Explore the vast range of titles available.

Transgender women face a serious risk of HIV infection. Despite this, there is limited knowledge and use of Pre-exposure prophylaxis (PrEP). We measured the continuity of prevention across services in the PrEP cascade and correlates of PrEP use among trans women in San Francisco enrolled in the 2019/20 National HIV Behavioral Surveillance Study. Knowledge and use of PrEP among trans women in San Francisco increased in recent years; almost all (94.0%) had heard about PrEP, 64.7% had discussed PrEP with a healthcare provider, and 44.8% had taken PrEP in the past 12 months. PrEP use was associated with participation in a PrEP demonstration project (aOR = 31.44, p = 0.001) and condomless receptive anal intercourse (aOR = 3.63, p = 0.024). Injection drug use was negatively associated (aOR = 0.19, p = 0.014). Efforts are needed to combat the gender-based stigma and discrimination faced by trans women, which can result in avoidance and mistrust of the medical system.

Background To determine if improvements in social determinants of health for trans women and decreases in transphobic discrimination and violence occurred over three study periods during which extensive local programs were implemented to specifically address longstanding inequities suffered by the transgender community. Methods Interviewer-administered surveys from repeated cross-sectional Transwomen Empowered to Advance Community Health (TEACH) studies in 2010, 2013 and 2016-2017 in San Francisco collected experiences with transphobia violence and discrimination. Respondent-driven sampling was used to obtain a sample of participants who identified as a trans woman. Results Violence due to gender identity was prevalent; in each study period, verbal abuse or harassment was reported by over 83% of participants, and physical abuse or harassment was reported by over 56%. Adverse social determinants of health including homelessness, living below the poverty limit, methamphetamine use, depression, PTSD, and anxiety all significantly increased from 2010 to 2016. When testing for trends, housing discrimination and physical violence were both more likely in 2016-2017 compared to the two earlier study periods. Housing discrimination (aOR 1.41, 95% CI 1.00-1.98) and physical violence due to gender identity/presentation (aOR 1.39, 95% CI 1.00-1.92) both significantly increased from 2010 to 2016. Conclusion Our findings are particularly alarming during a period when significant public health resources and community-based initiatives specifically for trans women were implemented and could have reasonably led us to expect improvements. Despite these efforts, physical violence and housing discrimination among trans women worsened during the study periods. To ensure future improvements, research and interventions need to shift the focus and burden from trans people to cisgender people who are the perpetuators of anti-trans sentiment, stigma, discrimination and victimization.

Digital technology is an important tool for engaging and delivering care to and for young people living with HIV. This research letter examines how 120 out-of-care young people living with HIV in San Francisco use digital technology, the attitudes they have toward technology, and the anxiety they feel about being without technology. Our findings emphasize the importance of being aware of the unintended consequences of digital health interventions.

Background: The HIV epidemic has revealed considerable disparities in health among sexual and gender minorities of color within the Unites States, disproportionately affecting cisgender men who have sex with men (MSM) and trans women. Social inequities further disadvantage those with intersectional identities through homophobia, antitrans discrimination, and racism, shaping not only those at risk for HIV infection but also HIV prevention and care outcomes. Digital interventions have great potential to address barriers and improve HIV care among cisgender MSM and trans women; however, efficacy of digital HIV care interventions vary and need further examination. Objective: This study assessed the 12-month efficacy of a 6-month digital HIV care navigation intervention among young people living with HIV in San Francisco, California. We examined dose-response relationships among intervention exposure (eg, text messaging), viral suppression, and mental health. Health electronic navigation (eNav) is a 6-month, text message–based, digital HIV care navigation intervention, in which young people living with HIV are connected to their own HIV care navigator through text messaging to improve engagement in HIV primary care. Methods: This study had a single-arm, prospective, pre-post design. Eligibility criteria for the study included the following: identifying as cisgender MSM or trans women, being between the ages of 18 and 34 years, being newly diagnosed with HIV, or not being engaged or retained in HIV care or having a detectable viral load. We assessed and analyzed sociodemographics, intervention exposure, and HIV care and mental health outcome data for participants who completed the 6-month Health eNav intervention. We assessed all outcomes using generalized estimating equations to account for within-subjects correlation, and marginal effects of texting engagement on all outcomes were calculated over the entire 12-month study period. Finally, we specified an interaction between texting engagement and time to evaluate the effects of texting engagement on outcomes. Results: Over the entire 12-month period, this study shows that every one-text increase in engagement was associated with an increased odds of undetectable viral load (adjusted odds ratio 1.01, 95% CI 1.00-1.02; P=.03). Mean negative mental health experiences decreased significantly at 12 months compared to baseline for every one-text increase in engagement (coefficient on interaction term 0.97, 95% CI 0.96-0.99; P<.01). Conclusions: Digital care navigation interventions including Health eNav may be a critical component in the health delivery service system as the digital safety net for those whose social vulnerability is exacerbated in times of crisis, disasters, or global pandemics owing to multiple social inequities. We found that increased engagement in a digital HIV care navigation intervention helped improve viral suppression and mental health—intersecting comorbid conditions—6 months after the intervention concluded. Digital care navigation may be a promising, effective, sustainable, and scalable intervention. International Registered Report Identifier (IRRID): RR2-10.2196/16406

