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Relativistic reflection features are commonly observed in the X-ray spectra of accreting black holes. In the presence of high quality data and with the correct astrophysical model, X-ray reflection spectroscopy can be quite a powerful tool to probe the strong gravity region, study the morphology of the accreting matter, measure black hole spins, and possibly test Einstein’s theory of general relativity in the strong field regime. In the last decade, there has been significant progress in the development of the analysis of these features, thanks to more sophisticated astrophysical models and new observational facilities. Here we review the state-of-the-art in relativistic reflection modeling, listing assumptions and simplifications that may affect, at some level, the final measurements and may be investigated better in the future. We review black hole spin measurements and the most recent efforts to use X-ray reflection spectroscopy for testing fundamental physics.

The ultraluminous X-ray source CXO J133815.6+043255 is a strong candidate for a bona fide intermediate-mass black hole residing in the outskirts of NGC 5252. We present 22 GHz radio observations of this source obtained serendipitously in an ongoing high-frequency imaging survey of radio-quiet Active Galactic Nuclei (AGNs), and use this new data point to construct the broadband radio spectral energy distribution (SED). We find that the SED exhibits a spectral slope of α = −0.66 ± 0.02, consistent with a steep spectrum from optically thin synchrotron emission from an unresolved jet. We also find that the L R/L X ratio is approximately 10−3, inconsistent with radio-quiet AGN and many ULXs but consistent with low-luminosity AGN and radio-loud quasars. Together, these observations support the conclusion that CXO J133815.6+043255 is an intermediate-mass black hole producing a low-mass analog of radio jets seen in classical quasars.

Kaluza–Klein theory is a popular alternative theory of gravity, with both non-rotating and rotating black hole solutions known. This allows for the possibility that the theory could be observationally tested. We present a model which calculates the reflection spectrum of a black hole accretion disk system, where the black hole is described by a rotating solution of the Kaluza–Klein theory. We also use this model to analyze X-ray data from the stella-mass black hole in GRS 1915+105 and provide constraints on the free parameters of the Kaluza–Klein black holes.

Increased levels of pro-inflammatory cytokines have been reported in postmortem brain samples and in the blood of depressed subjects. However, the inflammatory pathways that lead to depressive-like symptoms are not well understood. Using the learned helplessness (LH) model of depression, we examined the role of C1q, the initiator of classical complement pathway in mediating stress-induced depressive-like behavior in mice. We observed no significant changes in social behavior, despair behavior, spatial memory, and aggressive behavior between the wild type (WT) and C1q knockout (KO) mice. However, C1q deletion exacerbated the inescapable electric foot shock-induced learned helplessness behavior in mice. We found significant reductions in C1q mRNA levels in the prefrontal cortex (PFC) of WT helpless mice as compared to the naïve mice. Increased levels of pro-inflammatory cytokines were found in the PFC of C1q KO mice. These findings suggest that classical complement pathway-mediated learned helplessness behavior is accompanied by neuroinflammatory changes under stressful conditions.

The study estimates the contribution of changes in world prices, exchange rates, and trade policies in explaining the variability of domestic prices under the scenario of incomplete transmission of changes and a counterfactual scenario of complete pass-through. We utilize data from the Indian wheat market for the period 2006–09 and 2017–20. The findings reveal an improvement in the pass-through of changes from the landed price to domestic markets. The price transmission elasticity increased from 50% in 2006/07–2008/09 to 67% during 2017/18–2019/20. The policy response to rising (declining) global prices of decreasing (increasing) import tariffs had a significant effect on prices. The variation in exchange rate offsets the impact of declining or rising global prices on domestic prices.

Chronic stress is a major risk factor in the pathophysiology of many neuropsychiatric disorders. Further, chronic stress conditions can promote neuroinflammation and inflammatory responses in both humans and animal models. Type I interferons (IFN-I) are critical mediators of the inflammatory response in the periphery and responsible for the altered mood and behavior. However, the underlying mechanisms are not well understood. In the present study, we investigated the role of IFN-I signaling in chronic stress-induced changes in neuroinflammation and behavior. Using the chronic restraint stress model, we found that chronic stress induces a significant increase in serum IFNβ levels in mice, and systemic blockade of IFN-I signaling attenuated chronic stress-induced infiltration of macrophages into prefrontal cortex and behavioral abnormalities. Furthermore, complement component 3 (C3) mediates systemic IFNβ-induced changes in neuroinflammation and behavior. Also, we found significant increases in the mRNA expression levels of IFN-I stimulated genes in the prefrontal cortex of depressed suicide subjects and significant correlation with C3 and inflammatory markers. Together, these findings from animal and human postmortem brain studies identify a crucial role of C3 in IFN-I-mediated changes in neuroinflammation and behavior under chronic stress conditions.

