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IntroductionImplementation of low-intensity, evidence-based psychological interventions can help meet the mental health and psychosocial needs of people with cancer, especially in low-resource settings where there is a dearth of mental health specialists. In this study, we will conduct a feasibility randomised controlled trial (RCT) of the stress management intervention Self-Help Plus, which has been translated and adapted to Vietnamese, vSH+, among people newly diagnosed with breast or gynaecological cancer in Viet Nam.Methods and analysisAt six participating hospitals, individuals diagnosed with breast or gynaecologic cancer within the past year will be recruited, consented and randomised into either enhanced usual care (EUC) or EUC plus the vSH+ intervention, which consists of four sessions each lasting approximately 75 min. Quantitative surveys will be administered at three time points: enrolment/baseline (T0), after 6 weeks (T1) and after 4 months (T2). A qualitative evaluation component, which will include in-depth interviews with patients, implementers and healthcare staff and managers, as well as focus group discussions with caregivers, will assess the acceptability and feasibility of the vSH+ intervention.Ethics and disseminationEthical reviews for the study were obtained from Boston University, Hanoi University of Public Health (HUPH) and all the participating hospital sites. On completion of data collection and analyses, the research team will prepare and submit abstracts to scientific conferences as well as manuscripts to peer-reviewed journals. We will also conduct dissemination events to report the trial results to relevant stakeholders.Trial registration numberNCT06398067.

Background This study evaluates the effectiveness of a training program on mental health literacy (MHL) outcomes among participating nurses. Method A mixed method approach was used. Quantitative data were collected with pre- and posttraining MHL assessment surveys. Qualitative data were gathered through semistructured interviews to evaluate the acceptability of the training program. Results A total of 144 nurses participated in the training and completed training assessments. The global MHL score showed a significant increase, rising from 113.3 (SD = 9.8) to 117.1 (SD = 11.9) after the workshop. Conclusion The training program made measurable strides in enhancing certain aspects of MHL among oncology nurses, yet it fell short in addressing some domains for effective mental health care. To fully empower nurses, future iterations of the program must prioritize practical skill-building, targeted learning in underperforming domains, and a more interactive, flexible training approach. [J Contin Educ Nurs. 2025;56(7):283–292.]

Background Vietnam is one of the most rapidly aging countries in the world and the likelihood that someone may have dementia rises dramatically as the population ages. Although caring for persons living with dementia is important, little is known about the circumstances under which community healthcare professionals in Vietnam provide dementia care. This study aimed to describe the practice of caring for persons with dementia among community healthcare professionals in Vietnam. Methods This qualitative descriptive study was conducted with 23 community healthcare professionals recruited from 10 primary healthcare centers, representing 10 of 24 districts in Ho Chi Minh City, Vietnam. Participants were physicians ( n  = 11), physician’s assistants ( n  = 8) and community nurses ( n  = 4). Data were collected through in-depth face-to-face semi-structured interviews. Interview data were audio recorded, transcribed verbatim, and analyzed using content analysis. Results The mean age of the 23 participants was 44.6 ± 8.8 years; most were female ( n  = 16, 69.6%); and the mean time of working in the field of dementia care was 15.9 ± 8.4 years. Analysis of the interview data revealed five categories, which informed how care was provided: 1) Knowledge about dementia and its prevalence among older adults; 2) Identification of dementia in Vietnam; 3) Lack of attention to early diagnosis of dementia and difficulty in providing continuous care; 4) Dependence on family members for prompt and continuous care; and 5) challenges to providing dementia care. Despite having knowledge about dementia, some healthcare professionals incorrectly viewed dementia as an inevitable part of the ageing process. Participants reported that their limited training and practical experience in caring for persons with dementia caused a lack of confidence in dementia care. Conclusions The quality of care provided to persons living with dementia was negatively impacted by the limited training of healthcare personnel. The diagnosis, treatment, and provision of supportive services to persons living with dementia and their families are substantial challenges for the Vietnamese healthcare system. It is crucial to initiate and cultivate dementia care education programs aimed at expanding curricula for physicians, physicians’ assistants, and nurses.