Introduction Little is known about differences in HIV risk for trans women by partner gender, particularly with respect to social determinants of health and partner-level factors that affect behavior. We examined differences in demographic, social determinants, and HIV-related risk behaviors for trans women with cisgender men and trans women sexual partners. Materials and methods Data are from a cross-sectional survey of trans women and their sexual partners conducted between April 2020 and January 2021. Interviews were held remotely via videoconference during shelter-in-place ordinances due to the Covid-19 pandemic. This analysis characterized associations between HIV risk and preventive behaviors comparing trans women with cisgender men partners to trans women with trans women partners. Results A total of 336 sexual partners were identified from 156 trans women. Trans women with cisgender men partners were significantly more likely to be from racial/ethnic minority populations and all Black/African American and Latina trans women participants had cisgender men partners only. Trans women with cisgender men partners had significantly less education and employment and more incarceration and recidivism than trans women with trans women partners. Trans women and their cisgender men partners had shared experiences of unstable housing, incarceration, and HIV. Trans women with cisgender men partners reported significantly more sex exchange partners, receptive condomless sex, and HIV compared to trans women with trans women partners. Conclusions Trans women with cisgender men sexual partners faced higher HIV risk than trans women with trans women sexual partners. These risks may be related to the social and economic drivers that both trans women and their cisgender men partners faced, namely structural racism that may explain barriers to education and employment, along with incarceration and recidivism. Interventions focused on economic stability, workforce development and post incarceration re-entry housing and employment support for trans women and their cisgender men partners may have the most impact on reducing HIV risk and incidence.

Trans women have been understudied in the Hepatitis C virus (HCV) epidemic, yet data suggest they may be at elevated risk of the disease. Using data collected from the Centers for Disease Control and Prevention’s (CDC) National HIV Behavioral Surveillance (NHBS) survey, we measured HCV seropositivity, viremia, and associated risk factors for HCV infection among trans women in San Francisco from June 2019 to February 2020. Respondent-driven sampling (RDS) was used to obtain a diverse, community-based sample of 201 trans women, of whom 48 (23.9%, 95% CI 17.9% - 30.0%) were HCV seropositive. HCV seropositivity significantly increased with increasing age (adjusted prevalence ratio [APR] 1.04 per year, 95% CI 1.01–1.07) and history of injection drug use (APR 4.44, 95% CI 2.15–9.18). We also found that many had HCV viremia as twelve (6.0% of the total sample, 95% CI 2.7% - 9.3%) were RNA-positive for HCV. Trans women are highly impacted by HCV and could benefit from access to regular and frequent HCV screening and treatment access. HCV screening could be offered regularly in trans-specific health services, in the community, in jails and prisons, and integrated syringe exchange programs where treatment access or referral are also available.

Despite high HIV prevalence, the reasons trans women acquire HIV are not well understood. Trans women are often mis-classified or aggregated with men who have sex with men (MSM) in epidemiologic studies and HIV surveillance data. Trans women enrolled in the 2019/2020 National HIV Behavioral Surveillance Study in San Francisco were asked an open-ended question about how they were infected with HIV. The most common responses were “Sex with a straight cisgender man partner when the respondent identified as a trans woman” (43.0%); “Sexual assault” (13.9%); “Injection drug use (IDU)” (10.1%); “IDU or sexual contact” (7.6%) and “Sex with a partner who injected drugs” (7.6%). Sex with a cisgender man partner prior to identifying as a trans women (MSM contact) was not mentioned by any respondent. HIV prevention strategies targeting MSM will fail to reach trans women and many of their cisgender men partners.

Motivational interviewing (MI) is a counseling approach to facilitate behavior change. MI has been widely applied to in-person–delivered, health behavior change interventions; however, mobile health (mHealth) interventions are beginning to adopt and expand the reach of MI in health promotion practice with the use of mobile phones and digital platforms. This study examines whether the use of MI skills (e.g., OARS [open-ended questions, affirmations, reflective listening, and summaries]) promotes change talk in an SMS text messaging intervention for young people living with HIV in San Francisco. We undertake a novel method of analyzing text message intervention data in order to characterize the microprocesses of change talk. Data were collected via computer-assisted self-interviewing surveys of self-reported sociodemographic information, and two-way text messages facilitated by a digital HIV care navigator during the 6-month intervention. We qualitatively assessed all text messages exchanged for the utilization of four basic MI skills on the part of the interventionist (OARS) and participant change talk. This study found that high levels of all four MI skills—and moderate levels of open-ended questions only—were associated with more change talk compared to low levels. Additionally, using three or more MI skills was associated with change talk. Future research is needed to inform how to analyze large amounts of data passively collected as a native part of implementing mHealth and text messaging applications of MI interventions.

