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This paper reports a general overview of current research on analysis and control of the power grid with grid scale PV-based power generations as well as of various consequences of grid scale integration of PV generation units into the power systems. Moreover, the history of PV renewable growth, deregulation of power system and issues related to grid-connected PV systems considering its contribution to various responsibilities like frequency control, virtual inertia capabilities and voltage regulation are discussed. Moreover, various outcomes of the high-penetrated grid with PV power plants such as power quality, active and reactive power control, protection, balancing and reliability under various loading conditions are reviewed and discussed.

Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to supportive care and liver transplantation. Here we utilize the acetaminophen (APAP) and thioacetamide (TAA) ALF models in characterizing 56,527 single-cell transcriptomes to define the mouse ALF cellular atlas. We demonstrate that unique, previously uncharacterized stellate cell, endothelial cell, Kupffer cell, monocyte and neutrophil subsets, and their intricate intercellular crosstalk, drive ALF. We unravel a common MYC-dependent transcriptional program orchestrating stellate, endothelial and Kupffer cell activation during ALF, which is regulated by the gut microbiome through Toll-like receptor (TLR) signaling. Pharmacological inhibition of MYC, upstream TLR signaling checkpoints or microbiome depletion suppress this cell-specific, MYC-dependent program, thereby attenuating ALF. In humans, we demonstrate upregulated hepatic MYC expression in ALF transplant recipients compared to healthy donors. Collectively we demonstrate that detailed cellular/genetic decoding may enable pathway-specific ALF therapeutic intervention. A single-cell map of transcriptomic changes during acute liver failure unveils new insights into pathogenesis and potential therapeutic targets.

As new grid codes have been created to permit the integration of large scale photovoltaic power plants into the transmission system, the enhancement of the local control of the photovoltaic (PV) generators is necessary. Thus, the objective of this paper is to present a local controller of active and reactive power to comply the new requirements asked by the transmission system operators despite the variation of ambient conditions without using extra devices. For this purpose, the control considers the instantaneous capability curves of the PV generator which vary due to the change of solar irradiance, temperature, dc voltage and modulation index. To validate the control, the PV generator is modeled in DIgSILENT PowerFactory ® and tested under different ambient conditions. The results show that the control developed can modify the active and reactive power delivered to the desired value at different solar irradiance and temperature.

Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown. To determine whether proximal tubules and glomerular and tubular urinary space are enlarged in obese subjects with proteinuria and glomerular hyperfiltration. Kidney biopsies from 11 non-diabetic obese with proteinuria and 14 non-diabetic lean patients with a creatinine clearance above 50 ml/min and with mild or no interstitial fibrosis were retrospectively analyzed using morphometric methods. The cross-sectional area of the proximal tubular epithelium and lumen, the volume of the glomerular tuft and of Bowman's space and the nuclei number per tubular profile were estimated. Creatinine clearance was higher in the obese than in the lean group (P=0.03). Proteinuria was similarly increased in both groups. Compared to the lean group, the obese group displayed a 104% higher glomerular tuft volume (P=0.001), a 94% higher Bowman's space volume (P=0.003), a 33% higher cross-sectional area of the proximal tubular epithelium (P=0.02) and a 54% higher cross-sectional area of the proximal tubular lumen (P=0.01). The nuclei number per proximal tubular profile was similar in both groups, suggesting that the increase in tubular volume is due to hypertrophy and not to hyperplasia. Obesity-related glomerular hyperfiltration is associated with proximal tubular epithelial hypertrophy and increased glomerular and tubular urinary space volume in subjects with proteinuria. The expanded glomerular and urinary space is probably a direct consequence of glomerular hyperfiltration. These effects may be involved in the pathogenesis of obesity-related renal disease.

This paper reviews the current techniques used in energy management systems to optimize energy schedules into microgrids, accounting for uncertainties for various time frames (day-ahead and real-time operations). The current uncertainties affecting applications, including residential, commercial, virtual power plants, electric mobility, and multi-carrier microgrids, are the main subjects of this article. We outline the most recent modeling approaches to describe the uncertainties associated with various microgrid applications, such as prediction errors, load consumption, degradation, and state of health. The modeling approaches discussed in this article are probabilistic, possibilistic, information gap theory, and deterministic. Then, the paper presents and compares the current optimization techniques, considering the uncertainties in their problem formulations, such as stochastic, robust, fuzzy optimization, information gap theory, model predictive control, multiparametric programming, and machine learning techniques. The optimization techniques depend on the model used, the data available, the specific application, the real-time platform, and the optimization time. We hope to guide researchers to identify the best optimization technique for energy scheduling, considering the specific uncertainty and application. Finally, the most challenging issues to enhance microgrid operations, despite uncertainties by considering new trends, are discussed.

