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Although reports in adults suggest that breaks in sedentary time are associated with reduced cardiometabolic risk, these findings have yet to be replicated in children. To investigate whether objectively measured sedentary behavior, sedentary bouts or breaks in sedentary time are independently associated with cardiometabolic risk in a cohort of Canadian children aged 8-11 years with a family history of obesity. Data from 286 boys and 236 girls living in Quebec, Canada, with at least one biological parent with obesity (QUALITY cohort) were collected from 2005-2008, and analyzed in 2013. Sedentary behavior, light and moderate-to-vigorous physical activity were measured over 7 days using accelerometry. Leisure time computer/video game use and TV viewing over the past 7 days were self-reported. Outcomes included waist circumference, body mass index Z-score, fasting insulin, fasting glucose, triglycerides, HDL-cholesterol, C-reactive protein and a continuous cardiometabolic risk score. After adjustment for confounders, breaks in sedentary time and the number of sedentary bouts lasting 1-4 minutes were associated with reduced cardiometabolic risk score and lower BMI Z-score in both sexes (all p<0.05). The number of sedentary bouts lasting 5-9 minutes was negatively associated with waist circumference in girls only, while the number of bouts lasting 10-14 minutes was positively associated with fasting glucose in girls, and with BMI Z-score in boys (all p<0.05). Leisure time computer/video game use was associated with increased cardiometabolic risk score and waist circumference in boys, while TV viewing was associated with increased cardiometabolic risk, waist circumference, and BMI Z-score in girls (all p<0.05). These results suggest that frequent interruptions in sedentary time are associated with a favourable cardiometabolic risk profile and highlight the deleterious relationship between screen time and cardiometabolic risk among children with a family history of obesity.

Background The importance of muscular fitness (MF) in the performance of activities of daily living is unequivocal. Additionally, emerging evidence has shown MF can reduce cardiometabolic risk in children and adolescents. Objectives The purpose of this study was to examine and summarize the evidence regarding the relationship between MF phenotypes (i.e., maximum muscular strength/power, muscular endurance, and maximum muscular strength/power/endurance) and cardiometabolic variables (obesity, blood pressure, lipids, glucose homeostasis, inflammatory markers, and clustered cardiometabolic variables) in children and adolescents. Design This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and was registered with PROSPERO, number CRD42020179273. Data Sources A systematic review was performed on five databases (PubMed, EMBASE, SciELO, Scopus, and Web of Knowledge) from database inception to May 2020, with complementary searches in reference lists. Eligibility Criteria for Selecting Studies Eligibility criteria included (1) a study sample of youth aged ≤ 19 years, (2) an assessment of MF with individual or clustered cardiometabolic variables derived from adjusted models (regardless of test/measurement adopted or direction of reported association), and (3) a report of the association between both, using observational studies. Only original articles published in peer-reviewed journals in English, Portuguese, and Spanish languages were considered. The quality of the included studies was assessed by using the National Heart, Lung, and Blood Institute checklist. The percentage of results reporting a statistically significant inverse association between each MF phenotype and cardiometabolic variables was calculated. Results Of the 23,686 articles initially identified, 96 were included (77 cross-sectional and 19 longitudinal), with data from children and adolescents from 35 countries. The score for the quality of evidence ranged from 0.33 to 0.92 (1.00 maximum). MF assessed by maximum muscular strength/power was inversely associated with lower obesity (64/113 total results (56.6%)) and reduction in clustered cardiometabolic risk (28/48 total results (58.3%)). When assessed by muscular endurance, an inverse association with obesity (30/44 total results (68.1%)) and cardiometabolic risk (5/8 total results (62.5%)) was identified. Most of the results for the relationship between MF phenotypes with blood pressure, lipids, glucose homeostasis, and inflammatory markers indicated a paucity of evidence for these interrelationships (percentage of results below 50.0%). Conclusion MF assessed by maximum muscular strength/power or muscular endurance is potentially associated with lower obesity and lower risk related to clustered cardiometabolic variables in children and adolescents. There is limited support for an inverse association between MF with blood pressure, lipids, glucose homeostasis biomarkers, and inflammatory markers in children and adolescents.