Black and Latino men who have sex with men (MSM) face disproportionately high rates of HIV in the United States, yet uptake of pre-exposure prophylaxis (PrEP), a highly effective HIV prevention medication, remains critically low in these communities. Paying people money or rewards to take PrEP, is a strategy called conditional cash transfers (CCTs), and they have shown promise in HIV prevention globally, but no research has asked Black and Latino MSM what kind of CCT interventions they would actually want, or whether their sexual health history and life circumstances shape those preferences.Data were drawn from the Incentives and Prevention Study (TIPS), a pilot study conducted in Los Angeles County with 133 Black and Latino MSM. Three interconnected studies are presented. Study One used in-depth interviews with 20 participants to explore how Black and Latino MSM felt about the idea of a PrEP-based CCT, whether it felt worth it, burdensome, or likely to work. Studies Two and Three used a discrete choice experiment (DCE), a method in which participants repeatedly chose between hypothetical CCT intervention designs to reveal which features mattered most, examining whether participant’s PrEP use status and housing stability shaped those preferences.Study One found broad support for PrEP-based CCTs and identified specific burdens to participating in a PrEP-based CCT such as stigma, access barriers, and medical mistrust that varied by race/ethnicity and PrEP experience. Study Two found that Black and Latino MSM regardless of whether they were currently using PrEP or not strongly preferred higher payment amounts, more frequent payments, and cash over gift cards, with PrEP type playing a minimal role in their choices. The one stand out difference was that current PrEP users placed a stronger preference for higher payment amounts compared to non-PrEP users, suggesting that Black and Latino MSM already engaged in HIV prevention may respond more strongly to financial incentives to further sustain their engagement with HIV prevention. Study Three found that housing stability did not change these preferences, with Black and Latino MSM in both stable and unstable housing wanting the same program design.These findings challenge a common assumption in HIV prevention — that programs must be extensively tailored by subgroups to be effective. The data show that when it comes to CCT intervention design for increasing PrEP use, Black and Latino MSM want the same things regardless of their PrEP history or housing situation. What requires consideration and tailoring is the implementation itself — accessible locations to participate, flexible hours, transportation support, and culturally grounded outreach. This dissertation is among the first to rigorously explore CCT intervention acceptability and examine CCT design preferences among this population, and its findings provide direct evidence how to design CCT interventions that improve PrEP use. That evidence is essential for HIV prevention organizations, programs, and local jurisdictions considering utilizing financial incentives as a strategy to improve HIV prevention outcomes. To be effective, these programs must be financially meaningful, accessible, and built with the community at the center. Limitations include a relatively small sample from Los Angeles County, which constrains the generalizability to other geographic settings and broader communities at risk for HIV. The sample size also limits the statistical power for the quantitative analyses, meaning that some real differences in CCT design preference across subgroups may exist but were too small to detect with the number of participants enrolled. Therefore, these findings should be interpreted as initial and exploratory evidence.

Transgender women (hereafter \"trans women\") face social marginalization, stigma, and discrimination and experience a high burden of HIV. More recently, trans women have been identified as having a high risk for hepatitis C (HCV) infection. The interaction between these two diseases and the risks for HIV/HCV co-infection among trans women are understudied. To characterize epidemiological, behavioral, and socio-structural interactions between HIV and HCV infections among trans women. This cross-sectional study examined data from a community-based survey of trans women in San Francisco recruited through respondent-driven sampling (RDS) in 2019/2020. Face-to-face interviews collected data on demographics, medical history, drug injection practices, sexual behavior, and socio-structural factors (e.g., poverty, housing insecurity, incarceration, social support). HIV and HCV antibodies were detected using oral fluid rapid tests and prior diagnosis and treatment were collected by self-report. Blood specimens were collected to confirm antibodies using ELISA. Multinomial logistic regression analysis characterized factors associated with HIV infection alone, HCV infection alone, and HIV/HCV co-infection compared to neither infection. Among 201 trans women recruited, HIV prevalence was 42.3%; HCV infection by history or current seroprevalence was 28.9%; evidence for both HIV and HCV infection was present for 18.9%. Two-thirds of trans women (67.2%) had been incarcerated; 30.8% had ever injected drugs. History of injection drug use and receiving emotional support from family were factors found in common for HIV infection, HCV infection, and HIV/HCV co-infection compared to no infection. Having a sexual partner who injects drugs was associated with HIV infection alone. Not lacking care due to cost and older age were associated with co-infection. Older age was also associated with HCV infection. Of trans women with HIV infection, 91.8% had accessed HIV care, whereas only 62% with HCV had accessed some form of care. Our study found high levels of HIV, HCV, and HIV/HCV co-infection among trans women in San Francisco. We found common associations between HIV and HCV through injection practices and emotional support, but having a sexual partner who injects drugs was not associated with HCV infection alone or co-infection. We note a substantial gap in the treatment of HCV for trans women, including those in HIV care, that needs to be urgently addressed.