing how new ways of eating, drinking, speaking and worshipping developed in the newly created Atlantic World. This book uses close readings of original sources to produce new interpretations of its subject.

تقوم هذه الدراسة التي جاءت تحت عنوان (الصين المتغيرة) الباحثون (جون ثورنتون، ستيفاني كلين، أندرو سمول) للإضاءة على المحادثات التي أجريت طوال الشهور الأربعة عشرة الأخيرة الماضية مع مجموعة عريضة من الصينيين ومن ذلك أعضاء اللجنة المركزية للحزب الشيوعي الصيني وهي المجموعة القيادية في الصين المكونة من 370 قائدا وكبار المسؤولين الحكوميين وفي هذا السياق يطرح الكتاب إشكالية مهمة وهي هل على الصين أن تأخذ بالديمقراطية حسب المفهوم الذي لها أنها تقدم رؤية جديدة، فكبار المسؤولين يشددون على وجوب المحافظة على قيادة الحزب الشيوعي الصيني عن طريق الشكل التداوي الذي يسمح للأفراد والجماعات بالمشاركة في اتخاذ القرارات، أكثر من التنافس المفتوح والمتعدد الأحزاب على السلطة.

A substantial impediment to progress in trials of new therapies in neuromuscular disorders is the absence of responsive outcome measures that correlate with patient functional deficits and are sensitive to early disease processes. Irrespective of the primary molecular defect, neuromuscular disorder pathological processes include disturbance of intramuscular water distribution followed by intramuscular fat accumulation, both quantifiable by MRI. In pathologically distinct neuromuscular disorders, we aimed to determine the comparative responsiveness of MRI outcome measures over 1 year, the validity of MRI outcome measures by cross-sectional correlation against functionally relevant clinical measures, and the sensitivity of specific MRI indices to early muscle water changes before intramuscular fat accumulation beyond the healthy control range. We did a prospective observational cohort study of patients with either Charcot-Marie-Tooth disease 1A or inclusion body myositis who were attending the inherited neuropathy or muscle clinics at the Medical Research Council (MRC) Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK. Genetic confirmation of the chromosome 17p11·2 duplication was required for Charcot-Marie-Tooth disease 1A, and classification as pathologically or clinically definite by MRC criteria was required for inclusion body myositis. Exclusion criteria were concomitant diseases and safety-related MRI contraindications. Healthy age-matched and sex-matched controls were also recruited. Assessments were done at baseline and 1 year. The MRI outcomes—fat fraction, transverse relaxation time (T2), and magnetisation transfer ratio (MTR)—were analysed during the 12-month follow-up, by measuring correlation with functionally relevant clinical measures, and for T2 and MTR, sensitivity in muscles with fat fraction less than the 95th percentile of the control group. Between Jan 19, 2010, and July 7, 2011, we recruited 20 patients with Charcot-Marie-Tooth disease 1A, 20 patients with inclusion body myositis, and 29 healthy controls (allocated to one or both of the 20-participant matched-control subgroups). Whole muscle fat fraction increased significantly during the 12-month follow-up at calf level (mean absolute change 1·2%, 95% CI 0·5–1·9, p=0·002) but not thigh level (0·2%, −0·2 to 0·6, p=0·38) in patients with Charcot-Marie-Tooth disease 1A, and at calf level (2·6%, 1·3–4·0, p=0·002) and thigh level (3·3%, 1·8–4·9, p=0·0007) in patients with inclusion body myositis. Fat fraction correlated with the lower limb components of the inclusion body myositis functional rating score (ρ=–0·64, p=0·002) and the Charcot-Marie-Tooth examination score (ρ=0·63, p=0·003). Longitudinal T2 and MTR changed consistently with fat fraction but more variably. In muscles with a fat fraction lower than the control group 95th percentile, T2 was increased in patients compared with controls (regression coefficients: inclusion body myositis thigh 4·0 ms [SE 0·5], calf 3·5 ms [0·6]; Charcot-Marie-Tooth 1A thigh 1·0 ms [0·3], calf 2·0 ms [0·3]) and MTR reduced compared with controls (inclusion body myositis thigh −1·5 percentage units [pu; 0·2], calf −1·1 pu [0·2]; Charcot-Marie-Tooth 1A thigh −0·3 pu [0·1], calf −0·7 pu [0·1]). MRI outcome measures can monitor intramuscular fat accumulation with high responsiveness, show validity by correlation with conventional functional measures, and detect muscle water changes preceding marked intramuscular fat accumulation. Confirmation of our results in further cohorts with these and other muscle-wasting disorders would suggest that MRI biomarkers might prove valuable in experimental trials. Medical Research Council UK.

