Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
68
result(s) for
"Toyoshima, Hideki"
Sort by:
Assessment of dental arch stability after orthodontic treatment and oral rehabilitation in complete unilateral cleft lip and palate and non-clefts patients using 3D stereophotogrammetry
Background
Although arch stability has been studied in patients without a cleft, evidence for patients with a cleft is sparse. Therefore, we compared the dimensions and stability of dental arches in cleft lip and palate patients and those without a cleft.
Methods
Forty participants, 20 with a complete unilateral cleft lip and palate and 20 non-cleft patients aged from 18 to 30 years, with anterior and/or posterior crossbite and receiving orthodontic treatment were evaluated retrospectively. Eighty gypsum casts were digitized using a laser model scanner casts for both groups made immediately after the orthodontic treatment was completed (T1). Also, for the Cleft Lip and Palate group, casts were obtained and digitized 1 year after implant-supported rehabilitation (T2) and for the Non-Cleft Lip and Palate group, 1 year after the conclusion of the orthodontic treatment (T2). The formula: Δ = T2-T1 evaluated the stability of dental arches for inter-canine distances (C-C′), inter-molar distances (M-M’), arch length (I-M), palate surface and volume. The dimensions of the dental arches were measured digitally. The independent
t
test was used for statistical analysis (α = 0.05).
Results
A statistical difference was found in the stability of the groups for inter-canine (cleft area) measurement. At the times T1 and T2, a statistically significant difference was found in the arch length, surface and volume.
Conclusions
This study concluded that in the Cleft Lip and Palate group, the maxillary dimensions were not stabilized after 1 year of orthodontic and prosthodontic treatment (mainly for the inter-canine linear measurement) and that the transverse arch dimensions were smaller compared with those of non-cleft patients.
Journal Article
Satellite-to-ground quantum-limited communication using a 50-kg-class microsatellite
The recent rapid growth of satellite-constellation programmes for remote sensing and communications, enabled by the availability of small-sized and low-cost satellites, has provided impetus for the development of high-capacity laser communication (lasercom) in space. Quantum-limited communication can enhance the performance of lasercom and is also a prerequisite for the intrinsically hack-proof secure communication known as quantum key distribution. Here, we report a quantum-limited communication experiment between a microsatellite (48 kg, 50 cm cube) in low Earth orbit and a ground station. Non-orthogonal polarization states were transmitted from the satellite at a 10 MHz repetition rate. On the ground, by post-processing the received quantum states with ∼0.146 photons per pulse, clock data recovery and polarization reference-frame synchronization were successfully achieved, even under remarkable Doppler shifts. The quantum states were discriminated by a receiver with four photon counters, with a quantum bit error rate below 5%, validating the applicability of our technology to satellite-to-ground lasercom and quantum key distribution.
The feasibility of satellite-to-ground quantum communication is demonstrated by using a microsatellite in low-Earth orbit. The quantum states are discriminated by a ground receiver with four photon-counters with a quantum bit error rate below 5%.
Journal Article
Interleukin‐6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy
Overcoming the immunosuppressive state in tumor microenvironments is a critical issue for improving the efficacy of cancer immunotherapy. Interleukin (IL)‐6, a pleiotropic cytokine, is highly produced in the tumor‐bearing host. Previous studies have indicated that IL‐6 suppresses the antigen presentation ability of dendritic cells (DC) through activation of signal transducer and activator of transcription 3 (STAT3). Thus, we focused on the precise effect of the IL‐6/STAT3 signaling cascade on human DC and the subsequent induction of antitumor T cell immune responses. Tumor‐infiltrating CD11b+CD11c+ cells isolated from colorectal cancer tissues showed strong induction of the IL‐6 gene, downregulated surface expression of human leukocyte antigen (HLA)‐DR, and an attenuated T cell‐stimulating ability compared with those from peripheral blood mononuclear cells, suggesting that the tumor microenvironment suppresses antitumor effector cells. In vitro experiments revealed that IL‐6‐mediated STAT3 activation reduced surface expression of HLA‐DR on CD14+ monocyte‐derived DC. Moreover, we confirmed that cyclooxygenase 2, lysosome protease and arginase activities were involved in the IL‐6‐mediated downregulation of the surface expression levels of HLA class II on human DC. These findings suggest that IL‐6‐mediated STAT3 activation in the tumor microenvironment inhibits functional maturation of DC to activate effector T cells, blocking introduction of antitumor immunity in cancers. Therefore, we propose in this review that blockade of the IL‐6/STAT3 signaling pathway and target molecules in DC may be a promising strategy to improve the efficacy of immunotherapies for cancer patients.
