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The aspects, related to the influence of the electrohydraulic shock method use in a water-cement slurry passing in a closed chamber (activation reactor) with a pre-applied pressure to the system under various processing modes are highlighted in the article. In order to test the effect of this method on water-cement slurry, an installation was developed, consisting of: a high-voltage source, a high-voltage diode, capacitor banks, a closing element and an activation reactor. The necessary experiments were carried out on the completed installation. The procedure for conducting experiments is described in the work, shows a schematic diagram of the installation for performing activation, a diagram of the reactor, and the processing modes. Several activation modes were considered, depending on: the number of pulses (1-4), pulse energy (0.5-8 kJ), water-cement ratio (0.2-0.35), time intervals for starting treatment from the moment the cement was mixed with water (0 -120 minutes), volume and shape of the container (activation reactor), holding temperature (20-60°C), etc. According to the results of the data obtained, it was experimentally established that the use of electric pulse treatment of water-cement suspension has a positive effect on strength (cup compressive strength) indicators, obtained as a result of processing cement stone samples at different times of hardening (1-3 days). The compressive strength of the treated specimens’ increases in comparison with the untreated specimens, increase in strength reaches up to 45%, depending on the activation mode. The resulting effect was achieved due to many factors (high pressure, magnetic, temperature, energy, ultrasonic and other influences), which were applied in the most optimal period of time (stage) of the cement grain hydration process.

Today, cancer continues to be one of the most dangerous diseases, annually causing the deaths of more than 9 million people in the world. Therefore, new and more effective methods of cancer therapy are in demand. As monoclonal antibody-based immunotherapy has already shown its effectiveness, antibody-drug conjugates (ADC), one of its successful variants, have significant and not yet fully realized potential. ADCs are monoclonal antibodies bound to cytotoxic drugs through linkers. In many clinical trials and already in standard clinical practice, ADCs have demonstrated significant advantages over the combination therapy with unmodified antibodies and chemotherapeutic drugs. Due to new achievements in the field of molecular immunology and biotechnology, the potential of ADCs is assessed as a breakthrough, which will allow ADCs to become the most sought-after anticancer drugs in the coming years. Owing to ADCs it has become possible to deliver drugs to tumor cells in a targeted manner without significant toxic effects on healthy tissues and organs. To date, 15 ADC drugs have been approved worldwide for use in clinic, and more than a hundred more drugs of this class are at various stages of clinical trials. At the same time, ADC therapy is associated with certain side effects and limited efficacy. Therefore there is a need to develop more advanced conjugates. This review describes the history of the development of ADC as a therapeutic class of molecules, their structure, targets, and mechanism of action. It also outlines the prospects and directions for further development of ADCs.

A one-dimensional plasmon-polariton which is characterized by non-linear dispersion is supported by electromagnetic field interacting with topologically protected helical state. The electronic helical state arises at the surface of topological insulator in the close proximity of the ferromagnet. In a two-dimensional Dirac magnet these electro-optical excitations are limited by domain walls. Topological electronic imagining of domain walls can provide generally a novel tool to couple magnetic dynamics with both transport and optical properties of helical electronic states An exact dispersion relation for the topological plasmon-polariton were obtained.

This article presents a research on Hexagonal Boron Nitride (h-BN) monolayer cell strain effect 2 % and 4 %. Structure of h-BN with nitrogen vacancy, with boron vacancy and with divacancy was considered for this. The calculations were carried out within framework of the density functional formalism with gradient corrections and using the VASP package. Vanderbilt Ultra-Soft Pseudopotential was used in the course of the calculations. It is possible to conclude that nitrogen vacancies are the most stable, regardless of monolayer deformation on the results obtained. Understanding of atomic scale stability and dynamics of defects in such systems is crucial for predicting their properties and applications in electronics.

Modeling of heating a monolithic tape grillage using heating insulated wires in the ELCUT Pro 6.3 software and computing complex and the WinConcret add-on are discussed in the article. This type of concrete heating is used at a multi-storey residential complex \"Alye Parusa\" in Microdistrict \"Severny\", a rural settlement of the Tomsk region near the river. The initial parameters were introduced for the object under construction in Elcut Pro software package with the WinConcret add-in. As a result of the calculation, an analysis of the temperature fields in the section of a monolithic tape grillage was carried out, as well as graphs of the temperature dependence on time and graphs of the strength dependence on the heating time. It was found that when concrete was heated with the help of insulated heating wires, the thermal energy was distributed more evenly over the entire cross section of the grillage, which led to an increase in the entire structure strength.