\"A landmark presentation that will radically redefine our understanding of Africa's relationship with the West, Kongo: Power and Majesty, opening at The Metropolitan Museum of Art this September, will focus on one of the continent's most influential artistic traditions, from the earliest moment of direct engagement between African and European leaders at the end of the 15th century through the early 20th century. The creative output of Kongo artists of Central Africa will be represented by 134 works drawn from more than 50 institutional and private collections across Europe and the United States, reflecting five hundred years of encounters and shifting relations between European and Kongo leaders. From a dynamic assembly of 15 monumental power figures to elegantly carved ivories and finely woven textiles, the exhibition will explore how the talents of Central Africa's most gifted artists were directed toward articulating a culturally distinct vernacular of power.\"--Metropolitan Museum of Art website

Research conducted into the demography of the Kingdom of Kongo some forty years ago, employing baptismal statistics left by missionaries, has been in need of revision thanks to challenges by more recent scholarship. This article revises the estimated population of Kongo by addressing these challenges, drawing on newly discovered documentary sources. Using this new evidence, the estimate for the kingdom's population in the mid-seventeenth century has been elevated from 509,000 to around 790,000. The original article's claims about levels of fertility and mortality have been retained. The article also addresses questions concerning the validity of missionary statistics and the impact of the slave trade, which was small before 1700 but then increasingly large thereafter, reaching very high levels by the early nineteenth century. While a quantitative estimate of the later population is not possible given the limitations of sources for this period, it is likely that the population of the kingdom fell as slave exports peaked.

In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included. We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to receive either endovascular thrombectomy within 12 h of symptom onset or standard care (control), with a primary outcome of reduced disability on the modified Rankin Scale (mRS) at 90 days. By direct access to the study databases, we extracted individual patient data that we used to assess the primary outcome of reduced disability on mRS at 90 days in the pooled population and examine heterogeneity of this treatment effect across prespecified subgroups. To account for between-trial variance we used mixed-effects modelling with random effects for parameters of interest. We then used mixed-effects ordinal logistic regression models to calculate common odds ratios (cOR) for the primary outcome in the whole population (shift analysis) and in subgroups after adjustment for age, sex, baseline stroke severity (National Institutes of Health Stroke Scale score), site of occlusion (internal carotid artery vs M1 segment of middle cerebral artery vs M2 segment of middle cerebral artery), intravenous alteplase (yes vs no), baseline Alberta Stroke Program Early CT score, and time from stroke onset to randomisation. We analysed individual data for 1287 patients (634 assigned to endovascular thrombectomy, 653 assigned to control). Endovascular thrombectomy led to significantly reduced disability at 90 days compared with control (adjusted cOR 2·49, 95% CI 1·76–3·53; p<0·0001). The number needed to treat with endovascular thrombectomy to reduce disability by at least one level on mRS for one patient was 2·6. Subgroup analysis of the primary endpoint showed no heterogeneity of treatment effect across prespecified subgroups for reduced disability (pinteraction=0·43). Effect sizes favouring endovascular thrombectomy over control were present in several strata of special interest, including in patients aged 80 years or older (cOR 3·68, 95% CI 1·95–6·92), those randomised more than 300 min after symptom onset (1·76, 1·05–2·97), and those not eligible for intravenous alteplase (2·43, 1·30–4·55). Mortality at 90 days and risk of parenchymal haematoma and symptomatic intracranial haemorrhage did not differ between populations. Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location. These findings will have global implications on structuring systems of care to provide timely treatment to patients with acute ischaemic stroke due to large vessel occlusion. Medtronic.