Background A prominent gap in the literature is the lack of evidence from low-middle-income countries on the association between adherence to 24-Hour Movement Guidelines (physical activity, sleep, and screen time) and cardiometabolic risk factors among adolescents. This study examined the association between adherence to the 24-Hour Movement Guidelines and cardiometabolic risk factors among Brazilian adolescents. Methods The probabilistic sample consisted of 29,226 adolescents (60.5% females) aged 12 to 17 years. This school-based cross-sectional study was conducted across all geographical regions of Brazil. Body mass and height were measured to estimate body mass index. Waist circumference, blood pressure, and venous blood samples were collected to estimate fasting glucose, triglycerides, and HDL cholesterol. Cardiometabolic risk factors were classified according to International Diabetes Federation criteria. Data on 24-hour movement behaviors (moderate- to vigorous-intensity physical activity, sleep duration, and recreational screen time) were collected using a self-administered questionnaire and classified according to the Canadian 24-Hour Movement Guidelines. Binary logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI). Results For males, lower ORs for high blood pressure [OR: 0.34 (95%CI: 0.20–0.58)], high triglycerides [OR: 0.47 (0.28–0.78)], metabolic syndrome [OR: 0.36 (0.17–0.78)], and the presence of two [OR: 0.49 (0.32–0.58)] and ≥ 3 cardiometabolic risk factors [OR: 0.35 (0.15–0.80)] were observed in adolescents who met the 24-Hour Movement Guidelines compared to peers who did not meet the guidelines. For females, no association was found between adherence to 24-Hour Movement Guidelines and cardiometabolic risks. Conclusion Meeting 24-Hour Movement Guidelines was beneficial for reducing the odds of cardiometabolic risk factors in males.

The aims of this study were to estimate all-cause and cause-specific mortality and years of life lost, investigated by disability-adjusted life-years (DALYs), due to colorectal cancer attributable to physical inactivity in Brazil and in the states; to analyze the temporal trend of these estimates over 25 years (1990-2015) compared with global estimates and according to the socioeconomic status of states of Brazil. Databases from the Global Burden of Disease Study (GBD) for Brazil, Brazilian states and global information were used. It was estimated the total number and the age-standardized rates of deaths and DALYs for colorectal cancer attributable to physical inactivity in the years 1990 and 2015. We used the Socioeconomic Development Index (SDI). Physical inactivity was responsible for a substantial number of deaths (1990: 1,302; 2015: 119,351) and DALYs (1990: 31,121; 2015: 87,116) due to colorectal cancer in Brazil. From 1990 to 2015, the mortality and DALYs due to colorectal cancer attributable to physical inactivity increased in Brazil (0.6% and 0.6%, respectively) and decreased around the world (-0.8% and -1.1%, respectively). The Brazilian states with better socioeconomic indicators had higher rates of mortality and morbidity by colorectal cancer due to physical inactivity (p<0.01). Physical inactivity was responsible for deaths and DALYs due to colorectal cancer in Brazil. Over 25 years, the Brazilian population showed more worrisome results than around the world. Actions to combat physical inactivity and greater cancer screening and treatment are urgent in the Brazilian states.

Background The aim of this study was to estimate the mortality from all causes as a result of physical inactivity in Brazil and in Brazilian states over 28 years (1990–2017). Methods Data from the Global Burden of Disease (GBD) study for Brazil and states were used. The metrics used were the summary exposure value (SEV), the number of deaths, age-standardized mortality rates, and the fraction of population risk attributable to physical inactivity. Results The Brazilian population presented risk of exposure to physical inactivity of (age-standardized SEV) of 59% (95% U.I. 22–97) in 1990 and 59% in 2017 (95% U.I. 25–99). Physical inactivity contributed a significant number of deaths (1990, 22,537, 95% U.I. 12,157–34,745; 2017, 32,410, 95% U.I. 17,976–49,657) in the analyzed period. These values represented mortality rates standardized by age (per 100,000 inhabitants) of 31 (95% U.I. 17–48) in 1990 and 15 (95% U.I. 8–23) in 2017. From 1990 to 2017, a decrease in standardized death rate from all causes attributable to physical inactivity was observed in Brazil (− 52%, 95% U.I. − 54 to − 49). The Brazilian states with better socioeconomic conditions presented greater reductions in age-standardized mortality (male: rho = 0.80; female: rho 0.84) over the period of 28 years. Conclusions These findings support the promotion of physical activity in the Brazilian population for the prevention of early mortality.

Objective. The aim of this study was to identify the prevalence of excess television time and verify correlated factors in adolescent males and females. Methods. This cross-sectional study included 2,105 adolescents aged from 13 to 18 years from the city of Aracaju, Northeastern Brazil. Television time was self-reported, corresponding to the time spent watching television in a typical week. Several correlates were examined including age, skin color, socioeconomic status, parent education, physical activity level, consumption of fruits and vegetables, smoking status, alcohol use, and sports team participation. Results. The prevalence excess television time (≥2 hours/day) in girls and boys was 70.9% and 66.2%, respectively. Girls with low socioeconomic status or inadequate consumption of fruits and vegetables were more likely to have excess television time. Among boys, those >16 years of age or with black skin color were more likely to have excess television time. Conclusions. Excess television time was observed in more than two-thirds of adolescents, being more evident in girls. Correlated factors differed according to sex. Efforts to reduce television time among Brazilian adolescents, and replace with more active pursuits, may yield desirable public health benefits.

