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In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGFβ results in an increase of migratory invasive properties. The analysis of the dynamics of gene expression by next-generation sequencing revealed that TGFβ stimulation orchestrates the upregulation of numerous motility- and actin cytoskeleton-related genes. Among these the non-muscle myosin 10 ( MYO10 ) showed the highest upregulation in a LUSC patient cohort of the Cancer Genome Atlas (TCGA). Knockdown of MYO10 abrogated TGFβ-induced collagen gel invasion of SK-MES1 cells. The analysis of MYO10 mRNA expression in paired tissues of 151 LUSC patients with corresponding 80-month clinical follow-up data showed that the mRNA expression ratio of MYO10 in tumor and tumor-free tissue is prognostic for overall survival of LUSC patients and predictive for the response of these patients to adjuvant chemotherapy. Thus, MYO10 represents a new clinical biomarker for this aggressive disease and due to its role in cellular motility and invasion could serve as a potential molecular target for therapeutic interventions in patients with LUSC.

A scheme for accumulating radioactive ions, which is geared toward a quasicontinuous low-intensity flux, is discussed. It is based on individual correction of the trajectory and momentum deflection of each ion in the transport channel and individual ion injection into the accumulator ring. The advantages of this scheme are low accumulator acceptance 5-10 p.mm.mrad, high ion accumulation rate - up to 10 super(3) sec super(-1) - with beam intensity after the fragment separator 10 super(3)-10 super(4) sec super(-1), and a 10 super(4)-10 super(5)-fold decrease of the pulse intensity of the primary beam on the productive target.

The DELSY (Dubna electron synchrotron) accelerator complex, including a 1.2-GeV electron storage ring, is under construction at JINR. This complex is a high-luminosity source of synchrotron radiation. It contains a linear accelerator-injector and a family of free-electron lasers operating in a wide spectral range from infrared radiation (λ [asymptotically =] 100 μm) to high-energy x-rays (ε^sub ω^ [asymptotically =] 0 keV). The DELSY source will make it possible to expand current research performed at JINR on the condensed-state and atomic physics, biology and medicine, crystallography and x-ray spectroscopy, nuclear physics, and metrology. The project is being implemented in three phases.[PUBLICATION ABSTRACT]

The main goal of the Tera Watt A Cumulator project (Institute for Theoretical and Experimental Physics, Moscow) is accumulation in the storage ring of an intense ion beam, its longitudinal compression and the use of the extracted beam for plasma experiments. However, beam parameters at the target are decreased because of extreme transverse heating and growth of the beam momentum spread due to intrabeam scattering. These effects can be suppressed by application of the electron cooling system (ECS). Design study of ECS has been performed in the Joint Institute for Nuclear Research. The design project and characteristics of the system are described, as well as analysis of the accumulation kinetics in the presence of the cooling system. Design work has shown that because of the small length of the straight section (2.35 m), the effective length of the cooling system is small (about 55–60 cm). Nevertheless, for long accumulation times (>100 s), the system allows us to significantly improve the beam parameters at the target (specific energy, specific power, and so on) and to suppress the beam losses by an order of magnitude.

An accelerator complex DÉLSI (Dubnen Electron Synchrotron) is planned for constuction as source of synchrotron radiation with high brightness in a wide spectral range - from far infrared (100 μm) up to high-energy x-ray (50 keV). This will make it possible to perform a wide range of research at the Joint Institute of Nuclear Research. The DÉLSI complex includes a linear electron accelerator up to energy 800 MeV and a storage ring with a 136 m perimeter at 1.2 GeV, in which a 10 T wiggler and an undulator (0.75 T, 150 periods) are built-in. The linear electron accelerator of the DÉLSI complex will be used for injection and for producing free-electron lasers. The parameters of synchrotron radiation from the bending magnets and built-in devices of the DÉLSI complex, the magnetic structure of the storage ring with the wiggler and undulator switched off, the effect of built-in devices on the ring optics, and the effect of errors on the closed orbit are examined; the synchrotron radiation parameters are briefly described.[PUBLICATION ABSTRACT]

The Weakly Interacting Massive Particles (WIMPs) are among the main candidates for the relic dark matter (DM). The idea of the direct DM detection relies on elastic in-dependent (SD) and spin-independent (SI) interaction of WIMPs with target nuclei. The importance of the SD WIMP-nucleus interaction for reliable DM detection is argued. The absolute lower bound for the detection rate can naturally be due to SD interaction. An experiment aimed at detecting DM with sensitivity higher than 10^{-5} event/day/kg should have a non-zero-spin target.