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تم اختيار هذا الكتاب الذي تم نشره بشكل إلكتروني على موقع مؤسسة Augment الفرنسية الأصل، والتي تعتبر من أكبر المؤسسات على مستوى العالم في إنتاج وتطبيق تكنولوجيا الواقع المعزز AUGMENTED REALITY ثلاثي الأبعاد، حيث احتوى الكتاب على تفاصيل كثيرة تقنية تخص أدوات التكنولوجيا وكيفية إنتاجها وأنواعها واستخداماتها وطرق توظيفها في مجالات العمل التجاري، وذلك كله هو أساس احتياجنا في العملية التعليمية لكيفية الإنتاج والتخطيط والبناء، وبالتالي فهو مدخل جيد لدراسة كيفية التوظيف لهذه التكنولوجيا المهمة في العملية التعليمية بكل أبعاده.

Converging lines of evidence suggest that microglia are relevant to Parkinson's disease pathogenesis, justifying exploration of therapeutic agents thought to attenuate pathogenic microglial function. We sought to test the safety and efficacy of NLY01—a brain-penetrant, pegylated, longer-lasting version of exenatide (a glucagon-like peptide-1 receptor agonist) that is believed to be anti-inflammatory via reduction of microglia activation—in Parkinson's disease. We report a 36-week, randomised, double-blind, placebo-controlled study of NLY01 in participants with early untreated Parkinson's disease conducted at 58 movement disorder clinics in the USA. Participants meeting UK Brain Bank or Movement Disorder Society research criteria for Parkinson's disease were randomly allocated (1:1:1) to one of two active treatment groups (2·5 mg or 5·0 mg NLY01) or matching placebo, based on a central computer-generated randomisation scheme using permuted block randomisation with varying block sizes. All participants, investigators, coordinators, study staff, and sponsor personnel were masked to treatment assignments throughout the study. The primary efficacy endpoint for the primary analysis population (defined as all randomly assigned participants who received at least one dose of study drug) was change from baseline to week 36 in the sum of Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts II and III. Safety was assessed in the safety population (all randomly allocated participants who received at least one dose of the study drug) with documentation of adverse events, vital signs, electrocardiograms, clinical laboratory assessments, physical examination, and scales for suicidality, sleepiness, impulsivity, and depression. This trial is complete and registered at ClinicalTrials.gov, NCT04154072. The study took place between Jan 28, 2020, and Feb 16, 2023. 447 individuals were screened, of whom 255 eligible participants were randomly assigned (85 to each study group). One patient assigned to placebo did not receive study treatment and was not included in the primary analysis. At 36 weeks, 2·5 mg and 5·0 mg NLY01 did not differ from placebo with respect to change in sum scores on MDS-UPDRS parts II and III: difference versus placebo –0·39 (95% CI –2·96 to 2·18; p=0·77) for 2·5 mg and 0·36 (–2·28 to 3·00; p=0·79) for 5·0 mg. Treatment-emergent adverse events were similar across groups (reported in 71 [84%] of 85 patients on 2·5 mg NLY01, 79 [93%] of 85 on 5·0 mg, and 73 [87%] of 84 on placebo), with gastrointestinal disorders the most commonly observed class in active groups (52 [61%] for 2·5 mg, 64 [75%] for 5·0 mg, and 30 [36%] for placebo) and nausea the most common event overall (33 [39%] for 2·5 mg, 49 [58%] for 5·0 mg, and 16 [19%] for placebo). No deaths occurred during the study. NLY01 at 2·5 and 5·0 mg was not associated with any improvement in Parkinson's disease motor or non-motor features compared with placebo. A subgroup analysis raised the possibility of motor benefit in younger participants. Further study is needed to determine whether these exploratory observations are replicable. D&D Pharmatech—Neuraly.

