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Objectives The coronavirus disease (COVID‐19) pandemic has forced many employees to alter both their work style and lifestyle. This study aimed to examine how the combination of changes in overtime working hours and social interaction affects the full‐time employees’ mental well‐being, focusing on the difference in household composition. Methods In November 2020, we conducted a cross‐sectional Internet survey that included 4388 Japanese men and women aged 25–64 years, who continued the same full‐time job during the pandemic. We performed a logistic regression analysis using a combination of the changes in overtime working hours and social interaction as an independent variable, and the presence/absence of deterioration of mental well‐being as the dependent variable. Results Overall, 44% of participants reported the deterioration of mental well‐being compared to before the outbreak. The multivariate analysis revealed that the participants coded as “increased overtime/decreased interaction” were significantly associated with the deterioration of mental well‐being compared to those with “unchanged overtime/unchanged interaction” (odds ratio [OR] 2.14, 95% confidence interval [CI] 1.59–2.89). Moreover, this association was relatively stronger among single‐person households (OR 2.66, 95% CI 1.50–4.69). Conclusions The negative combination of increasing overtime working hours and decreasing social interaction may have an impact on the deterioration of mental well‐being during the COVID‐19 pandemic, and this association was comparably strong among single‐person households. In the pandemic, it is necessary to pay close attention to both overtime working hours and the presence of social interaction to address the mental well‐being among employees.

Human papillomavirus (HPV) infection remains a principal cause of cervical cancer worldwide. Although large-scale vaccination efforts have substantially lowered HPV infection rates and precancerous lesions, not all regions have achieved high coverage. In Japan, proactive HPV vaccine recommendations were suspended from 2013 to 2022 due to concerns over alleged adverse events, causing vaccination rates to drop from over 70% to below 1%. This narrative review synthesized research published from 2014 to 2025 in PubMed, Cochrane Library, and Google Scholar, focusing on English-language studies. Inclusion criteria encompassed analyses of HPV vaccine efficacy or safety, policies related to vaccination in Japan or other countries, and investigations into vaccine hesitancy or media influences. Data were categorized into five thematic areas: historical and policy contexts, evidence of vaccine safety and efficacy, societal drivers of hesitancy, communication strategies, and administrative or clinical interventions. Evidence robustly confirms the HPV vaccine’s favorable safety profile, with severe adverse events appearing exceedingly rare. Nonetheless, media sensationalism and limited risk communication in Japan perpetuated mistrust, impeding vaccination uptake. Comparisons with Denmark and Ireland indicate that transparent, interactive risk communication can restore coverage to near-pre-suspension levels. Japan’s recent policy reforms, including reinstating proactive recommendations and catch-up initiatives, have begun to reverse vaccination hesitancy. Sustained policy support, evidence-based messaging, and empathetic engagement with communities are central to rebuilding trust in the HPV vaccine. Lessons from best international practices emphasize the importance of multifaceted interventions, collaborative stakeholder engagement, and transparent risk communication to reduce the burden of HPV-related malignancies.