Cholangiopathies are poorly understood disorders with no effective therapy. The extrahepatic biliary tree phenotype is less studied compared to the intrahepatic biliary injury in both human disease and Mdr2 −/− mice, the established cholestatic mouse model. This study aimed to characterize the extra hepatic biliary tree of Mdr2 −/− mice at various ages and to determine if injury can be repaired with the antioxidant and glutathione precursor N -acetyl- L -Cysteine treatment (NAC). We characterized extra hepatic bile ducts (EHBD)s at various ages from 2 to 40 weeks old FVB/N and Mdr2 −/− mice. We examined the therapeutic potential of local NAC ex vivo using EHBD explants at early and late stages of injury; and systematic therapy by in vivo oral administration for 3 weeks. EHBD and liver sections were assessed by histology and immunofluorescent stains. Serum liver enzyme activities were analyzed, and liver spatial protein expression analysis was performed. Mdr2 −/− mice developed progressive EHBD injury, similar to extrahepatic PSC. NAC treatment of ex vivo EHBD explants led to improved duct morphology. In vivo, oral administration of NAC improved liver fibrosis, and decreased liver enzyme activities. Spatial protein analysis revealed cell-type specific differential response to NAC, collectively indicating a transition from pro-apoptotic into proliferative state. NAC treatment should be further investigated as a potential therapeutic option for human cholangiopathies.

The mitochondrial inner membrane possesses distinct subdomains including cristae, which are lamellar structures invaginated into the mitochondrial matrix and contain the respiratory complexes. Generation of inner membrane domains requires the complex interplay between the respiratory complexes, mitochondrial lipids and the recently identified mitochondrial contact site and cristae organizing system (MICOS) complex. Proper organization of the mitochondrial inner membrane has recently been shown to be important for respiratory function in yeast. Here we aimed at a molecular diagnosis in a brother and sister from a consanguineous family who presented with a neurodegenerative disorder accompanied by hyperlactatemia, 3-methylglutaconic aciduria, disturbed hepatocellular function with abnormal cristae morphology in liver and cerebellar and vermis atrophy, which suggest mitochondrial dysfunction. Using homozygosity mapping and exome sequencing the patients were found to be homozygous for the p.(Gly15Glufs*75) variant in the QIL1/MIC13 (C19orf70) gene. QIL1/MIC13 is a constituent of MICOS, a six subunit complex that helps to form and/or stabilize cristae junctions and determine the placement, distribution and number of cristae within mitochondria. In patient fibroblasts both MICOS subunits QIL1/MIC13 and MIC10 were absent whereas MIC60 was present in a comparable abundance to that of the control. We conclude that QIL1/MIC13 deficiency in human, is associated with disassembly of the MICOS complex, with the associated aberration of cristae morphology and mitochondrial respiratory dysfunction. 3-Methylglutaconic aciduria is associated with variants in genes encoding mitochondrial inner membrane organizing determinants, including TAZ, DNAJC19, SERAC1 and QIL1/MIC13.

MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that is involved in oncogenesis and shows remarkable tissue specificity. Their potential for tumor classification suggests they may be used in identifying the tissue in which cancers of unknown primary origin arose, a major clinical problem. We measured miRNA expression levels in 400 paraffin-embedded and fresh-frozen samples from 22 different tumor tissues and metastases. We used miRNA microarray data of 253 samples to construct a transparent classifier based on 48 miRNAs. Two-thirds of samples were classified with high confidence, with accuracy >90%. In an independent blinded test-set of 83 samples, overall high-confidence accuracy reached 89%. Classification accuracy reached 100% for most tissue classes, including 131 metastatic samples. We further validated the utility of the miRNA biomarkers by quantitative RT-PCR using 65 additional blinded test samples. Our findings demonstrate the effectiveness of miRNAs as biomarkers for tracing the tissue of origin of cancers of unknown primary origin.

As telecommunication networks become increasingly critical for societal functioning, ensuring their resilience in the face of energy disruptions is paramount. This review paper comprehensively analyzes strategies and challenges associated with achieving energy resilience in telecommunication networks. It explores various aspects, including policies, energy backup systems, renewable energy integration, and energy management techniques. This paper discusses how these strategies can be implemented to build resilience across three phases: preparedness (referring to the proactive measures taken in advance), response and relief, recovery and reconstruction. Additionally, it discusses the challenges associated with implementing energy resilience measures, taking into account policies, sustainability and environment, and climate change. By synthesizing existing research and identifying research gaps, this review paper aims to provide insights into the state-of-the-art practices and future directions for enhancing energy resilience in telecommunications, enabling robust and uninterrupted communication services.