هذا الكتاب يقدم لك طريقة حياة حولتني أنا فليكس دنيس المؤلف من هيبي معدم يستجدي السيجارة ويتسول رغيف العيش إلى مليونير يجلس بمكتبه الفخم بإحدى أجمل بقاع العالم في جزر الكاريبي يطل من نافذته على أروع مناظر الدنيا ويلوك المحار المدخن ويحكي لك كيف أصبح أغنى ناشر مجلا بانجلترا وواحدا من أصحاب المشاريع عبر القارية إذا لم يكن هدفك الوحد هو الإثراء وإذا لم تمتلك إرادة حديدية لتحقيق هذا فلن يفيدك هذا الكتاب.ساخبركم بنجاحاتي وفشلي باسرار صناعتي لثروتي وباخطائي كي تتجنبوها في رحلة صعودكم.

The aim of this study was to design surfactants based on histidine (His) for hydrophobic ion-pairing and evaluate their safety and efficacy. Lauryl, palmitoyl and oleyl alcohol, as well as 2-hexyl-1-decanol were converted into surfactants with histidine as head-group via esterification. The synthesized His-surfactants were characterized regarding pK a , critical micellar concentration (CMC), biodegradability, toxicity on Caco-2 cells, and ability to provide endosomal escape. Furthermore, the suitability of these agents to be employed as counterions in hydrophobic ion pairing was evaluated. Chemical structures were confirmed by 1 H-NMR, FT-IR, and MS. The synthesized surfactants showed pK a values ranging from 4.9 to 6.0 and CMC values in the range of 0.3 to 7.0 mM. Their biodegradability was proven by enzymatic cleavage within 24 h. Below the CMC, His-surfactants did not show cytotoxic effects on Caco-2 cells (cell viability > 80%). All His-surfactants showed the ability to provide endosomal escape in a pH-dependent manner in the range of 5.2 to 6.8. Complexes formed between His-surfactants and heparin or plasmid DNA (pDNA) via hydrophobic ion pairing showed at least 100-fold higher lipophilicity than the correspondent model drugs. According to these results, His-surfactants might be a promising safe tool for delivering hydrophilic macromolecular drugs and nucleic acids. Graphical abstract

كتاب \"مقدمة لطرائق البحث في علم النفس\" واحدة من ثلاثة كتب صممت لمعالجة ثلاثة مداخل رئيسة في البحث السيكولوجي والتحليل كما تمارس في وقتنا الحاضر. ونحن لا نعتقد أنه بهذا القصد يمكن تناول طرائق البحث وتحليل البيانات بطريقة فرضية في مجلد واحد، على الرغم من أنك سوف تجد أمثلة لكتب جيدة تعتمد على هذه الصيغة في معظم المكتبات التي تبيع الكتب الجامعية ؛ فعلم النفس الحديث متنوع بدرجة كبيرة من حيث أشكال البحوث التي يستخدمها، والتعقد المنهجي والإحصائي الذي يتميز به في وقتنا الحاضر والذي كأن من الصعب تخيله منذ أعوام قليلة سابقة. ومما يسيء للطلبة تقديم تلك الأساسيات القليلة التي ربما كانت كافية فيما سبق.ولكن يتعذر أن تكون كافية الآن للوفاء باحتياجاتهم. ونحن نرى أن التقدم الكبير في علم النفس الحديث يعني أن مصادر التدريس ينبغي أن تحاول جاهدة التحديث المتواصل، ومواكبة الخبرات التربوية المتنوعة التي تقدمها الجامعات المختلفة. وكل مجلد من المجلدات الثلاث، وهي : مقدمة لطرائق البحث في علم النفس، ومقدمة الإحصاء في علم النفس، ومقدمة لحزمة البرامج الإحصائية (SPSS) في علم النفس، صممت بالأساس على شكل \"موديولات\". أي أننا لا نتوقع أن تتم معالجة محتوياتها جميعا بواسطة الأساتذة، ولكن، توجد قائمة تشتمل على فصول مستقلة بذاتها يمكن الاختيار منها اختيارا مناسبا.