Journal Article
Lack of interleukin‐6 in the tumor microenvironment augments type‐1 immunity and increases the efficacy of cancer immunotherapy
Conquering immunosuppression in tumor microenvironments is crucial for effective cancer immunotherapy. It is well known that interleukin (IL)‐6, a pleiotropic cytokine, is produced in the tumor‐bearing state. In the present study, we investigated the precise effects of IL‐6 on antitumor immunity and the subsequent tumorigenesis in tumor‐bearing hosts. CT26 cells, a murine colon cancer cell line, were intradermally injected into wild‐type and IL‐6‐deficient mice. As a result, we found that tumor growth was decreased significantly in IL‐6‐deficient mice compared with wild‐type mice and the reduction was abrogated by depletion of CD8+ T cells. We further evaluated the immune status of tumor microenvironments and confirmed that mature dendritic cells, helper T cells and cytotoxic T cells were highly accumulated in tumor sites under the IL‐6‐deficient condition. In addition, higher numbers of interferon (IFN)‐γ‐producing T cells were present in the tumor tissues of IL‐6‐deficient mice compared with wild‐type mice. Surface expression levels of programmed death‐ligand 1 (PD‐L1) and MHC class I on CT26 cells were enhanced under the IL‐6‐deficient condition in vivo and by IFN‐γ stimulation in vitro. Finally, we confirmed that in vivo injection of an anti‐PD‐L1 antibody or a Toll‐like receptor 3 ligand, polyinosinic‐polycytidylic acid, effectively inhibited tumorigenesis under the IL‐6‐deficient condition. Based on these findings, we speculate that a lack of IL‐6 produced in tumor‐bearing host augments induction of antitumor effector T cells and inhibits tumorigenesis in vivo, suggesting that IL‐6 signaling may be a promising target for the development of effective cancer immunotherapies. IL‐6 produced in the tumor hosts suppresses antitumor immunity involving the activation of effector T cells and dendritic cells. Lack of IL‐6 facilitates cancer immunotherapies using immune checkpoint inhibitors and immunological adjuvants.
Journal Article
Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer
BackgroundLipids have immunomodulatory functions and the potential to affect cancer immunity.MethodsThe associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated in 148 patients with non-small cell lung cancer who received nivolumab.ResultsWhen each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol (P < 0.001), high-density lipoprotein (HDL)-cholesterol (P = 0.014), total cholesterol (P = 0.007), lauric acid (P = 0.015), myristic acid (P = 0.022), myristoleic acid (P = 0.035), stearic acid (P = 0.028), linoleic acid (P = 0.005), arachidic acid (P = 0.027), eicosadienoic acid (P = 0.017), dihomo-γ-linolenic acid (P = 0.036), and behenic acid levels (P = 0.032) were associated with longer PFS independent of programmed death ligand 1 (PD-L1) expression. Meanwhile, increased LDL-cholesterol (P < 0.001), HDL-cholesterol (P = 0.009), total cholesterol (P = 0.036), linoleic acid (P = 0.014), and lignoceric acid levels (P = 0.028) were associated with longer OS independent of PD-L1 expression. When multiple lipids were evaluated simultaneously, LDL-cholesterol (P = 0.003), HDL-cholesterol (P = 0.036), and lauric acid (P = 0.036) were independently predictive of PFS, and LDL-cholesterol (P = 0.008) and HDL-cholesterol (P = 0.031) were predictive of OS. ORR was not associated with any serum lipid.ConclusionsBased on the association of prolonged survival in patients with increased serum cholesterol and long-chain fatty acid levels, serum lipid levels may be useful for predicting the efficacy of immune checkpoint inhibitor therapy.
Journal Article
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
Nakajo-Nishimura syndrome (NNS) is a disorder that segregates in an autosomal recessive fashion. Symptoms include periodic fever, skin rash, partial lipomuscular atrophy, and joint contracture. Here, we report a mutation in the human proteasome subunit beta type 8 gene (PSMB8) that encodes the immunoproteasome subunit β5i in patients with NNS. This G201V mutation disrupts the β-sheet structure, protrudes from the loop that interfaces with the β4 subunit, and is in close proximity to the catalytic threonine residue. The β5i mutant is not efficiently incorporated during immunoproteasome biogenesis, resulting in reduced proteasome activity and accumulation of ubiquitinated and oxidized proteins within cells expressing immunoproteasomes. As a result, the level of interleukin (IL)-6 and IFN-γ inducible protein (IP)-10 in patient sera is markedly increased. Nuclear phosphorylated p38 and the secretion of IL-6 are increased in patient cells both in vitro and in vivo, which may account for the inflammatory response and periodic fever observed in these patients. These results show that a mutation within a proteasome subunit is the direct cause of a human disease and suggest that decreased proteasome activity can cause inflammation.