We demonstrate that in ferromagnets with the D 3h point group of symmetry a possible origin of phase transition from a collinear ferromagnetic state to a non-collinear state can be the fourth order contributions to the free energy density that are allowed by this point group of symmetry. At the same time, Dzyaloshinskii-Moria interaction vanishes in such materials. Via symmetry analysis we derive seven possible fourth order contributions to the free energy density with respect to the unit vector of the local magnetization direction but only two of them can be considered as independent. Moreover, for two-dimensional systems only one survives. Considered symmetry class is essential because a large group of two-dimensional intrinsic ferromagnets belongs to it, for example a monolayer Fe 3 GeTe 2 . The four-spin chiral exchange does also manifest itself in peculiar magnon spectra and favors spin waves.

Our study presents the results of a comparative assessment of meat productivity and biological value of meat in bulls of various breeds. The work was carried out at OJSC named after N.E. Tokarlikov of the Almetyevsk region of the Republic of Tatarstan using industrial technology in three groups (18 heads in each group): I - Simmental, II - Black-and-White and III - Hereford. Relatively high rates of meat productivity and qualitative characteristics of the meat were determined in Hereford bulls: meat weight was 1.7 and 4.5% more compared with Simmental and Black-and-White peers. The meat index in animals of the meat direction (4.59) is higher by 7.5 and 5.5% compared to analogues of I and II groups. The specific gravity of the protein did not have significant differences (18.60-19.05%). At the same time, a higher level of fat was noted in meat from beef cattle - by 1.05 and 1.51%. They also favorably differed in essential amino acids content in the proteins of muscle tissue. Their amino acid score was above 100%. A more balanced ratio of essential amino acids was established in individuals of beef cattle when calculating the biological value of the protein. Meat from animals of Hereford breed was differed by relatively high level of non-essential amino acids - 318.8 mg per 1 g of protein, which is 1.3 and 10.4% more than in the peers of the first two groups.

The article considers methodological and fundamental aspects of the basic methods of calculating the equipment for electric preheating of a concrete mix in the technology of concreting structures in the cold season. Although the technology of electric preheating of the concrete mix has been known since the beginning of the 60s of the last century, until now there have been no adequate methods for designing and calculating the equipment to implement it. In the paper, authors classify the known methods for calculating the electric preheating of a concrete mix. They present the calculation method, which allows us to create high-quality and reliable equipment for the practical implementation of the considered method. Based on the similarity theory, the authors offer a generalized description of the heating process. The use of the resulting dimensionless dependence of the electric preheating parameters and its graphic interpretation allow one to continuously and visually control all the three groups of parameters (technological, design and electro technical) simultaneously.

Digital and Semi-Digital Hadronic Calorimeters ((S)DHCAL) were suggested for future Colliders as part of the particle-flow concept. Though studied mostly with Resistive Plate Chambers (RPC), studies focusing on Micro-Pattern Gaseous Detector (MPGD)-based sampling elements have shown the potential advantages using such techniques. In 2018, eight 48x48 cm2 sampling elements based on resistive Micromegas and Resistive Plate WELL (RPWELL) technologies were assembled. They were tested within a small MPGD-based SDHCAL prototype incorporating in addition three 16x16 cm2 Micromegas detectors and steel absorber plates recording hadronic showers of low-energy pions at the CERN/PS beam line. Preliminary results and analysis methodology are presented, using data samples recorded with pions with momenta in the range from 2 to 6 GeV/c.

The use of silver, which is a potent antibiotic, has attracted our interest in testing it as an anti-stress drug for technological stresses such as transportation and pre-slaughter handling. Based on the results, we have developed a new technology for improving the quality of food raw materials, including the intramuscular injection of ultrafine particles (UFP) of silver at a dose of 0.01 mg / kg of live weight. This allows improving the quality characteristics of by-products (liver, kidneys, lungs), which is characterized by an increase of both saturated fatty acid (namely, palmitic one) by 23.7% and unsaturated (oleic) acid by 38.6%; and at a dosage of 0.05 mg / kg of live weight - in terms of myristic, palmitic and oleic fatty acids compared to the control group without the drug administration. This contributed to a decrease in the activity of free radical oxidation in animals and increased adaptive abilities. However, the best adaptive qualities with an increase in the amount of corresponding fatty-acids were animals who were intramuscularly injected with UFP of silver at a dose of 0.01 mg/kg of body weight.