The aim of this study was to identify the relationship between health-related physical fitness components (aerobic fitness, muscle strength, flexibility, and body fat) and resting heart rate (RHR) in Brazilian adolescents. The study included 695 schoolchildren (14–19 years) from public schools of the city of São José, Brazil. RHR was evaluated using an automated oscillometric sphygmomanometer. Aerobic fitness was assessed by the modified Canadian Aerobic Fitness Test; muscle strength was measured by handgrip dynamometer; flexibility was assessed by the sit-and-reach test; and body fat was assessed indirectly by sum of two skinfold thicknesses (triceps and subscapular). Sociodemographic variables, habitual physical activity, sexual maturation, and body mass index were the covariates. Cardiorespiratory fitness (β = -0.11; 95%CI: -0.14, -0.08) and handgrip strength (β = -0.10; 95%CI: -0.18, -0.01) were inversely associated with RHR in boys. For girls, cardiorespiratory fitness (β = -0.09; 95%CI: -0.12, -0.06) was inversely associated with RHR. In both sexes, body fat (β = 0.50; 95%CI: 0.25, 0.75 for boys; β = 0.17; 95%CI: 0.36, 2.72 for girls) was directly associated with RHR. The RHR is measured more easily than the physical fitness tests, so it is recommended to assess adolescent’s heath in large surveillance systems.

The aims of this study were to estimate all-cause and cause-specific mortality and years of life lost, investigated by disability-adjusted life-years (DALYs), due to colorectal cancer attributable to physical inactivity in Brazil and in the states; to analyze the temporal trend of these estimates over 25 years (1990-2015) compared with global estimates and according to the socioeconomic status of states of Brazil. Databases from the Global Burden of Disease Study (GBD) for Brazil, Brazilian states and global information were used. It was estimated the total number and the age-standardized rates of deaths and DALYs for colorectal cancer attributable to physical inactivity in the years 1990 and 2015. We used the Socioeconomic Development Index (SDI). Physical inactivity was responsible for a substantial number of deaths (1990: 1,302; 2015: 119,351) and DALYs (1990: 31,121; 2015: 87,116) due to colorectal cancer in Brazil. From 1990 to 2015, the mortality and DALYs due to colorectal cancer attributable to physical inactivity increased in Brazil (0.6% and 0.6%, respectively) and decreased around the world (-0.8% and -1.1%, respectively). The Brazilian states with better socioeconomic indicators had higher rates of mortality and morbidity by colorectal cancer due to physical inactivity (p<0.01). Physical inactivity was responsible for deaths and DALYs due to colorectal cancer in Brazil. Over 25 years, the Brazilian population showed more worrisome results than around the world. Actions to combat physical inactivity and greater cancer screening and treatment are urgent in the Brazilian states.

Background The purpose of this study was to determine the validity of the SC-StepRx pedometer to assess moderate and vigorous physical activity during treadmill walking and running in a heterogeneous sample of children and youth aged 10-17 years. Methods Physical activity intensity assessed via indirect calorimetry served as the criterion standard. A convenience sample of 40 participants (20 boys, 20 girls) wore 6 SC-StepRx pedometers, 2 ActiGraph GT3X accelerometers, 2 Actical accelerometers, 1 Walk4Life MVP pedometer and 1 NL-1000 pedometer while walking/running at speeds approximating 2, 3, 4, 6 and 7 METs. Associations between indirect calorimetry and each activity monitor were assessed using linear regression analyses in SAS 9.2. Results Estimates of moderate and vigorous physical activity from all monitors were significantly associated with the criterion standard of indirect calorimetry. The strongest associations with the criterion measure were observed for the SC-StepRx with moderate/vigorous thresholds of 110/130 steps•minute −1 , and the NL-1000 (R 2  = 0.82, p <0.05). The SC-StepRx with moderate/vigorous thresholds of 110/130 steps•minute −1 also exhibited the highest combined sensitivity (92.9%) and specificity (96.5%) for correctly identifying a bout of moderate-to-vigorous physical activity. Conclusions This study demonstrates that the SC-StepRx pedometer is a valid tool for the measurement of moderate and vigorous physical activity in children and youth.

The aims of this study were as follows: to estimate the mortality and years of life lost, assessed by disability-adjusted life years (DALYs), due to breast cancer attributable to physical inactivity in Brazilian women; to compare the estimates attributable to physical inactivity and to other modifiable risk factors; and to analyse the temporal evolution of these estimates within Brazilian states over 25 years (1990–2015), compared with global estimates. Databases from the Global Burden of Disease Study for Brazil, Brazilian states, and other parts of the world were used. Physical inactivity has contributed to a substantial number of deaths (1990: 875; 2015: 2,075) and DALYs (1990: 28,089; 2015: 60,585) due to breast cancer in Brazil. Physical inactivity was responsible for more deaths and DALYs (~12.0%) due to breast cancer than other modifiable risk factors (~5.0%). The Brazilian states with better socioeconomic indicators had higher age-standardized rates of mortality and morbidity due to breast cancer attributable to physical inactivity. From 1990 to 2015, mortality due to breast cancer attributable to physical inactivity increased in Brazil (0.77%; 95%U.I.: 0.27–1.47) and decreased (−2.84%; 95%U.I.: −4.35 – −0.10) around the world. These findings support the promotion of physical activity in the Brazilian female population to prevent and manage breast cancer.