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Protection of normal tissues against ionizing radiation-induced damages is a critical issue in clinical and environmental radiobiology. One of the ways of accomplishing radiation protection is through the use of radioprotectors. In the search for the most effective radioprotective agent, factors such as toxicity, effect on tumors, number of tissues protected, ease of administration, long-term stability, and compatibility with other drugs need to be assessed. Thus, in the present study, we systematically review existing studies on a chemical radioprotector, Ex-RAD, with the aim of examining its efficacy of radiation protection as well as underlying mechanisms. To this end, a systematic search of the electronic databases including Pubmed, Scopus, Embase, and Google Scholar was conducted to retrieve articles investigating the radioprotective effect of Ex-RAD. From an initial search of 268 articles, and after removal of duplicates as well as applying the predetermined inclusion and exclusion criteria, 10 articles were finally included for this systematic review. Findings from the reviewed studies indicated that Ex-RAD showed potentials for effective radioprotection of the studied organs with no side effect. Furthermore, the inhibition of apoptosis through p53 signaling pathway was the main mechanism of radioprotection by Ex-RAD. However, its radioprotective effect would need to be investigated for more organs in future studies.

Aim Despite remarkable theoretical evidence of positive outcomes of patient and family‐centred care, it is rarely performed in the intensive care setting. The aim of this review was to assess the barriers to patient and family‐centred care among healthcare providers, patients and family members in adult intensive care units. Design A systematic review of both qualitative and quantitative studies. Methods The search strategy sought for published peer‐reviewed research papers limited to English language from conception to 2018. The review protocol was registered in the CRD Prospero database (CRD42018086838). Literature search was carried out in four databases: EMBASE, Cochrane Library, PubMed and Scopus where keywords “barriers,” “patient and family centered care,” “patient‐centered care” and “intensive care unit” appeared in any part of the reference. Hand search of reference lists of identified papers was also done to capture all pertinent materials. Each study was assessed by three independent reviewers against the inclusion criteria. Evidence was graded according to sampling quality, quantity and measurement of intended outcomes. Screening of studies and citations resulted in seven studies that were included in the analysis. Results Barriers to patient and family‐centred care broadly fall under four categories; lack of understanding of what is needed to achieve patient and family‐centred care, organizational barriers, individual barriers and interdisciplinary barriers.

Objective: The objective of this study was to evaluate the thyroid glands' radiation dose and the risk of thyroid cancer induction from head or neck computed tomography (CT) examinations. Methods: In a prospective study, we evaluated all participants of all ages and sex referred for Head or Neck CT Scan at the University College Hospital, Ibadan and Me Cure Healthcare Limited, Ibadan, Oyo State, Nigeria. Thyroid radiation dose was estimated with impact scan calculator, and real-time dose measurement with thermoluminescent badge dosimeters (TLDs). Data were analysed and P < 0.05 was considered statistically significant. Results: One hundred and sixty-three participants (128 adults and 35 children) participated in the study. In most participants (74%), the tube voltage was 120 kVp. The estimated median thyroid gland dose by the imPACT scan calculator was 4.95 mGy (range = 1.20-30.0 mGy) and 4.40 mGy (range = 3.0-5.10 mGy), while the real-time dose measured by the TLD was 4.79 mGy (range = 1.73-96.7 mGy) and 2.33 mGy (range = 1.20-3.73 mGy) at Centre A and B, respectively. The estimated median thyroid cancer risk was 2.88 × 10−6 (maximum range of 52 × 10−6) at centre A and a median value of 3.20 × 10−6 with a cancer risk estimate that may reach 17.9 × 10−6 recorded at centre B, compared to a cumulative thyroid cancer risk of 0.12 × 10−5 among the general Nigerian population. Conclusions: Scanner specifications and technique may significantly contribute to variations seen in thyroid radiation doses. There may be a need to optimise centre protocols and apply dose reference levels for head and neck CT examinations to reduce thyroid cancer risk in Nigeria.

Our purpose was to evaluate the application of volumetric histogram parameters obtained from conventional MRI and apparent diffusion coefficient (ADC) images for grading the meningioma tumors. Tumor volumetric histograms of preoperative MRI images from 45 patients with the diagnosis of meningioma at different grades were analyzed to find the histogram parameters. Kruskal-Wallis statistical test was used for comparison between the parameters obtained from different grades. Multi-parametric regression analysis was used to find the model and parameters with high predictive value for the classification of meningioma. Mode; standard deviation on post-contrast T1WI, T2-FLAIR, and ADC images; kurtosis on post-contrast T1WI and T2-FLAIR images; mean and several percentile values on ADC; and post-contrast T1WI images showed significant differences among different tumor grades (P < 0.05). The multi-parametric linear regression showed that the ADC histogram parameters model had a higher predictive value, with cutoff values of 0.212 (sensitivity = 79.6%, specificity = 84.3%) and 0.180 (sensitivity = 70.9%, specificity = 80.8%) for differentiating the grade I from II, and grade II from III, respectively. The multi-parametric model of volumetric histogram parameters in some of the conventional MRI series (i.e., post-contrast T1WI and T2-FLAIR images) along with the ADC images are appropriate for predicting the meningioma tumors' grade.

Background: The benefits of adherence to optimal infant and young child feeding (IYCF) to both the mothers and their infants below two years are well documented. However, compliance to optimal IYCF practices has been noted to vary in different settings. This study sought to establish factors influencing mothers' adherence to optimal infant and young child feeding practices for babies below two years in Mpigi town council- Mpigi District. Methods: The study was a cross-sectional study carried out among 264 mothers of babies between six months to two years of age attending postnatal care units of health facilities in Mpigi town council, Uganda: Mpigi Health Center (HC) IV and Kyaali HC III. Purposive sampling method was used to select the health centers while simple random sampling was then used to select the sample from the selected centers. A self-administered questionnaire was used to collect data. Data entry and analysis was performed using SPSS version 16. Results: 264 participants were invited to participate in the study, 100% of these fully completed the survey. The majority of the mothers were aged 20 to 34 years (80.3%). After scoring each participant using the four characteristics which included: initiation of breastfeeding within the first hour following birth, exclusive breastfeeding up to 6 months followed by continued breastfeeding with appropriate complementary foods upto 2 years and beyond, the majority of the participants were adherent (79.6%) to IYCF practices while 20.4% were non adherent to IYCF practices. Conclusion: A good estimate of adherence to optimal IYCF practices was revealed in this study. Sustaining well-established policies to support IYCF programmes is recommended to maintain optimal IYCF practices.