This study examines the impact of India's wheat export ban on the domestic wheat market amid the 2022 food price crisis. Study uses nonlinear autoregressive distributed lag (NARDL) approach. Findings show an asymmetric transmission of changes in global prices to domestic prices in the long and short run under an open trade regime. The transmission elasticity for positive changes in world wheat prices is 53 percentage points higher than that of a negative change in world wheat prices. We found a symmetric relationship between the world and domestic wholesale wheat prices in the export-restricted regime. Export ban was not successful in curbing rise in wheat price increases.

Iron-sulfur (Fe-S) cluster proteins carry out essential cellular functions in diverse organisms, including the human pathogen Mycobacterium tuberculosis ( Mtb ). The mechanisms underlying Fe-S cluster biogenesis are poorly defined in Mtb . Here, we show that Mtb SufT (Rv1466), a DUF59 domain-containing essential protein, is required for the Fe-S cluster maturation. Mtb SufT homodimerizes and interacts with Fe-S cluster biogenesis proteins; SufS and SufU. SufT also interacts with the 4Fe-4S cluster containing proteins; aconitase and SufR. Importantly, a hyperactive cysteine in the DUF59 domain mediates interaction of SufT with SufS, SufU, aconitase, and SufR. We efficiently repressed the expression of SufT to generate a SufT knock-down strain in Mtb (SufT-KD) using CRISPR interference. Depleting SufT reduces aconitase’s enzymatic activity under standard growth conditions and in response to oxidative stress and iron limitation. The SufT-KD strain exhibited defective growth and an altered pool of tricarboxylic acid cycle intermediates, amino acids, and sulfur metabolites. Using Seahorse Extracellular Flux analyzer, we demonstrated that SufT depletion diminishes glycolytic rate and oxidative phosphorylation in Mtb . The SufT-KD strain showed defective survival upon exposure to oxidative stress and nitric oxide. Lastly, SufT depletion reduced the survival of Mtb in macrophages and attenuated the ability of Mtb to persist in mice. Altogether, SufT assists in Fe-S cluster maturation and couples this process to bioenergetics of Mtb for survival under low and high demand for Fe-S clusters.

We present X-ray intraday variability, cross-correlated variability, and power spectrum density analysis of the binary black hole blazar candidate OJ 287. The X-ray pointed observations of the source were carried out on eight occasions by the EPIC-pn camera on board the XMM-Newton satellite from 2005 November to 2022 November. The good time intervals range between 3.6 and 24.1 hr. Three energy bands—0.2–2 keV (soft), 2–10 keV (hard), and 0.2–10 keV (total)—have been used to estimate variability. Low amplitude variations are observed in four, five, and six light curves in soft, hard, and total energy bands, respectively. Only two observation IDs have shown variation in the all energy bands. The discrete correlation function of the light curves in soft and hard energy bands peaks at zero lag, suggesting that the emission in both bands was cospatial and came from the same population of leptons. Red noise dominates the power spectral densities of variable light curves. According to our flux and spectrum investigations, both particle acceleration and synchrotron cooling mechanisms contribute significantly to the emission from this blazar.

Inflammation and synapse loss have been associated with deficits in social behavior and are involved in pathophysiology of many neuropsychiatric disorders. Synapse loss, characterized by reduction in dendritic spines can significantly disrupt synaptic connectivity and neural circuitry underlying social behavior. Chronic stress is known to induce loss of spines and dendrites in the prefrontal cortex (PFC), a brain region implicated in social behavior. However, the underlying mechanisms are not well understood. In the present study, we investigated the role of type I Interferon (IFN-I) signaling in chronic unpredictable stress (CUS)-induced synapse loss and behavior deficits in mice. We found increased expression of type I IFN receptor (IFNAR) in microglia following CUS. Conditional knockout of microglial IFNAR in adult mice rescued CUS-induced social behavior deficits and synapse loss. Bulk RNA sequencing data show that microglial IFNAR deletion attenuated CUS-mediated changes in the expression of genes such as Keratin 20 (Krt20), Claudin-5 (Cldn5) and Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) in the PFC. Cldn5 and Nr4a1 are known for their roles in synaptic plasticity. Krt20 is an intermediate filament protein responsible for the structural integrity of epithelial cells. The reduction in Krt20 following CUS presents a novel insight into the potential contribution of cytokeratin in stress-induced alterations in neuroplasticity. Overall, these results suggest that microglial IFNAR plays a critical role in regulating synaptic plasticity and social behavior deficits associated with chronic stress conditions.