The eradication of bacterial biofilms poses an enormous challenge owing to the inherently low antibiotic susceptibility of the resident microbiota. The complexation of antibiotics with polyphosphate can substantially improve antimicrobial performance. Nanoparticular complexes of the model drug colistin and polyphosphate (CP-NPs) were developed and characterized in terms of their particle size and morphology, polydispersity index (PDI), zeta potential, and cytotoxicity. Enzyme-triggered monophosphate and colistin release from the CP-NPs was evaluated in the presence of alkaline phosphatase (AP). Subsequently, antimicrobial efficacy was assessed by inhibition experiments on planktonic cultures, as well as time-kill assays on biofilms formed by the model organism . The CP-NPs exhibited a spherical morphology with particle sizes <200 nm, PDI <0.25, and negative zeta potential. They showed reduced cytotoxicity toward two human cell lines and significantly decreased hemotoxicity compared with native colistin. Release experiments with AP verified the enzymatic cleavage of polyphosphate and subsequent release of monophosphate and colistin from CP-NPs. Although CP-NPs were ineffective against planktonic cultures, they showed major activity against bacterial biofilms, outperforming native colistin treatment. Strongly elevated AP levels in the biofilm state were identified as a potential key factor for the observed findings. Accordingly, polyphosphate-based nanocomplexes represent a promising tool to tackle bacterial biofilm.

The words and photographs of people who have witnessed tsunamis, along with the science, history, and protection efforts surrounding this watery disaster.

In the past decade there have been significant changes in the operations of security and intelligence agencies throughout Europe. Those in the former Eastern Europe have undergone the most obvious changes in their targets and the legal context within which they operate, but these changes have affected all the agencies to some extent. It is these changes that will provide the context of structures and processes through which the agencies will respond to the September 11, 2001 attack on New York and Washington. This edited collection of papers by an international group of experts in the study of security and intelligence examines recent and current developments in the light of the rule of law and democracy and specifically addresses a number of common themes. Firstly, security and intelligence agencies are placed within the broader context of their parent state, including whether their powers originate in legislation or executive decree and the form of oversight. Secondly, the types of agency - civilian, military, foreign and domestic - are considered in the context of their historical development, including the transition from authoritarian to liberal state forms. Thirdly, the changes in their mandate and targets are discussed, in particular, towards 'terrorism', 'transnational organized crime' and economic intelligence. Finally, each author considers the enduring issue of how the impact of security and intelligence agencies is to be assessed in terms both of security and human rights. This book represents the first systematic attempt to present a collection of contemporary studies on the shifts in this crucial aspect of the operation of all states, and to do so within a framework of common themes. Although significant differences remain in the operation of security intelligence, all the authors highlight the common dilemmas that accompany the attempt to provide security but to do so democratically. Contents: Introduction, Jean-Paul Brodeur, Peter Gill and Dennis Töllborg. The Beloved Lands of Undercover: Democracy and secrecy: the French intelligence community, Jean-Paul Brodeur and Nicolas Dupeyron; Intelligence services in Belgium: a story of legitimation and legalization, Lode van Outrive. From Dictatorship to Democracy: The Spanish intelligence services, Andrea Giménez-Salinas; National security in Hungary, Istvan Szikinger; Security services in Poland and their oversight, Andrzej Rzeplinski. Security Intelligence in Stable Democracies: Security and intelligence structures in The Netherlands, Peter Klerks; Internal security in Sweden, Iain Cameron and Dennis Töllborg; The globalization of security and intelligence agencies: a report on the Canadian intelligence community, Jean-Paul Brodeur. Security Intelligence in Old and New ’Superpowers’: Security intelligence services in the United Kingdom, Peter Gill; Parliament, media and the control of intelligence services in Germany, Shlomo Shpiro. Conclusion: National security and political policing: some thoughts on values, ends and law, Laurence Lustgarten; Bibliography; Index. Jean-Paul Brodeur is Full Professor at the School of Criminology and a Researcher at the International Centre for Comparative Criminology, both at the University of Montréal, Canada. He was also President of the Canadian Association for the Study of Intelligence Security (CASIS) Peter Gill is a Reader in Politics and Security at the School of Social Science, Liverpool John Moores University, UK. He is currently Chair of the Security Intelligence Studies Group ( a working group of the UK Political Studies Association and the British International Studies Association). Dennis Töllborg is Professor of Legal Science at Gothenburg School of Law and Economics, University of Gothenburg, Sweden.