Journal Article
Statistical verifications and deep-learning predictions for satellite-to-ground quantum atmospheric channels
Laser communications from small satellite platforms empowers the establishment of quantum key distribution (QKD), relying on quantum superposition states of single photons to realize unconditional security between distant parties at a global scale. Although recent breakthrough experiments have demonstrated the feasibility of satellite-to-ground QKD links, the underlying statistical characteristics of quantum atmospheric channels have not been well-understood and experimentally verified in the literature. In this paper, we highlight that classical atmospheric statistical models can be applied for describing random fluctuations of the quantum channels. To verify this fact, we report a statistical verification study of quantum atmospheric channels from the world’s first low-Earth orbit (LEO) 50-kg-class microsatellite-to-ground quantum-limited communication experiment. The verified statistical model is then applied to numerically investigate the quantum bit-error rate (QBER) and secret-key length (SKL) of a decoy-state efficient Bennett-Brassard 1984 (BB84) QKD protocol with optimized parameters considering finite-key effects, implemented over a LEO 6-unit (6U)-CubeSat-to-ground link. Important insights of the physical channel effects including pointing errors and atmospheric turbulence on the QBER and SKL are then revealed. Finally, we present a study using a deep-learning-based long short-term memory (LSTM) recurrent neural network (RNN) for predicting photon-count fluctuations over quantum atmospheric channels.
This study confirms that a classical channel model can be used for describing random fluctuations in LEO-to-ground quantum atmospheric channels. It shows that practical engineering designs for future QKD missions can be conveniently conducted using the verified channel model, and that deep learning can predict channel fluctuations.
Journal Article
Serum interferon-λ3 as a short-term biomarker of disease control in anti-MDA5-positive dermatomyositis-associated ILD
This study aimed to assess the clinical utility of serum interferon-lambda 3 (IFN-λ3) as a sequential biomarker for treatment response and disease control in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD). Serum IFN-λ3 levels were measured in 24 patients with anti-MDA5 antibody-positive DM-ILD at diagnosis and 1 month after initiating immunosuppressive therapy. Patients were categorized into two groups based on clinical outcomes: a good control group (
n
= 16; survived without relapse for ≥ 1 year) and a poor control group (
n
= 8; died from ILD progression or relapse within 1 year). Changes in serum IFN-λ3 levels and differences between groups were analyzed. In the good control group, serum IFN-λ3 levels significantly decreased from 94.6 to 12.7 pg/mL (
p
< 0.001), whereas no significant change was observed in the poor control group (129.0 to 118.8 pg/mL). Furthermore, serum IFN-λ3 levels at 1 month were significantly lower in the good control group than in the poor control group (
p
= 0.004). Serum IFN-λ3 levels may reflect short-term treatment response and could serve as a useful sequential biomarker for assessing disease control in patients with anti-MDA5 antibody-positive DM-ILD.
Journal Article
Retroperitoneal leakage causing ultrafiltration failure during continuous ambulatory peritoneal dialysis: a case report and literature review
Background
Peritoneal dialysis (PD) is associated with various complications, and the leakage of dialysate can lead to the discontinuation of PD. Retroperitoneal leakage (RPL) can be diagnosed on the basis of dialysate leakage, and, because there are few reports of this complication, clinicians often have an incomplete understanding of its diagnosis, causes, and treatment options.
Case presentation
A 59-year-old man who underwent continuous ambulatory peritoneal dialysis (CAPD) 1 year prior to admission was referred to our department owing to right-sided abdominal swelling and persistent ultrafiltration failure (UFF). No abnormalities were observed at the catheter exit or tunnel site. Plain abdominal computed tomography (CT) revealed that the catheter was not malpositioned and that fluid had accumulated in the right retroperitoneal space, causing edema in the abdominal wall. If UFF persists, CAPD must be discontinued and patients must be hospitalized. Subsequently, computed tomographic peritoneography (CTP) following the instillation of 2 L of dialysate with contrast agent revealed clear progression of the contrast agent into the right retroperitoneal space, confirming RPL owing to retroperitoneal injury at the dorsal aspect of the ascending colon.
Conclusions
As a rare complication of PD, RPL causes few local symptoms and is therefore often unrecognized, resulting in UFF. Thus, CTP is useful for diagnosing RPL in the presence of dialysate leakage. However, if we were fully educated on RPL, we could have diagnosed it when plain CT scans were performed.
Journal Article