Background Web-based interventions have been acknowledged as a valuable resource in managing caregiving duties, enhancing coping abilities, and improving quality of life (QoL), thereby alleviating burden and mitigating stress. The aim of this study is to examine the effectiveness of a web-based education program on the knowledge, coping strategies, burden, and QoL of caregivers of patients with colorectal cancer. Method A quasi-experimental design was conducted in two randomly selected hospitals. The experimental and control groups consisted of 62 and 65 participants, respectively. The experimental group underwent a web-based education program (WBEP) for 12 weeks and received regular care, and the control group received only regular care. Data were gathered at four intervals: baseline and then 3, 6, and 12 weeks from baseline. Generalized estimating equations were used to understand the effectiveness of the treatment. Results Compared to the mean scores in the control group, those in the experimental group for dysfunctional coping significantly decreased at 6 (14.96 ± 6.57) and 12 weeks (13.92 ± 6.46); emotion-focused coping also significantly declined at 3 (20.52 ± 7.54), 6 (17.25 ± 8.91), and 12 weeks (15.91 ± 8.69); and burden scores were significantly lower at 12 weeks (16.01 ± 10.63). Conclusions The WBEP demonstrated a positive effect on the experimental group in decreasing the use of emotion-focused coping, dysfunctional coping, and burden of care for caregivers but not on knowledge and QoL. The results indicate that healthcare professionals should recognize that a WBEP is an effective method by which medical professionals can engage with and provide support to the caregivers of cancer patients.

Objective There is no single study that has examined nursing research priorities in Vietnam. This study aimed to gain consensus from experts on the nursing research priorities in Vietnam. Methods A three-round modified Delphi study was used in this study. A focus group discussion among experts was conducted in round I to identify the nursing research priorities (n=23). Data in round I were analyzed using content analysis. In round II, participants were invited to rate the importance of each nursing priority topic in a 5-point Likert scale questionnaire, which had a 74% (n=17) response rate. In round III, the questionnaire was returned to the experts (n=17) until consensus was reached. Data from round II and round III were analyzed to produce mean score and final rank. Results The top 12 research priority lists were identified, which included subthemes and areas of possible investigations. All priorities were classified into three groups in the rank order, namely: (i) nursing management and leadership, which included (1) nursing care quality, (2) management and leadership of nurse managers, (3) nursing image, (4) professional nurse competency, and (5) human resource management; (ii) nursing education, which included (1) knowledge-specific domain, (2) the linkage between education and practice, and (3) nurse teacher workforce; and (iii) nursing service, which included (1) adult nursing concern, (2) patient safety, (3) public health nursing concern, and (4) quality of life of patients and nurses. Conclusions Consensus among experts was achiever, and the findings are considered as the basis of resources to the most essential research needs in Vietnam.

Metabolic syndrome is more prevalent in women than in men in Vietnam, although data among women of reproductive age remain limited. A cross-sectional study was conducted in Bac Giang Province, Vietnam, in 2019 to estimate the prevalence of metabolic syndrome and its components, and to determine associations with sociodemographic and health factors in 194 overweight and obese women aged 20–45 years. Anthropometric indicators, plasma glucose and lipid concentrations, blood pressure, sociodemographic characteristics, medical status, medication/supplement use, and energy intake were measured. The prevalence of metabolic syndrome was 47.4% (95% CI: 40.5, 54.5%). Metabolic syndrome was significantly associated with obesity (OR: 4.14; 95% CI: 1.45, 11.85), and hypertension (OR: 25.40; 95% CI: 3.18, 202.89). Dyslipidemia, high plasma glucose concentrations, and hypertension were common. High parity was associated with higher plasma glucose and lower total cholesterol concentrations. Unemployment and higher plasma triglyceride concentrations were associated with higher total cholesterol concentrations. Increased systolic blood pressure and medical status were associated with higher triglyceride concentrations. Obesity was associated with high plasma glucose. These findings highlight the need for targeted interventions, including lifestyle modifications, routine clinical screening, and socioeconomic support for vulnerable groups, to prevent and manage metabolic syndrome in overweight and obese women of reproductive age.

Background Non-invasive multi-cancer early detection (MCED) tests have shown promise in enhancing early cancer detection. However, their clinical utility across diverse populations remains underexplored, limiting their routine implementation. This study aims to validate the clinical utility of a multimodal non-invasive circulating tumor DNA (ctDNA)-based MCED test, SPOT-MAS (Screening for the Presence Of Tumor by DNA Methylation And Size). Methods We conducted a multicenter prospective study, K-DETEK (ClinicalTrials.gov identifier: NCT05227261), involving 9057 asymptomatic individuals aged 40 years or older across 75 major hospitals and one research institute in Vietnam. Participants were followed for 12 months. Results Of the 9024 eligible participants, 43 (0.48%) tested positive for ctDNA. Among these, 17 were confirmed with malignant lesions in various primary organs through standard-of-care (SOC) imaging and biopsy, with 9 cases matching our tissue of origin (TOO) predictions. This resulted in a positive predictive value of 39.53% (95%CI 26.37–54.42) and a TOO accuracy of 52.94% (95%CI 30.96–73.83). Among the 8981 participants (99.52%) who tested negative, 8974 were confirmed cancer-free during a 12-month period after testing, yielding a negative predictive value of 99.92% (95% CI 99.84–99.96). The test demonstrated an overall sensitivity of 70.83% (95%CI 50.83–85.09) and a specificity of 99.71% (95% CI 99.58–99.80) for detecting various cancer types, including those without SOC screening options. Conclusions This study presents a prospective validation of a multi-cancer early detection (MCED) test conducted in a lower middle-income country, demonstrating the potential of SPOT-MAS for early cancer detection. Our findings indicate that MCED tests could be valuable additions to national cancer screening programs, particularly in regions where such initiatives are currently limited. Trial registration ClinicalTrials.gov ID: NCT05227261. Date of registration: 07/02/2022.

