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In high-dimensional data analysis, Feature Selection (FS) is one of the most fundamental issues in machine learning and requires the attention of researchers. These datasets are characterized by huge space due to a high number of features, out of which only a few are significant for analysis. Thus, significant feature extraction is crucial. There are various techniques available for feature selection; among them, the filter techniques are significant in this community, as they can be used with any type of learning algorithm and drastically lower the running time of optimization algorithms and improve the performance of the model. Furthermore, the application of a filter approach depends on the characteristics of the dataset as well as on the machine learning model. Thus, to avoid these issues in this research, a combination of feature reduction (CFR) is considered designing a pipeline of filter approaches for high-dimensional microarray data classification. Considering four filter approaches, sixteen combinations of pipelines are generated. The feature subset is reduced in different levels, and ultimately, the significant feature set is evaluated. The pipelined filter techniques are Correlation-Based Feature Selection (CBFS), Chi-Square Test (CST), Information Gain (InG), and Relief Feature Selection (RFS), and the classification techniques are Decision Tree (DT), Logistic Regression (LR), Random Forest (RF), and k-Nearest Neighbor (k-NN). The performance of CFR depends highly on the datasets as well as on the classifiers. Thereafter, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method is used for ranking all reduction combinations and evaluating the superior filter combination among all.

Globally, cancer stands as the second leading cause of mortality. Various strategies have been proposed to address this issue, with a strong emphasis on utilizing gene expression data to enhance cancer detection methods. However, challenges arise due to the high dimensionality, limited sample size relative to its dimensions, and the inherent redundancy and noise in many genes. Consequently, it is advisable to employ a subset of genes rather than the entire set for classifying gene expression data. This research introduces a model that incorporates Ranked-based Filter (RF) techniques for extracting significant features and employs Extreme Learning Machine (ELM) for data classification. The computational cost of using RF technique over high dimensional data is low. However extraction of significant genes using one or two stage of reduction is not effective. Thus, a 4-stage feature reduction strategy is applied. The reduced data is then utilized for classification using few variants of ELM model and activation function. Subsequently, a two-stage grading approach is implemented to determine the most suitable classifier for data classification. This analysis is conducted over four microarray gene expression data using four activation function with seven learning based classifiers, from which it is shown that II-ELM classifier outperforms in terms of performance matrix and ROC graph.