L’origine et la nature de l’invasion Jaga du Kongo est l’un des débats les plus anciens de l’historiographie africaine. Ce projet, utilisant plusieurs documents récemment découverts, soutient que l’invasion n’était pas une révolte locale, ne découlait pas d’une crise constitutionnelle et qu’elle impliquait une armée petite mais très compétente qui est entrée dans le pays par l’Empire de Mwene Muji pendant le règne du roi Bernardo Ier. The origin and nature of the Jaga invasion of Kongo is one of the longest standing debates in Africa’s historiography. This project, using a number of newly discovered documents, argues that the invasion was not a local revolt, did not stem from a constitutional crisis, and that it involved a small but highly competent army that entered the country through the Empire of Mwene Muji during the reign of king Bernardo I.

The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence between these areas and anatomical landmarks on the human superior temporal gyri is not straightforward, and at present not completely understood. However it is not controversial that there is a hierarchical organization of auditory stimuli processing in the auditory system. The aims of this study were to demonstrate that it is possible to non-invasively and robustly identify auditory projections between the auditory thalamus/brainstem and different functional levels of auditory analysis in the cortex of human subjects in vivo combining functional magnetic resonance imaging (fMRI) with diffusion MRI, and to investigate the possibility of differentiating between different components of the auditory pathways (e.g. projections to areas responsible for sound, pitch and melody processing). We hypothesized that the major limitation in the identification of the auditory pathways is the known problem of crossing fibres and addressed this issue acquiring DTI with b-values higher than commonly used and adopting a multi-fibre ball-and-stick analysis model combined with probabilistic tractography. Fourteen healthy subjects were studied. Auditory areas were localized functionally using an established hierarchical pitch processing fMRI paradigm. Together fMRI and diffusion MRI allowed the successful identification of tracts connecting IC with AC in 64 to 86% of hemispheres and left sound areas with homologous areas in the right hemisphere in 86% of hemispheres. The identified tracts corresponded closely with a three-dimensional stereotaxic atlas based on postmortem data. The findings have both neuroscientific and clinical implications for delineation of the human auditory system in vivo. •We combine fMRI and DTI to successfully identify the auditory pathways in volunteers.•Tractography results are comparable to postmortem atlas data.•Clinical fMRI/DTI can successfully identify cortico-subcortical auditory pathways.•Ascending and descending auditory pathways cannot be differentiated with MRI.

Temporal lobe epilepsy (TLE) is associated with widespread brain alterations. Using quantitative susceptibility mapping (QSM) alongside transverse relaxation rate (), we investigated regional brain susceptibility changes in 36 patients with left‐sided (LTLE) or right‐sided TLE (RTLE) secondary to hippocampal sclerosis, and 27 healthy controls (HC). We compared three susceptibility calculation methods to ensure image quality. Correlations of susceptibility and with age of epilepsy onset, frequency of focal‐to‐bilateral tonic–clonic seizures (FBTCS), and neuropsychological test scores were examined. Weak‐harmonic QSM (WH‐QSM) successfully reduced noise and removed residual background field artefacts. Significant susceptibility increases were identified in the left putamen in the RTLE group compared to the LTLE group, the right putamen and right thalamus in the RTLE group compared to HC, and a significant susceptibility decrease in the left hippocampus in LTLE versus HC. LTLE patients who underwent epilepsy surgery showed significantly lower left‐versus‐right hippocampal susceptibility. Significant changes were found between TLE and HC groups in the amygdala, putamen, thalamus, and in the hippocampus. Specifically, decreased R 2 * was found in the left and right hippocampus in LTLE and RTLE, respectively, compared to HC. Susceptibility and were significantly correlated with cognitive test scores in the hippocampus, globus pallidus, and thalamus. FBTCS frequency correlated positively with ipsilateral thalamic and contralateral putamen susceptibility and with in bilateral globi pallidi. Age of onset was correlated with susceptibility in the hippocampus and putamen, and with in the caudate. Susceptibility and changes observed in TLE groups suggest selective loss of low‐myelinated neurons alongside iron redistribution in the hippocampi, predominantly ipsilaterally, indicating QSM's sensitivity to local pathology. Increased susceptibility and in the thalamus and putamen suggest increased iron content and reflect disease severity.