Eight polythiophene derivatives containing pyrazoline side groups were synthesized by a chemical oxidative coupling polymerization using FeCl 3 . The crystal structures of four monomers were determined which confirm the almost perpendicular orientation of the thiophene and pyrazoline rings, while the other substituents are more coplanar. Analyses of IR, 1 H-NMR, Raman and UV-Vis spectra demonstrated that the suggested polymerization was successful to generate the synthesized polythiophenes with the expected structures. The morphology of the synthesized polythiophenes was studied by SEM. The different substituents attached to the 1- and 3-positions of the pyrazoline side chain led to differences in optical properties, electrical conductivity, and thermal stability of the synthesized polythiophenes. By adding a pyrazoline side chain to polythiophenes, some polymers achieve good solubility, electrical conductivity of about 1.3 × 10 -6 S/cm, high fluorescence intensity (above 40,000 a.u.) at 505-550 nm and thermal stability up to 590°C in the air.

Time-restricted eating (TRE) is a promising and cost-effective dietary approach for weight management. This study aimed to evaluate the effects of TRE on weight loss in three adult populations using pre- and post-intervention analyses while also investigating its underlying mechanism. A systematic search was conducted across four databases (PubMed, Web of Science, Scopus, and the CENTRAL) up until January 28, 2024, specifically focusing on prospective studies that examined the efficacy of TRE in achieving weight loss. A random effects model was employed to conduct meta-analyses, while heterogeneity was assessed using the I 2 statistic (PROSPERO: CRD42023439317). The study encompassed 36 selected studies involving 44 effect sizes and 914 participants. The effectiveness of the TRE was found to vary across health conditions, with modest weight loss observed in healthy individuals (pooled effect size -1.04 Kg, 95% CI: -1.42 to -0.65) and more significant weight reduction seen in participants with chronic diseases (pooled effect size -3.33 Kg, 95% CI: -5.05 to -1.62) and overweight/obesity (pooled effect size -4.21 Kg, 95% CI: -5.23 to -3.10). The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. These findings support the efficacy of this lifestyle intervention for weight loss maintenance and guide the development of its clinical guidelines.

Introduction Monitoring the population‐level emergence and transmission of HIV drug resistance (HIVDR) is necessary for supporting public health programmes. This study provides a nationally representative prevalence estimate of HIVDR in people initiating antiretroviral therapy (ART) and estimates of acquired HIVDR and viral load (VL) suppression in people who have received it for 12 or ≥48 months in Vietnam. Methods The study was conducted between September 2017 and March 2018 following World Health Organization guidance. Thirty ART clinics were randomly sampled using probability proportional to size sampling from a total of 367 ART clinics in the country. Results and Discussion In total, 409 patients initiating ART were enrolled into the survey of pre‐treatment HIVDR. The prevalence of any pre‐treatment HIVDR was 5.8% (95% CI 3.4–9.5%), and the prevalence of non‐nucleoside reverse transcriptase inhibitor resistance was 3.4% (95% CI 1.8–6.2%). Four hundred twenty‐nine patients on ART for 12±3 months and 723 patients on ART for ≥48 months were enrolled into the surveys of acquired HIVDR. The prevalence of VL suppression (defined as <1000 copies/ml) in patients on ART for 12±3 and ≥48 months was 95.5% (95% CI 91.3–97.8%) and 96.1% (95% CI 93.2–97.8%), respectively. Among individuals with viral non‐suppression, any HIVDR was detected in 11/14 (weighted prevalence 74.3%) of those on ART for 12±3 months and in 24/27 (weighted prevalence 88.5%) of those receiving ART for ≥48 months. Conclusions This nationally representative study of HIVDR found high levels of VL suppression among those on ART for 12 and ≥48 months. Overall, high levels of VL suppression at both time points suggested good adherence among patients receiving ART and quality of treatment services in Vietnam. Clinical Trial Number Not applicable