يعد هذا الكتاب منفردا ويتناول مدخلا يتعلق بالتحليل الإحصائي خطوة بخطوة باستخدام الحزمة SPSS مناسبة لبيئة النوافذ Windows وقابلة للتطبيق على الإصدارات من 10 إلى 21. وهي مناسبة للطلاب والباحثين الذين يودون تحليل البيانات السيكلوجية، والاجتماعية، والجنائية، والصحية، وما شابه ذلك. وتتغير الحزمة SPSS بتغير الزمن، ولكن هذا الكتاب سوف يكون مفيدا أيضا لأولئك الذين يستخدمون الإصدارات السابقة للحزمة SPSS، حيث إن هذه التغيرات التي تؤثر في هذا الكتاب يصعب بعامة ملاحظتها. وعلى الرغم من أن الإصدارات الستة السابقة لهذه الحزمة بها إحصاءات مبينة في عنوانها، والإصدارين 17، 18 أطلق عليها \"إحصاءات PASW\"، إلا أننا سوف نشير بعامة إلى جميع الإصدارات بالأحرف SPSS ما لم تحدثنا عن إصدارات معينة-وفي أي الحالات سوف نشير لهذه الإصدارات بأعداد. وهذا ما يفعله بعامة معظم المستخدمين. والإسم الرسمي للإصدار الأخير وقت إصدار هذا الكتاب هو IBM SPSS Statitistics، الإصدار 22 (الإصدار 22.0.0).وقد اهتم هذا الكتاب بتحديث إصداره الخامس \"مقدمة للحزمة الإحصائية SPSS في علم النفس\" بحيث يشمل التغيرات الحديثة في هذه الحزمة. وتقدم بنيته أسرع الطرق الممكنة للتحليل المحوسب للبيانات باستخدام الحزمة SPSS، حتى عند استخدام الأساليب الأكثر تطورا. وقد تم وصف كل أسلوب إحصائي بعناية، وخطوة بخطوة، باستخدام ومضات على شاشات تحليل بيانات SPSS ومخرجاتها. وقد وجه انتباه المستخدم إلى الشاشات مباشرة، وما تدل عليه كل منها، وسبب أهميتها. وبعبارة أخرى، اعتنى قدر المستطاع في الكتاب بالتعليم الفردي وجها لوجه.

This study examined frontal lobe subregions in 46 normal children and adolescents (25 females, mean age: 11.08, SD: 3.07; and 21 males, mean age: 10.76, SD: 2.61) to assess the effects of age and gender on volumetric measures as well as hemispheric asymmetries. Superior, middle, inferior, and orbito-frontal gray, white, and cerebrospinal (CSF) volumes were manually delineated in high-resolution magnetic resonance imaging (MRI) data to assess possible morphological changes. We report a significant age-related increase in the white matter of the left inferior frontal gyrus (IFG) in boys ( P = 0.007). Additionally, the left IFG was significantly larger in boys compared to girls ( P = 0.004). Boys showed increased gray matter volume relative to girls even after correcting for total cerebral volume. Also, boys were found to have significant Right > Left asymmetry patterns with greater right hemispheric volumes for total cerebral volume, total cerebral white matter, MFG white matter, and SFG white matter ( P < 0.001). Girls showed significant Right > Left asymmetry patterns in total cerebral and SFG white matter ( P < 0.001). These findings suggest continued modification of the IFG during normal development in boys, and significant gender differences in IFG gray matter between boys and girls that may be possibly linked to gender differences in speech development and lateralization of language.